... may refer to: 2-Quinolone 4-Quinolone Quinolone antibiotics This set index article lists chemical compounds articles ...

It and 2-quinolone are the two most important parent (meaning simplified) quinolones. 4-Quinolone exists in equilibrium with a ... The hydroxyquinolines tautomerize to the quinolones. Andriole, VT The Quinolones. Academic Press, 1989. Shi, Pengfei; Wang, ... the 4-quinolone antibiotics, represent a large class of important drugs. The chemical synthesis of quinolones often involves ... 4-Quinolone is an organic compound derived from quinoline. ... 4-quinolone is of little intrinsic value but its derivatives, ...

... at Curlie Healthcare-associated Infections (HAIs)- Quinolones and the Clinical Laboratory CDC Information ... Although not formally a quinolone, nalidixic acid is considered the first quinolone drug. It was introduced in 1962 for ... Quinolones should also not be given to people with a known hypersensitivity to the drug class. The basic pharmacophore, or ... Quinolones are associated with a small risk of tendonitis and tendon rupture; a 2013 review found the incidence of tendon ...

The isomer 4-quinolone is the parent of a large class of quinolone antibiotics. One example is Ravesilone. Tashima, Toshihiko ( ... 2-Quinolone is an organic compound related structurally to quinoline. It is the majority tautomer in equilibrium with 2- ... Media related to 2-Quinolone at Wikimedia Commons (Use dmy dates from December 2021, Articles without InChI source, ECHA ...

Committee on Safety of Medicines; Medicines and Healthcare products Regulatory Agency (2008). "Quinolones". United Kingdom: ...

Although quinolones are highly toxic to mammalian cells in culture, its mechanism of cytotoxic action is not known. Quinolone ... Flumequine is the first quinolone compound with a fluorine atom at the C6-position of the related quinolone basic molecular ... Significant and harmful residues of quinolones have been found in animals treated with quinolones and later slaughtered and ... The quinolones (Third Edition 2000) By Vincent T. Andriole Chapter I History and overview By Dr. Peter Ball (page 5) King DE, ...

Some quinolones exert an inhibitory effect on the cytochrome P-450 system, thereby reducing theophylline clearance and ... Quinolones, including norfloxacin, may enhance the effects of oral anticoagulants, including warfarin or its derivatives or ... The toxicity of drugs that are metabolised by the cytochrome P450 system is enhanced by concomitant use of some quinolones. ... The first members of the quinolone antibacterial class were relatively low potency drugs such as nalidixic acid, used mainly in ...

... is a quinolone antibiotic useful for the treatment of a number of bacterial infections. When taken by mouth or ... quinolones for community-acquired pneumonia: meta-analysis of randomized controlled trials". Clinical Microbiology and ... Atarashi S. "Research and Development of Quinolones in Daiichi Sankyo Co., Ltd" (PDF). Daiichi. Archived from the original (PDF ... Simultaneous use of corticosteroids is present in almost one-third of quinolone-associated tendon rupture. Tendon damage may ...

Quinolones Rubinstein E (2001). "History of quinolones and their side effects". Chemotherapy. 47 Suppl 3 (3): 3-8, discussion ...

... is a quinolone antibiotic used to treat bacterial infections. Pefloxacin has not been approved for use in the United ... Casparian JM, Luchi M, Moffat RE, Hinthorn D (May 2000). "Quinolones and tendon ruptures". South. Med. J. 93 (5): 488-91. doi: ... Drlica K, Zhao X (1 September 1997). "DNA gyrase, topoisomerase IV, and the 4-quinolones". Microbiol Mol Biol Rev. 61 (3): 377- ...

Recently new quinolones were added. Outpatient treatment has become possible even at the onset of the disease, and now we can ...

... like other quinolones and fluoroquinolones, are bactericidal drugs, actively killing bacteria. Quinolones inhibit the bacterial ... Quinolones can enter cells easily and therefore are often used to treat intracellular pathogens such as Legionella pneumophila ... Quinolones Psaty BM (December 2008). "Clinical trial design and selected drug safety issues for antibiotics used to treat ...

Quinolones Alksne L (February 2003). "Balofloxacin Choongwae". Current Opinion in Investigational Drugs. 4 (2): 224-9. PMID ...

Despite quinolones ability to target TopII, they can also inhibit TopIV based on the organisms and type of quinolone. ... 1989) model of quinolone inhibitor binding proposed that, in each DNAgyrase-DNA complex, four quinolone molecules associate ... In particular, smaller quinolones have shown to bind with high affinity in the multi-drug efflux pump in Escherichia coli and ... Quinolones are amongst the most commonly used antibiotics for bacterial infections in humans, and are used to treat illness ...

Quinolones can be an effective alternative. A 2012 study has shown that the presence of Enterobacter cloacae B29 in the gut of ...

Synthetic quinolone antibiotics were discovered by George Lesher and coworkers as a byproduct of chloroquine manufacture in the ... In a technical sense, it is a naphthyridone, not a quinolone: its ring structure is a 1,8-naphthyridine nucleus that contains ... Nalidixic acid (tradenames Nevigramon, NegGram, Wintomylon and WIN 18,320) is the first of the synthetic quinolone antibiotics ... "Disabling and potentially permanent side effects lead to suspension or restrictions of quinolone and fluoroquinolone ...

