List of EC numbers (EC 3)
... pyruvate kinase]-phosphatase EC 3.1.3.50: sorbitol-6-phosphatase EC 3.1.3.51: dolichyl-phosphatase EC 3.1.3.52: [3-methyl-2- ... pyridoxal phosphatase EC 3.1.3.75: phosphoethanolamine/phosphocholine phosphatase EC 3.1.3.76: lipid-phosphate phosphatase EC ...
Ornithine decarboxylase
The pyridoxal phosphate cofactor binds lysine 69 at the C-terminus end of the barrel domain. The active site is at the ... 2000), which demonstrated that the cyclin-dependent kinase (Cdk) inhibitor p21Cip1 is also degraded by the proteasome in a ... Lysine 69 on ornithine decarboxylase (ODC) binds the cofactor pyridoxal phosphate to form a Schiff base. Ornithine displaces ... "Mechanism of formation of the internal aldimine in pyridoxal 5'-phosphate-dependent enzymes". Journal of the American Chemical ...
Riboflavin
FAD contributes to conversion of tryptophan to niacin (vitamin B3) and the conversion of vitamin B6 to the coenzyme pyridoxal 5 ... Conversions of riboflavin to the cofactors FMN and FAD are carried out by the enzymes riboflavin kinase and FAD synthetase ... From riboflavin to FMN is the function of zinc-requiring riboflavin kinase; the reverse is accomplished by a phosphatase. From ... Conversion of vitamin B6 to its coenzyme, pyridoxal 5'-phosphate synthase, involves the enzyme, pyridoxine 5'-phosphate oxidase ...
Reactive aldehyde species
Only two RASP, retinaldehyde and pyridoxal (or pyridoxal phosphate), appear to effect essential non-inflammatory physiologic ... as has been described with MAP kinase, protein kinase C, and other proteins that potentiate cytokine release and other aspects ...
Choline
Hemicholinium-3 is a more general inhibitor, but also moderately inhibits choline kinases. More specific choline kinase ... "Plants synthesize ethanolamine by direct decarboxylation of serine using a pyridoxal phosphate enzyme". The Journal of ... Choline can also be produced by the CDP-choline route, cytosolic choline kinases (CK) phosphorylate choline with ATP to ...
Alanine transaminase
... require the coenzyme pyridoxal phosphate, which is converted into pyridoxamine in the first phase of the reaction, when an ... including creatine kinase. Many drugs may elevate ALT levels, including zileuton, omega-3 acid ethyl esters (Lovaza), anti- ...
1-Aminocyclopropane-1-carboxylate synthase
Lin, E. C. C.; Kistler, W. S.; Zwaig, N. (June 1970). "Glycerol Kinase, the Pacemaker for the Dissimilation of Glycerol in ... source) It is a pyridoxal phosphate (PLP) dependent gamma-elimination (?). In the gamma elimination, PLP acts as a sink twice ( ... They are natural toxins that cause slow binding inhibition by interfering with the coenzyme pyridoxal phosphate. ACC synthase ... It employs one cofactor, pyridoxal phosphate. The reaction catalyzed by 1-aminocyclopropane-1-carboxylic acid synthase (ACS) is ...
Carnitine
HTML is then cleaved by HTML aldolase (HTMLA, a pyridoxal phosphate requiring enzyme), yielding 4-trimethylaminobutyraldehyde ( ... ATP concentration decreases and AMP concentration increases leading to the activation of AMP-activated protein kinase (AMPK). ...
AKR1B1
Affinity labeling of an active site lysine by pyridoxal 5'-phosphate and pyridoxal 5'-diphospho-5'-adenosine". The Journal of ... "Tonicity-responsive enhancer binding protein regulates the expression of aldose reductase and protein kinase C δ in a mouse ...
Metadoxine
Pyridoxal phosphate dependent enzymes also play a role in the biosynthesis of four important neurotransmitters: serotonin (5-HT ... and social interaction and reversed the overactivation of the biomarkers Akt and extracellular signal-regulated kinase (ERK) in ... is a precursor of coenzymes including pyridoxal 5'-phosphate (PLP), which accelerates the metabolic degradation of ethanol and ...
Carbohydrate sulfotransferase
ATP sulfurylase first generates adenosine-5'-phosphosulfate (APS) and then APS kinase transfers a phosphate from ATP to APS to ... Kamio, K.; Honke, K.; Makita, A. (Dec 1995). "Pyridoxal 5'-phosphate binds to a lysine residue in the adenosine 3'-phosphate 5 ... PAPS is synthesized in the cytosol from ATP and sulfate through the sequential action of ATP sulfurylase and APS kinase. ... which is analogous to a conserved lysine in the active ATP binding site of kinases. Protein sequence alignment studies indicate ...
Cofactor (biochemistry)
Eliot AC, Kirsch JF (2004). "Pyridoxal phosphate enzymes: mechanistic, structural, and evolutionary considerations". Annu. Rev ... and adenylate kinase, but calcium activates these enzymes in allosteric regulation, often binding to these enzymes in a complex ...
Citric acid cycle
The GTP that is formed by GDP-forming succinyl-CoA synthetase may be utilized by nucleoside-diphosphate kinase to form ATP (the ... in which pyridoxal phosphate is a cofactor. In this reaction the glutamate is converted into alpha-ketoglutarate, which is a ...
Lysine
AAA is then formed via a pyridoxal 5′-phosphate (PLP)-dependent aminotransferase (PLP-AT) (E.C 2.6.1.39), using glutamate as ... Kobashi N, Nishiyama M, Tanokura M (March 1999). "Aspartate kinase-independent lysine synthesis in an extremely thermophilic ...
Serotonin
63) investigated the role of [] protein kinase[] in the phase change in S. gregaria: ... cAMP-dependent protein kinase A (PKA ... and the coenzyme pyridoxal phosphate. The TPH-mediated reaction is the rate-limiting step in the pathway. TPH has been shown to ... the phosphorylation of p44/p42 mitogen-activated protein kinase activation in bovine aortic endothelial cell cultures.[ ... "5-hydroxytryptamine stimulates phosphorylation of p44/p42 mitogen-activated protein kinase activation in bovine aortic ...
Norepinephrine
McCrink KA, Brill A, Lymperopoulos A (2015). "Adrenal G protein-coupled receptor kinase-2 in regulation of sympathetic nervous ... with pyridoxal phosphate as a cofactor. Dopamine is then converted into norepinephrine by the enzyme dopamine β-monooxygenase ( ...