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*  DAB2IP
Disabled homolog 2-interacting protein is a protein that in humans is encoded by the DAB2IP gene. DAB2IP is a Ras (MIM 190020) ... 2004). "Identification of a novel RAS GTPase-activating protein (RASGAP) gene at 9q34 as an MLL fusion partner in a patient ... The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 7 (6): 347-55. doi: ... "Entrez Gene: DAB2IP DAB2 interacting protein". Wang, Zhi; Tseng Ching-Ping; Pong Rey-Chen; Chen Hong; McConnell John D; Navone ...
*  Farnesyltransferase
... 's targets include members of the Ras superfamily of small GTP-binding proteins critical to cell cycle ... S-farnesyl protein + diphosphate Thus, the two substrates of this enzyme are farnesyl diphosphate and protein-cysteine, whereas ... Farnesyltransferase posttranslationally-modifies proteins by adding an isoprenoid lipid called a farnesyl group to the -SH of ... There are four binding pockets in FTase, which accommodate the last four amino acids on the carboxyl-terminus of a protein. ...
*  Ras subfamily
Ras is a family of related proteins which is expressed in all animal cell lineages and organs. All Ras protein family members ... Activating mutations of the Ras protein and upstream elements of the Ras protein may play a role in more than two-thirds of all ... RRAS2 Mutations in the Ras family of proto-oncogenes (comprising H-Ras, N-Ras and K-Ras) are very common, being found in 20% to ... Ras is a G protein, or a guanosine-nucleotide-binding protein. Specifically, it is a single-subunit small GTPase, which is ...
*  Farnesyltransferase inhibitor
... ras). Many proteins can exist in a cell in various locations, and the addition of a farnesyl group targets proteins to the ... Of the three members (H, N and K) of the Ras family, K-Ras is the form found most often mutated in cancer. As noted above, as ... It was thought that by inhibiting FT, ras will not be activated, therefore preventing cancer growth. The problem was that ras ... to the pre-Ras protein. Also, a related enzyme geranylgeranyltransferase I (GGTase I) has the ability to transfer a ...
*  RAS p21 protein activator 1
... or RasGAP (Ras GTPase activating protein), also known as RASA1, is a 120-kDa cytosolic human ... Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in ... 1997). "Ras-GTPase activating protein (GAP): a putative effector for Ras". Cell. Signal. 9 (2): 153-8. doi:10.1016/S0898-6568( ... Ger M, Zitkus Z, Valius M (October 2011). "Adaptor protein Nck1 interacts with p120 Ras GTPase-activating protein and regulates ...
*  GTPase-activator protein for Ras-like GTPase
... is a family of evolutionarily related proteins. Ras proteins are membrane- ... As it is the GTP bound form of ras which is active, these proteins are said to be down-regulators of ras. The Ras GTPase- ... Note: There are distinctly different GAPs for the rap and rho/rac subfamilies of ras-like proteins (reviewed in reference) that ... This intrinsic GTPase activity of ras is stimulated by a family of proteins collectively known as 'GAP' or GTPase-activating ...
*  Kim Sung-Hou
He also published many papers on the structures of protein molecules including human Ras, human cyclin dependent kinase 2 and ... Tong, L., Milburn, MV, de Vos, AM and Kim, S.-H. (1989). "Structure of Ras Protein". Science. 245 (244): 244. Bibcode:1989Sci ... small heat shock protein. He is a member of the U.S. National Academy of Science and a fellow of the American Academy of Arts ...
*  RASAL3
RAS protein activator like 3 is a protein that in humans is encoded by the RASAL3 gene. GRCh38: Ensembl release 89: ... RAS protein activator like 3". Retrieved 2016-07-16. Saito S, Kawamura T, Higuchi M, Kobayashi T, Yoshita-Takahashi M, Yamazaki ... a novel hematopoietic RasGAP protein, regulates the number and functions of NKT cells". Eur. J. Immunol. 45 (5): 1512-23. doi: ...
*  RASAL2
Ras GTPase-activating protein nGAP is an enzyme that in humans is encoded by the RASAL2 gene. This gene encodes a protein that ... "Entrez Gene: RASAL2 RAS protein activator like 2". Maekawa M, Nakamura S, Hattori S (1993). "Purification of a novel ras GTPase ... GAPs function as activators of Ras superfamily of small GTPases. The protein encoded by this gene is able to complement the ... 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation ...
*  Christopher Marshall (doctor)
His track record includes the discovery of the N-Ras oncogene , the identification of farnesylation of Ras proteins, and the ... His work in the field of cell signalling showed how RAS and other signalling proteins are involved in transmitting signals from ... Hancock, JF; Magee, AI; Childs, JE; Marshall, CJ (June 1989). "All ras proteins are polyisoprenylated but only some are ... Hall, A; Marshall, CJ; Spurr, NK; Weiss, RA. "Identification of transforming gene in two human sarcoma cell lines as a new ...
