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*  CRKL
"The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins". Leukemia. 11 (3): 376-85 ... Lin H, Martelli MP, Bierer BE (January 2001). "The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T ... Smit L, van der Horst G, Borst J (April 1996). "Sos, Vav, and C3G participate in B cell receptor-induced signaling pathways and ... Crk-like protein is a protein that in humans is encoded by the CRKL gene. v-CRK avian sarcoma virus CT10-homolog-like contains ...
*  List of MeSH codes (D12.776.476)
... proto-oncogene proteins c-vav MeSH D12.776.476.325.300.600 -- ral guanine nucleotide exchange factor MeSH D12.776.476.325. ... oncogene proteins v-raf MeSH D12.776.476.400.842.374 -- proto-oncogene proteins a-raf MeSH D12.776.476.400.842.437 -- proto- ... oncogene proteins b-raf MeSH D12.776.476.400.842.500 -- proto-oncogene proteins c-raf MeSH D12.776.476.450.169.500 -- mitogen- ... oncogene protein p21(ras) MeSH D12.776.476.525.500.600 -- proto-oncogene proteins p21(ras) MeSH D12.776.476.525.700.050 -- ...
*  VAV1
Proto-oncogene vav is a protein that in humans is encoded by the VAV1 gene. The protein encoded by this proto-oncogene is a ... Shigematsu H, Iwasaki H, Otsuka T, Ohno Y, Arima F, Niho Y (May 1997). "Role of the vav proto-oncogene product (Vav) in ... Adams JM, Houston H, Allen J, Lints T, Harvey R (1992). "The hematopoietically expressed vav proto-oncogene shares homology ... Bustelo XR, Barbacid M (1992). "Tyrosine phosphorylation of the vav proto-oncogene product in activated B cells". Science. 256 ...
*  Zyxin
"SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin". Oncogene. 12 (7): ... Degenhardt YY, Silverstein S (2001). "Interaction of Zyxin, a Focal Adhesion Protein, with the E6 Protein from Human ... SH3 domains of proteins involved in signal transduction pathways while the LIM domains are likely involved in protein-protein ... and characterization of a zyxin-related protein that binds the focal adhesion and microfilament protein VASP (vasodilator- ...
*  HNRPK
"Association of the vav proto-oncogene product with poly(rC)-specific RNA-binding proteins". Mol. Cell. Biol. 15 (3): 1324-32. ... The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the ... It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also ... Kim JH, Hahm B, Kim YK, Choi M, Jang SK (May 2000). "Protein-protein interaction among hnRNPs shuttling between nucleus and ...
*  VAV3
1996). "SH3 domain-dependent interaction of the proto-oncogene product Vav with the focal contact protein zyxin". Oncogene. 12 ... This gene is a member of the VAV gene family. The VAV proteins are guanine nucleotide exchange factors (GEFs) for Rho family ... Movilla N, Bustelo XR (1999). "Biological and regulatory properties of Vav-3, a new member of the Vav family of oncoproteins". ... VAV3 vav 3 oncogene". Blagoev, Blagoy; Kratchmarova Irina; Ong Shao-En; Nielsen Mogens; Foster Leonard J; Mann Matthias (March ...
*  SH3 domain
Signal transducing adaptor proteins CDC24 Cdc25 PI3 kinase Phospholipase Ras GTPase-activating protein Vav proto-oncogene GRB2 ... The SH3 proteins interact with adaptor proteins and tyrosine kinases. Interacting with tyrosine kinases SH3 proteins usually ... SH3 domain mediated protein-protein interaction networks, i.e., SH3 interactomes, revealed that worm SH3 interactome resembles ... It has also been identified in several other protein families such as: PI3 Kinase, Ras GTPase-activating protein, CDC24 and ...
*  Calponin homology domain
Most proteins have two copies of the CH domain, however some proteins such as calponin and the human vav proto-oncogene (P15498 ... Hartwig JH (1995). "Actin-binding proteins. 1: Spectrin super family". Protein Prof. 2 (7): 703-800. PMID 7584474. Gimona M, ... is a family of actin binding domains found in both cytoskeletal proteins and signal transduction proteins. The domain is about ... Saraste M, Castresana J (1995). "Does Vav bind to F-actin through a CH domain?". FEBS Lett. 374 (2): 149-151. doi:10.1016/0014- ...
