... oncogene protein p21(ras) MeSH D12.776.157.325.515.500.600 - proto-oncogene proteins p21(ras) MeSH D12.776.157.325.515.700 - ... rap gtp-binding proteins MeSH D12.776.157.325.515.475.100 - rap1 gtp-binding proteins MeSH D12.776.157.325.515.500 - ras ... smad1 protein MeSH D12.776.157.057.170.500.200 - smad2 protein MeSH D12.776.157.057.170.500.300 - smad3 protein MeSH D12.776. ... smad proteins, inhibitory MeSH D12.776.157.057.170.249.600 - smad6 protein MeSH D12.776.157.057.170.249.700 - smad7 protein ...
... oncogene protein p21(ras) MeSH D12.776.476.525.500.600 - proto-oncogene proteins p21(ras) MeSH D12.776.476.525.700.050 - cdc42 ... proto-oncogene proteins a-raf MeSH D12.776.476.400.842.437 - proto-oncogene proteins b-raf MeSH D12.776.476.400.842.500 - proto ... proto-oncogene proteins c-vav MeSH D12.776.476.325.300.600 - ral guanine nucleotide exchange factor MeSH D12.776.476.325. ... oncogene proteins c-raf MeSH D12.776.476.450.169.500 - mitogen-activated protein kinase 1 MeSH D12.776.476.450.169.750 - ...
... oncogene protein p21(ras) MeSH D08.811.277.040.330.300.400.500.600 - proto-oncogene proteins p21(ras) MeSH D08.811.277.040. ... proto-oncogene proteins c-cbl MeSH D08.811.464.938.750.562 - proto-oncogene proteins c-mdm2 MeSH D08.811.464.938.750.750 - skp ... proto-oncogene proteins b-raf MeSH D08.811.913.696.620.682.700.559.842.500 - proto-oncogene proteins c-raf MeSH D08.811.913.696 ... proto-oncogene proteins c-akt MeSH D08.811.913.696.620.682.700.759 - proto-oncogene proteins c-bcr MeSH D08.811.913.696.620.682 ...
... is called a proto-oncogene. The K-Ras protein is a GTPase, a class of enzymes which convert the nucleotide guanosine ... the K-Ras protein, was first found as a p21 GTPase. Like other members of the ras subfamily of GTPases, the K-Ras protein is an ... This proto-oncogene is a Kirsten ras oncogene homolog from the mammalian Ras gene family. A single amino acid substitution, and ... is a gene that provides instructions for making a protein called K-Ras, a part of the RAS/MAPK pathway. The protein relays ...
... proto-oncogene proteins c-yes MeSH D12.776.624.664.700.200 - proto-oncogene proteins p21(ras) MeSH D12.776.624.664.700.202 - ... oncogene protein gp140(v-fms) MeSH D12.776.964.700.750.710 - oncogene protein p21(ras) MeSH D12.776.964.700.750.750 - oncogene ... oncogene protein gp140(v-fms) MeSH D12.776.964.775.750.710 - oncogene protein p21(ras) MeSH D12.776.964.775.750.750 - oncogene ... proto-oncogene proteins c-abl MeSH D12.776.624.664.700.168 - proto-oncogene proteins c-akt MeSH D12.776.624.664.700.169 - proto ...
"Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1 ... a protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain". Cell. 76 (6): ... In cells absent of c-jun, the expression of p53 (cell cycle arrest inducer) and p21 (CDK inhibitor and p53 target gene) is ... The proto-oncogene c-Jun is the cellular homolog of the viral oncoprotein v-jun (P05411). The viral homolog v-jun was ...
... as well as a number of proto-oncogenes (Raf, Myc, Myb, Rel, Src, Mos, ABL). The UPS is also involved in the regulation of ... To recognize protein as designated substrate, 19S complex has subunits that are capable to recognize proteins with a special ... Simon JH, Gaddis NC, Fouchier RA, Malim MH (1998). "Evidence for a newly discovered cellular anti-HIV-1 phenotype". Nat. Med. 4 ... as well as with the induction of p21. In addition, patients with higher PSMD2 expression indicated a poorer prognosis and a ...
