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*  SPTLC1
It converts L-serine and palmitoyl CoA to 3-oxosphinganine with pyridoxal 5'-phosphate as a cofactor. The product of this gene ...
*  SPTLC2
It catalyzes the pyridoxal 5'-phosphate dependent condensation of L-serine and palmitoyl CoA to 3-oxosphinganine. Mutations in ...
*  Eflornithine
... eflornithine undergoes decarboxylation with the aid of cofactor pyridoxal 5'-phosphate (PLP). Because of its additional ... As the phosphate of PLP is stabilized by Arg 277 and a Gly-rich loop (235-237), the difluoromethyl group of eflornithine is ...
*  ALPL
Fedde KN, Whyte MP (1990). "Alkaline phosphatase (tissue-nonspecific isoenzyme) is a phosphoethanolamine and pyridoxal-5'- ... phosphate ectophosphatase: normal and hypophosphatasia fibroblast study". Am. J. Hum. Genet. 47 (5): 767-75. PMC 1683690 . PMID ...
*  Alcoholic liver disease
The elevated AST to ALT ratio is due to deficiency of pyridoxal-6-phosphate, which is required in the ALT enzyme synthetic ...
*  Hypophosphatasia
The decrease in ALP activity leads to an increase in pyridoxal 5'-phosphate (PLP) in the blood, and correlates with disease ... TNSALP hydrolyzes several substances, including inorganic pyrophosphate (PPi) and pyridoxal 5'-phosphate (PLP), a major form of ... inorganic phosphate (Pi) and vitamin D metabolites usually are not reduced. Craniosynostosis, the premature closure of skull ...
*  Cycloserine
The first enzyme is a pyridoxal 5'-phosphate-dependent enzyme which converts the L-alanine to the D-alanine form. The second ...
*  L-cysteate sulfo-lyase
Denger K, Smits TH, Cook AM (2006). "L-cysteate sulpho-lyase, a widespread pyridoxal 5'-phosphate-coupled desulphonative enzyme ...
*  Mimosine
Some rhizobia are known to produce rhizomimosinase, which consumes pyridoxal 5′-phosphate to degrade mimosine into 3,4- ...
*  Pyridoxine 5'-phosphate oxidase
... pyridoxal 5'-phosphate + NH3 + H2O2 pyridoxine phosphate + oxygen <=> H2O2 + pyridoxal phosphate Pyridoxine 5'-phosphate ... Pyridoxal 5'-phosphate is an effective product inhibitor. Since pyridoxal 5'-phosphate, the active form of vitamin B6, is the ... phosphate substrate, whereas the pyridoxine 5'-phosphate oxidase in E. coli has a higher specificity pyridoxal-5'-phosphate ... In the absence of pyridoxal 5'-phosphate (PLP), the active site of the enzyme is in an "open" conformation. Once substrate ...
*  Adenosylmethionine decarboxylase
... phosphate. These proteins can be divided into two main groups which show little sequence similarity either to each other, or to ... amino acid decarboxylases AdoMetDC uses a covalently bound pyruvate residue as a cofactor rather than the more common pyridoxal ...
*  Natural product
Vitamin B6 (pyridoxol, pyridoxal, and pyridoxamine) as pyridoxal 5′-phosphate is a cofactor for many enzymes especially ... aromatic amino acids and phenylpropanoids Mevalonate pathway and methyletrythritol phosphate pathway → terpenoids and steroids ...
*  National Centre for Cell Science
CS1 maint: Multiple names: authors list (link) "Pyridoxal 5′ phosphate protects islets against streptozotocin-induced beta-cell ...
*  Hereditary sensory and autonomic neuropathy type I
SPT is a pyridoxal-5'-phosphate-dependent enzyme that catalyzes the first and rate-limiting step in the de novo biosynthesis of ...
*  PDXK
... a step required for the conversion of vitamin B6 to pyridoxal-5-phosphate, an important cofactor in intermediary metabolism. ... Pyridoxal kinase is an enzyme that in humans is encoded by the PDXK gene. The protein encoded by this gene phosphorylates ... "Entrez Gene: PDXK pyridoxal (pyridoxine, vitamin B6) kinase". Chern CJ, Beutler E (1976). "Biochemical and electrophoretic ... 2004). "Expression of a novel pyridoxal kinase mRNA splice variant, PKH-T, in human testis". Asian J. Androl. 6 (2): 83-91. ...