*  List of MeSH codes (D12.644)
... proto-oncogene proteins c-crk MeSH D12.644.360.024.326 --- proto-oncogene proteins c-vav MeSH D12.644.360.024.334 --- smad ... oncogene proteins v-raf MeSH D12.644.360.400.842.374 --- proto-oncogene proteins b-raf MeSH D12.644.360.400.842.500 --- proto- ... oncogene protein p21(ras) MeSH D12.644.360.525.500.600 --- proto-oncogene proteins p21(ras) MeSH D12.644.360.525.700 --- rho ... proto-oncogene proteins c-vav MeSH D12.644.360.325.300.600 --- ral guanine nucleotide exchange factor MeSH D12.644.360.325. ...
*  Tyrosine kinase 2
1996). "Interaction of the c-cbl proto-oncogene product with the Tyk-2 protein tyrosine kinase". Biochem. Biophys. Res. Commun ... 1997). "Thrombopoietin and thrombin induce tyrosine phosphorylation of Vav in human blood platelets". Blood. 89 (8): 2789-98. ... "The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex". J. ... Non-receptor tyrosine-protein kinase TYK2 is an enzyme that in humans is encoded by the TYK2 gene. Tyk2 was the first member of ...
*  List of MeSH codes (D12.776)
... proto-oncogene proteins c-sis MeSH D12.776.624.664.700.198 - proto-oncogene proteins c-vav MeSH D12.776.624.664.700.199 - proto ... proto-oncogene proteins c-abl MeSH D12.776.624.664.700.168 - proto-oncogene proteins c-akt MeSH D12.776.624.664.700.169 - proto ... proto-oncogene proteins c-bcr MeSH D12.776.624.664.700.172 - proto-oncogene proteins c-cbl MeSH D12.776.624.664.700.174 - proto ... proto-oncogene proteins c-fes MeSH D12.776.624.664.700.179 - proto-oncogene proteins c-fos MeSH D12.776.624.664.700.180 - proto ...
*  Adapter molecule crk
... also known as proto-oncogene c-Crk or p38 is a protein that in humans is encoded by the CRK gene. The CRK ... Oncogene. 8 (10): 2853-5. PMID 8378094. Smit L, van der Horst G, Borst J (1996). "Sos, Vav, and C3G participate in B cell ... Crk Info with links in the Cell Migration Gateway Proto-Oncogene Proteins c-crk at the US National Library of Medicine Medical ... Koval AP, Karas M, Zick Y, LeRoith D (1998). "Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth ...
*  Mycoplasma
... and vav. The activity of proto-oncogenes is not the only cellular function that is affected; tumour suppressor genes are ... The protein also causes the growth, morphology, and the gene expression of the cells to change, causing them to become a more ... Chromosomal translocation and extra chromosomes help create abnormally high activity of certain proto-oncogenes, which caused ... Hu X, Yu J, Zhou X, Li Z, Xia Y, Luo Z, Wu Y (Jan 2014). "A small GTPase-like protein fragment of Mycoplasma promotes tumor ...
*  PIK3R1
Shigematsu H, Iwasaki H, Otsuka T, Ohno Y, Arima F, Niho Y (1997). "Role of the vav proto-oncogene product (Vav) in ... tyrosine kinase receptors and Src homology 3 domain proteins". Oncogene. 10 (8): 1475-83. PMID 7537362. Kapeller R, Toker A, ... Protein Pept. Sci. 5 (1): 1-8. doi:10.2174/1389203043486955. PMID 14965316. Joseph AM, Kumar M, Mitra D (2005). "Nef: " ... Leavitt SA, SchOn A, Klein JC, Manjappara U, Chaiken IM, Freire E (2004). "Interactions of HIV-1 proteins gp120 and Nef with ...
*  Syk
"Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product". Immunity. 5 (6): 591-604. doi: ... Without Syk, the protein it makes, and genetic disruption in a panel of 55 genes thought also to be controlled by Syk, breast ... Evidence for a constitutive in vivo association of Vav with Grb2, Raf-1, and ERK2 in an active complex". The Journal of ... Sada K, Minami Y, Yamamura H (September 1997). "Relocation of Syk protein-tyrosine kinase to the actin filament network and ...
