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*  C1orf173
NCBI (April 2015). "MDM2 MDM2 proto-oncogene, E3 ubiquitin protein ligase [ Homo sapiens (human) ]". Miyamoto-Sato E; Fujimori ... Glutamate-rich protein 3, also known as Uncharacterized Protein C1orf173 or Chromosome 1 Open Reading Frame 173, is a protein ... The C1orf173 protein has been predicted or experimentally observed to interact with the following proteins: CRISPLD2 GIMAP4 ... a nuclear protein based on PSORT II analysis and the suggested protein interactions found between c1orf173 and other proteins ...
*  List of MeSH codes (D08)
... proto-oncogene proteins c-cbl MeSH D08.811.464.938.750.562 --- proto-oncogene proteins c-mdm2 MeSH D08.811.464.938.750.750 --- ... proto-oncogene proteins c-bcr MeSH D08.811.913.696.620.682.700.776 --- proto-oncogene proteins c-pim-1 MeSH D08.811.913.696. ... proto-oncogene proteins c-kit MeSH D08.811.913.696.620.682.725.400.075 --- proto-oncogene proteins c-met MeSH D08.811.913.696. ... proto-oncogene proteins c-fyn MeSH D08.811.913.696.620.682.725.800.590 --- proto-oncogene proteins c-hck MeSH D08.811.913.696. ...
*  CBL (gene)
"The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase". Biochem. Biophys. Res. Commun. 257 ... "Identification of c-Cbl as a new ligase for insulin-like growth factor-I receptor with distinct roles from Mdm2 in receptor ... "The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src ... "The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the ...
*  List of MeSH codes (D12.776)
... proto-oncogene proteins c-maf MeSH D12.776.624.664.700.185 - proto-oncogene proteins c-mdm2 MeSH D12.776.624.664.700.186 - ... proto-oncogene proteins c-abl MeSH D12.776.624.664.700.168 - proto-oncogene proteins c-akt MeSH D12.776.624.664.700.169 - proto ... proto-oncogene proteins c-bcr MeSH D12.776.624.664.700.172 - proto-oncogene proteins c-cbl MeSH D12.776.624.664.700.174 - proto ... proto-oncogene proteins c-fes MeSH D12.776.624.664.700.179 - proto-oncogene proteins c-fos MeSH D12.776.624.664.700.180 - proto ...
*  Polypurine reverse-Hoogsteen hairpin
... and proto-oncogenes (MDM2) as part of a cancer gene therapy strategy. Their preclinical proof of principle has been proven in ... Upon binding to their targets, PPRHs can decrease the mRNA and protein levels of the selected genes. Their action has been ...
*  Geoffrey M. Cooper
More specifically, he focuses on "the roles of proto-oncogene proteins as elements of signal transduction pathways that control ... Identification of the MDM2 oncoproteinas a substrate for CPP32-like apoptotic proteases. J. Biol. Chem. 272:15049-15052. Lopes ... Identification of COUP-TF as a transcriptional repressor of the c-mos proto-oncogene. J. Biol. Chem. 274:36796-36800. Erhardt, ... Regulation of neuronal survival by the Ser/Thr protein kinase Akt. Science 275:661-665. Erhardt, P., Tomaselli, K.J., and ...
*  ABL (gene)
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell ... MDM2, NCK1, NEDD9, NTRK1, P73, PAG1, PAK2, PSTPIP1, RAD9A, RAD51, RB1, RFX1, RYBP, SHC1, SORBS2, SPTA1, SPTAN1, TERF1, VAV1, ... Activity of ABL1 protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene ... Abelson murine leukemia viral oncogene homolog 1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene ( ...
*  HRAS
... is in the Ras family, which also includes two other proto-oncogenes: KRAS and NRAS. These proteins all are regulated in ... Harms KL, Chen X (May 2006). "p19ras brings a new twist to the regulation of p73 by Mdm2". Science's STKE. 2006 (337): pe24. ... HRAS has been shown to be a proto-oncogene. When mutated, proto-oncogenes have the potential to cause normal cells to become ... The rate of conversion is usually slow but can be sped up dramatically by an accessory protein of the GTPase activating protein ...
*  PSMD10
"Retinoblastoma protein modulates gankyrin-MDM2 in regulation of p53 stability and chemosensitivity in cancer cells". Oncogene. ... as well as a number of proto-oncogenes (Raf, Myc, Myb, Rel, Src, Mos, Abl). The UPS is also involved in the regulation of ... It plays a key role in regulating the cell cycle via protein-protein interactions with the cyclin-dependent kinase CDK4. It ... "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3: 89. doi:10.1038/msb4100134 ...