... oncogene protein p21(ras) MeSH D12.644.360.525.500.600 - proto-oncogene proteins p21(ras) MeSH D12.644.360.525.700 - rho gtp- ... 14-3-3 proteins MeSH D12.644.360.024.318 - proto-oncogene proteins c-crk MeSH D12.644.360.024.326 - proto-oncogene proteins c- ... oncogene proteins v-raf MeSH D12.644.360.400.842.374 - proto-oncogene proteins b-raf MeSH D12.644.360.400.842.500 - proto- ... proto-oncogene proteins c-bcl-2 MeSH D12.644.360.075.718.100 - bcl-associated death protein MeSH D12.644.360.075.718.400 - bcl- ...
"Cables1 controls p21/Cip1 protein stability by antagonizing proteasome subunit alpha type 3". Oncogene. 34 (19): 2538-45. doi: ... as well as a number of proto-oncogenes (Raf, Myc, Myb, Rel, Src, Mos, ABL). The UPS is also involved in the regulation of ... Simon JH, Gaddis NC, Fouchier RA, Malim MH (December 1998). "Evidence for a newly discovered cellular anti-HIV-1 phenotype". ... The eukaryotic proteasome recognized degradable proteins, including damaged proteins for protein quality control purpose or key ...
"Physical association between Src homology 3 elements and the protein product of the c-cbl proto-oncogene". J. Biol. Chem. 269 ( ... Ger M, Zitkus Z, Valius M (October 2011). "Adaptor protein Nck1 interacts with p120 Ras GTPase-activating protein and regulates ... Bokoch GM, Wang Y, Bohl BP, Sells MA, Quilliam LA, Knaus UG (October 1996). "Interaction of the Nck adapter protein with p21- ... "The Nck SH2/SH3 adaptor protein is present in the nucleus and associates with the nuclear protein SAM68". Oncogene. 14 (2): 223 ...
Mulcahy LS, Smith MR, Stacey DW (1985). "Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 ... Cyclin D1-CDK4 also enables the activation of cyclin E-CDK2 complex by sequestering Cip/Kip family CDK inhibitory proteins p21 ... Dowdy SF, Hinds PW, Louie K, Reed SI, Arnold A, Weinberg RA (May 1993). "Physical interaction of the retinoblastoma protein ... Motokura T, Arnold A (June 1993). "PRAD1/cyclin D1 proto-oncogene: genomic organization, 5' DNA sequence, and sequence of a ...
Proto-oncogene c-KIT is the gene encoding the receptor tyrosine kinase protein known as tyrosine-protein kinase KIT, CD117 ( ... proto-oncogene". Oncogene. 7 (11): 2207-2217. PMID 1279499. Spritz RA, Droetto S, Fukushima Y (November 1992). "Deletion of the ... Duronio V, Welham MJ, Abraham S, Dryden P, Schrader JW (March 1992). "p21ras activation via hemopoietin receptors and c-kit ... Proto-Oncogene+Proteins+c-kit at the U.S. National Library of Medicine Medical Subject Headings (MeSH) C-kit receptor entry in ...
IPR003327 The Myc Protein NCBI Human Myc protein Myc cancer gene myc+Proto-Oncogene+Proteins at the U.S. National Library of ... "Tumor induction by ras and myc oncogenes in fetal and neonatal brain: modulating effects of developmental stage and retroviral ... The first to be discovered was its capability to drive cell proliferation (upregulates cyclins, downregulates p21), but it also ... "The proto-oncogene c-myc in hematopoietic development and leukemogenesis". Oncogene. 21 (21): 3414-21. doi:10.1038/sj.onc. ...
"Molecular cloning of the human proto-oncogene Wnt-5A and mapping of the gene (WNT5A) to chromosome 3p14-p21". Genomics. 18 (2 ... Dealy, CN; Roth, A; Ferrari, D; Brown, AM; Kosher, RA (October 1993). "Wnt-5a and Wnt-7a are expressed in the developing chick ... Protein Wnt-5a is a protein that in humans is encoded by the WNT5A gene. The WNT gene family consists of structurally related ... It encodes a protein showing 98%, 98%, and 87% amino acid identity to the mouse, rat and the xenopus Wnt5a protein, ...
