Sprague Dawley, the trademark used by Envigo) is not. The average litter size of the Sprague Dawley rat is 11.0. These rats ... This breed of rat was first produced by the Sprague Dawley farms (later to become the Sprague Dawley Animal Company) in Madison ... Shorn rats were bred from Sprague Dawley rats in Connecticut in 1998. They also suffer from severe kidney problems. The Lewis ... Most are derived from the albino Wistar rat, which is still widely used. Other common strains are the Sprague Dawley, Fischer ...
... in Sprague Dawley rats". Pharmacognosy Research. 5 (2): 113-7. doi:10.4103/0974-8490.110541. PMC 3685759. PMID 23798886. Ali, ...
The study used 100 male and 100 female Sprague Dawley rats, divided into twenty groups with 10 rats each. Ten diets were tested ... if the survival of the rats is less than 50% at 104 weeks (which is likely for Sprague-Dawley rats) the recommended number of ... Sprague-Dawley rats have a lifespan of about two years and have a high risk of cancer over their lifespan (one study concluded ... Suzuki, H; Mohr, U; Kimmerle, G (1979). "Spontaneous endocrine tumors in Sprague-Dawley rats". Journal of Cancer Research and ...
Suzuki H, Mohr U, Kimmerle G (October 1979). "Spontaneous endocrine tumors in Sprague-Dawley rats". Journal of Cancer Research ... Criticisms included insufficient statistical power and that Séralini's Sprague-Dawley rats were inappropriate for a lifetime ... "Sprague Dawley" (PDF). Harlan. Archived from the original (PDF) on September 29, 2013. Retrieved October 26, 2012. Butler D ( ... "Mortality and In-Life Patterns in Sprague-Dawley" (PDF). Huntingdon Life Sciences. Archived from the original (PDF) on October ...
Sprague-Dawley rats (lab rats) were tested on. The oral median lethal dose in male lab rats was determined to be 23.58 mL/kg ... The median lethal dose in the female lab rats was found to be 19.52 mL/kg BW (15.64 mL/kg BW lower, 24.35 mL/kg BW upper). The ... Charlie ration or "C-Rats" was the name for the field meal then given to troops.) This cookbook came wrapped around a two-ounce ...
"Developmental toxicity evaluation of butylparaben in Sprague-Dawley rats". Birth Defects Research Part B: Developmental and ...
Wan J, Ernstgård L, Song B, Shoaf S (2006). "Chlorzoxazone metabolism is increased in fasted Sprague-Dawley rats". J Pharm ... Dong DL, Luan Y, Feng TM, Fan CL, Yue P, Sun ZJ, Gu RM, Yang BF (2006). "Chlorzoxazone inhibit contraction of rat thoracic ...
Liu, T.Y.; Chen, C.C.; Chen, C.L.; Chi, C.W. (1999). "Safrole-induced Oxidative Damage in the Liver of Sprague-Dawley Rats". ... "Safrole-induced Oxidative Damage in the Liver of Sprague-Dawley Rats". Food and Chemical Toxicology. 37 (7): 697-702. doi: ... hydroxysafrole in rats. Further metabolites of safrole that have been found in urine of both rats and humans include 1,2- ... In rats, safrole and related compounds produced both benign and malignant tumors after intake through the mouth. Changes in the ...
King C, Kendrick F (1962). "Teratogenic effects of thalidomide in the Sprague Dawley rat". The Lancet. 280 (7265): 409-17. doi: ... Similar results were also published showing these effects in rats and other species. Lynette Rowe, who was born without limbs, ... McColl JD, Globus M, Robinson S (1965). "Effect of some therapeutic agents on the developing rat fetus". Toxicology and Applied ...
"Acute oral toxicity studies of Swietenia macrophylla seeds in Sprague Dawley rats". Pharmacognosy Research. 7 (1): 38-44. doi: ...
"Pharmacokinetics of ketamine and xylazine in young and old Sprague-Dawley rats". Journal of the American Association for ... In young rats the half life is one hour. Xylazine has a large volume of distribution (Vd). The Vd = 1.9-2.5 for horses, cattle ... in rat and human urine using GC-MS, LC-MSn, and LC-HR-MSn". Analytical and Bioanalytical Chemistry. 405 (30): 9779-9789. doi: ... which is used in rats, mice, hamsters, and guinea pigs. Xylazine is widely used in veterinary medicine as a sedative, muscle ...
"Developmental toxicity of mangafodipir trisodium and manganese chloride in Sprague-Dawley rats". Teratology. 52 (2): 109-115. ... "Alteration of iron homeostasis following chronic exposure to manganese in rats". Brain Research. 833 (1): 125-132. doi:10.1016/ ...
For example, in one experiment, male Sprague-Dawley rats were given either a low fat or a high fat diet, with the high fat diet ... "Selective breeding for diet-induced obesity and resistance in Sprague-Dawley rats". American Journal of Physiology. 273. " ... Rats have also been used in the diet-induced obesity model. Commonly used in medical research, rats were specifically chosen to ... The results of the study illustrate that the high fat diet rats had a higher adiposity index than the low fat diet rats. Dogs ...
