*  Pyruvate kinase
Mammals have two pyruvate kinase genes, PK-LR (which encodes for pyruvate kinase isozymes L and R) and PK-M (which encodes for ... Once pyruvate kinase synthesizes pyruvate, pyruvate either enters the TCA cycle for further production of ATP under aerobic ... Because the substrate for pyruvate kinase is a simple phospho-sugar, and the product is an ATP, pyruvate kinase is a possible ... Therefore, pyruvate kinase deficiency can cause chronic nonspherocytic hemolytic anemia (CNSHA). Pyruvate kinase deficiency is ...
*  Pyruvate dehydrogenase lipoamide kinase isozyme 1
It codes for an isozyme of pyruvate dehydrogenase kinase (PDK). Pyruvate dehydrogenase (PDH) is a part of a mitochondrial ... "Site specificity of four pyruvate dehydrogenase kinase isoenzymes toward the three phosphorylation sites of human pyruvate ... "Entrez Gene: PDK1 pyruvate dehydrogenase kinase, isozyme 1". Park J, Li Y, Kim SH, Kong G, Shrestha R, Tran Q, Hong J, Hur GM, ... Hur H, Xuan Y, Kim YB, Lee G, Shim W, Yun J, Ham IH, Han SU (Jan 2013). "Expression of pyruvate dehydrogenase kinase-1 in ...
*  Pyruvate kinase deficiency
... is an inherited metabolic disorder of the enzyme pyruvate kinase which affects the survival of red ... "Pyruvate kinase deficiency: MedlinePlus Medical Encyclopedia". www.nlm.nih.gov. Retrieved 2015-11-11. "Pyruvate kinase ... "Pyruvate Kinase Deficiency: Practice Essentials, Background, Pathophysiology". 2016-08-23. "Pyruvate Kinase Deficiency Clinical ... "Pyruvate kinase deficiency". Haematologica. 92 (6): 721-723. doi:10.3324/haematol.11469. ISSN 0390-6078. "Pyruvate Kinase ...
*  pyruvate kinase)-phosphatase
In enzymology, a [pyruvate kinase]-phosphatase (EC 3.1.3.49) is an enzyme that catalyzes the chemical reaction [pyruvate kinase ... This enzyme is also called pyruvate kinase phosphatase. Jett MF, Hue L, Hers HG (1981). "Pyruvate kinase phosphatase". FEBS ... pyruvate kinase] + phosphate Thus, the two substrates of this enzyme are pyruvate kinase phosphate and H2O, whereas its two ... products are pyruvate kinase and phosphate. This enzyme belongs to the family of hydrolases, specifically those acting on ...
*  Pyruvate dehydrogenase kinase
... (also pyruvate dehydrogenase complex kinase, PDC kinase, or PDK; EC 2.7.11.2) is a kinase enzyme ... Pyruvate dehydrogenase kinase is activated by ATP, NADH and acetyl-CoA. It is inhibited by ADP, NAD+, CoA-SH and pyruvate. Each ... Pyruvate dehydrogenase kinase should not be confused with Phosphoinositide-dependent kinase-1, which is also sometimes known as ... "Site Specificity of Four Pyruvate Dehydrogenase Kinase Isoenzymes toward the Three Phosphorylation Sites of Human Pyruvate ...
*  Pyruvate, water dikinase) kinase
... (EC 2.7.11.33, PSRP, PEPS kinase) is an enzyme with systematic name ADP:(pyruvate, water ... pyruvate, water dikinase) kinase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular ... Burnell, J.N. (2010). "Cloning and characterization of Escherichia coli DUF299: a bifunctional ADP-dependent kinase-Pi- ... This enzyme catalyses the following chemical reaction ADP + [pyruvate, water dikinase] ⇌ {\displaystyle \rightleftharpoons } ...
*  Pyruvate, phosphate dikinase) kinase
... (EC 2.7.11.32, PPDK regulatory protein, pyruvate, phosphate dikinase regulatory protein, ... pyruvate, phosphate dikinase) kinase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and ... Burnell, J.N.; Chastain, C.J. (2006). "Cloning and expression of maize-leaf pyruvate, Pi dikinase regulatory protein gene". ... Chastain, C.J.; Xu, W.; Parsley, K.; Sarath, G.; Hibberd, J.M.; Chollet, R. (2008). "The pyruvate, orthophosphate dikinase ...
