Dexamethasone-induced Ras-related protein 1 (RASD1) is a protein that in humans is encoded by the RASD1 gene on chromosome 17. ... This protein is a small GTPase belonging to the Ras superfamily. As a Ras superfamily member, RASD1 shares several motifs ... "RASD1 - Dexamethasone-induced Ras-related protein 1 precursor - Homo sapiens (Human) - RASD1 gene & protein". www.uniprot.org. ... As a member of the Ras superfamily of small G-proteins, RASD1 regulates signal transduction pathways through both G proteins ...

Ras-related protein Rap-1b, also known as GTP-binding protein smg p21B, is a protein that in humans is encoded by the RAP1B ... "Nucleotide sequence of a human cDNA encoding a ras-related protein (rap1B)". Nucleic Acids Res. 16 (15): 7719. doi:10.1093/nar/ ... Rousseau-Merck MF, Pizon V, Tavitian A, Berger R (1990). "Chromosome mapping of the human RAS-related RAP1A, RAP1B, and RAP2 ... 2004). "The GTPase-activating protein Rap1GAP uses a catalytic asparagine". Nature. 429 (6988): 197-201. Bibcode:2004Natur.429 ...

Hayashi N, Yokoyama N, Seki T, Azuma Y, Ohba T, Nishimoto T (June 1995). "RanBP1, a Ras-like nuclear G protein binding to Ran/ ... Bischoff FR, Ponstingl H (December 1991). "Mitotic regulator protein RCC1 is complexed with a nuclear ras-related polypeptide ... "A 47-kDa human nuclear protein recognized by antikinetochore autoimmune sera is homologous with the protein encoded by RCC1, a ... Nemergut ME, Lindsay ME, Brownawell AM, Macara IG (May 2002). "Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide ...

One of the more memorable contributions is the work on the oncoprotein Ras where he showed how the protein looks in 3D and how ... Valencia, Alfonso; Chardin, Pierre; Wittinghofer, Alfred; Sander, Chris (1991). "The ras protein family: Evolutionary tree and ... "Time-resolved X-ray crystallographic study of the conformational change in Ha-Ras p21 protein on GTP hydrolysis". Nature. 345 ( ... "The Ras-RasGAP Complex: Structural Basis for GTPase Activation and Its Loss in Oncogenic Ras Mutants". Science. 277 (5324): 333 ...

Song G, Campos B, Wagoner LE, Dedman JR, Walsh RA (Mar 1998). "Altered cardiac annexin mRNA and protein levels in the left ... ANXA6 has been shown to interact with RAS p21 protein activator 1. GRCh38: Ensembl release 89: ENSG00000197043 - Ensembl, May ... lipid binding domain of P120GAP mediates protein-protein interactions with Ca2+-dependent membrane-binding proteins. Evidence ... membrane-associated Ca2+-binding protein p68 a novel member of a protein family". The EMBO Journal. 7 (1): 21-7. doi:10.1002/j. ...

Ras-related protein Rab-2B is a protein that in humans is encoded by the RAB2B gene. RAB2B is required for protein transport ... "RAB2B - Ras-related protein Rab-2B - Homo sapiens (Human) - RAB2B gene & protein". www.uniprot.org. Retrieved 2019-10-18. " ... Overview of all the structural information available in the PDB for UniProt: Q8WUD1 (Ras-related protein Rab-2B) at the PDBe-KB ... These proteins associate with effector proteins (GARIL4 and GARIL5) to create complexes. In order to do its biological function ...

RAS guanyl-releasing protein 1 is a protein that in humans is encoded by the RASGRP1 gene. RAS guanyl nucleotide-releasing ... "Entrez Gene: RASGRP1 RAS guanyl releasing protein 1 (calcium and DAG-regulated)". Dower NA, Stang SL, Bottorff DA, Ebinu JO, ... 1998). "RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs". Science. 280 (5366 ... 2007). "Defective expression of Ras guanyl nucleotide-releasing protein 1 in a subset of patients with systemic lupus ...

Chardin P (1991). "Small GTP-binding proteins of the ras family: a conserved functional mechanism?". Cancer Cells. 3 (4): 117- ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode:2005Natur. ... Rnd2 is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a member of the Rnd subgroup of the Rho family ... Tanaka H, Fujita H, Katoh H, Mori K, Negishi M (2002). "Vps4-A (vacuolar protein sorting 4-A) is a binding partner for a novel ...

Tanaka S, Hanafusa H (1998). "Guanine-nucleotide exchange protein C3G activates JNK1 by a ras-independent mechanism. JNK1 ... Mitogen-activated protein kinase kinase kinase 11 is an enzyme that in humans is encoded by the MAP3K11 gene. The protein ... "The JIP group of mitogen-activated protein kinase scaffold proteins". Mol. Cell. Biol. 19 (10): 7245-54. doi:10.1128/mcb.19.10. ... "The JIP Group of Mitogen-Activated Protein Kinase Scaffold Proteins". Mol. Cell. Biol. 19 (10): 7245-54. doi:10.1128/mcb.19.10. ...

