Loading...
*  Ras subfamily
The G4 motif contains a LVGNKxDL motif, and provides specific interaction to guanine. The G5 motif contains a SAK consensus ... The process of exchanging the bound nucleotide is facilitated by guanine nucleotide exchange factors (GEFs) and GTPase ... RRAS2 Mutations in the Ras family of proto-oncogenes (comprising H-Ras, N-Ras and K-Ras) are very common, being found in 20% to ... Ras inhibitors are being studied as a treatment for cancer and other diseases with Ras overexpression. The first two ras genes ...
*  RAPGEF4
... a Ras exchange motif (REM) domain, and a Ras association (RA) domain. Epac2B is devoid of the first cNBD-A domain and Epac2C is ... Epac2 functions as a guanine nucleotide exchange factor for the Ras-like small GTPase Rap upon cAMP stimulation. Epac2 is ... Rap guanine nucleotide exchange factor (GEF) 4 (RAPGEF4), also known as exchange protein directly activated by cAMP 2 (EPAC2) ... Zhong N, Zucker RS (Jan 2005). "cAMP acts on exchange protein activated by cAMP/cAMP-regulated guanine nucleotide exchange ...
*  RASGRP4
... family of Ras guanine nucleotide exchange factors. It contains a Ras exchange motif, a diacylglycerol-binding domain, and two ... RAS guanyl releasing protein 4 is a protein in humans that is encoded by the RASGRP4 gene in chromosome 19. The protein encoded ... This protein was shown to activate H-Ras in a cation-dependent manner in vitro. Expression of this protein in myeloid cell ... provided by RefSeq, Apr 2009]. "Entrez Gene: RAS guanyl releasing protein 4". Retrieved 2013-01-31. ...
*  RASGRP2
This protein can activate small GTPases, including RAS and RAP1/RAS3. The nucleotide exchange activity of this protein can be ... 2 tandem repeats of EF-hand calcium-binding motifs, and a C-terminal diacylglycerol/phorbol ester-binding domain. ... 2000). "Characterization of RasGRP2, a plasma membrane-targeted, dual specificity Ras/Rap exchange factor". J. Biol. Chem. 275 ... RAS guanyl-releasing protein 2 is a protein that in humans is encoded by the RASGRP2 gene. The protein encoded by this gene is ...
*  NEDD9
... Crk complexes activate Rho and Ras family GTPases via the recruitment of their nucleotide exchange factors (GEFs), such ... Phosphorylation of these motifs can be activated by mechanical forces such as cytoskeletal stretch. Other phosphorylation ... Merrill RA, Ahrens JM, Kaiser ME, Federhart KS, Poon VY, Clagett-Dame M (2004). "All-trans retinoic acid-responsive genes ... Merrill RA, See AW, Wertheim ML, Clagett-Dame M (2004). "Crk-associated substrate (Cas) family member, NEDD9, is regulated in ...
*  Sodium-hydrogen exchange regulatory cofactor 2
Hall RA, Ostedgaard LS, Premont RT, Blitzer JT, Rahman N, Welsh MJ, Lefkowitz RJ (July 1998). "A C-terminal motif found in the ... exchange to Na+/H+ exchange". Biochemistry. 41 (41): 12336-42. doi:10.1021/bi0259103. PMID 12369822. This article incorporates ... Sodium-hydrogen exchange regulatory cofactor NHE-RF2 (NHERF-2) also known as tyrosine kinase activator protein 1 (TKA-1) or SRY ... Sodium-hydrogen exchange regulatory cofactor 2 has been shown to interact with SGK, Actinin alpha 4, Parathyroid hormone ...
*  RRAGB
All GTPases of the Ras superfamily have in common the presence of six conserved motifs involved in GTP/GDP binding, three of ... These proteins represent cellular switches that are operated by GTP-exchange factors and factors that stimulate their intrinsic ... Ras-related GTP-binding protein B is a protein that in humans is encoded by the RRAGB gene. Ras-homologous GTPases constitute a ... "Entrez Gene: RRAGB Ras-related GTP binding B". Ross MT, Grafham DV, Coffey AJ, et al. (2005). "The DNA sequence of the human X ...
*  GoLoco motif
... a Galphai/o binding motif and potential guanine-nucleotide exchange factor". Trends Biochem. Sci. 24 (9): 340-1. doi:10.1016/ ... Ponting CP (1999). "Raf-like Ras/Rap-binding domains in RGS12- and still-life-like signalling proteins". J. Mol. Med. 77 (10): ... GoLoco motif is a protein structural motif. In heterotrimeric G-protein signalling, cell surface receptors (GPCRs) are coupled ... acts as a GDI on G-alpha(i). The crystal structure of the GoLoco motif in complex with G-alpha(i) has been solved. It consists ...