*  NFKBIB
Fenwick C, Na SY, Voll RE, Zhong H, Im SY, Lee JW, Ghosh S (2000). "A subclass of Ras proteins that regulate the degradation of ... NF-kappa-B inhibitor beta is a protein that in humans is encoded by the NFKBIB gene. NFKB1 (MIM 164011) or NFKB2 (MIM 164012) ... Chen Y, Wu J, Ghosh G (June 2003). "KappaB-Ras binds to the unique insert within the ankyrin repeat domain of IkappaBbeta and ... Lee JW, Choi HS, Gyuris J, Brent R, Moore DD (1995). "Two classes of proteins dependent on either the presence or absence of ...
*  NKIRAS2
Fenwick C, Na SY, Voll RE, Zhong H, Im SY, Lee JW, Ghosh S (Feb 2000). "A subclass of Ras proteins that regulate the ... NF-κB inhibitor interacting Ras-like 2 is a protein that in humans is encoded by the NKIRAS2 gene. Model organisms have been ... Tago K, Funakoshi-Tago M, Sakinawa M, Mizuno N, Itoh H (Oct 2010). "KappaB-Ras is a nuclear-cytoplasmic small GTPase that ... NFKB inhibitor interacting Ras-like 2". Retrieved 2011-08-30. "Salmonella infection data for Nkiras2". Wellcome Trust Sanger ...
*  Sankar Ghosh
Fenwick, C., et al., A subclass of Ras proteins that regulate the degradation of IkappaB. Science, 2000. 287(5454): p. 869-73. ... Kopp, E.B. and S. G hosh, NF-kappa B and rel proteins in innate immunity. Adv Immunol, 1995. 58: p. 1-27. Kopp, E. and S. Ghosh ... 17(8): p. 4390-6. May, M.J. and S. Ghosh, Rel/NF-kappa B and I kappa B proteins: an overview. Semin Cancer Biol, 1997. 8(2): p ... Ma, X.Y., et al., The interferon-inducible p202a protein modulates NF-kappaB activity by inhibiting the binding to DNA of p50/ ...
*  RASGRF1
Ras protein-specific guanine nucleotide-releasing factor 1 is a protein in humans that is encoded by the RASGRF1 gene. The ... Functional analysis has demonstrated that this protein stimulates the dissociation of GDP from RAS protein. The studies of the ... and G protein beta-gamma subunit. Mouse studies also indicated that the Ras-GEF signaling pathway mediated by this protein may ... Ras protein-specific guanine nucleotide-releasing factor 1". Retrieved 2013-04-07. ...
*  RHEB
... functions differently compared to other proteins in the Ras superfamily. Similar to those in the Ras superfamily, the ... The protein is a lipid-anchored, cell-membrane protein with five repeats of the RAS-related GTP-binding region. Also present ... "The Ras-related protein Rheb is farnesylated and antagonizes Ras signaling and transformation". The Journal of Biological ... RHEB also known as Ras homolog enriched in brain (RHEB) is a GTP-binding protein that is ubiquitously expressed in humans and ...
*  RASGRF2
Ras-specific guanine nucleotide-releasing factor 2 is a protein that in humans is encoded by the RASGRF2 gene. RAS (MIM 190020 ... 1998). "The exchange factor Ras-GRF2 activates Ras-dependent and Rac-dependent mitogen-activated protein kinase pathways". Curr ... 2002). "Dematin interacts with the Ras-guanine nucleotide exchange factor Ras-GRF2 and modulates mitogen-activated protein ... 1997). "Mapping of the Ras-GRF2 gene (GRF2) to mouse chromosome 13C3-D1 and human chromosome 5q13, near the Ras-GAP gene". ...
*  CHKA
Ramírez de Molina A, Penalva V, Lucas L, Lacal JC (2002). "Regulation of choline kinase activity by Ras proteins involves Ral- ... The protein encoded by this gene is the initial enzyme in the sequence and may play a regulatory role. The encoded protein also ... Dubois T, Howell S, Zemlickova E, Aitken A (2002). "Identification of casein kinase Ialpha interacting protein partners". FEBS ...
*  RALGDS
Ramírez de Molina A, Penalva V, Lucas L, Lacal JC (2002). "Regulation of choline kinase activity by Ras proteins involves Ral- ... "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras ... "Identification of the guanine nucleotide dissociation stimulator for Ral as a putative effector molecule of R-ras, H-ras, K-ras ... Ehrhardt GR, Leslie KB, Lee F, Wieler JS, Schrader JW (October 1999). "M-Ras, a widely expressed 29-kD homologue of p21 Ras: ...