The Ras regulated protein RhbA has also been implicated in nitrogen assimilation. RhbA was found to be transcriptionally ... The loss of any of the above SrbA processing proteins results in a dysfunctional copy of SrbA and a subsequent loss of in vitro ... Calvo AM, Wilson RA, Bok JW, Keller NP (September 2002). "Relationship between secondary metabolism and fungal development". ... SrbA functionality in hypoxia is dependent upon an upstream cleavage process carried out by the proteins RbdB, SppA, and Dsc A- ...

Ras guanyl-releasing protein 3 is a protein that in humans is encoded by the RASGRP3 gene. Members of the RAS (see HRAS; MIM ... "Entrez Gene: RASGRP3 RAS guanyl releasing protein 3 (calcium and DAG-regulated)". Brodie C, Steinhart R, Kazimirsky G, ... "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome ... "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi: ...

The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is ... Ras-related protein Rap-1A is a protein that in humans is encoded by the RAP1A gene. The product of this gene belongs to the ... family of Ras-related proteins. These proteins share approximately 50% amino acid identity with the classical RAS proteins and ... "A human protein selected for interference with Ras function interacts directly with Ras and competes with Raf1". Molecular and ...

Protein tyrosine phosphatase non-receptor 11 (PTPN11) interaction with GAB2 is part of the Ras pathway. Mutations found in ... GRB2-associated-binding protein 2 also known as GAB2 is a protein that in humans is encoded by the GAB2 gene. GAB2 is a docking ... GAB proteins were one of the first docking proteins identified in the mammalian signal transduction pathway. GAB2 along with ... The two main pathways of GAB proteins are SHP2 and PI3K. GAB protein binding to SHP2 molecules acts as an activator whose main ...

Ramírez de Molina A, Penalva V, Lucas L, Lacal JC (2002). "Regulation of choline kinase activity by Ras proteins involves Ral- ... The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also ... Dubois T, Howell S, Zemlickova E, Aitken A (2002). "Identification of casein kinase Ialpha interacting protein partners". FEBS ... Jamra RA, Williams J, McMaster CR, Platzer K (June 2022). "Bi-allelic variants in CHKA cause a neurodevelopmental disorder with ...

Maijgren S, Sur I, Nilsson M, Toftgård R (2004). "Involvement of RFX proteins in transcriptional activation from a Ras- ... DNA-binding protein RFX2 is a protein that in humans is encoded by the RFX2 gene. This gene is a member of the regulatory ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ... The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional ...

"The association of human c-Ha-ras sequences with chromatin and nuclear proteins". Biochemical and Biophysical Research ... to bind and cleave protein-unbound regions of DNA on chromatin. DNA bound to histones or other chromatin-bound proteins (e.g. ... And finally, the protein-DNA complex can be isolated, with the DNA being subsequently purified and sequenced. The resulting ... If a region of DNA is bound by the nucleosome core (i.e. histones) or other chromatin-bound proteins (e.g. transcription ...

Kinsella BT, Erdman RA, Maltese WA (1991). "Carboxyl-terminal isoprenylation of ras-related GTP-binding proteins encoded by ... Rac2 (Ras-related C3 botulinum toxin substrate 2) is a small (~21 kDa) signaling G protein (to be specific, a GTPase), and is a ... "Entrez Gene: RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)". Gorvel JP, Chang TC ... Didsbury J, Weber RF, Bokoch GM, Evans T, Snyderman R (1989). "rac, a novel ras-related family of proteins that are botulinum ...

"Broadly expressed SNT-like proteins link FGF receptor stimulation to activators of Ras". Oncogene. 13 (4): 721-9. PMID 8761293 ... 2004). "Proteins associated with type II bone morphogenetic protein receptor (BMPR-II) and identified by two-dimensional gel ... Fibroblast growth factor receptor substrate 3 is a protein that in humans is encoded by the FRS3 gene. The protein encoded by ... 1999). "Association of atypical protein kinase C isotypes with the docker protein FRS2 in fibroblast growth factor signaling". ...

Qian YW, Lee EY (1995). "Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast ... Histone-binding protein RBBP4 (also known as RbAp48, or NURF55) is a protein that in humans is encoded by the RBBP4 gene. This ... Qian YW; Lee EY (1995). "Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast ... Zhang Q, Vo N, Goodman RH (2000). "Histone binding protein RbAp48 interacts with a complex of CREB binding protein and ...

