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*  DAB2IP
... is a Ras (MIM 190020) GTPase-activating protein (GAP) that acts as a tumor suppressor gene and is inactivated by ... 2004). "Identification of a novel RAS GTPase-activating protein (RASGAP) gene at 9q34 as an MLL fusion partner in a patient ... Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2". J Biol Chem. 277 (15): ... Characterization of a novel GTPase-activating protein associated with N-terminal domain of DOC-2/DAB2". J. Biol. Chem. United ...
*  Ras subfamily
GTPase Activating Protein inactivates Ras by activating its GTPase activity. Thus, GAPs accelerate Ras inactivation. GEFs ... Activating mutations of the Ras protein and upstream elements of the Ras protein may play a role in more than two-thirds of all ... and GTPase activating proteins (GAPs). As per its classification, Ras has an intrinsic GTPase activity, which means that the ... Ras is a G protein, or a guanosine-nucleotide-binding protein. Specifically, it is a single-subunit small GTPase, which is ...
*  SYNGAP1
Synaptic Ras GTPase-activating protein 1, also known as synaptic Ras-GAP 1 or SYNGAP1, is a protein that in humans is encoded ... "Regulation of the neuron-specific Ras GTPase-activating protein, synGAP, by Ca2+/calmodulin-dependent protein kinase II". The ... SYNGAP1 is a ras GTPase-activating protein that is critical for the development of cognition and proper synapse function. ... Chen HJ, Rojas-Soto M, Oguni A, Kennedy MB (May 1998). "A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM ...
*  RASAL2
Ras GTPase-activating protein nGAP is an enzyme that in humans is encoded by the RASAL2 gene. This gene encodes a protein that ... RASAL2 RAS protein activator like 2". Maekawa M, Nakamura S, Hattori S (1993). "Purification of a novel ras GTPase-activating ... a characteristic domain of GTPase-activating proteins (GAPs). GAPs function as activators of Ras superfamily of small GTPases. ... The protein encoded by this gene is able to complement the defective RasGAP function in a yeast system. Two alternatively ...
*  RAS p21 protein activator 1
... or RasGAP (Ras GTPase activating protein), also known as RASA1, is a 120-kDa cytosolic human ... 1997). "Ras-GTPase activating protein (GAP): a putative effector for Ras". Cell. Signal. 9 (2): 153-8. doi:10.1016/S0898-6568( ... Ger M, Zitkus Z, Valius M (October 2011). "Adaptor protein Nck1 interacts with p120 Ras GTPase-activating protein and regulates ... Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in ...
*  DLGAP4
Chen HJ, Rojas-Soto M, Oguni A, Kennedy MB (1998). "A synaptic Ras-GTPase activating protein (p135 SynGAP) inhibited by CaM ... "PSD-95 promotes CaMKII-catalyzed serine phosphorylation of the synaptic RAS-GTPase activating protein SynGAP after transient ... "Transient cerebral ischemia increases tyrosine phosphorylation of the synaptic RAS-GTPase activating protein, SynGAP". J. Cereb ... Disks large-associated protein 4 (DAP-4) also known as SAP90/PSD-95-associated protein 4 (SAPAP-4) is a protein that in humans ...
*  RASA4
This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein ... Ras GTPase-activating protein 4 is an enzyme that in humans is encoded by the RASA4 gene. ... levels result in the translocation of this protein to the plasma membrane, where it activates Ras GTPase activity. Consequently ... "Entrez Gene: RASA4 RAS p21 protein activator 4". Nagase T, Ishikawa K, Miyajima N, et al. (1998). "Prediction of the coding ...
*  RASA3
1990). "Inhibition of the ras p21 GTPase-activating protein-stimulated GTPase activity of c-Ha-ras p21 by smg p21 having the ... Ras GTPase-activating protein 3 is an enzyme that in humans is encoded by the RASA3 gene. The protein encoded by this gene is ... 1995). "The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine ... Acting as a suppressor of RAS function, the protein enhances the weak intrinsic GTPase activity of RAS proteins resulting in ...
*  CD5 (protein)
"Thymocyte activation induces the association of the proto-oncoprotein c-cbl and ras GTPase-activating protein with CD5". Eur. J ... CD5 serves to mitigate activating signals from the BCR so that the B-1 cells can only be activated by very strong stimuli (such ... Protein Eng. 11 (10): 847-53. doi:10.1093/protein/11.10.847. PMID 9862202. Perez-Villar JJ, Whitney GS, Bowen MA, Hewgill DH, ... Van de Velde H, von Hoegen I, Luo W, Parnes JR, Thielemans K (1991). "The B-cell surface protein CD72/Lyb-2 is the ligand for ...