*  Human genetic resistance to malaria
Pyruvate kinase (PK) deficiency, also called erythrocyte pyruvate kinase deficiency, is an inherited metabolic disorder of the ... enzyme pyruvate kinase. In this condition, a lack of pyruvate kinase slows down the process of glycolysis. This effect is ... which in a state of pyruvate kinase deficiency rapidly become deficient in ATP and can undergo hemolysis. Therefore, pyruvate ... Ayi K, Min-Oo G, Serghides L, Crockett M, Kirby-Allen M, Quirt I, Gros P, Kain KC (2008). "Pyruvate kinase deficiency and ...
*  David Ian Stuart
Stuart, David Ian (1979). X-ray studies on pyruvate kinase. exlibrisgroup.com (PhD thesis). University of Bristol. David Ian ... working on the structure of the enzyme pyruvate kinase in the laboratory of Hilary Muirhead. Stuart moved to Oxford in 1979 and ...
*  Tumor marker
Kaura, B; Bagga, R; Patel, FD (2004). "Evaluation of the Pyruvate Kinase isoenzyme tumor (Tu M2-PK) as a tumor marker for ... Wechsel, HW; Petri, E; Bichler, KH; Feil, G (1999). "Marker for renal cell carcinoma (RCC): The dimeric form of pyruvate kinase ... Hardt, PD; Ngoumou, BK; Rupp, J; Schnell-Kretschmer, H; Kloer, HU (2000). "Tumor M2-pyruvate kinase: A promising tumor marker ... Kumar, Yogesh; Tapuria, Niteen; Kirmani, Naveed; Davidson, Brian R. (2007). "Tumour M2-pyruvate kinase: A gastrointestinal ...
*  HERC1
2003). "Interaction between HERC1 and M2-type pyruvate kinase". FEBS Lett. 539 (1-3): 78-84. doi:10.1016/S0014-5793(03)00205-9 ...
*  Protein domain
The TIM-barrel in pyruvate kinase is 'discontinuous', meaning that more than one segment of the polypeptide is required to form ... An appropriate example is pyruvate kinase (see first figure), a glycolytic enzyme that plays an important role in regulating ... "The Crystal Structure of Toxoplasma gondii Pyruvate Kinase 1". PLoS ONE. 5 (9): 3. doi:10.1371/journal.pone.0012736. PMC ... which is itself a tyrosine kinase. See also: SH3 domain. Zinc finger DNA binding domain (ZnF_GATA) : ZnF_GATA domain-containing ...
*  Glutaminolysis
Mazurek, S; Grimm H; Boschek CB; Vaupel P; Eigenbrodt E (2002). "Pyruvate kinase type M2: a crossroad in the tumor metabolome ... Eigenbrodt, E; Kallinowski F; Ott M; Mazurek S; Vaupel P (1998). "Pyruvate kinase and the interaction of amino acid and ... pyruvate + NAD(P)H + H+ + CO2 pyruvate + NADH + H+ → lactate + NAD+ The reactions of the glutaminolytic pathway take place ... Due to low glutamate dehydrogenase and glutamate pyruvate transaminase activities, in tumor cells the conversion of glutamate ...
*  Morpheein
Ibsen, KH; Schiller, KW; Haas, TA (1971). "Interconvertible kinetic and physical forms of human erythrocyte pyruvate kinase". ... 2001). "X-ray structure of HPr kinase: A bacterial protein kinase with a P-loop nucleotide-binding domain". The EMBO Journal. ... "Alanine-mediated reversible inactivation of tumour pyruvate kinase caused by a tetramer-dimer transition". FEBS Letters. 50 (3 ... 2004). "HPr kinase/phosphorylase, a Walker motif A-containing bifunctional sensor enzyme controlling catabolite repression in ...
*  Inborn errors of carbohydrate metabolism
Phosphoglycerate kinase deficiency affects step 7 of glycolysis. Pyruvate kinase deficiency affects the 10th and last step of ... the pyruvate not converted feeds the citric acid cycle (CAC); both via pyruvate dehydrogenase (PDC, with Acetyl-CoA as ... Note: gluconeogenesis is taking place only in the liver and not in other cells like e.g. muscle cells.) The pyruvate created by ... During glycolysis ATP, NADH (both a energy transport form used inside cells) as well as pyruvate are produced. Glycolysis is ...