*  RGS16
Chatterjee TK, Fisher RA (Aug 2000). "Cytoplasmic, nuclear, and golgi localization of RGS proteins. Evidence for N-terminal and ... Wieland T, Bahtijari N, Zhou XB, Kleuss C, Simon MI (Sep 2000). "Polarity exchange at the interface of regulators of G protein ... RGS domain sequences as intracellular targeting motifs". The Journal of Biological Chemistry. 275 (31): 24013-21. doi:10.1074/ ... Villasenor A, Wang ZV, Rivera LB, Ocal O, Asterholm IW, Scherer PE, Brekken RA, Cleaver O, Wilkie TM (2010). "Rgs16 and Rgs8 in ...
*  GRB2
Lepley RA, Fitzpatrick FA (Sep 1994). "5-Lipoxygenase contains a functional Src homology 3-binding motif that interacts with ... Pandey P, Kharbanda S, Kufe D (Sep 1995). "Association of the DF3/MUC1 breast cancer antigen with Grb2 and the Sos/Ras exchange ... The N-terminal SH3 domain binds to proline-rich peptides and can bind to the Ras-guanine exchange factor SOS. The C-terminal ... "The endocytic protein intersectin is a major binding partner for the Ras exchange factor mSos1 in rat brain". The EMBO Journal ...
*  ARHGEF6
1998). "RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs". Science. 280 (5366 ... Rho guanine nucleotide exchange factor 6 is a protein that, in humans, is encoded by the ARHGEF6 gene. Rho GTPases play a ... The encoded protein belongs to a family of cytoplasmic proteins that catalyse the exchange of GDP for GTP in some Rho-family ... 2001). "Involvement of alpha-PAK-interacting exchange factor in the PAK1-c-Jun NH(2)-terminal kinase 1 activation and apoptosis ...
*  ARHGEF7
The encoded protein belongs to a family of cytoplasmic proteins that activate the Ras-like family of Rho proteins by exchanging ... "Paxillin LD4 motif binds PAK and PIX through a novel 95-kD ankyrin repeat, ARF-GAP protein: A role in cytoskeletal remodeling ... a Rac/Cdc42-specific guanine nucleotide exchange factor, via the Ras/ERK/PAK2 pathway is required for basic fibroblast growth ... Rho guanine nucleotide exchange factor 7 is a protein that in humans is encoded by the ARHGEF7 gene. Rho GTPase play a ...
*  USP8
... a deubiquitinating enzyme that interacts with the ras guanine nucleotide exchange factor CDC25(Mm)/Ras-GRF1". J. Biol. Chem. ... "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I ... "A deubiquitinating enzyme UBPY interacts with the Src homology 3 domain of Hrs-binding protein via a novel binding motif PX(V/I ...
*  Beta-2 adrenergic receptor
Hall RA, Ostedgaard LS, Premont RT, Blitzer JT, Rahman N, Welsh MJ, Lefkowitz RJ (Jul 1998). "A C-terminal motif found in the ... "The beta2-adrenergic receptor interacts with the Na+/H+-exchanger regulatory factor to control Na+/H+ exchange". Nature. 392 ( ... Hall RA, Premont RT, Chow CW, Blitzer JT, Pitcher JA, Claing A, Stoffel RH, Barak LS, Shenolikar S, Weinman EJ, Grinstein S, ... Kobilka BK, Dixon RA, Frielle T, Dohlman HG, Bolanowski MA, Sigal IS, Yang-Feng TL, Francke U, Caron MG, Lefkowitz RJ (Jan 1987 ...
*  Sodium-hydrogen antiporter 3 regulator 1
Hall RA, Ostedgaard LS, Premont RT, Blitzer JT, Rahman N, Welsh MJ, Lefkowitz RJ (July 1998). "A C-terminal motif found in the ... 1998). "NHE-RF, a regulatory cofactor for Na(+)-H+ exchange, is a common interactor for merlin and ERM (MERM) proteins". J. ... Hall RA, Ostedgaard LS, Premont RT, et al. (1998). "A C-terminal motif found in the β2-adrenergic receptor, P2Y1 receptor and ... Hall RA, Premont RT, Chow CW, Blitzer JT, Pitcher JA, Claing A, Stoffel RH, Barak LS, Shenolikar S, Weinman EJ, Grinstein S, ...
*  RAPGEF3
... and function as nucleotide exchange factors for the Rap subfamily of RAS-like small GTPases. Since the landmark discovery of ... cAMP also prompts conformational changes within the regulatory lobe that lead to the exposure of a lipid binding motif, ... Rap guanine nucleotide exchange factor 3 also known as exchange factor directly activated by cAMP 1 (EPAC1) or cAMP-regulated ... De Rooij and colleagues performed a database search for proteins with sequence homology to both GEFs for Ras and Rap1 and to ...
*  TNK2
2000). "Stimulation of Ras guanine nucleotide exchange activity of Ras-GRF1/CDC25(Mm) upon tyrosine phosphorylation by the ... "The tyrosine kinase ACK1 associates with clathrin-coated vesicles through a binding motif shared by arrestin and other adaptors ... Kato J, Kaziro Y, Satoh T (2000). "Activation of the guanine nucleotide exchange factor Dbl following ACK1-dependent tyrosine ...