*  RASEF
Ras and EF-hand domain-containing protein also known as Ras-related protein Rab-45 is a protein that in humans is encoded by ... The basic members of this group of proteins are Ras oncogens. It's divided into five major families (Ras, Rho, Arf/Sar, Ran and ... This could provoke a malignant tumor if combined with a separate mutation in a protein's RAS group. Nowadays, there is ... Rojas AM, Fuentes G, Rausell A, Valencia A (January 2012). "The Ras protein superfamily: evolutionary tree and role of ...
*  Neuroblastoma RAS viral oncogene homolog
These ras genes have GTP/GDP binding and GTPase activity, and their normal function may be as G-like regulatory proteins ... The N-ras proto-oncogene is a member of the Ras gene family. It is mapped on chromosome 1, and it is activated in HL60, a ... Yuasa Y, Gol RA, Chang A, et al. (1984). "Mechanism of activation of an N-ras oncogene of SW-1271 human lung carcinoma cells". ... The mammalian ras gene family consists of the harvey and kirsten ras genes (HRAS and KRAS), an inactive pseudogene of each (c- ...
*  SOS1
Genetic analysis indicated that CDC25 is essential for activation of RAS proteins. In Drosophila, the protein encoded by the ' ... RAS genes (e.g., MIM 190020) encode membrane-bound guanine nucleotide-binding proteins that function in the transduction of ... Kim MJ, Chang JS, Park SK, Hwang JI, Ryu SH, Suh PG (July 2000). "Direct interaction of SOS1 Ras exchange protein with the SH3 ... Binding of GTP activates RAS proteins, and subsequent hydrolysis of the bound GTP to GDP and phosphate inactivates signaling by ...
*  Dale Brown Emeagwali
Her most notable achievement in this area involves ras oncogene. Ras proteins play a vital role in the transmission of signals ... When the gene that initiates the ras protein becomes mutated, the signals are disrupted in a way that can cause the cells to ... "Sequence Homology Between the Structural Proteins of Kilham Rat Virus," Journal of Virology 1989 "Modulation of Ras Expression ... Brown, D. D.; Salzman, L. A. (1984-03-01). "Sequence homology between the structural proteins of Kilham rat virus". Journal of ...
*  Cysmethynil
... which plays in key role for the Ras protein. Ras is one of the components in the cell that is responsible for controlling cell ... Ras gets methylated by the Icmt enzyme, a signal that allows Ras to go to its destination (plasma membrane) that can lead to ... Icmt can be inhibited from adding the methyl group, inactivating Ras such that it no longer sends a signal to the cell to have ... Certain mutations in Ras can leave it in the "on" configuration, such that uncontrolled cell growth results. ...
*  RAPGEF1
The protein encoded by this gene is a human guanine nucleotide releasing protein for Ras protein. It belongs to the adaptor- ... Src homology 2 domains are globular protein modules present in a large variety of functionally distinct proteins. They mediate ... "Mapping of the human C3G gene coding a guanine nucleotide releasing protein for Ras family to 9q34.3 by fluorescence in situ ... to the small GTPase Rap1 via the large docking protein Gab1 and the adapter protein CRKL". The Journal of Biological Chemistry ...
*  DHHC domain
Others such as ZDHHC9 showed specificity only toward the H-Ras protein. However, a recent study questions the involvement of ... Mitchell DA, Vasudevan A, Linder ME, Deschenes RJ (June 2006). "Protein palmitoylation by a family of DHHC protein S- ... Mitchell DA, Vasudevan A, Linder ME, Deschenes RJ (June 2006). "Protein palmitoylation by a family of DHHC protein S- ... Smotrys JE, Schoenfish MJ, Stutz MA, Linder ME (September 2005). "The vacuolar DHHC-CRD protein Pfa3p is a protein ...
*  Phage display
... is a laboratory technique for the study of protein-protein, protein-peptide, and protein-DNA interactions that ... Gao C, Mao S, Lo CH, Wirsching P, Lerner RA, Janda KD (May 1999). "Making artificial antibodies: a format for phage display of ... a gene encoding a protein of interest is inserted into a phage coat protein gene, causing the phage to "display" the protein on ... characterize small molecules-protein interactions and map protein-protein interactions. Users can use three dimensional ...
*  RasGEF domain
Ras proteins are membrane-associated molecular switches that bind GTP and GDP and slowly hydrolyze GTP to GDP. The balance ... McCormick F, Boguski MS (1993). "Proteins regulating Ras and its relatives". Nature. 366 (6456): 643-654. doi:10.1038/366643a0 ... Boguski, MS; McCormick, F (1993). "Proteins regulating Ras and its relatives". Nature. 366 (6456): 643-54. doi:10.1038/366643a0 ... Activators of the Ras superfamily of proteins". BioEssays. 17 (5): 395-404. doi:10.1002/bies.950170507. PMID 7786285. Li, N; ...