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*  Nalidixic acid
Synthetic quinolone antibiotics were discovered by George Lesher and coworkers as a byproduct of chloroquine manufacture in the ... In a technical sense, it is a naphthyridone, not a quinolone: its ring structure is a 1,8-naphthyridine nucleus that contains ... Amfonelic acid Oxolinic acid Emmerson AM, Jones AM (May 2003). "The quinolones: decades of development and use" (pdf). The ... Nalidixic acid (tradenames Nevigramon, Neggram, Wintomylon and WIN 18,320) is the first of the synthetic quinolone antibiotics ...
*  Grepafloxacin
This is a racemate, ie a 1: 1 mixture of ( R ) - and the ( S ) - form: Quinolones "Glaxo Wellcome voluntary withdrawn Raxar ( ... The preparation of quinolones bearing a substituent at position 5 is complicated by the greater electrophilic character of the ... This last intermediate is then taken on to the quinolone (9) by essentially the same scheme as that used to prepare difloxacin ...
*  Fleroxacin
As quinolones are known to induce arthropathy in juvenile animals, administration of the drug to breast-feeding women cannot be ... Fleroxacin is a quinolone antibiotic. It is sold under the brand names Quinodis and Megalocin. Fleroxacin is a bactericidal ... Like other quinolones and fluoroquinolones the compound eradicates bacteria by interfering with DNA replication (bacterial DNA ... Yoshida H, Nakamura M, Bogaki M, Ito H, Kojima T, Hattori H, Nakamura S (April 1993). "Mechanism of action of quinolones ...
*  4-Quinolone
It and 2-quinolone are the two most important parent (meaning simplified) quinolones. 4-Quinolone exists in equilibrium with a ... The hydroxyquinolines tautomerize to the quinolones. Andriole, VT The Quinolones. Academic Press, 1989. Shi, Pengfei; Wang, ... the 4-quinolone antibiotics represent a large class of important drugs. The chemical synthesis of quinolones often involves ... 4-Quinolone is an organic compound derived from quinoline. ... 4-Quinolone is of little intrinsic value but its derivatives, ...
*  Quinolone antibiotic
... at Curlie (based on DMOZ) Healthcare-associated Infections (HAIs)- Quinolones and the Clinical Laboratory ... Although not formally a quinolone, nalidixic acid is considered the first quinolone drug. It was introduced in 1962 for ... Norris, S; Mandell, GL (1988). "The quinolones: history and overview". The quinolones: history and overview. San Diego: ... VT The Quinolones. Academic Press, 1989. Andersson MI, MacGowan AP (2003). "Development of the quinolones". Journal of ...
*  2-Quinolone
The isomer 4-quinolone is the parent of a large class of quinolone antibiotics. Tashima, Toshihiko (2015). "The structural use ... 2-Quinolone is an organic compound related structurally to quinoline. It is the majority tautomer in equilibrium with 2- ...
*  Benzodiazepine withdrawal syndrome
Committee on Safety of Medicines; Medicines and Healthcare products Regulatory Agency (2008). "Quinolones". United Kingdom: ...
*  Rufloxacin
Quinolones Rafalsky, V.; Andreeva, I.; Rjabkova, E. (2006). "Quinolones for uncomplicated acute cystitis in women". Cochrane ... Rufloxacin is a quinolone antibiotic. It is sold under the brand names, Ruflox, Monos, Qari, Tebraxin, Uroflox, Uroclar. ...
*  Sparfloxacin
... , like other quinolones and fluoroquinolones, are bactericidal drugs, actively killing bacteria. Quinolones inhibit ... Quinolones can enter cells easily and therefore are often used to treat intracellular pathogens such as Legionella pneumophila ... Quinolones Psaty, BM. (Dec 2008). "Clinical trial design and selected drug safety issues for antibiotics used to treat ...
*  Flumequine
Allergy to quinolones Eight cases of quinolone allergy F. F. Arboit 1 , JC Bessot 2 , F. Arboit 1, JC Bessot 2, F. De Blay 2 , ... Although quinolones are highly toxic to mammalian cells in culture, its mechanism of cytotoxic action is not known. Quinolone ... Flumequine is the first quinolone compound with a fluorine atom at the C6-position of the related quinolone basic molecular ... Significant and harmful residues of quinolones have been found in animals treated with quinolones and later slaughtered and ...
*  Norfloxacin
Some quinolones exert an inhibitory effect on the cytochrome P-450 system, thereby reducing theophylline clearance and ... Quinolones, including norfloxacin, may enhance the effects of oral anticoagulants, including warfarin or its derivatives or ... "Quinolones for uncomplicated acute cystitis in women". Cochrane Database Syst Rev. 3 (3): CD003597. doi:10.1002/14651858. ... The toxicity of drugs that are metabolised by the cytochrome P450 system is enhanced by concomitant use of some quinolones. ...
*  Lomefloxacin
Quinolones Rubinstein, E. (2001). "History of quinolones and their side effects". Chemotherapy. 47 (Suppl 3): 3-8; discussion ...
