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*  Chimerin 1
... is a GTPase activating protein specific for RAC GTP-binding proteins. It is expressed primarily in the brain and may ... This gene encodes GTPase-activating protein for p21-rac and a phorbol ester receptor. It plays an important role in ocular ... Buttery P, Beg AA, Chih B, Broder A, Mason CA, Scheiffele P (February 2006). "The diacylglycerol-binding protein α1-chimaerin ... the C-terminal RhoGAP domain and the central C1 domain similar to protein kinase C. When lipid diacylglycerol (DAG) binds to ...
*  Alan Hall
In parallel with this experiment, Hall showed that the presence of Rac, another Ras-related GTP-binding protein, is implicated ... "The small GTP-binding protein rac regulates growth factor-induced membrane ruffling". Cell. 70: 401-410. doi:10.1016/0092-8674( ... In 1993, Alan Hall was awarded the Feldberg Foundation Prize for his work on the role GTP-binding proteins played on signal ... Ridley, Anne; Hall, Alan (7 August 1992). "The small GTP-binding protein rho regulates the assembly of focal adhesions and ...
*  Membrane ruffling
The GTP-binding protein Rac is the regulator of this membrane ruffling. Changes in the Polyphosphoinositide metabolism and ... A number of actin-binding and organizing proteins localize to membrane ruffles and potentially target to transducing molecules ...
*  NCKAP1
"Interaction of Nck-associated protein 1 with activated GTP-binding protein Rac". The Biochemical Journal. 322 (Pt 3): 873-8. ... Nck-associated protein 1 is a protein that in humans is encoded by the NCKAP1 gene. NCKAP1 has been shown to interact with RAC1 ... and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". ... "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi: ...
*  ARHGDIA
"Mapping the binding site for the GTP-binding protein Rac-1 on its inhibitor RhoGDI-1". Structure. 8 (1): 47-55. doi:10.1016/ ... "Mapping the binding site for the GTP-binding protein Rac-1 on its inhibitor RhoGDI-1". Structure. 8 (1): 47-55. doi:10.1016/ ... Li X, Bu X, Lu B, Avraham H, Flavell RA, Lim B (February 2002). "The hematopoiesis-specific GTP-binding protein RhoH is GTPase ... Hoffman GR, Nassar N, Cerione RA (2000). "Structure of the Rho family GTP-binding protein Cdc42 in complex with the ...
*  Rho family of GTPases
Bustelo XR, Sauzeau V, Berenjeno IM (2007). "GTP-binding proteins of the Rho/Rac family: regulation, effectors and functions in ... This protein cannot be inactivated normally, through GTP hydrolysis, and is thus "stuck on". When a Rho protein activated in ... Because Rho proteins are G-proteins and plasma membrane bound, their location can be easily controlled. In each situation, ... A second target to explain the role of the Rho proteins in cancer is their regulatory proteins. Rho proteins are very tightly ...
*  RAC1
"Mapping the binding site for the GTP-binding protein Rac-1 on its inhibitor RhoGDI-1". Structure. 8 (1): 47-55. doi:10.1016/ ... "Interaction of Nck-associated protein 1 with activated GTP-binding protein Rac". The Biochemical Journal. 322 (3): 873-8. doi: ... rac1 GTP-Binding Protein at the US National Library of Medicine Medical Subject Headings (MeSH) RAC1 Info with links in the ... Yayoshi-Yamamoto S, Taniuchi I, Watanabe T (Sep 2000). "FRL, a novel formin-related protein, binds to Rac and regulates cell ...
*  PAK4
They serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of biological ... PAK4 interacts specifically with the GTP-bound form of Cdc42Hs and weakly activates the JNK family of MAP kinases. PAK4 is a ... PAK proteins, a family of serine/threonine p21-activating kinases, include PAK1, PAK2, PAK3 and PAK4. PAK proteins are critical ... Serine/threonine-protein kinase PAK 4 is an enzyme that in humans is encoded by the PAK4 gene. PAK4 is one of six members of ...
*  P21-activated kinases
They serve as targets for the small GTP binding proteins CDC42 and Rac and have been implicated in a wide range of biological ...
