Purine nucleoside phosphorylase
... purine deoxynucleoside phosphorylase purine deoxyribonucleoside phosphorylase purine nucleoside phosphorylase purine ... Purine nucleoside phosphorylase, PNP, PNPase or inosine phosphorylase (EC 2.4.2.1) is an enzyme that in humans is encoded by ... Purine nucleoside phosphorylase is an enzyme involved in purine metabolism. PNP metabolizes inosine into hypoxanthine and ... "Purine nucleoside phosphorylase. 3. Reversal of purine base specificity by site-directed mutagenesis". Biochemistry. 36 (39): ...
Purine nucleoside phosphorylase deficiency
"eMedicine - Purine Nucleoside Phosphorylase Deficiency : Article by Alan P Knutsen". Retrieved July 25, 2010. "Boy first in UK ... Purine nucleoside phosphorylase deficiency is a rare autosomal recessive metabolic disorder which results in immunodeficiency. ... Markert ML (1991). "Purine nucleoside phosphorylase deficiency". Immunodefic Rev. 3 (1): 45-81. PMID 1931007. Online Mendelian ... Toro A, Grunebaum E (Oct 2006). "TAT-mediated intracellular delivery of purine nucleoside phosphorylase corrects its deficiency ...
Xanthosine phosphorylase
... is a purine nucleoside phosphorylase, it involves in the purine metabolism. When human lacks PNP, ... making it a member of the purine nucleoside phosphorylase group. This protein can degrade all purine nucleosides (including ... Xanthosine phosphorylase is a member of the purine nucleoside phosphorylase group, and its main functions are nucleoside ... Xanthosine phosphorylase(PNP-ĮĮ) is a kind of purine nucleoside phosphorylases (PNPs) in E. coli and it is located in the ...
List of OMIM disorder codes
MAPBPIP Immunodeficiency due to purine nucleoside phosphorylase deficiency; 613179; PNP Immunodeficiency with hyper IgM, type 4 ... PRPS1 Phosphorylase kinase deficiency of liver and muscle, autosomal recessive; 261750; PHKB Phosphoserine aminotransferase ...
Quinine
... may target the malaria purine nucleoside phosphorylase enzyme. The UV absorption of quinine peaks around 350 nm (in UVA ...
Xanthine
It is also created from xanthosine by purine nucleoside phosphorylase. Xanthine is subsequently converted to uric acid by the ... Xanthine is a product on the pathway of purine degradation. It is created from guanine by guanine deaminase. It is created from ... is a purine base found in most human body tissues and fluids, as well as in other organisms. Several stimulants are derived ...
Intron-mediated enhancement
"Intron requirement for expression of the human purine nucleoside phosphorylase gene". Nucleic Acids Research. 20 (12): 3191- ...
Arsenic biochemistry
The arsenic (V) can be converted to arsenic (III) by the enzyme purine nucleoside phosphorylase. This is classified as a ... Some As-containing nucleosides (sugar derivatives) are also known. Several of these organoarsenic compounds arise via ... Isolation and identification of an arsenic-containing nucleoside". Journal of the Chemical Society, Perkin Transactions 1 (11 ...
Polynucleotide phosphorylase
The same abbreviation (PNPase) is also used for another, otherwise unrelated enzyme, Purine nucleoside phosphorylase. Model ... Polynucleotide+Phosphorylase at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: Biology (Articles ... Polynucleotide Phosphorylase (PNPase) is a bifunctional enzyme with a phosphorolytic 3' to 5' exoribonuclease activity and a 3 ... I. Polynucleotide phosphorylase of azotobacter vinelandii". Biochimica et Biophysica Acta. 20 (1): 269-85. doi:10.1016/0006- ...
Clofarabine
"Antitumor activity of 2-fluoror-2'deoxyadenosine against tumors that express Escherichia coli purine nucleoside phosphorylase ... Clofarabine is a purine nucleoside antimetabolite marketed in the United States and Canada as Clolar. In Europe and Australia/ ... Clofarabine is a second-generation purine nucleoside analog designed to overcome biological limitations observed with ara-A and ... Purines, Purine antagonists, Arabinosides, Halohydrins, Sanofi, Hydroxymethyl compounds). ...
5-Fluoro-5-deoxy-D-ribose 1-phosphate
It is formed by the purine nucleoside phosphorylase mediated phosphorolytic cleavage of 5'-deoxy-5'-fluoroadenosine. It is ...
Pyrimidine-nucleoside phosphorylase
"Purification and characterization of purine nucleoside phosphorylase and pyrimidine nucleoside phosphorylase from Bacillus ... a pyrimidine-nucleoside phosphorylase (EC 2.4.2.2) is an enzyme that catalyzes the chemical reaction a pyrimidine nucleoside + ... Saunders PP, Wilson BA, Saunders GF (1969). "Purification and comparative properties of a pyrimidine nucleoside phosphorylase ... The systematic name of this enzyme class is pyrimidine-nucleoside:phosphate alpha-D-ribosyltransferase. This enzyme is also ...
Forodesine
April 2001). "Immucillin H, a powerful transition-state analog inhibitor of purine nucleoside phosphorylase, selectively ... is a transition-state analog inhibitor of purine nucleoside phosphorylase studied for the treatment of patients with T-cell ...
