"Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5". The EMBO Journal. 17 (7): ... Zahraoui A, Touchot N, Chardin P, Tavitian A (Jul 1989). "The human Rab genes encode a family of GTP-binding proteins related ... "Rab5 association with the angiotensin II type 1A receptor promotes Rab5 GTP binding and vesicular fusion". The Journal of ... Ras-related protein Rab-5A is a protein that in humans is encoded by the RAB5A gene. RAB5A localizes to early endosomes where ...
"Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5". The EMBO Journal. 17 (7): ... Zahraoui A, Touchot N, Chardin P, Tavitian A (Jul 1989). "The human Rab genes encode a family of GTP-binding proteins related ... "Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5". The EMBO Journal. 17 (7): ... Bailly E, McCaffrey M, Touchot N, Zahraoui A, Goud B, Bornens M (Apr 1991). "Phosphorylation of two small GTP-binding proteins ...
... rab4 gtp-binding proteins MeSH D08.811.277.040.330.300.400.400.200 - rab5 gtp-binding proteins MeSH D08.811.277.040.330.300. ... gtp-binding protein alpha subunits MeSH D08.811.277.040.330.300.200.100.100 - gtp-binding protein alpha subunits, g12-g13 MeSH ... gtp-binding protein alpha subunits, gi-go MeSH D08.811.277.040.330.300.200.100.200.500 - gtp-binding protein alpha subunit, gi2 ... gtp-binding protein alpha subunits, gq-g11 MeSH D08.811.277.040.330.300.200.100.400 - gtp-binding protein alpha subunits, gs ...
... domain-containing proteins based on their Rab-binding activity". Genes to Cells. 11 (9): 1023-37. doi:10.1111/j.1365-2443.2006. ... Pan X, Eathiraj S, Munson M, Lambright DG (2006). "TBC-domain GAPs for Rab GTPases accelerate GTP hydrolysis by a dual-finger ... and his coworkers found a specific interaction between RUTBC3/RabGAP-5 and Rab5A that activates the GTPase activity of Rab5 ... Such activity of TBC proteins does not always require a close physical interaction although few TBC proteins have shown clear ...
... is a RAB5A effector protein which binds via an N-terminal zinc finger domain and is required for fusion of early and late ... EEA1 plays a role in endocytosis and is recruited by Rab5-GTP to endosomal membranes. EEA1 may be regulated through ... Due to the proteins importance in vesicular trafficking, a number of intracellular bacteria prevent EEA1 recruitment to the ... EEA1 binds directly to the phospholipid phosphatidylinositol 3-phosphate through its C-terminal FYVE domain and forms a ...
... encoding a small GTP-binding protein homologous to the Ras-related RAB gene". Cytogenet Cell Genet. 73 (1-2): 137-9. doi: ... 2004). "RIN3: a novel Rab5 GEF interacting with amphiphysin II involved in the early endocytic pathway". J. Cell Sci. 116 (Pt ... Ras-related protein Rab-5C is a protein that in humans is encoded by the RAB5C gene. RAB5C belongs to the Ras-related protein ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: ...
... proteins with which Rab interacts and through which it functions, only bind the GTP-bound form of Rab. Rab effectors are very ... GDI1 gene has been shown through brain extracts of the mutant mice to lead to the accumulation of the Rab4 and Rab5 proteins, ... catalyzes the conversion from GDP-bound to GTP-bound form, thereby activating the Rab. The inherent GTP hydrolysis of Rabs can ... The specific binding of the effector to the Rab protein allows the Rab protein to be effective, and conversely, the ...
... rab3a gtp-binding protein MeSH D12.776.476.525.400.150 - rab4 gtp-binding proteins MeSH D12.776.476.525.400.200 - rab5 gtp- ... rac gtp-binding proteins MeSH D12.776.476.525.700.100.100 - rac1 gtp-binding protein MeSH D12.776.476.525.700.200 - rhoa gtp- ... rab1 gtp-binding proteins MeSH D12.776.476.525.400.050 - rab2 gtp-binding protein MeSH D12.776.476.525.400.100 - rab3 gtp- ... gtp-binding protein alpha subunits, g12-g13 MeSH D12.776.476.375.100.200 - gtp-binding protein alpha subunits, gi-go MeSH ...
It binds GTP and is involved in endosome dynamics and reorganization of the actin cytoskeleton, and it may coordinate membrane ... "RhoD binds the Rab5 effector Rabankyrin-5 and has a role in trafficking of the platelet-derived growth factor receptor". ... RhoD (Ras homolog gene family, member D) is a small (~21 kDa) signaling G protein (more specifically a GTPase), and is a member ... Jaffe AB, Aspenström P, Hall A (February 2004). "Human CNK1 acts as a scaffold protein, linking Rho and Ras signal transduction ...
"Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5". The EMBO Journal. 17 (7): ... Rab GTPase-binding effector protein 1 is an enzyme that in humans is encoded by the RABEP1 gene. It belongs to rabaptin protein ... "Distinct Rab-binding domains mediate the interaction of Rabaptin-5 with GTP-bound Rab4 and Rab5". The EMBO Journal. 17 (7): ... "Entrez Gene: RABEP1 rabaptin, RAB GTPase binding effector protein 1". Mattera R, Arighi CN, Lodge R, Zerial M, Bonifacino JS ( ...
... rab4 gtp-binding proteins MeSH D12.776.157.325.515.400.200 - rab5 gtp-binding proteins MeSH D12.776.157.325.515.450 - ral gtp- ... binding proteins MeSH D12.776.157.325.515.462 - ran gtp-binding protein MeSH D12.776.157.325.515.475 - rap gtp-binding proteins ... gtp-binding protein alpha subunits, g12-g13 MeSH D12.776.157.325.332.100.200 - gtp-binding protein alpha subunits, gi-go MeSH ... gtp-binding protein alpha subunit, gi2 MeSH D12.776.157.325.332.100.300 - gtp-binding protein alpha subunits, gq-g11 MeSH ...
Members of the RAB family of RAS-related GTP-binding proteins are important regulators of vesicular transport and are located ... "Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7". The Journal of Cell Biology. 183 (3): ... Ras-related protein Rab-7a is a protein that in humans is encoded by the RAB7A gene. Ras-related protein Rab-7a is involved in ... These proteins are GTPases and act like a switch which is turned on and off by GTP and GDP molecules. Melanoma cells retain a ...
... rab4 gtp-binding proteins MeSH D12.644.360.525.400.200 - rab5 gtp-binding proteins MeSH D12.644.360.525.450 - ral gtp-binding ... ran gtp-binding protein MeSH D12.644.360.525.475 - rap gtp-binding proteins MeSH D12.644.360.525.475.100 - rap1 gtp-binding ... rab2 gtp-binding protein MeSH D12.644.360.525.400.100 - rab3 gtp-binding proteins MeSH D12.644.360.525.400.100.100 - rab3a gtp- ... rho gtp-binding proteins MeSH D12.644.360.525.700.050 - cdc42 gtp-binding protein MeSH D12.644.360.525.700.050.500 - cdc42 gtp- ...
"A novel Golgi membrane protein is part of a GTPase-binding protein complex involved in vesicle targeting". The EMBO Journal. 19 ... Jan 1997). "The GDP/GTP cycle of Rab5 in the regulation of endocytotic membrane traffic". Cold Spring Harbor Symposia on ... "protein YIF1A isoform 2 [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2020-07-28. "protein YIF1A isoform 1 ... early growth response 1 GATA-binding factor 1 Transcription factor CP2-like 1 (LBP-9) X-box binding protein RFX1 Estrogen ...
... clathrin-adaptors and various binding proteins. The SNX-BAR dimer enters the nucleation complex via direct binding or lateral ... The nucleation complex is formed through the interaction of VPS complex with GTP-activated Rab7 with clathrin, ... "Regulation of retromer recruitment to endosomes by sequential action of Rab5 and Rab7". The Journal of Cell Biology. 183 (3): ... the cargo binding function of this complex is contributed by the core heterotrimer through the binding of Vps26 and Vps35 ...
βCTF recruits APPL1 to rab5 endosomes, where it stabilizes active GTP-Rab5, leading to pathologically accelerated endocytosis, ... July 1999). "DRBP76, a double-stranded RNA-binding nuclear protein, is phosphorylated by the interferon-induced protein kinase ... Protein kinase RNA-activated also known as protein kinase R (PKR), interferon-induced, double-stranded RNA-activated protein ... "The direct binding of the catalytic subunit of protein phosphatase 1 to the PKR protein kinase is necessary but not sufficient ...
Rab5 GDP/GTP exchange factor is a protein that in humans is encoded by the RABGEF1 gene. RABGEF1 forms a complex with rabaptin- ... 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation ... 1997). "A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: ...
GTP-binding protein regulators, Protein families). ... The mechanism of REP-1-mediated membrane association of Rab5 is ... "Rab escort protein-1 is a multifunctional protein that accompanies newly prenylated rab proteins to their target membranes". ... GDIs bind to the GDP-bound form of Rho and Rab small GTPases and not only prevent exchange (maintaining the small GTPase in an ... site-directed mutagenesis has shown these regions to play a critical role in the binding of Rab proteins. Dirac-Svejstrup AB, ...