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*  Rap GTP-binding protein
... also known as Ras-related proteins or simply RAP is a type of small GTPase, similar in structure to Ras ... rap GTP-Binding Proteins at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text ... The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is ... replaced by threonine in RAP proteins. RAP counteracts the mitogenic function of RAS because it can interact with RAS GAPs and ...
*  RASGEF1A
"RasGEF1A and RasGEF1B are guanine nucleotide exchange factors that discriminate between Rap GTP-binding proteins and mediate ... RasGEF domain family, member 1A is a protein that in humans is encoded by the RASGEF1A gene. GRCh38: Ensembl release 89: ...
*  RAP1B
Ras-related protein Rap-1b, also known as GTP-binding protein smg p21B, is a protein that in humans is encoded by the RAP1B ... Scrima A, Thomas C, Deaconescu D, Wittinghofer A (2008). "The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine ... 2004). "The GTPase-activating protein Rap1GAP uses a catalytic asparagine". Nature. 429 (6988): 197-201. doi:10.1038/ ... to lipid rafts is promoted by palmitoylation at Cys176 and Cys177 and is required for efficient protein activation in human ...
*  DIRAS3 (gene)
... homology with Ras and Rap, two other small GTP binding proteins. This gene is a maternally imprinted putative tumor suppressor ... GTP-binding protein Di-Ras3 (DIRAS3) also known as aplysia ras homology member I (ARHI) is a protein that in humans is encoded ... This change in structure has no effect on protein expression levels or its GTP-binding ability, suggesting the extension's ... While ARHI still binds GTP with high affinity, its hydrolysis of GTP to GDP is relatively low because of these differences. ...
*  RAP2A
"Identification of a specific effector of the small GTP-binding protein Rap2". European Journal of Biochemistry / FEBS. 252 (2 ... Ras-related protein Rap-2a is a protein that in humans is encoded by the RAP2A gene. RAP2A is a member of the Ras-related ... Ménétrey J, Cherfils J (Nov 1999). "Structure of the small G protein Rap2 in a non-catalytic complex with GTP". Proteins. 37 (3 ... "Identification of a specific effector of the small GTP-binding protein Rap2". European Journal of Biochemistry / FEBS. 252 (2 ...
*  GTPase-activator protein for Ras-like GTPase
Ras proteins are membrane-associated molecular switches that bind GTP and GDP and slowly hydrolyze GTP to GDP. This intrinsic ... Note: There are distinctly different GAPs for the rap and rho/rac subfamilies of ras-like proteins (reviewed in reference) that ... or GTPase-activating proteins. As it is the GTP bound form of ras which is active, these proteins are said to be down- ... GTPase-activator protein for Ras-like GTPase is a family of evolutionarily related proteins. ...
*  Binding protein
C4b-binding protein Rap GTP-binding protein Calmodulin-binding proteins Iron-binding proteins Thyroxine-binding proteins Folate ... DNA-binding protein Single-strand binding protein Telomere-binding protein RNA-binding protein Poly(A)-binding protein Nuclear ... binding protein Syntaxin binding protein 2 Oxysterol-binding protein E3 binding protein Iron-responsive element-binding protein ... element-binding protein GTP-binding protein Retinaldehyde-binding protein 1 Ccaat-enhancer-binding proteins Androgen-binding ...
*  MRAS
"The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 ( ... a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras". The Journal of Biological Chemistry. 276 ... "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 ( ... Ras-related protein M-Ras, also known as muscle RAS oncogene homolog and R-Ras3, is a protein that in humans is encoded by the ...
*  RRAS
"The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 ( ... and Rap". Proc. Natl. Acad. Sci. U.S.A. 91 (26): 12609-13. doi:10.1073/pnas.91.26.12609. PMC 45488 . PMID 7809086. Ortiz-Vega S ... "The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1". Oncogene. 21 ( ... Ras-related protein R-Ras is a protein that in humans is encoded by the RRAS gene. RRAS has been shown to interact with: ARAF, ...
*  Rap1
GTPases are inactive when in their GDP-bound form, and become active when they bind to GTP. GTPase activating proteins (GAPs) ... Ras and Rap are regulated by different sets of guanine nucleotide exchange factors and GTPase-activating proteins, thus ... and GEFs promoting the GTP-bound (active) form. When bound to GTP, small GTPases regulate myriad cellular processes. These ... RIAM (Rap1-GTP-interacting adapter molecule) is a broadly expressed adaptor protein that contains an RA (Ras association)-like ...