She showed that pathways included the growth factor-receptor-RAS protein signalling cascade. She has shown that these molecular ...

This protein is responsible for regulating the RAS-mediated cell growth signaling pathway. In contrast to schwannomas, another ... GAP accelerates the conversion of the active GTP-bound RAS to its inactive GDP-bound form, inactivating RAS and reducing RAS- ... Loss of RAS control leads to increased activity of other signaling pathways including RAF, ERK1/2, PI3K, PAK and mTOR-S6 kinase ... Genes that code for proteins that regulate cell growth, such as NF1 and TP53, are referred to as tumor suppressor genes. ...

"A lipid-anchored Grb2-binding protein that links FGF-receptor activation to the Ras/MAPK signaling pathway". Cell. 89 (5): 693- ... "Docking protein FRS2 links the protein tyrosine kinase RET and its oncogenic forms with the mitogen-activated protein kinase ... Lim YP, Low BC, Lim J, Wong ES, Guy GR (July 1999). "Association of atypical protein kinase C isotypes with the docker protein ... Lim YP, Low BC, Lim J, Wong ES, Guy GR (1999). "Association of atypical protein kinase C isotypes with the docker protein FRS2 ...

"RAS-MAPK-MSK1 pathway modulates ataxin 1 protein levels and toxicity in SCA1". Nature. 498 (7454): 325-331. Bibcode:2013Natur. ... Another protein shown to have significant interactions with ataxin 1 is the leucine-rich acidic nuclear protein or LANP. Its ... Molecular chaperones are introduced proteins that may have interactions with the mutant protein that reduce toxicity by various ... results in a larger than normal number of consecutive glutamine amino acid residues in the protein. This mutant protein causes ...

"The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with ... Rac1, also known as Ras-related C3 botulinum toxin substrate 1, is a protein found in human cells. It is encoded by the RAC1 ... Didsbury J, Weber RF, Bokoch GM, Evans T, Snyderman R (Oct 1989). "rac, a novel ras-related family of proteins that are ... "Interaction of Nck-associated protein 1 with activated GTP-binding protein Rac". The Biochemical Journal. 322 (3): 873-8. doi: ...

Ras-related C3 botulinum toxin substrate 3 (Rac3) is a G protein that in humans is encoded by the RAC3 gene. It is an important ... "Entrez Gene: RAC3 ras-related C3 botulinum toxin substrate 3 (rho family, small GTP binding protein Rac3)". Courjal F, Chuchana ... Didsbury J, Weber RF, Bokoch GM, Evans T, Snyderman R (October 1989). "rac, a novel ras-related family of proteins that are ... October 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. ...

Maijgren S, Sur I, Nilsson M, Toftgård R (2004). "Involvement of RFX proteins in transcriptional activation from a Ras- ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ... "RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom". Nucleic Acids Res. 24 (5): 803-7. ... The protein encoded by this gene is structurally related to regulatory factors X1, X2, X4, and X5. It is a transcriptional ...

Maijgren S, Sur I, Nilsson M, Toftgård R (2004). "Involvement of RFX proteins in transcriptional activation from a Ras- ... The RFX protein family is conserved in S. pombe, S. cerevisiae, C. elegans, mice and humans. There are seven known RFX proteins ... Emery P, Durand B, Mach B, Reith W (1996). "RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic ... "RFX proteins, a novel family of DNA binding proteins conserved in the eukaryotic kingdom". Nucleic Acids Res. 24 (5): 803-7. ...

Ramírez de Molina A, Penalva V, Lucas L, Lacal JC (2002). "Regulation of choline kinase activity by Ras proteins involves Ral- ... "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras ... "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras ... Ehrhardt GR, Leslie KB, Lee F, Wieler JS, Schrader JW (October 1999). "M-Ras, a widely expressed 29-kD homologue of p21 Ras: ...

"A retinoblastoma-binding protein related to a negative regulator of Ras in yeast". Nature. 364 (6438): 648-52. Bibcode: ... a larger 127 kDa protein). Together, the two proteins form a UV-damaged DNA binding protein complex (UV-DDB). If humans have a ... DNA damage-binding protein 2 is a protein that in humans is encoded by the DDB2 gene. As indicated by Rapić-Otrin et al. in ... The WD40 motif identified in DDB2 is characteristic of proteins involved in the recognition of chromatin proteins. The C- ...

Wang D, Li Z, Messing EM, Wu G (2002). "Activation of Ras/Erk pathway by a novel MET-interacting protein RanBPM". J. Biol. Chem ... The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to ... PTEN (phosphatase and tensin homolog) is a tumor suppressor gene encoding a protein PTEN, which possesses lipid and protein ... a typical protein-protein interaction region. A juxtamembrane segment that contains: A serine residue (Ser 985), which inhibits ...