Adenine phosphoribosyltransferase
... decreased purine nucleoside phosphorylase and adenosine deaminase activity". Blut. 39 (5): 309-15. doi:10.1007/BF01014193. PMID ... It has the unique ability to metabolize cytokinins-a plant hormone that can exist as a base, nucleotide, or nucleoside-into ... In humans, two residues in the hood domain hydrogen bond with the purine for further specificity: Val25 with the hydrogens on ... Although the flexible loop does not interact with the hood during purine recognition, it is thought to close over the active ...
Omenn syndrome
Purine nucleoside phosphorylase deficiency List of cutaneous conditions Santagata S, Villa A, Sobacchi C, Cortes P, Vezzoni P ( ...
Adenosine deaminase
Inosine can then be deribosylated (removed from ribose) by another enzyme called purine nucleoside phosphorylase (PNP), ... The carboxyl group of Glu217, roughly coplanar with the substrate purine ring, is in position to form a hydrogen bond with N1 ... The carboxyl group of Asp296, also coplanar with the substrate purine ring, forms hydrogen bond with N7 of the substrate. The ... ADA is considered one of the key enzymes of purine metabolism. The enzyme has been found in bacteria, plants, invertebrates, ...
5'-Deoxy-5'-fluoroadenosine
Purine nucleoside phosphorylase mediates a phosphorolytic cleavage of the adenine base to generate 5-fluoro-5-deoxy-D-ribose-1- ...
2-Fluoroadenine
"Radical Dehalogenation and Purine Nucleoside Phosphorylase E. coli: How Does an Admixture of 2′,3′-Anhydroinosine Hinder 2- ...
GSTO1
... glutathione S-transferase omega 1-1 and purine nucleoside phosphorylase polymorphisms in European and indigenous Americans". ...
Nezelof syndrome
The defect is a type of purine nucleoside phosphorylase deficiency with inactive phosphorylase, this results in an accumulation ...
Nucleotide phosphatase
... may refer to: Purine-nucleoside phosphorylase, an enzyme Nucleotidase, an enzyme This set index page ...
MTAP
... is a trimer enzyme that shares a similar structure and functions with mammalian purine nucleoside phosphorylases (PNPs) ... "Genomic cloning of methylthioadenosine phosphorylase: a purine metabolic enzyme deficient in multiple different cancers". ... MTAP is a phosphorylase, which is an enzyme that catalyzes the addition of an inorganic phosphate to another molecule. MTAP is ... Adenine is one of the purine bases of nucleic acids, which build both DNA and RNA. Through the recovery of adenine, MTAP plays ...
PNPase
... can refer to: Polynucleotide phosphorylase, an RNA degrading protein Purine nucleoside phosphorylase, an enzyme involved ... in purine metabolism This disambiguation page lists articles associated with the title PNPase. If an internal link led you here ...
Purine metabolism
A nuclease frees the nucleotide A nucleotidase creates guanosine Purine nucleoside phosphorylase converts guanosine to guanine ... then a nucleotidase creates inosine Purine nucleoside phosphorylase acts upon inosine to create hypoxanthine Xanthine oxidase ... Purine metabolism refers to the metabolic pathways to synthesize and break down purines that are present in many organisms. ... Modulation of purine metabolism has pharmacotherapeutic value. Purine synthesis inhibitors inhibit the proliferation of cells, ...
List of skin conditions
Omenn syndrome Purine nucleoside phosphorylase deficiency Severe combined immunodeficiency (alymphocytosis, Glanzmann-Riniker ...
White blood cell
... purine nucleoside phosphorylase deficiency, genetic polymorphism Blood cell dysfunction - aplastic anemia Infectious diseases ...
Arthur J. Ammann
Working with E. R. Giblett in 1972, Ammann described the first patient with purine nucleoside phosphorylase deficiency in ... Nucleoside-phosphorylase deficiency in a child with severely defective T-cell immunity and normal B-cell immunity. Lancet, 1: ... "Nucleoside-phosphorylase deficiency in a child with severely defective T-cell immunity and normal B-cell immunity". The Lancet ...
Inosine
Purine nucleoside phosphorylase intraconverts inosine and hypoxanthine. Inosine is also an intermediate in a chain of purine ... Nucleosides, Purines, Antiviral drugs, Hydroxymethyl compounds, Ophthalmology drugs). ... which cannot operate purine salvage pathways) is selectively targeted by the purine deficiency resulting from inosine ... Inosine is a nucleoside that is formed when hypoxanthine is attached to a ribose ring (also known as a ribofuranose) via a β-N9 ...
List of geneticists
Purine Nucleoside Phosphorylase Michael Ashburner (born 1942), British Drosophila geneticist and polymath William Astbury (1898 ...
List of diseases (P)
... freckle like pigmentation Punctate inner choroidopathy Pure red cell aplasia Puretic syndrome Purine nucleoside phosphorylase ...
Phosphorylase
Purine nucleoside phosphorylase (PNPase) Nucleotidyltransferases (EC 2.7.7) Enzymes that have phosphorolytic 3' to 5' ... glycogen phosphorylase starch phosphorylase maltodextrin phosphorylase Enzymes that break down nucleosides into their ... Phosphorylase is also a common name used for glycogen phosphorylase in honor of Earl W. Sutherland Jr., who in the late 1930s ... Phosphorylase a is the more active R form of glycogen phosphorylase that is derived from the phosphorylation of the less active ...