*  Carbohydrate sulfotransferase
Kamio, K.; Honke, K.; Makita, A. (Dec 1995). "Pyridoxal 5'-phosphate binds to a lysine residue in the adenosine 3'-phosphate 5 ... ATP sulfurylase first generates adenosine-5'-phosphosulfate (APS) and then APS kinase transfers a phosphate from ATP to APS to ... PAPS moves between the cytosol and the Golgi lumen via PAPS/PAP (3'-phosphoadenosine-5'-phosphate) translocase, a transmembrane ...
*  Ethanolamine-phosphate phospho-lyase
... and ethanolamine-phosphate phospho-lyase (deaminating). It employs one cofactor, pyridoxal phosphate. Fleshood HL, Pitot HC ( ... The systematic name of this enzyme class is ethanolamine-phosphate phosphate-lyase (deaminating acetaldehyde-forming). Other ... phosphate Thus, the two substrates of this enzyme are ethanolamine phosphate and H2O, whereas its 3 products are acetaldehyde, ... NH3, and phosphate. This enzyme belongs to the family of lyases, specifically those carbon-oxygen lyases acting on phosphates. ...
*  Sphinganine-1-phosphate aldolase
... pyridoxal phosphate. Stoffel W, LeKim D, Sticht G (1969). "Distribution and properties of dihydrosphingosine-1-phosphate ... sphinganine-1-phosphate alkanal-lyase, sphinganine-1-phosphate lyase, and sphinganine-1-phosphate palmitaldehyde-lyase. This ... In enzymology, a sphinganine-1-phosphate aldolase (EC 4.1.2.27) is an enzyme that catalyzes the chemical reaction sphinganine 1 ... The systematic name of this enzyme class is sphinganine-1-phosphate palmitaldehyde-lyase (phosphoethanolamine-forming). Other ...
*  ATC code C10
C10AX02 Probucol C10AX03 Tiadenol C10AX05 Meglutol C10AX06 Omega-3-triglycerides C10AX07 Magnesium pyridoxal 5-phosphate ...
*  Vigabatrin
... a Pyridoxal 5'-Phosphate, and [2Fe-2S] Cluster-containing Enzyme, Complexed with γ-Ethynyl-GABA and with the Antiepilepsy Drug ...
*  Carboxynorspermidine decarboxylase
CO2 This enzyme contains pyridoxal 5'-phosphate. Lee, J.; Sperandio, V.; Frantz, D.E.; Longgood, J.; Camilli, A.; Phillips, M.A ...
*  L-glutamyl-(BtrI acyl-carrier protein) decarboxylase
CO2 This enzyme binds pyridoxal 5'-phosphate. Li, Y.; Llewellyn, N.M.; Giri, R.; Huang, F.; Spencer, J.B. (2005). "Biosynthesis ...
*  Metanx
... and pyridoxal 5'-phosphate (vitamin B6). It is a vitamin B supplement. Metanx is indicated for the dietary management of ... 3 mg Pyridoxal 5'-phosphate: 35 mg Methylcobalamin: 2 mg Metanx is used for treating: Painful diabetic neuropathy, Diabetic ...
*  Serine racemase
Mammalian serine racemase is a pyridoxal 5'-phosphate dependent enzyme that catalyzes both the racemization of L-serine to D- ...
*  UDP-4-amino-4-deoxy-L-arabinose aminotransferase
L-glutamate This protein is a pyridoxal 5'-phosphate enzyme. Breazeale, S.D.; Ribeiro, A.A.; Raetz, C.R. (2003). "Origin of ...
*  Tryptophan synthase
The β subunits catalyze the irreversible condensation of indole and serine to form tryptophan in a pyridoxal phosphate (PLP) ... The α subunits catalyze the reversible formation of indole and glyceraldehyde-3-phosphate (G3P) from indole-3-glycerol ...