*  Ofloxacin
quinolones for community-acquired pneumonia: meta-analysis of randomized controlled trials". Clin. Microbiol. Infect. 19 (4): ... Drlica K, Zhao X (1 September 1997). "DNA gyrase, topoisomerase IV, and the 4-quinolones". Microbiol Mol Biol Rev. 61 (3): 377- ... Research and Development of Quinolones in Daiichi Sankyo Co., Ltd. Archived 2016-10-12 at the Wayback Machine. Page accessed ... Simultaneous use of corticosteroids is present in almost one-third of quinolone-associated tendon rupture. Tendon damage may ...
*  Pefloxacin
... is a quinolone antibiotic used to treat bacterial infections. Pefloxacin has not been approved for use in the United ... Casparian JM, Luchi M, Moffat RE, Hinthorn D (May 2000). "Quinolones and tendon ruptures". South. Med. J. 93 (5): 488-91. doi: ... and the 4-quinolones". Microbiol Mol Biol Rev. 61 (3): 377-92. PMC 232616 . PMID 9293187. Khaliq Y, Zhanel GG (October 2005). " ...
*  Leprosy in Japan
Recently new quinolones were added. Outpatient treatment has become possible even at the onset of the disease, and now we can ...
*  Balofloxacin
Quinolones Alksne, L. (Feb 2003). "Balofloxacin Choongwae". Curr Opin Investig Drugs. 4 (2): 224-9. PMID 12669387. ...
*  Enterobacter
Quinolones can be an effective alternative. A recent study has shown that the presence of Enterobacter cloacae B29 in the gut ...
*  Sitafloxacin
Quinolone Anderson, DL. (Jul 2008). "Sitafloxacin hydrate for bacterial infections". Drugs Today (Barc). 44 (7): 489-501. doi: ...
*  Difloxacin
Quinolone Chidiac, C.; Mouton, Y. (1991). "Quinolones in the treatment of lower respiratory tract infections caused by ... Individuals with a history of hypersensitivity to quinolones should avoid this product. In humans, there is a risk of user ... Therefore, the concurrent oral administration of quinolones with foods, supplements or other preparations containing any of ... may substantially interfere with the absorption of quinolones from the intestinal tract resulting in decreased bioavailability ...
*  Conrad-Limpach synthesis
1992). "Cytotoxicity of quinolones toward eukaryotic cells. Identification of topoisomerase II as the primary cellular target ... Although the reaction product is often shown as a hydroxyquinoline (the enol form), it is believed that the quinolone (keto ... The synthesis of 4-hydroxyquinolines and 4-quinolones is of great importance to a variety of fields, but most notably to the ... there is some discrepancy on whether a substituted 4-hydroxyquinoline or a substituted 4-quinolone is the final product of the ...
*  Production of antibiotics
However a recent investigation into the origin of quinolones have discovered that a description for quinolones happened in 1949 ... These include the quinolone class, of which nalidixic acid is often credited as the first to be discovered. Like other ... Emmerson, A. M.; Jones, A. M. (2003-05-01). "The quinolones: decades of development and use". Journal of Antimicrobial ... Bisacchi, Gregory S. (2015-06-25). "Origins of the Quinolone Class of Antibacterials: An Expanded "Discovery Story"". Journal ...
*  Enoxacin
The quinolone is also active against Gram-negative bacteria After oral administration enoxacin is rapidly and well absorbed ... "Quinolones for uncomplicated acute cystitis in women". Cochrane Database Syst Rev. 3 (3): CD003597. doi:10.1002/14651858. ... De Sarro A, Zappalá M, Chimirri A, Grasso S, De Sarro GB (July 1993). "Quinolones potentiate cefazolin-induced seizures in DBA/ ... Quinolones and fluoroquinolones are bactericidal drugs, eradicating bacteria by interfering with DNA replication. Like other ...
*  Nadifloxacin
Quinolones Murata K, Tokura Y (March 2007). "[Anti-microbial therapies for acne vulgaris: anti-inflammatory actions of anti- ... Nadifloxacin does not show cross-resistance with other new quinolones. Nadifloxacin inhibits the enzyme DNA gyrase that is ... Kuwahara K, Kitazawa T, Kitagaki H, Tsukamoto T, Kikuchi M (April 2005). "Nadifloxacin, an antiacne quinolone antimicrobial, ... risking the development of quinolone resistances. During the treatment some patients may develop some adverse effects ...
*  Clinafloxacin
Appelbaum, PC (1999). "Quinolone activity against anaerobes". Drugs. 58 Suppl 2: 60-4. PMID 10553708. Retrieved 13 September ... Nord, C. E. (1999). "Use of newer quinolones for the treatment of intraabdominal infections: Focus on clinafloxacin". Infection ... Rubinstein, E. (2001). "History of quinolones and their side effects". Chemotherapy. 47 Suppl 3: 3-8; discussion 44-8. doi: ...
*  Temafloxacin
Quinolones "Recalling the Omniflox (Temafloxacin) Tablets" (pdf). Food and Drug Administration. 1992-06-05. Retrieved 2014-10- ... Gentry LO (December 1991). "Review of quinolones in the treatment of infections of the skin and skin structure". J. Antimicrob ... Rubinstein, E. "History of quinolones and their side effects". Chemotherapy. 47 Suppl 3: 3-8; discussion 44-8. doi:10.1159/ ...