*  Small GTPase
A typical G-protein is active when bound to GTP and inactive when bound to GDP (i.e. when the GTP is hydrolyzed to GDP). The ... Rap, Rheb, and Rad. Miro is a recent contributor to the superfamily. Each subfamily shares the common core G domain, which ... GTP-binding protein regulators Wennerberg K, Rossman KL, Der CJ (March 2005). "The Ras superfamily at a glance". J. Cell Sci. ... Therefore, a G-protein can be switched on and off. GTP hydrolysis is accelerated by GTPase activating proteins (GAPs), while ...
*  RGS17
The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a ... "Modulation of rap activity by direct interaction of Galpha(o) with Rap1 GTPase-activating protein". The Journal of Biological ... Regulator of G-protein signaling 17 is a protein that in humans is encoded by the RGS17 gene. This gene encodes a member of the ... This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers ...
*  RAPGEF2
... is a cyclic AMP binding protein. Members of the RAS subfamily of GTPases function in signal transduction as GTP/GDP- ... Rap guanine nucleotide exchange factor 2 is a protein that in humans is encoded by the RAPGEF2 gene. ... 1999). "nRap GEP: a novel neural GDP/GTP exchange protein for rap1 small G protein that interacts with synaptic scaffolding ... serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between ...
*  GoLoco motif
Ponting CP (1999). "Raf-like Ras/Rap-binding domains in RGS12- and still-life-like signalling proteins". J. Mol. Med. 77 (10): ... When the ligand is associated to the receptor, GDP is displaced from G-alpha and GTP is bound. The GTP/G-alpha complex ... A GTPase activator for the nuclear ras-related regulatory protein RAP-1A. Drosophila protein Rapsynoid (also known as Partner ... Two classes of intracellular proteins act as inhibitors of G protein activation: GTPase activating proteins (GAPs), which ...
*  List of MeSH codes (D08)
... ran gtp-binding protein MeSH D08.811.277.040.330.300.400.475 --- rap gtp-binding proteins MeSH D08.811.277.040.330.300.400.475. ... gtp-binding protein alpha subunit, gi2 MeSH D08.811.277.040.330.300.200.100.300 --- gtp-binding protein alpha subunits, gq-g11 ... gtp-binding protein alpha subunits, g12-g13 MeSH D08.811.277.040.330.300.200.100.200 --- gtp-binding protein alpha subunits, gi ... rab gtp-binding proteins MeSH D08.811.277.040.330.300.400.400.025 --- rab1 gtp-binding proteins MeSH D08.811.277.040.330.300. ...
*  RAP2B
1993). "Association of the low molecular weight GTP-binding protein rap2B with the cytoskeleton during platelet aggregation". ... Ras-related protein Rap-2b is a protein that in humans is encoded by the RAP2B gene. RAP2B belongs to the Ras-related protein ... a RAS-related GTP-binding protein from platelets". Proc Natl Acad Sci U S A. 87 (17): 6527-31. doi:10.1073/pnas.87.17.6527. PMC ... glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and ...
*  RAPGEF5
... serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between ... Rap guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the RAPGEF5 gene. Members of the RAS (see ... and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, ... "Entrez Gene: RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5". de Rooij J, Rehmann H, van Triest M, et al. (2000). " ...
*  RASGRP1
1998). "RasGRP, a Ras guanyl nucleotide- releasing protein with calcium- and diacylglycerol-binding motifs". Science. 280 (5366 ... regulated nucleotide exchange factor specifically activating Ras through the exchange of bound GDP for GTP. It activates the ... 2007). "A LAD-III syndrome is associated with defective expression of the Rap-1 activator CalDAG-GEFI in lymphocytes, ... RAS guanyl-releasing protein 1 is a protein that in humans is encoded by the RASGRP1 gene. RAS guanyl nucleotide-releasing ...
*  Ultrasensitivity
GTP). Small GTPases, such as Ran and Ras, can exist in either a GTP-bound form (active) or a GDP-bound form (inactive), and the ... Bradshaw, JM; Kubota, Y; Meyer, T; Schulman, H (2003). "An ultrasensitive Ca2+/calmodulin-dependent protein kinase II-protein ... which activates RAP through degradation of Rap GAP. Ultrasensitivity was observed both in a dose-dependent manner (nH=5±0.2), ... Upon binding to GDP-bound Gαi, Pins is activated and recruits Mud to achieve polarized distribution of cortical factors. N- ...