"Developmental toxicity of mangafodipir trisodium and manganese chloride in Sprague-Dawley rats". Teratology. 52 (2): 109-115. ... Furthermore, young rats who were choline-deficient performed as poorly on memory tasks as older rats while older rats that were ... VAD rats had more trouble learning a Radial arm maze than rats who had normal levels of the vitamin. The healthy rats were able ... while rats who had choline-enriched diets showed a diminished memory loss compared to both the choline-low diet and control rat ...
"Acrylonitrile-induced oxidative stress and oxidative DNA damage in male Sprague-Dawley rats". Toxicol. Sci. 111 (1): 64-71. doi ... Using rat studies, withdrawal after repeated exposure to nicotine results in less responsive nucleus accumbens cells, which ... "Imaging localised dynamic changes in the nucleus accumbens following nicotine withdrawal in rats". NeuroImage. 22 (2): 847-854 ...
"Acrylonitrile-induced oxidative stress and oxidative DNA damage in male Sprague-Dawley rats". Toxicol. Sci. 111 (1): 64-71. doi ...
Acrylonitrile-induced oxidative stress and oxidative DNA damage in male Sprague-Dawley rats. Toxicol Sci. 2009;111(1):64-71. ...
"Acrylonitrile-induced oxidative stress and oxidative DNA damage in male Sprague-Dawley rats". Toxicol. Sci. 111 (1): 64-71. doi ...
... -induced oxidative stress and oxidative DNA damage in male Sprague-Dawley rats. Toxicol Sci. 2009;111(1):64-71. ... Acrylonitrile increases cancer in high dose tests in male and female rats and mice and induces apoptosis in human umbilical ... Routes of exposure include inhalation, oral, and to a certain extent dermal uptake (tested with volunteer humans and in rat ... Acrylonitrile is moderately toxic with LD50 = 81 mg/kg (rats). It undergoes explosive polymerization. The burning material ...
... in male Sprague-Dawley rats". Journal of Toxicology and Environmental Health, Part A. 64 (8): 645-60. doi:10.1080/ ...
"Acrylonitrile-induced oxidative stress and oxidative DNA damage in male Sprague-Dawley rats". Toxicological Sciences. 111 (1): ...
Acrylonitrile-induced oxidative stress and oxidative DNA damage in male Sprague-Dawley rats. Toxicol Sci. 2009 Sep;111(1):64-71 ... especially in rats' blood cells. Comet assays are one of the most common tests for genotoxicity. The technique involves lysing ...
In Sprague Dawley rats, atomoxetine reduces NR2B protein content without altering transcript levels. Aberrant glutamate and ... In addition to rats, atomoxetine has also been found to induce similar region-specific catecholamine level alteration in mice. ... In rats, atomoxetine increased prefrontal cortex catecholamine concentrations without altering dopamine levels in the striatum ... However, both mouse and rat microdialysis studies have failed to find an increase in extracellular serotonin in the prefrontal ...
... is a species of oral Streptococcus bacteria first isolated from Sprague-Dawley rats, hence its name. ... "A new species of oral Streptococcus isolated from Sprague--Dawley rats, Streptococcus orisratti sp. nov". International Journal ...
"Subchronic toxicity study of eastern black nightshade (Solanum ptychanthum) berries in Sprague-Dawley rats." Journal of Food ... A. Davis, K. Renner, C. Sprague, L. Dyer, D. Mutch (2005). Integrated Weed Management. MSU. (Articles containing Ancient Greek ...
"Phospholipid metabolism in livers of young and old fisher 344 and Sprague-Dawley rats". Experimental Gerontology. 16 (2): 163- ... These conclusions are based on the models that were used during these studies as these effects were caused in rats instead of ... During the studies it was also concluded that mice are more resilient to MCT than rats, meaning that more mice survived the ... MCA and retronecine are then condensed to form MCT via an unknown mechanism: MCT is detoxified in rats by the liver via ...
"Trans-Nonachlor and cis-Nonachlor Toxicity in Sprague-Dawley Rats: Comparison with Technical Chlordane". Toxicological Sciences ...
Babin, Michael (1997). "The uptake and distribution of diethyltoluenediamine in the male sprague dawley rat". Louisiana State ...
"In vivo mammary tumourigenesis in the Sprague-Dawley rat and microdosimetric correlates". Physics in Medicine and Biology. 49 ( ... Relative biological effectiveness factors comparing gamma rays to HZE ions were measured in mice or rats for tumors of the skin ... "The Low Carcinogenicity of Electron Radiation Relative to Argon Ions in Rat Skin". Radiation Research. 135 (2): 178-188. ...
Laham, S; Potvin M (1987). "Biological conversion of benzaldehyde to benzylmercapturic acid in the Sprague-Dawley rat". Drug ... Studies in rats have shown that p-cresol is primarily conjugated with glucuronide to produce p-cresylglucuronide, though this ...
"Urinary tract effects of phensuximide in the Sprague-Dawley and Fischer 344 rat". J Appl Toxicol. 6 (5): 349-56. doi:10.1002/ ...