*  Protein kinase B
Proto-Oncogene Proteins c-akt at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular ... MDM2). Akt could promote growth factor-mediated cell survival both directly and indirectly. BAD is a pro-apoptotic protein of ... Protein kinase B (PKB), also known as Akt, is a serine/threonine-specific protein kinase that plays a key role in multiple ... Franke TF, Kaplan DR, Cantley LC, Toker A (January 1997). "Direct regulation of the Akt proto-oncogene product by ...
*  TP53
Some oncogenes can also stimulate the transcription of proteins that bind to MDM2 and inhibit its activity. If the TP53 gene is ... Finlay, C. A.; Hinds, P. W.; Levine, A. J. (1989-06-30). "The p53 proto-oncogene can act as a suppressor of transformation". ... In a negative feedback loop, MDM2 itself is induced by the p53 protein. Mutant p53 proteins often fail to induce MDM2, causing ... Phosphorylation of the N-terminal end of p53 by the above-mentioned protein kinases disrupts Mdm2-binding. Other proteins, such ...
*  Heat shock protein 90kDa alpha (cytosolic), member A1
The proto-oncogene MYC is also found to induce HSP90AA1 gene expression and binds proximally to the TSS as verified by ChIP-SEQ ... Peng Y, Chen L, Li C, Lu W, Chen J (Nov 2001). "Inhibition of MDM2 by hsp90 contributes to mutant p53 stabilization". The ... Kang J, Kim T, Ko YG, Rho SB, Park SG, Kim MJ, Kwon HJ, Kim S (Oct 2000). "Heat shock protein 90 mediates protein-protein ... Heat shock protein HSP 90-alpha is a protein that in humans is encoded by the HSP90AA1 gene. The gene, HSP90AA1, encodes the ...
*  Pier Paolo Pandolfi
"Role of the proto-oncogene POKEMON in cellular transformation and ARF repression." Nature, 433:278-285, 2005. A. Lunardi, J. ... Pandolfi has also presented a theory describing how non-coding RNAs as well as protein coding messenger RNAs can cross-talk ... "PML regulates p53 stability through nucleolar sequestration of Mdm2." Nature Cell Biology, 7:665-672, 2004. Z.chen, L.C. ... "Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF." Science, 316: 860-866, 2007. L.-Z. He, M. ...
*  EP300
Na SY, Choi JE, Kim HJ, Jhun BH, Lee YC, Lee JW (October 1999). "Bcl3, an IkappaB protein, stimulates activating protein-1 ... "p300/MDM2 complexes participate in MDM2-mediated p53 degradation". Mol. Cell. 2 (4): 405-15. doi:10.1016/s1097-2765(00)80140-9 ... Eid JE, Kung AL, Scully R, Livingston DM (September 2000). "p300 interacts with the nuclear proto-oncoprotein SYT as part of ... Oncogene. 22 (1): 151-6. doi:10.1038/sj.onc.1206067. PMID 12527917. Yamamoto N, Yamamoto S, Inagaki F, Kawaichi M, Fukamizu A, ...
*  Akt/PKB signaling pathway
Key proteins involved are PI3K (phosphatidylinositol 3-kinase) and Akt (Protein Kinase B). Initial stimulation by one of the ... Mdm2), a key regulator of DNA damage responses, at Ser166 and Ser186. Phosphorylation of Mdm2 by Akt upregulates its ubiquitin- ... Carracedo A, Pandolfi PP (2008). "The PTEN-PI3K pathway: of feedbacks and cross-talks". Oncogene. 27 (41): 5527-5541. doi: ... "NEDD4-1 Is a Proto-Oncogenic Ubiquitin Ligase for PTEN". Cell. 128 (1): 129-139. doi:10.1016/j.cell.2006.11.039. PMC 1828909 . ...
*  Proteasome
... as well as a number of proto-oncogenes (Raf, Myc, Myb, Rel, Src, Mos, Abl). The UPS is also involved in the regulation of ... These proteins are ubiquitinated by SCFTIR1, or SCF in complex with the auxin receptor TIR1. Degradation of Aux/IAA proteins ... via its affinity for the ubiquitin ligase MDM2. Gankyrin is anti-apoptotic and has been shown to be overexpressed in some tumor ... Proteins are tagged for degradation with a small protein called ubiquitin. The tagging reaction is catalyzed by enzymes called ...