*  Agrin
Since agrin fragments induce acetylcholine receptor aggregation as well as phosphorylation of the MuSK receptor, researchers ... Agrin is named based on its involvement in the aggregation of acetylcholine receptors during synaptogenesis. In humans, this ... The receptor that seems to be required for formation of the neuromuscular junction (NMJ) is called the MuSK receptor (Muscle ... The nerve secretes agrin, resulting in phosphorylation of the MuSK receptor. It seems that the MuSK receptor recruits casein ...
*  MuSK protein
"Casein kinase 2-dependent serine phosphorylation of MuSK regulates acetylcholine receptor aggregation at the neuromuscular ... "Auto-antibodies to the receptor tyrosine kinase MuSK in patients with myasthenia gravis without acetylcholine receptor ... MuSK (for Muscle-Specific Kinase) is a receptor tyrosine kinase required for the formation and maintenance of the neuromuscular ... of acetylcholine receptors (AChR). Both CK2 and Dok-7 are required for MuSK-induced formation of the neuromuscular junction, ...
*  Platelet
Aggregation begins minutes after activation, and occurs as a result of turning on the GPIIb/IIIa receptor, allowing these ... Third, they connect to each other through receptor bridges: aggregation. Formation of this platelet plug (primary hemostasis) ... These receptors trigger intraplatelet signaling, which converts GPIIb/IIIa receptors to their active form to initiate ... Platelet GP1b-IX-V receptor binds with VWF; and GPVI receptor and integrin alpha2beta1 bind with collagen. The intact ...
*  Glanzmann's thrombasthenia
... which is an integrin aggregation receptor on platelets. This receptor is activated when the platelet is stimulated by ADP, ... aggregation). In contrast, glycoproteinIb receptors are normal with Glanzmann's thrombasthenia. The role of GpIb is to enable ... GpIb receptors are deficient in a disease known as Bernard-Soulier syndrome. Understanding of the role of GpIIb/IIIa in ... Platelet aggregation is normal with ristocetin, but impaired with other agonists such as ADP, thrombin, collagen or epinephrine ...
*  Jeffrey Scott Flier
Kahn, CR; Baird, KL; Jarrett, DB; Flier, JS (1978). "Direct demonstration that receptor crosslinking or aggregation is ... Harrison, L.; Flier, J; Itin, A; Kahn, C.; Roth, J (1979). "Radioimmunoassay of the insulin receptor: a new probe of receptor ... "Direct demonstration that receptor crosslinking or aggregation is important in insulin action". Proceedings of the National ... Moller, David E.; Flier, Jeffrey S. (1988). "Detection of an Alteration in the Insulin-Receptor Gene in a Patient with Insulin ...
*  Lymphocyte antigen 96
... leading to Toll-like receptor-4 aggregation and signal transduction". The Journal of Biological Chemistry. 278 (48): 48313-20. ... Abreu MT, Vora P, Faure E, Thomas LS, Arnold ET, Arditi M (August 2001). "Decreased expression of Toll-like receptor-4 and MD-2 ... Ohnishi T, Muroi M, Tanamoto K (May 2003). "MD-2 is necessary for the toll-like receptor 4 protein to undergo glycosylation ... Dziarski R, Wang Q, Miyake K, Kirschning CJ, Gupta D (February 2001). "MD-2 enables Toll-like receptor 2 (TLR2)-mediated ...
*  Fas receptor
Upon ensuing death domain (DD) aggregation, the receptor complex is internalized via the cellular endosomal machinery. This ... The Fas receptor is a death receptor on the surface of cells that leads to programmed cell death (apoptosis). It is one of two ... FAS receptor is located on the long arm of chromosome 10 (10q24.1) in humans and on chromosome 19 in mice. The gene lies on the ... Apoptosis-inducing Fas receptor is dubbed isoform 1 and is a type 1 transmembrane protein. Many of the other isoforms are rare ...
*  N-Formylmethionine
"Aggregation of complement receptors on human neutrophils in the absence of ligand". The Journal of Cell Biology. 105 (3): 1137- ... Formyl peptide receptor 1 Formyl peptide receptor 2 Formyl peptide receptor 3 Sherman F, Stewart JW, Tsunasawa S (July 1985). " ... formyl peptide receptor 1 (FPR1) and formyl peptide receptor 2 (FPR2) G protein coupled receptors (see also formyl peptide ... Immunology at MCG 1/phagstep "The Innate Immune System: Pattern-Recognition Receptors, Antigen-Nonspecific Antimicrobial Body ...
