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*  FYN
Proto-oncogene tyrosine-protein kinase Fyn (p59-FYN, Slk, Syn, MGC45350, Gene ID 2534) is an enzyme that in humans is encoded ... By definition as a proto-oncogene, Fyn codes for proteins that help regulate cell growth. Changes in its DNA sequence transform ... Fyn is a member of the Src-family of kinases (SFK), the first proto-oncogene to be identified. The discovery of the Src-family ... Fyn is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been ...
*  Tau protein
... has been shown to interact with proto-oncogene tyrosine-protein kinase: Alpha-synuclein, FYN, S100B, and YWHAZ. ... Tau proteins (or τ proteins, after the Greek letter with that name) are proteins that stabilize microtubules. They are abundant ... Tau protein is a highly soluble microtubule-associated protein (MAP). In humans, these proteins are found mostly in neurons ... Tau protein is a highly soluble microtubule-associated protein (MAP). Through its isoforms and phosphorylation tau protein ...
*  Fyn (disambiguation)
Fyn or FYN may refer to: Fyn, or Funen, Denmark FYN, encoding the proto-oncogene tyrosine-protein kinase Fyn Freshwater, ...
*  Proto-oncogene tyrosine-protein kinase Src
Src, Fyn and Yes are expressed ubiquitously in all cell types while the others are generally found in hematopoietic cells. c- ... Proto-oncogene tyrosine-protein kinase Src, also known as proto-oncogene c-Src or simply c-Src , is a non-receptor tyrosine ... This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this ... Src (pronounced "sarc" as it is short for sarcoma) is a proto-oncogene encoding a tyrosine kinase originally discovered by J. ...
*  List of MeSH codes (D12.776)
... proto-oncogene proteins c-fos MeSH D12.776.624.664.700.180 - proto-oncogene proteins c-fyn MeSH D12.776.624.664.700.181 - proto ... proto-oncogene proteins c-abl MeSH D12.776.624.664.700.168 - proto-oncogene proteins c-akt MeSH D12.776.624.664.700.169 - proto ... proto-oncogene proteins c-bcr MeSH D12.776.624.664.700.172 - proto-oncogene proteins c-cbl MeSH D12.776.624.664.700.174 - proto ... proto-oncogene proteins c-jun MeSH D12.776.624.664.700.183 - proto-oncogene proteins c-kit MeSH D12.776.624.664.700.184 - proto ...
*  List of MeSH codes (D08)
... proto-oncogene proteins c-fyn MeSH D08.811.913.696.620.682.725.800.590 --- proto-oncogene proteins c-hck MeSH D08.811.913.696. ... proto-oncogene proteins c-bcr MeSH D08.811.913.696.620.682.700.776 --- proto-oncogene proteins c-pim-1 MeSH D08.811.913.696. ... proto-oncogene proteins c-kit MeSH D08.811.913.696.620.682.725.400.075 --- proto-oncogene proteins c-met MeSH D08.811.913.696. ... proto-oncogene proteins c-yes MeSH D08.811.913.696.620.682.725.800.630 --- proto-oncogene proteins pp60(c-src) MeSH D08.811. ...
*  HNRPK
"Association of the vav proto-oncogene product with poly(rC)-specific RNA-binding proteins". Mol. Cell. Biol. 15 (3): 1324-32. ... Fyn, and Lyn SH3-binding proteins: implications for a function of SH3 domains". Mol. Cell. Biol. 14 (7): 4509-21. PMC 358823 . ... The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene is located in the ... It is distinct among other hnRNP proteins in its binding preference; it binds tenaciously to poly(C). This protein is also ...
*  YES1
Proto-oncogene tyrosine-protein kinase Yes is an enzyme that in humans is encoded by the YES1 gene. This gene is the cellular ... 1991). "Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human ... Zhao YH, Krueger JG, Sudol M (1991). "Expression of cellular-yes protein in mammalian tissues". Oncogene. 5 (11): 1629-35. PMID ... The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity ...
*  CENTG1
"PIKE-A is a proto-oncogene promoting cell growth, transformation and invasion". Oncogene. 26 (34): 4918-27. doi:10.1038/sj.onc. ... Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the AGAP2 gene. ... Tang X, Feng Y, Ye K (2007). "Src-family tyrosine kinase fyn phosphorylates phosphatidylinositol 3-kinase enhancer-activating ... Werden SJ, Barrett JW, Wang G, Stanford MM, McFadden G (2007). "M-T5, the ankyrin repeat, host range protein of myxoma virus, ...