*  G3BP2
Ras GTPase-activating protein-binding protein 2 is an enzyme that in humans is encoded by the G3BP2 gene. G3BP2 has been shown ... "Entrez Gene: G3BP2 GTPase activating protein (SH3 domain) binding protein 2". Prigent, M; Barlat I; Langen H; Dargemont C ( ... 2007). "Modulation of p53 and MDM2 activity by novel interaction with Ras-GAP binding proteins (G3BP)". Oncogene. 26 (29): 4209 ... of a mouse orthologue of the human ras-GAP-SH3-domain binding protein and structural confirmation that these proteins contain ...
*  G3BP1
Ras GTPase-activating protein-binding protein 1 is an enzyme that in humans is encoded by the G3BP1 gene. This gene encodes one ... 1999). "Upregulation of the RAS-GTPase activating protein (GAP)-binding protein (G3BP) in proliferating RPE cells". J. Cell. ... "A Ras-GTPase-activating protein SH3-domain-binding protein". Mol Cell Biol. 16 (6): 2561-9. PMC 231246 . PMID 8649363. Costa M ... "Vaccinia virus intermediate stage transcription is complemented by Ras-GTPase-activating protein SH3 domain-binding protein ( ...
*  Btk-type zinc finger
Mammalian Ras GTPase-activating proteins (RasGAP), which regulate the activation of inactive GDP-bound Ras by converting GDP to ... Mammalian Tec, Bmx, and Itk proteins, which are tyrosine protein kinases of the Tec subfamily. Drosophila tyrosine-protein ... while PRRs are commonly involved in protein-protein interactions, including interactions with G proteins. The TH domain may be ... Proteins known to contain a Btk-type zinc finger include: Mammalian Bruton's tyrosine kinase (Btk), a protein tyrosine kinase ...
*  IQGAP2
"The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with ... Ras GTPase-activating-like protein IQGAP2 is an enzyme that in humans is encoded by the IQGAP2 gene. This gene encodes a member ... "Entrez Gene: IQGAP2 IQ motif containing GTPase activating protein 2". McCallum SJ, Wu WJ, Cerione RA (1996). "Identification of ... The protein contains three IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with ...
*  IQGAP1
Ras GTPase-activating-like protein IQGAP1 (IQGAP1) also known as p195 is a ubiquitously expressed protein that in humans is ... It was hypothesized that IQGAP1 would act as a GTPase activating protein (GAP) protein, promoting the switch of ras GTPases ... This domain is highly similar to the functional subunit of Ras GTPase-activating proteins (GAPs) and was thus thought to have ... "Entrez Gene: IQGAP1 IQ motif containing GTPase activating protein 1". White CD, Brown MD, Sacks DB (June 2009). "IQGAPs in ...
*  GTPase-activating protein
"Epigenetic Silencing of a Ca2+-Regulated Ras GTPase-Activating Protein RASAL Defines a New Mechanism of Ras Activation in Human ... EIF5 is a GTPase-activating protein. Furthermore, YopE is a protein domain that is a Rho GTPase-activating protein (GAP), which ... GTPase-activating proteins or GTPase-accelerating proteins (GAPs) are a family of regulatory proteins whose members can bind to ... With a nonfunctional G protein enzyme, GAPs cannot activate the GTPase activity, and the G protein is constitutively on. This ...
*  HCK
"The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck ... "The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck ... Tyrosine-protein kinase HCK is an enzyme that in humans is encoded by the HCK gene. The protein encoded by this gene is a ... Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1". The Journal of Biological Chemistry. 277 ( ...
*  NCK1
Ger M, Zitkus Z, Valius M (October 2011). "Adaptor protein Nck1 interacts with p120 Ras GTPase-activating protein and regulates ... "Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth ... Zhao C, Ma H, Bossy-Wetzel E, Lipton SA, Zhang Z, Feng GS (September 2003). "GC-GAP, a Rho family GTPase-activating protein ... The WASp binds to the SH3 domains within the N-terminus of the protein and after Nck1 has been activated by the signal from the ...
*  SEMA4D
By binding plexin B1 receptor it functions as an R-Ras GTPase-activating protein (GAP) and repels axon growth cones in both the ... "Sema4D/plexin-B1 activates GSK-3β through R-Ras GAP activity, inducing growth cone collapse". EMBO Reports. 7 (7): 704-9. doi: ... In the immune system, CD100 binds CD72 to activate B cells and dendritic cells, though much about this interaction is still ... SEMA4D protein, human at the US National Library of Medicine Medical Subject Headings (MeSH). ...