*  RAP1A
"A novel small molecular weight GTP-binding protein with the same putative effector domain as the ras proteins in bovine brain ... Ras-related protein Rap-1A is a protein that in humans is encoded by the RAP1A gene. The product of this gene belongs to the ... The most striking difference between RAP proteins and RAS proteins resides in their 61st amino acid: glutamine in RAS is ... Boettner B, Govek EE, Cross J, Van Aelst L (Aug 2000). "The junctional multidomain protein AF-6 is a binding partner of the ...
*  List of MeSH codes (D12.776.157)
... ran gtp-binding protein MeSH D12.776.157.325.515.475 -- rap gtp-binding proteins MeSH D12.776.157.325.515.475.100 -- rap1 gtp- ... rab4 gtp-binding proteins MeSH D12.776.157.325.515.400.200 -- rab5 gtp-binding proteins MeSH D12.776.157.325.515.450 -- ral gtp ... gtp-binding protein alpha subunits, g12-g13 MeSH D12.776.157.325.332.100.200 -- gtp-binding protein alpha subunits, gi-go MeSH ... gtp-binding protein alpha subunit, gi2 MeSH D12.776.157.325.332.100.300 -- gtp-binding protein alpha subunits, gq-g11 MeSH ...
*  RGS14
GTP-bound G alpha subunits. Acting as a GTPase activating protein (GAP), the protein increases the rate of conversion of the ... 2001). "RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao". Biochem. J. 350 (1): 19-29 ... This protein contains one RGS domain, two Raf-like Ras-binding domains (RBDs), and one GoLoco motif. The protein attenuates the ... GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein ...
*  PDE6D
PDE delta subunit is thought to be a specific soluble transport factor for certain prenylated proteins and Arl2-GTP a regulator ... "cGMP binding to noncatalytic sites on mammalian rod photoreceptor phosphodiesterase is regulated by binding of its gamma and ... "The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases". The Journal ... interacts with the Arf-like protein Arl3 in a GTP specific manner". FEBS Letters. 458 (1): 55-9. doi:10.1016/S0014-5793(99) ...
*  Signal recognition particle receptor
... both of which contain a GTP-binding domain, while the prokaryotic SRP receptor comprises only the monomeric loosely membrane- ... is a multimeric protein, which along with its conjugate receptor (SR), is involved in targeting secretory proteins to the rough ... including Rap-Raf, Ras-PI3K(gamma), Ras-RalGDS, and Arl2-PDE(delta). The Signal recognition particle (SRP) ... SR-alpha binds to the SRP54 subunit of the SRP complex. The SR-beta subunit is a transmembrane GTPase that anchors the SR-alpha ...
*  List of MeSH codes (D12.644)
... ral gtp-binding proteins MeSH D12.644.360.525.462 --- ran gtp-binding protein MeSH D12.644.360.525.475 --- rap gtp-binding ... rab gtp-binding proteins MeSH D12.644.360.525.400.025 --- rab1 gtp-binding proteins MeSH D12.644.360.525.400.050 --- rab2 gtp- ... rab3a gtp-binding protein MeSH D12.644.360.525.400.150 --- rab4 gtp-binding proteins MeSH D12.644.360.525.400.200 --- rab5 gtp- ... rac1 gtp-binding protein MeSH D12.644.360.525.700.200 --- rhoa gtp-binding protein MeSH D12.644.360.525.700.300 --- rhob gtp- ...
*  Chromosome 14 (human)
... encoding protein Uncharacterized protein C14orf79 CDC42BPB: encoding protein CDC42 binding protein kinase beta CHMP4A: Charged ... GTPase-activating Rap/Ran-GAP domain-like 1 GCH1: GTP cyclohydrolase 1 (dopa-responsive dystonia) GPHB5: Glycoprotein hormone ... encoding protein MicroRNA 3173 MIS18BP1: encoding protein MIS18 binding protein 1 MOAP1: encoding protein Modulator of ... beta-5 GSKIP encoding protein GSK3B interacting protein HHIPL1: encoding protein HHIP-like protein 1 IFI27: encoding protein ...