The psoralen is applied first to sensitise the skin, then UVA light is applied to clean up the skin problem. Psoralens are also ... Psoralen is a mutagen, and is used for this purpose in molecular biology research. Psoralen intercalates into DNA and on ... Psoralens are used in tanning accelerators, because psoralen increases the skin's sensitivity to light. Some patients have had ... Research on psoralen has historically focused on interactions with DNA and RNA (in particular, ICL formation). Psoralen, ...

In enzymology, a psoralen synthase (EC 1.14.13.102) is an enzyme that catalyzes the chemical reaction (+)-marmesin + NADPH + H+ ... O2 ⇌ {\displaystyle \rightleftharpoons } psoralen + NADP+ + acetone + 2 H2O The 4 substrates of this enzyme are (+)-marmesin, ... NADPH, H+, and O2, whereas its 4 products are psoralen, NADP+, acetone, and H2O. This enzyme belongs to the family of ... "Molecular cloning and functional characterization of psoralen synthase, the first committed monooxygenase of furanocoumarin ...

Halogens and amines are included among the vast functionalities that could be included in the psoralen/coumarin backbone. Acton ... Heindel has shown that psoralens and coumarins can be useful as photoactivated inhibitors of epidermal growth factor. ... 5,216,176 of Heindel discloses a large number of psoralens and coumarins that have some effectiveness as photoactivated ... Heindel, Ned D.; Choudhuri, Mridula; Ressner, Joel; Foster, Natalie (January 1985). "Aminomethyl psoralens. Electrophilic ...

Psoralen is a natural drug obtained from the fruit of Psoralea corylifolia. Methoxsalen and Trioxsalen are synthetic psoralens ... After 2 hours of taking the oral dose of 20 mg/day of a psoralen, skin is exposed to sunlight. Eyes, ears and other normally ... Melanin "Definition of Psoralen". The Free Medical Dictionary. Retrieved 8 August 2012. "Definition of Methoxsalen". The Free ...

This process is then repeated twice more, first to remove the hydroxyisopropyl substituent from marmesin (4) to form psoralen ( ... Bisagni, E. Synthesis of psoralens and analogues. J. Photochem. Photobiol. B. 1992, 14, 23-46. Voznesensky, A. I.; Schenkman, J ...

Psoralen, the parent furocoumarin. Sigurdsson S, Ogmundsdottir HM, Gudbjarnason S (July-August 2004). "Antiproliferative effect ...

PUVA means UVA + psoralen. It consists of irradiation of the skin with the UVA ultraviolet light, from a fluorescent bulb or ...

Interactive structure for psoralen and crosslinked DNA Psoralen Ultraviolet A Light Treatment (CS1 maint: others, CS1 errors: ... Psoralens are used in the medical treatment of skin diseases, such as psoriasis and vitiligo. Mitomycin C (MMC) is from a class ... Psoralens can form two types of monoadducts and one diadduct (an interstrand crosslink) with thymine. These adducts result in ... Psoralens are natural compounds (furocoumarins) present in plants. These compounds intercalate into DNA at 5'-AT sequence sites ...

Psoralens) in Plants". Journal of Investigative Dermatology. 39 (3): 225-239. doi:10.1038/jid.1962.106. PMID 13941836. C. ...

Like Ficus carica, the South American species Brosimum gaudichaudii has been shown to contain both psoralen and bergapten. The ... Martins JE, Pozetti GL, Sodré M (1974). "Effects of psoralen and bergapten on irradiated skin". Int J Dermatol. 13 (3): 124-128 ... Pathak MA, Daniels Jr F, Fitzpatrick TB (September 1962). "The Presently Known Distribution of Furocoumarins (Psoralens) in ... Bergapten and xanthotoxin (also known as methoxsalen), two linear furanocoumarins derived from psoralen, are invariably found ...

The parent compounds of the most common isomers are psoralen and angelicin. Derivatives of these two compounds are referred to ... In particular, the linear furanocoumarins (psoralen, bergapten, and methoxsalen), which occur naturally in Apiaceae, Rutaceae, ... Psoralens) in Plants". Journal of Investigative Dermatology. 39 (3): 225-239. doi:10.1038/jid.1962.106. PMID 13941836. Zaynoun ...

Toxins which are associated with PCD include the psoralens. Psoralens are in fact used therapeutically for the treatment of ...

"Comparison of oral psoralen-UV-A with a portable tanning unit at home vs hospital-administered bath psoralen-UV-A in patients ... Like other psoralens it causes photosensitization of the skin. It is administered either topically or orally in conjunction ... Trioxsalen (trimethylpsoralen (TMP), trioxysalen (INN) or Trisoralen) is a furanocoumarin and a psoralen derivative. It is ... Thazhathveetil, AK; Liu, ST; Indig, FE; Seidman, MM (2007). "Psoralen conjugates for visualization of genomic interstrand cross ...