*  Adenosine diphosphate
P2Y1 receptors initiate platelet aggregation and shape change as a result of interactions with ADP. P2Y12 receptors further ... ADP interacts with a family of ADP receptors found on platelets (P2Y1, P2Y12, and P2X1), which leads to platelet activation. ... ISBN 0-07-121766-5. Murugappa S, Kunapuli SP (2006). "The role of ADP receptors in platelet function". Front. Biosci. 11: 1977- ... inhibiting further platelet activation via adenosine receptors. Nucleoside Nucleotide DNA RNA Oligonucleotide Apyrase Phosphate ...
*  CpG Oligodeoxynucleotide
Wu, CC; Lee, J; Raz, E; Corr, M; Carson, DA (2004). "Necessity of oligonucleotide aggregation for toll-like receptor 9 ... The CpG PAMP is recognized by the pattern recognition receptor (PRR) Toll-Like Receptor 9 (TLR9), which is constitutively ...
*  Protopine
It has been found to inhibit histamine H1 receptors and platelet aggregation, and acts as an analgesic. Protopine 6- ...
*  LDL-receptor-related protein-associated protein
It acts to inhibit the binding of all known ligands for these receptors, and may prevent receptor aggregation and degradation ... "39 kDa receptor-associated protein is an ER resident protein and molecular chaperone for LDL receptor-related protein". The ... "The 39-kDa receptor-associated protein interacts with two members of the low density lipoprotein receptor family, alpha 2- ... prevents ligand-induced ER retention and degradation of LDL receptor-related endocytic receptors". The EMBO Journal. 15 (11): ...
*  Disintegrin
... s act as receptor antagonists, inhibiting aggregation induced by ADP, thrombin, platelet-activating factor and ... They interact with the beta-1 and -3 families of integrins receptors. Integrins are cell receptors involved in cell-cell and ... sequence motif that binds specifically to integrin IIb-IIIa receptors on the platelet surface, thereby blocking the binding of ... endogenous inhibitor of platelet adhesion and aggregation. ADAM Protein Evolution of snake venom McLane MA, Sanchez EE, Wong A ...
*  GPR37
"Suppressive effects of 4-phenylbutyrate on the aggregation of Pael receptors and endoplasmic reticulum stress". J. Neurochem. ... "Entrez Gene: GPR37 G protein-coupled receptor 37 (endothelin receptor type B-like)". Imai Y, Soda M, Hatakeyama S, Akagi T, ... Zeng Z, Su K, Kyaw H, Li Y (1997). "A novel endothelin receptor type-B-like gene enriched in the brain". Biochem. Biophys. Res ... Probable G-protein coupled receptor 37 is a protein that in humans is encoded by the GPR37 gene. GPR37 has been shown to ...
*  Cyclic AMP receptors
In D. discoideum, the cyclic AMP receptors coordinate aggregation of individual cells into a multicellular organism, and ... Cyclic AMP receptors from slime molds are a distinct family of G-protein coupled receptors. These receptors control development ... cAMP receptor protein Devreotes PN, Kimmel AR, Johnson RL, Klein PS, Sun TJ, Saxe III CL (1988). "A chemoattractant receptor ... Ginsburg GT, Louis JM, Johnson R, Devreotes PN, Kimmel AR, Saxe III CL (1993). "CAR2, a prestalk cAMP receptor required for ...
*  Scaffold protein
Round, J.L., et al., Dlgh1 coordinates actin polymerization, synaptic T cell receptor and lipid raft aggregation, and effector ... Xiao, B., J.C. Tu, and P.F. Worley, Homer: a link between neural activity and glutamate receptor function. Curr Opin Neurobiol ... Round, J.L., et al., Scaffold protein Dlgh1 coordinates alternative p38 kinase activation, directing T cell receptor signals ... IRAK-tumor necrosis factor receptor-associated factor 6 (TRAF6) complex. J Biol Chem, 2003. 278(13): p. 10952-6. Yu, K.Y., et ...
*  Multiple electrode aggregometry
Activation of the P2Y1 receptor initiates platelet aggregation in response to ADP. The P2Y1 receptor is required for ADP- ... Fibrinogen then binds to the receptors, crosslinking several platelets and causing aggregation. Aggregation in TRAPtest may be ... Thrombin receptor activating peptide-6 (TRAP-6) activates platelets through the thrombin receptor protease activated receptor-1 ... Binding of fibrinogen to GPIIb/IIIa receptors leads to platelet-to-platelet bridges and results in platelet aggregation. ...