*  PAK1
These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of ... ARG-binding protein 2γ, hepatitis B virus X protein, STE20-related kinase adaptor protein α, RhoI, Klotho, N-acetylglucosaminyl ... Seoh ML, Ng CH, Yong J, Lim L, Leung T (March 2003). "ArhGAP15, a novel human RacGAP protein with GTPase binding property". ... Akinmade D, Talukder AH, Zhang Y, Luo WM, Kumar R, Hamburger AW (March 2008). "Phosphorylation of the ErbB3 binding protein ...
*  Tioguanine
... through inhibition of the GTP-binding protein (G protein) Rac1, which regulates the Rac/Vav pathway. An additional effect may ...
*  AKAP13
The DH domain is associated with guanine nucleotide exchange activation for the Rho/Rac family of small GTP-binding proteins, ... The A-kinase anchor proteins (AKAPs) are a group of structurally diverse proteins that have the common function of binding to ... of cAMP-dependent protein kinase with RII-anchoring proteins occurs through an amphipathic helix binding motif". J. Biol. Chem ... the first protein kinase A anchoring protein to integrate protein kinase A and Rho signaling". FEBS Lett. 507 (3): 264-8. doi: ...
*  Cytoskeleton
Septins are a group of the highly conserved GTP binding proteins found in eukaryotes. Different septins form protein complexes ... Rac for lamellipodia and Cdc42 for filopodia. Functions include: Muscle contraction Cell movement Intracellular transport/ ... Actin structures are controlled by the Rho family of small GTP-binding proteins such as Rho itself for contractile acto-myosin ... The same holds true for the actin-like proteins and their structure and ATP binding domain. Cytoskeletal proteins are usually ...
*  Rac3
... (Ras-related C3 botulinum toxin substrate 3) is a small (~21 kDa) monomeric GTP-binding protein G protein and is an ... It is a member of the Rac subfamily of the Rho family of small G proteins and is encoded by the gene RAC3. Courjal F, Chuchana ... RAC3 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH). ...
*  RhoG
Other proteins known to bind RhoG in its GTP-bound state include the microtubule-associated protein kinectin, Phospholipase D1 ... is sufficient to promote GTP-loading of Rac. RhoG-mediated Rac signalling has been shown to promote neurite outgrowth and cell ... RhoG (Ras homology Growth-related) (or ARGH) is a small (~21 kDa) monomeric GTP-binding protein (G protein), and is an ... Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG". The Journal of ...
*  RACGAP1
RAC (see RAC1; MIM 602048), and CDC42 (MIM 116952). GTPase-activating proteins (GAPs) bind activated forms of Rho GTPases and ... stimulate GTP hydrolysis. Through this catalytic function, Rho GAPs negatively regulate Rho-mediated signals. GAPs may also ... Rac GTPase-activating protein 1 is an enzyme that in humans is encoded by the RACGAP1 gene. Rho GTPases control a variety of ... "Entrez Gene: RACGAP1 Rac GTPase activating protein 1". Naud N, Touré A, Liu J, Pineau C, Morin L, Dorseuil O, Escalier D, ...
*  List of MeSH codes (D12.776.476)
... rac gtp-binding proteins MeSH D12.776.476.525.700.100.100 -- rac1 gtp-binding protein MeSH D12.776.476.525.700.200 -- rhoa gtp- ... rab1 gtp-binding proteins MeSH D12.776.476.525.400.050 -- rab2 gtp-binding protein MeSH D12.776.476.525.400.100 -- rab3 gtp- ... rab3a gtp-binding protein MeSH D12.776.476.525.400.150 -- rab4 gtp-binding proteins MeSH D12.776.476.525.400.200 -- rab5 gtp- ... gtp-binding protein alpha subunits, g12-g13 MeSH D12.776.476.375.100.200 -- gtp-binding protein alpha subunits, gi-go MeSH ...
*  Clostridium difficile toxin A
In Rac and Cdc42, the sugar moiety is transferred to the Thr-35. The glucosylation prevents proper binding of GTP and blocks ... Just I, Selzer J, von Eichel-Streiber C, Aktories K (March 1995). "The low molecular mass GTP-binding protein Rho is affected ... Small GTPases such as Rho, Rac, and Cdc42 regulate their activity by alternating between an active GTP-bound state, and an ... TcdA acts preferentially on the GDP-bound form of the GTPase proteins since this configuration exposes the threonine residue ...