In fact, psoralen, from which the family of linear furanocoumarins descends, is by far much more abundant in plants than ... Angelicin and psoralen are used in other skin disorders such as vitiligo and mycosis. DNA photobinding is the most studied ... Both psoralen and angelicin can be used in cancer therapeutics to suppress DNA replication in tumor cells and induce apoptosis ... In contrast, the isomer of angelicin, psoralen, was reported to be five to ten times more active than angelicin and cross-link ...

Health authorities have banned psoralen since July 1996. Tanning has gone in and out of fashion. In the United States and ... Autier P.; Dore J.-F.; Cesarini J.-P. (1997). "Should subjects who used psoralen sun tan activators be screened for melanoma ... Several tanning activators have used different forms of psoralen, which are known to be photocarcinogenic. ...

Bergamot contains the psoralen derivatives bergapten and bergamottin. The adverse effects of bergamot oil in this patient are ...

... using the sensitizing effects of the drug psoralen.: 686 The psoralen is applied or taken orally to sensitize the skin, then ... Psoralens are taken as pills (systemically) or can be applied directly to the skin, by soaking the skin in a solution that ... Psoralens are materials that make the skin more sensitive to UV light. They are photosensitizing agents found in plants ... For small spots of vitiligo, it is possible to use psoralen as drops, applied only on the spots. This method does not have side ...

Ultraviolet A (UVA) light, with or without psoralens have also been tried. UVA-1, a more specific wavelength of UVA light, is ...

Other crosslinking agents include mustard gas, mitomycin, and psoralen. In proteins, crosslinks are important in generating ...

The best known tanning activator is psoralen which is an ingredient of bergamot oil. Psoralen has been present in sunscreens in ... After the evidence for the photocarcinogenic potential of psoralen emerged, sunscreens which combined UVB filters and psoralen ... Psoralen tanning lotions were available in France, Belgium and Greece. The increased production of melanin is the reaction of ... In Switzerland, a ban was imposed on psoralen containing sunscreens in 1987 but it was loosely enforced for several years. In ...

Another hydroxylation is catalyzed by psoralen synthase to yield psoralen. A third hydroxylation by the enzyme psoralen 8- ...

Hanson, C. V.; Riggs, J. L.; Lennette, E. H. (1978). "Photochemical Inactivation of DNA and RNA Viruses by Psoralen Derivatives ...

One medication that has been proven to be photocarcinogenic is psoralen. This drug is used in photodynamic therapy for many ... Epidemiological studies dating back to the 1970s have shown a strong association between psoralen treatment and skin cancer ... The reason for this correlation is the high concentration of the photocarcinogenic compound psoralen in citrus fruits. ...

In contrast, when multiple viral genomes infected a host cell, psoralen-induced DNA cross-links were repaired; that is, MR ... Hall, J. D. (1982). "Repair of psoralen-induced crosslinks in cells multiply infected with SV40". Molecular & General Genetics ...

In the past, psoralen extracted from bergamot oil was used in tanning accelerators and sunscreens. Known to be ... Autier, P.; Dore, J.-F.; Cesarini, J.-P.; Boyle, P. (1997). "Should subjects who used psoralen suntan activators be screened ...

Psoralens are commonly used for vitiligo treatment, but have higher phototoxic and DNA mutagenic effects. While Khellin ...

Psoralens, Streptomycin, Sulfasalazine and Tetracycline. A condition called "drug-induced ulcer of the lip" is described as ...

For example, psoralen is a benzofuran derivative that occurs in several plants. Benzofuran is extracted from coal tar. It is ...

Neither psoralen nor bergapten were detected in the essential oil of fig fruits. Thus there is no conclusive evidence that fig ... Psoralen appears to be the primary furanocoumarin compound responsible for fig leaf-induced phytophotodermatitis.[citation ... The essential oil of fig leaves contains more than 10% psoralen, the highest concentration of any organic compound isolated ... The common fig contains significant quantities of two furanocoumarins, psoralen and bergapten. ...

The seeds of this plant contain a variety of coumarins, including psoralen. Corylifolium comes from similarity of the leaves to ... psoralen, isopsoralen and angelicin), meroterpenes (bakuchiol, and 3-hydroxybakuchiol). Cullen corylifolium, or bu gu zhi in ... such as treatment of lichen planus by psoralen extract combined with sunlight exposure. "Cullen corylifolium (L.) Medik". ...