*  PTPN7
Swieter M, Berenstein EH, Swaim WD, Siraganian RP (1995). "Aggregation of IgE receptors in rat basophilic leukemia 2H3 cells ... This PTP was shown to be involved in the regulation of T cell antigen receptor (TCR) signaling, which was thought to function ... Protein tyrosine phosphatase non-receptor type 7 is an enzyme that in humans is encoded by the PTPN7 gene. The protein encoded ... Saxena M, Williams S, Gilman J, Mustelin T (1998). "Negative regulation of T cell antigen receptor signal transduction by ...
*  Fas ligand
Upon ensuing death domain (DD) aggregation, the receptor complex is internalized via the cellular endosomal machinery. This ... DcR3: Decoy receptor 3 (DcR3) is a recently discovered decoy receptor of the tumor necrosis factor superfamily that binds to ... Its binding with its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of ... The Fas receptor (FasR), or CD95, is the most intensely studied member of the death receptor family. The gene is situated on ...
*  AP2M1
Chang MP, Mallet WG, Mostov KE, Brodsky FM (May 1993). "Adaptor self-aggregation, adaptor-receptor recognition and binding of ... "The adaptor complex 2 directly interacts with the alpha 1b-adrenergic receptor and plays a role in receptor endocytosis". The ... AP2M1 has been shown to interact with CTLA-4 and Alpha-1B adrenergic receptor. GRCh38: Ensembl release 89: ENSG00000161203 - ... Santini F, Marks MS, Keen JH (May 1998). "Endocytic clathrin-coated pit formation is independent of receptor internalization ...
*  Translocator protein
Bogan RL, Davis TL, Niswender GD (April 2007). "Peripheral-type benzodiazepine receptor (PBR) aggregation and absence of ... benzodiazepine receptor: regional mapping of the gene and characterization of the receptor expressed from cDNA". DNA Cell Biol ... "Peripheral" benzodiazepine receptors are also found in the brain, although only at around a quarter the expression levels of ... YL-IPA08 Ro5-4864 - original ligand with which TSPO receptor was characterised, now less used due to inter-species differences ...
*  CD84
"Platelet aggregation induces platelet aggregate stability via SLAM family receptor signaling". Blood. 106 (9): 3028-34. doi: ... Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C (Jun 2001). "Cell surface receptors Ly-9 and CD84 ... Sayós J, Martín M, Chen A, Simarro M, Howie D, Morra M, Engel P, Terhorst C (Jun 2001). "Cell surface receptors Ly-9 and CD84 ... Del Valle JM, Engel P, Martín M (May 2003). "The cell surface expression of SAP-binding receptor CD229 is regulated via its ...
*  Epidermal growth factor receptor
... reversible aggregation of the purified epidermal growth factor receptor". Biochemistry. 26 (5): 1443-51. doi:10.1021/ ... The epidermal growth factor receptor is a member of the ErbB family of receptors, a subfamily of four closely related receptor ... The epidermal growth factor receptor (EGFR; ErbB-1; HER1 in humans) is a transmembrane protein that is a receptor for members ... "Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ...
*  Adenosine diphosphate receptor inhibitor
What had been shown was that they were potent inhibitors of ADP-induced platelet aggregation, but the P2Y12 receptor had not ... P2Y12 receptor is a G-coupled receptor and is activated by adenosine diphosphate. ADP binds to the P2Y12 receptor that leads to ... This leads to a decrease in aggregation of platelets, prohibiting thrombus formation. The P2Y12 receptor is a surface bound ... Activation of the glycoprotein IIb/IIIa receptors increases thromboxane production and prolonged platelet aggregation. ...
*  P2Y12
The P2Y12 receptor is involved in platelet aggregation and is thus a biological target for the treatment of thromboembolisms ... "P2Y Receptors: P2Y12". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. ... Nicholas RA (Sep 2001). "Identification of the P2Y(12) receptor: a novel member of the P2Y family of receptors activated by ... This P2Y receptor family has several receptor subtypes with different pharmacological selectivity, which overlaps in some cases ...
*  Cyclopentenone prostaglandins
DP2 and DP1 are G protein-coupled receptors, with the DP2 receptor coupled to Gi alpha subunit-dependent depression of cellular ... "Cyclopentenone prostaglandin-induced unfolding and aggregation of the Parkinson disease-associated UCH-L1". Proceedings of the ... The PGJ2 series of cyclopentenone PGs bind to and activate the G protein-coupled receptor, Prostaglandin DP2 receptor, with 15- ... These PGJ2's also bind and activate a second G protein-coupled receptor, Prostaglandin DP1 receptor, but require high ...