*  Glucagon (medication)
Feliú JE, Hue L, Hers HG (Aug 1976). "Hormonal control of pyruvate kinase activity and of gluconeogenesis in isolated ... Glucagon stimulation of PKA also inactivates the glycolytic enzyme pyruvate kinase. In the 1920s, Kimball and Murlin studied ... cAMP-dependent protein kinase). This enzyme, in turn, activates phosphorylase kinase, which then phosphorylates glycogen ... The enzyme protein kinase A that was stimulated by the cascade initiated by glucagon will also phosphorylate a single serine ...
*  PKLR
"Entrez Gene: PKLR pyruvate kinase, liver and RBC". Beutler E, Baronciani L (1996). "Mutations in pyruvate kinase". Hum. Mutat. ... 1991). "Point mutations in the L-type pyruvate kinase gene of two children with hemolytic anemia caused by pyruvate kinase ... The protein encoded by this gene is a pyruvate kinase that catalyzes the production of phosphoenolpyruvate from pyruvate and ... Kanno H, Fujii H, Hirono A, Miwa S (1991). "cDNA cloning of human R-type pyruvate kinase and identification of a single amino ...
*  Tumor metabolome
Pyruvate kinase catalyses the ATP-generating step of glycolysis in which phosphoenolpyruvate (PEP) is converted to pyruvate. ... HIF1 then would activate the pyruvate dehydrogenase kinase (PDKs), which inactivate the mitochondrial pyruvate dehydrogenase ... Pyruvate kinase type M2 or PKM2 is present in embryonic, adult stem cells. It is also expressed by many tumor cells. The ... Mazurek, S.; Boschek, C. B.; Hugo, F.; Eigenbrodt, E. (2005). "Pyruvate kinase type M2 and its role in tumor growth and ...
*  Glucagon
Feliú JE, Hue L, Hers HG (August 1976). "Hormonal control of pyruvate kinase activity and of gluconeogenesis in isolated ... Glucagon stimulation of PKA also inactivates the glycolytic enzyme pyruvate kinase in hepatocytes. The hormone is synthesized ... cAMP-dependent protein kinase). This enzyme, in turn, activates phosphorylase kinase, which then phosphorylates glycogen ... The enzyme protein kinase A that was stimulated by the cascade initiated by glucagon will also phosphorylate a single serine ...
*  Singapura cat
Grahn, R. A.; Grahn, J. C.; Penedo, M. C.; Helps, C. R.; Lyons, L. A. (2012). "Erythrocyte Pyruvate Kinase Deficiency mutation ... Another issue that affects the breed is Pyruvate kinase deficiency, which leads to hemolytic anemia. Typical symptoms includes ...
*  Lewis C. Cantley
Christofk HR, Vander Heiden MG, Wu N, Asara JM, Cantley LC (March 2008). "Pyruvate kinase M2 is a phosphotyrosine-binding ... March 2008). "The M2 splice isoform of pyruvate kinase is important for cancer metabolism and tumour growth". Nature. 452 (7184 ... This approach was used to characterize the substrate specificity of a large number of protein kinases. The kinase specificity ... March 2004). "The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to ...
*  M2-PK Test
C. Tonus, M. Sellinger u. a.: Faecal pyruvate kinase isoenzyme type M2 for colorectal cancer screening: A meta-analysis. In: ... Carolin Tonus, Markus Sellinger, Konrad Koss, and Gero Neupert (August 14, 2012). "Faecal pyruvate kinase isoenzyme type M2 for ...
*  Cancer screening
Tonus, C; Sellinger, M; Koss, K; Neupert, G (August 2012). "Faecal pyruvate kinase isoenzyme type M2 for colorectal cancer ...
*  Fecal occult blood
Tonus, C; Sellinger, M; Koss, K; Neupert, G (14 August 2012). "Faecal pyruvate kinase isoenzyme type M2 for colorectal cancer ...
*  Guanosine diphosphate
GDP is converted into GTP with the help of pyruvate kinase and phosphoenolpyruvate. DNA Guanosine triphosphate Nucleoside ...
*  Metabolism
... where sugars such as glucose and fructose are converted into pyruvate and some ATP is generated. Pyruvate is an intermediate in ... Binding of the hormone to insulin receptors on cells then activates a cascade of protein kinases that cause the cells to take ... Gluconeogenesis converts pyruvate to glucose-6-phosphate through a series of intermediates, many of which are shared with ... The generation of glucose from compounds like pyruvate, lactate, glycerol, glycerate 3-phosphate and amino acids is called ...