*  PLCG1
Kim MJ, Chang JS, Park SK, Hwang JI, Ryu SH, Suh PG (July 2000). "Direct interaction of SOS1 Ras exchange protein with the SH3 ... For example, in T cells, Lck and Fyn (Src family kinases) phosphorylate immunoreceptor tyrosine-based activation motifs (ITAMs ... For example, when activated by SRC, the encoded protein causes the Ras guanine nucleotide exchange factor RASGRP1 to ... The SH2 domains bind phosphorylated tyrosine residues on target proteins via their FLVR sequence motifs, activating the ...
*  GNAI1
Kimple RJ, De Vries L, Tronchère H, Behe CI, Morris RA, Gist Farquhar M, Siderovski DP (Aug 2001). "RGS12 and RGS14 GoLoco ... is a heterotrimeric Galpha protein guanine nucleotide exchange factor". The Journal of Biological Chemistry. 278 (10): 8356-62 ... motifs are G alpha(i) interaction sites with guanine nucleotide dissociation inhibitor Activity". The Journal of Biological ... Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA (Apr 1996). "A "double adaptor" method for improved shotgun library ...
*  Rap1
Ras and Rap are regulated by different sets of guanine nucleotide exchange factors and GTPase-activating proteins, thus ... This is a functionally significant region of the αL cytoplasmic domain as deletion of the adjacent GFFKR motif results in a ... Rap1 (Ras-proximate-1 or Ras-related protein 1) is a small GTPase, which are small cytosolic proteins that act like cellular ... RIAM (Rap1-GTP-interacting adapter molecule) is a broadly expressed adaptor protein that contains an RA (Ras association)-like ...
*  CDC42
This process is regulated by guanine nucleotide exchange factors (GEFs) which promote the exchange of bound GDP for free GTP, ... Brill S, Li S, Lyman CW, Church DM, Wasmuth JJ, Weissbach L, Bernards A, Snijders AJ (September 1996). "The Ras GTPase- ... Requirement of the Cdc42/Rac interactive binding motif and changes in phosphorylation". The Journal of Biological Chemistry. ... Walker SJ, Wu WJ, Cerione RA, Brown HA (May 2000). "Activation of phospholipase D1 by Cdc42 requires the Rho insert region". ...
*  Gephyrin
"Identification of a gephyrin-binding motif in the GDP/GTP exchange factor collybistin". Biol. Chem. 382 (10): 1455-62. doi: ... Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madan A, Young AC, Shevchenko Y, Bouffard ... Meyer G, Kirsch J, Betz H, Langosch D (1995). "Identification of a gephyrin binding motif on the glycine receptor beta subunit ...
*  RHOA
Vikis HG, Stewart S, Guan KL (April 2002). "SmgGDS displays differential binding and exchange activity towards different Ras ... Functional assignment of the Hr1 repeat motif". J. Biol. Chem. 273 (5): 2698-705. doi:10.1074/jbc.273.5.2698. PMID 9446575. ... Ras homolog gene family, member A (RhoA) is a small GTPase protein in the Rho family. While the effects of RhoA activity are ... RhoA, and the other Rho GTPases, are part of a larger family of related proteins known as the Ras superfamily, a family of ...
*  RASGRP1
It functions as a diacylglycerol (DAG)-regulated nucleotide exchange factor specifically activating Ras through the exchange of ... 1998). "RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs". Science. 280 (5366 ... RAS guanyl nucleotide-releasing protein (RASGRP) is a member of a family of genes characterized by the presence of a Ras ... 2007). "Unusual interplay of two types of Ras activators, RasGRP and SOS, establishes sensitive and robust Ras activation in ...
*  CRSP3
Mo X, Kowenz-Leutz E, Xu H, Leutz A (Jan 2004). "Ras induces mediator complex exchange on C/EBP beta". Molecular Cell. 13 (2): ... Ko L, Cardona GR, Chin WW (May 2000). "Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions ... Mo X, Kowenz-Leutz E, Xu H, Leutz A (Jan 2004). "Ras induces mediator complex exchange on C/EBP beta". Molecular Cell. 13 (2): ... "External control of Her2 expression and cancer cell growth by targeting a Ras-linked coactivator". Proceedings of the National ...
*  Adapter molecule crk
1995). "The SH3 domain of Crk binds specifically to a conserved proline-rich motif in Eps15 and Eps15R". J. Biol. Chem. 270 (25 ... Pessin JE, Okada S (2002). "Insulin and EGF receptors integrate the Ras and Rap signaling pathways". Endocr. J. 46 Suppl: S11-6 ... Okada S, Pessin JE (1996). "Interactions between Src homology (SH) 2/SH3 adapter proteins and the guanylnucleotide exchange ... 1994). "CRK protein binds to two guanine nucleotide-releasing proteins for the Ras family and modulates nerve growth factor- ...