*  Caprin-1
"Vaccinia virus intermediate stage transcription is complemented by Ras-GTPase-activating protein SH3 domain-binding protein ( ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. doi:10.1038 ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: ... Caprin-1 is a protein that in humans is encoded by the CAPRIN1 gene. It is suggested that Caprin1 (a.k.a. RNG105) is essential ...
*  RAC1
"The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with ... Zhao C, Ma H, Bossy-Wetzel E, Lipton SA, Zhang Z, Feng GS (Sep 2003). "GC-GAP, a Rho family GTPase-activating protein that ... Zhang B, Chernoff J, Zheng Y (Apr 1998). "Interaction of Rac1 with GTPase-activating proteins and putative effectors. A ... Moon SY, Zang H, Zheng Y (Feb 2003). "Characterization of a brain-specific Rho GTPase-activating protein, p200RhoGAP". The ...
*  DNAJA3
... tid gene defines a novel Ras GTPase-activating protein (RasGAP)-binding protein". J. Biol. Chem. 276 (16): 13087-95. doi: ... tid gene defines a novel Ras GTPase-activating protein (RasGAP)-binding protein". J. Biol. Chem. 276 (16): 13087-95. doi: ... This protein belongs to the DNAJ/Hsp40 protein family, which is known for binding and activating Hsp70 chaperone proteins to ... where it can also interact with cytosolic proteins and possibly function to transport these proteins. This protein is ...
*  SH3 domain
Signal transducing adaptor proteins CDC24 Cdc25 PI3 kinase Phospholipase Ras GTPase-activating protein Vav proto-oncogene GRB2 ... It has also been identified in several other protein families such as: PI3 Kinase, Ras GTPase-activating protein, CDC24 and ... the Ras protein, and the Src kinase and many others. The SH3 proteins interact with adaptor proteins and tyrosine kinases. ... SH3 domain mediated protein-protein interaction networks, i.e., SH3 interactomes, revealed that worm SH3 interactome resembles ...
*  GTPase-activator protein for Ras-like GTPase
... these proteins are said to be down-regulators of ras. The Ras GTPase-activating proteins are quite large (from 765 residues for ... GTPase-activator protein for Ras-like GTPase is a family of evolutionarily related proteins. Ras proteins are membrane- ... This intrinsic GTPase activity of ras is stimulated by a family of proteins collectively known as 'GAP' or GTPase-activating ... Note: There are distinctly different GAPs for the rap and rho/rac subfamilies of ras-like proteins (reviewed in reference) that ...
*  List of MeSH codes (D12.776.476)
... ras gtpase-activating proteins MeSH D12.776.476.325.150.500.460 -- neurofibromin 1 MeSH D12.776.476.325.150.500.500 -- p120 ... ras) MeSH D12.776.476.525.500.600 -- proto-oncogene proteins p21(ras) MeSH D12.776.476.525.700.050 -- cdc42 gtp-binding protein ... mitogen-activated protein kinase 1 MeSH D12.776.476.450.169.750 -- mitogen-activated protein kinase 3 MeSH D12.776.476.450. ... 169.875 -- mitogen-activated protein kinase 6 MeSH D12.776.476.450.169.937 -- mitogen-activated protein kinase 7 MeSH D12.776. ...
*  CDC42
"The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with ... Zhao C, Ma H, Bossy-Wetzel E, Lipton SA, Zhang Z, Feng GS (September 2003). "GC-GAP, a Rho family GTPase-activating protein ... Nakamura T, Komiya M, Sone K, Hirose E, Gotoh N, Morii H, Ohta Y, Mori N (December 2002). "Grit, a GTPase-activating protein ... Zhang B, Chernoff J, Zheng Y (April 1998). "Interaction of Rac1 with GTPase-activating proteins and putative effectors. A ...
*  RHOB
Ras homolog gene family, member B, also known as RHOB, is a protein which in humans is encoded by the RHOB gene. RHOB is a ... "Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is ... 1998). "PRK1 is targeted to endosomes by the small GTPase, RhoB". J. Biol. Chem. 273 (9): 4811-4. doi:10.1074/jbc.273.9.4811. ... 1995). "Ultrastructural localization of ras-related proteins using epitope-tagged plasmids". J. Histochem. Cytochem. 43 (5): ...
*  ErbB
Activation of the receptor tyrosine kinases generates a signaling cascade where the Ras GTPase proteins are activated to a GTP- ... The RAS pathway can couple with the mitogen-activated protein kinase pathway or a number of other possible effectors. The PI3K/ ... Genetic Ras mutations are infrequent in breast cancer but Ras may be pathologically activated in breast cancer by ... Phosphorylated tyrosine residues act as binding sites for intracellular signal activators such as Ras. The Ras-Raf-MAPK pathway ...