*  Stress fiber
Cell migration takes place through the concerted action of three Rho family GTPases: Rho, Rac, and Cdc42. When GTP-bound, Rac ... Ridley, Anne J.; Hall, Alan (August 1992). "The small GTP-binding protein rho regulates the assembly of focal adhesions and ... Ridley, Anne J.; Hall, Alan (August 1992). "The small GTP-binding protein rho regulates the assembly of focal adhesions and ... When bound to GTP, Rho activates Rho-associated coiled-coil forming kinase (ROCK) and mammalian homologue of Drosophila ...
*  RAC2
... superoxide-generating NADPH oxidase by a small GTP-binding protein and its stimulatory and inhibitory GDP/GTP exchange proteins ... "Cryptic Rac-binding and p21(Cdc42Hs/Rac)-activated kinase phosphorylation sites of NADPH oxidase component p67(phox)". J. Biol ... "Entrez Gene: RAC2 ras-related C3 botulinum toxin substrate 2 (rho family, small GTP binding protein Rac2)". Gorvel JP, Chang TC ... Reibel L, Dorseuil O, Stancou R, Bertoglio J, Gacon G (1991). "A hemopoietic specific gene encoding a small GTP binding protein ...
*  ARHGDIG
Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG". J. Biol. Chem. ... del Pozo MA, Alderson NB, Kiosses WB, Chiang HH, Anderson RG, Schwartz MA (2004). "Integrins regulate Rac targeting by ... Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG". J. Biol. Chem. ... Li X, Bu X, Lu B, Avraham H, Flavell RA, Lim B (2002). "The Hematopoiesis-Specific GTP-Binding Protein RhoH Is GTPase Deficient ...
*  Pleckstrin homology domain
Mouse protein citron, a putative rho/rac effector that binds to the GTP-bound forms of rho and rac. Several S. cerevisiae ... Pleckstrin is one of the rare proteins to contain two PH domains. Ser/Thr protein kinases such as the Akt/Rac family, the beta- ... BUD4 and the BEM1-binding proteins BOI2 (BEB1) and BOI1 (BOB1). C. elegans protein MIG-10. Ceramide kinase, a lipid kinase that ... and proteins such as the βγ-subunits of heterotrimeric G proteins, and protein kinase C. Through these interactions, PH domains ...
*  GTPase-activator protein for Ras-like GTPase
Ras proteins are membrane-associated molecular switches that bind GTP and GDP and slowly hydrolyze GTP to GDP. This intrinsic ... Note: There are distinctly different GAPs for the rap and rho/rac subfamilies of ras-like proteins (reviewed in reference) that ... or GTPase-activating proteins. As it is the GTP bound form of ras which is active, these proteins are said to be down- ... GTPase-activator protein for Ras-like GTPase is a family of evolutionarily related proteins. ...
*  RHOB
Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG". J. Biol. Chem. ... "A novel partner for the GTP-bound forms of rho and rac". FEBS Lett. NETHERLANDS. 377 (2): 243-8. doi:10.1016/0014-5793(95)01351 ... Identification of a non-cytosolic GDI protein interacting with the small GTP-binding proteins RhoB and RhoG". J. Biol. Chem. ... RHOB is a member of the Rho GTP-binding protein family. RHOB has been shown to interact with CIT, ARHGEF3, ARHGDIG and RHPN2. ...
*  Dock180
... a small G protein of the Rac subfamily) is perhaps the best known inducer of Dock180 GEF activity. Active (GTP-bound) RhoG ... Subsequently it was reported that Dock180 was able to activate the small GTP-binding protein (G protein) Rac1 and this was ... and their activation requires the dissociation of GDP and binding of guanosine triphosphate (GTP). GEFs activate G proteins by ... which contribute to cellular signalling events by activating small G proteins. In their resting state G proteins are bound to ...
*  Dock11
Côté JF, Vuori K (August 2007). "GEF what? Dock180 and related proteins help Rac to polarize cells in new ways". Trends in Cell ... GTP-bound Cdc42, although this interaction required a small N-terminal region of Dock11 in addition to the DHR2 domain. Cdc42 ... Dock11 activates the small G protein Cdc42. Dock11 was identified as a protein which is highly expressed in Germinal center B ... Dock11 binds and activates nucleotide-free Cdc42 via its DHR2 domain and has also been reported to mediate positive feedback on ...