*  PLCG1
SH3 domain-mediated protein-protein interaction blocking drug". Oncogene. 21 (13): 2037-50. doi:10.1038/sj.onc.1205271. PMID ... Ohmichi M, Decker SJ, Pang L, Saltiel AR (August 1991). "Nerve growth factor binds to the 140 kd trk proto-oncogene product and ... "Nuclear association of tyrosine-phosphorylated Vav to phospholipase C-gamma1 and phosphoinositide 3-kinase during granulocytic ... Phospholipase C, gamma 1, also known as PLCG1, is a protein that in humans is encoded by the PLCG1 gene. The protein encoded by ...
*  AOC3
Bustelo XR, Barbacid M (May 1992). "Tyrosine phosphorylation of the vav proto-oncogene product in activated B cells". Science. ... is a proinflammatory protein derived from shedding of the transmembrane protein. It is highly expressed on the endothelium of ... "Crystal structure of the human vascular adhesion protein-1: unique structural features with functional implications". Protein ... This protein is a member of the semicarbazide-sensitive amine oxidase (SSAO) family and is associated with many vascular ...
*  BAG3
SH3 domain-mediated protein-protein interaction blocking drug". Oncogene. 21 (13): 2037-50. doi:10.1038/sj.onc.1205271. PMID ... Ohmichi M, Decker SJ, Pang L, Saltiel AR (August 1991). "Nerve growth factor binds to the 140 kd trk proto-oncogene product and ... "Nuclear association of tyrosine-phosphorylated Vav to phospholipase C-gamma1 and phosphoinositide 3-kinase during granulocytic ... BAG3 balances protein synthesis and protein degradation under mechanical stress. PLCG1 has been shown to interact with: FGFR1, ...
*  ABL (gene)
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell ... "Association of Bcr-Abl with the proto-oncogene Vav is implicated in activation of the Rac-1 pathway". J. Biol. Chem. 277 (14): ... Activity of ABL1 protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene ... Abelson murine leukemia viral oncogene homolog 1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene ( ...
*  CBL (gene)
"The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase". Biochem. Biophys. Res. Commun. 257 ... Marengère LE, Mirtsos C, Kozieradzki I, Veillette A, Mak TW, Penninger JM (July 1997). "Proto-oncoprotein Vav interacts with c- ... "The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src ... "The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the ...
*  CBLB (gene)
... a SH3 binding protein with homology to the c-cbl proto-oncogene". Oncogene. 10 (12): 2367-77. PMID 7784085. "Entrez Gene: CBLB ... 1997). "Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation". Oncogene ... CBL-B is an E3 ubiquitin-protein ligase that in humans is encoded by the CBLB gene. CBLB is a member of the CBL gene family. ... 1999). "A direct interaction between the adaptor protein Cbl-b and the kinase zap-70 induces a positive signal in T cells". ...
*  Erythropoietin receptor
Shigematsu H, Iwasaki H, Otsuka T, Ohno Y, Arima F, Niho Y (May 1997). "Role of the vav proto-oncogene product (Vav) in ... Feng GS, Ouyang YB, Hu DP, Shi ZQ, Gentz R, Ni J (May 1996). "Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine ... The erythropoietin receptor (EpoR) is a protein that in humans is encoded by the EPOR gene. EpoR is a 52kDa peptide with a ... Oncogene. 21 (21): 3368-76. doi:10.1038/sj.onc.1205326. PMID 12032775. Zon LI, Youssoufian H, Mather C, Lodish HF, Orkin SH ( ...
*  Janus kinase 2
Shigematsu H, Iwasaki H, Otsuka T, Ohno Y, Arima F, Niho Y (May 1997). "Role of the vav proto-oncogene product (Vav) in ... "The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase ... Sarkar S, Pollack BP, Lin KT, Kotenko SV, Cook JR, Lewis A, Pestka S (December 2001). "hTid-1, a human DnaJ protein, modulates ... Xie S, Lin H, Sun T, Arlinghaus RB (October 2002). "Jak2 is involved in c-Myc induction by Bcr-Abl". Oncogene. 21 (47): 7137-46 ...
*  GRB2
RET proto-oncogene, SH2B1, SH3KBP1, SHC1, SOS1, Src, Syk, TNK2, TrkA, VAV1, VAV2, VAV3, and Wiskott-Aldrich syndrome protein. ... "hSiah2 is a new Vav binding protein which inhibits Vav-mediated signaling pathways". Molecular and Cellular Biology. 19 (5): ... "The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the ... SH3 domain-mediated protein-protein interaction blocking drug". Oncogene. 21 (13): 2037-50. doi:10.1038/sj.onc.1205271. PMID ...