1992). "Cytotoxicity of quinolones toward eukaryotic cells. Identification of topoisomerase II as the primary cellular target ... Although the reaction product is often shown as a hydroxyquinoline (the enol form), it is believed that the quinolone (keto ... The synthesis of 4-hydroxyquinolines and 4-quinolones is of great importance to a variety of fields, but most notably to the ... there is some discrepancy on whether a substituted 4-hydroxyquinoline or a substituted 4-quinolone is the final product of the ...

Rubinstein E (2001). "History of quinolones and their side effects". Chemotherapy. 47 (Suppl 3): 3-8, discussion 44-8. doi: ...

As quinolones are known to induce arthropathy in juvenile animals, administration of the drug to breast-feeding women cannot be ... Fleroxacin is a quinolone antibiotic. It is sold under the brand names Quinodis and Megalocin. Fleroxacin is a bactericidal ... Like other quinolones and fluoroquinolones the compound eradicates bacteria by interfering with DNA replication (bacterial DNA ... Yoshida H, Nakamura M, Bogaki M, Ito H, Kojima T, Hattori H, Nakamura S (April 1993). "Mechanism of action of quinolones ...

However a recent investigation into the origin of quinolones have discovered that a description for quinolones happened in 1949 ... These include the quinolone class, of which nalidixic acid is often credited as the first to be discovered. Like other ... Emmerson, A. M.; Jones, A. M. (2003-05-01). "The quinolones: decades of development and use". Journal of Antimicrobial ... Bisacchi, Gregory S. (2015-06-25). "Origins of the Quinolone Class of Antibacterials: An Expanded "Discovery Story"". Journal ...

For example, WIN 18,320 was nalidixic acid, the first quinolone antibiotic. The Company was established in 1901 (then called ... "The Quinolones: Decades of Development and Use". Journal of Antimicrobial Chemotherapy. 51 (Suppl 1): 13-20. doi:10.1093/jac/ ...

The quinolone is also active against Gram-negative bacteria After oral administration enoxacin is rapidly and well absorbed ... Yoshida H, Nakamura M, Bogaki M, Ito H, Kojima T, Hattori H, Nakamura S (April 1993). "Mechanism of action of quinolones ... De Sarro A, Zappalá M, Chimirri A, Grasso S, De Sarro GB (July 1993). "Quinolones potentiate cefazolin-induced seizures in DBA/ ... Quinolones and fluoroquinolones are bactericidal drugs, eradicating bacteria by interfering with DNA replication. Like other ...

Quinolones Rafalsky V, Andreeva I, Rjabkova E (July 2006). "Quinolones for uncomplicated acute cystitis in women". The Cochrane ... Rufloxacin is a quinolone antibiotic. It is sold under the brand names, Ruflox, Monos, Qari, Tebraxin, Uroflox, Uroclar. ...

Appelbaum PC (1999). "Quinolone activity against anaerobes". Drugs. 58 Suppl 2: 60-4. doi:10.2165/00003495-199958002-00012. ... Rubinstein E (2001). "History of quinolones and their side effects". Chemotherapy. 47 Suppl 3 (3): 3-8, discussion 44-8. doi: ... Nord CE (1999). "Use of newer quinolones for the treatment of intraabdominal infections: focus on clinafloxacin". Infection. 27 ...

Rubinstein E (2001). "History of quinolones and their side effects". Chemotherapy. 47 Suppl 3 (3): 3-8, discussion 44-8. doi: ...

Quinolones "Recalling the Omniflox (Temafloxacin) Tablets" (PDF). Food and Drug Administration. 1992-06-05. Retrieved 2014-10- ... Gentry LO (December 1991). "Review of quinolones in the treatment of infections of the skin and skin structure". J. Antimicrob ... Rubinstein, E. (2001). "History of quinolones and their side effects". Chemotherapy. 47 Suppl 3 (3): 3-8, discussion 44-8. doi: ...

6). Quinolone antibacterial compounds were first developed in the 1960s and have been in clinical use since the 1980s. FQ ... Maxwell A, Bush NG, Germe T, McKie SJ (2018). "Non-quinolone topoisomerase inhibitors". In Fong IW, Drlica K (eds.). ... Bush NG, Diez-Santos I, Abbott LR, Maxwell A (December 2020). "Quinolones: Mechanism, Lethality and Their Contributions to ...

Praziquantel, a quinolone derivative. The effect of praziquantel on H. heterophyes causes deep lesions on their teguments, and ...

Quinolones show effective prophylaxis mainly with hematological cancer. However, in general, for every five people who are ... The risk of illness and death can be reduced by taking common antibiotics such as quinolones or trimethoprim/sulfamethoxazole ...

Commonly referred to as the first generation quinolones. This first generation also included other quinolone drugs such as ... Cinoxacin is a quinolone antibiotic that has been discontinued in the U.K. as well the United States, both as a branded drug or ... Cinoxacin was an older synthetic antimicrobial related to the quinolone class of antibiotics with activity similar to oxolinic ... Drlica K, Zhao X (September 1997). "DNA gyrase, topoisomerase IV, and the 4-quinolones". Microbiology and Molecular Biology ...