One such genetic aberration was mutations in the proto-oncogene Ras subfamily. Together with his team, Gustav was among the ... The peptides contain the various mutations that are present in the catalytic site of the Ras protein. In 1993, five patients ... "Characterisation of immune responses in pancreatic carcinoma patients after mutant p21 ras peptide vaccination". British ... first in the world to develop peptide-based cancer vaccines derived from mutated Ras proto-oncogenes. ...
Shigematsu H, Iwasaki H, Otsuka T, Ohno Y, Arima F, Niho Y (1997). "Role of the vav proto-oncogene product (Vav) in ... p21(ras), and phosphatidylinositol 3-kinase". J. Biol. Chem. 274 (18): 12722-9. doi:10.1074/jbc.274.18.12722. PMID 10212255. ... tyrosine kinase receptors and Src homology 3 domain proteins". Oncogene. 10 (8): 1475-83. PMID 7537362. Kapeller R, Toker A, ... Protein Pept. Sci. 5 (1): 1-8. doi:10.2174/1389203043486955. PMID 14965316. Joseph AM, Kumar M, Mitra D (2005). "Nef: " ...
... is in the Ras family, which also includes two other proto-oncogenes: KRAS and NRAS. These proteins all are regulated in ... GTPase HRas, from "Harvey Rat sarcoma virus", also known as transforming protein p21 is an enzyme that in humans is encoded by ... HRas is a small G protein in the Ras subfamily of the Ras superfamily of small GTPases. Once bound to Guanosine triphosphate, H ... When mutated, proto-oncogenes have the potential to cause normal cells to become cancerous. Some gene mutations are acquired ...
B-Raf proto-oncogene, casein kinase 2-interacting protein 1, and filamin A. Functions of PAK1 are regulated by its ability to ... Wang RA, Vadlamudi RK, Bagheri-Yarmand R, Beuvink I, Hynes NE, Kumar R (May 2003). "Essential functions of p21-activated kinase ... PAK proteins, a family of serine/threonine p21-activated kinases, include PAK1, PAK2, PAK3 and PAK4. These proteins serve as ... ARG-binding protein 2γ, hepatitis B virus X protein, STE20-related kinase adaptor protein α, RhoI, Klotho, N-acetylglucosaminyl ...
... and the proto-oncogenes c-kit, bcl-2, VEGF, H-ras and N-ras. Genome-wide surveys based on a quadruplex folding rule have been ... Fragile X mental retardation protein (FMRP) is a widely expressed protein coded by the FMR1 gene that binds to G-quadruplex ... Interaction of this G-quadruplex with TRF2 (also known as TERF2) resulted in epigenetic regulation of p21, which was tested ... The proto-oncogene c-myc forms a quadruplex in a nuclease hypersensitive region critical for gene activity. Other genes shown ...
"The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase". Biochem. Biophys. Res. Commun. 257 ... "The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins". FEBS Lett. 550 (1-3): ... Ng C, Jackson RA, Buschdorf JP, Sun Q, Guy GR, Sivaraman J (March 2008). "Structural basis for a novel intrapeptidyl H-bond and ... "The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src ...
Because viral genome insertion is not specific to proto-oncogenes and the chance of insertion near that proto-oncogene is low, ... p53 regulates the p21 gene, which produces a protein which binds to the Cyclin D-Cdk4/6 complex. This prevents Rb ... Chang Y, Moore PS, Weiss RA (October 2017). "Human oncogenic viruses: nature and discovery". Philosophical Transactions of the ... HPV instead degrades p53: the HPV protein E6 binds to a cellular protein called the E6-associated protein (E6-AP, also known as ...
... as well as a number of proto-oncogenes (Raf, Myc, Myb, Rel, Src, Mos, ABL). The UPS is also involved in the regulation of ... "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi: ... Simon JH, Gaddis NC, Fouchier RA, Malim MH (Dec 1998). "Evidence for a newly discovered cellular anti-HIV-1 phenotype". Nature ... identification of common effectors with p53 and p21(Waf1)". Proceedings of the National Academy of Sciences of the United ...
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell ... Wen ST, Van Etten RA (October 1997). "The PAG gene product, a stress-induced protein with antioxidant properties, is an Abl SH3 ... "Functional interaction between c-Abl and the p21-activated protein kinase gamma-PAK". Proc. Natl. Acad. Sci. U.S.A. 97 (26): ... Activity of ABL1 protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene ...
"The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase". Biochemical and Biophysical ... RAS p21 protein activator 1, and RASA3. GRCh38: Ensembl release 89: ENSG00000101336 - Ensembl, May 2017 GRCm38: Ensembl release ... "The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck ... "The Ras GTPase-activating protein (GAP) is an SH3 domain-binding protein and substrate for the Src-related tyrosine kinase, Hck ...
... a low-molecular weight protein inhibitor of cyclin-dependent protein kinases (CDKs) - which has been localised to the p21 ... RAS genes (NRAS, HRAS and KRAS) are also recurrently mutated (30% of TCGA cases) and mutations in the 61st or 12th codons ... If the mutations occur in protooncogenes or tumor suppressor genes, the rate of mitosis in the mutation-bearing cells can ... Davies MA, Samuels Y (October 2010). "Analysis of the genome to personalize therapy for melanoma". Oncogene. 29 (41): 5545-55. ...
RAF proto-oncogene serine/threonine-protein kinase, also known as proto-oncogene c-RAF or simply c-Raf or even Raf-1, is an ... Koyama S, Williams LT, Kikuchi A (July 1995). "Characterization of the interaction of Raf-1 with ras p21 or 14-3-3 protein in ... Han L, Colicelli J (March 1995). "A human protein selected for interference with Ras function interacts directly with Ras and ... RAF proto-oncogene serine/threonine-protein kinase) at the PDBe-KB. Portal: Biology (Articles with short description, Short ...
... p21 mRNA is clearly present and upregulated after the DDR in hESCs, but p21 protein is not detectable. In this cell type, p53 ... Finlay CA, Hinds PW, Levine AJ (June 1989). "The p53 proto-oncogene can act as a suppressor of transformation". Cell. 57 (7): ... Köbel M, Ronnett BM, Singh N, Soslow RA, Gilks CB, McCluggage WG (January 2019). "Interpretation of P53 Immunohistochemistry in ... or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins ( ...
... behaves as an oncogene in cell systems and is an established protooncogene causally involved in the pathogenesis of ... and Fbxos containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by ... such as p27 and p21. Here, SKP2 has been implicated in double negative feedback loops with both p21 and p27, that control cell ... Strack P, Caligiuri M, Pelletier M, Boisclair M, Theodoras A, Beer-Romero P, Glass S, Parsons T, Copeland RA, Auger KR, ...
Kerkhoff E, Rapp UR (1998). "Cell cycle targets of Ras/Raf signalling". Oncogene. 17 (11 Reviews): 1457-62. doi:10.1038/sj.onc. ... M-phase inducer phosphatase 1 also known as dual specificity phosphatase Cdc25A is a protein that in humans is encoded by the ... Thus, this degradation represents one axis of a DNA damage checkpoint, complementing induction of p53 and p21 in the inhibition ... Xia K, Lee RS, Narsimhan RP, Mukhopadhyay NK, Neel BG, Roberts TM (1999). "Tyrosine Phosphorylation of the Proto-Oncoprotein ...
Elevated levels of MIR22HG lncRNA were associated with increased levels of the proto-oncogene (i.e. potentially cancer-causing ... "Silencing of Long Noncoding RNA MIR22HG Triggers Cell Survival/Death Signaling via Oncogenes YBX1, MET, and p21 in Lung Cancer ... This RNA molecule is not translated into a protein but nonetheless may have important functions. MIR22HG ncRNA is greater than ... "Evidence of Cooperation between Hippo Pathway and RAS Mutation in Thyroid Carcinomas". Cancers. 13 (10): 2306. doi:10.3390/ ...