*  FER (gene)
Proto-oncogene tyrosine-protein kinase FER is an enzyme that in humans is encoded by the FER gene. Fer protein is a member of ... The role of Fyn and FER kinases". J. Biol. Chem. 275 (41): 32289-98. doi:10.1074/jbc.M003172200. PMID 10921917. Orlovsky K, Ben ... Kim, L; Wong T W (Sep 1998). "Growth factor-dependent phosphorylation of the actin-binding protein cortactin is mediated by the ... 1990). "The FER gene is evolutionarily conserved and encodes a widely expressed member of the FPS/FES protein-tyrosine kinase ...
*  Tyrosine kinase
This growth factor receptor is called c-kit and is produced by a proto-oncogene (c-kit). Mutation of c-kit causes the ... For example, the T-cell antigen receptor leads to intracellular signalling by activation of Lck and Fyn, two proteins that are ... Protein tyrosine kinase plays a role in this task, too. A protein tyrosine kinase called pp125 is likely at hand in the ... This protein tyrosine kinase is up to about 70% unique compared to some other protein tyrosine kinases, a figure that is unlike ...
*  HCK
"The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase". Biochemical and Biophysical ... Cheng G, Ye ZS, Baltimore D (1994). "Binding of Bruton's tyrosine kinase to Fyn, Lyn, or Hck through a Src homology 3 domain- ... Tyrosine-protein kinase HCK is an enzyme that in humans is encoded by the HCK gene. The protein encoded by this gene is a ... Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1". The Journal of Biological Chemistry. 277 ( ...
*  Lck
... and the proto oncogene product p56lck important?". Medical Hypotheses. 38 (4): 322-4. doi:10.1016/0306-9877(92)90025-8. PMID ... "CD44 selectively associates with active Src family protein tyrosine kinases Lck and Fyn in glycosphingolipid-rich plasma ... Lck is a 56-kilodalton protein. The N-terminal tail of Lck is myristoylated and palmitoylated, which tethers the protein to the ... Lck (or lymphocyte-specific protein tyrosine kinase) is a 56 kDa protein that is found inside specialized cells of the immune ...
*  PIK3R2
Lin H, Martelli MP, Bierer BE (Jan 2001). "The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell ... PIK3R2 has been shown to interact with: CRKL Cbl gene, Epidermal growth factor, FYN, HER2/neu, Macrophage colony-stimulating ... Pandey A, Lazar DF, Saltiel AR, Dixit VM (Dec 1994). "Activation of the Eck receptor protein tyrosine kinase stimulates ... "Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl". ...
*  Janus kinase 3
"JAK3 maps to human chromosome 19p12 within a cluster of proto-oncogenes and transcription factors". Genomics. 43 (1): 109-11. ... Tyrosine-protein kinase JAK3 is an enzyme that in humans is encoded by the JAK3 gene. Janus kinase 3 is a tyrosine kinase that ... Fusaki N, Iwamatsu A, Iwashima M, Fujisawa JI (March 1997). "Interaction between Sam68 and Src family tyrosine kinases, Fyn and ... Ji H, Zhai Q, Zhu J, Yan M, Sun L, Liu X, Zheng Z (April 2000). "A novel protein MAJN binds to Jak3 and inhibits apoptosis ...
*  Src family kinase
Molecular and Cellular Biology portal Proto-oncogene_tyrosine-protein_kinase_Src. ... Src kinase family is a family of non-receptor tyrosine kinases that includes nine members: Src, Yes, Fyn, and Fgr, forming the ... Src family kinases interact with many cellular cytosolic, nuclear and membrane proteins, modifying these proteins by ... Parsons SJ, Parsons JT (October 2004). "Src family kinases, key regulators of signal transduction". Oncogene. 23 (48): 7906-9. ...
*  CBL (gene)
"The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase". Biochem. Biophys. Res. Commun. 257 ... Deckert M, Elly C, Altman A, Liu YC (April 1998). "Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk ... "The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src ... "The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the ...
*  PTPN11
"Fyn kinase-directed activation of SH2 domain-containing protein-tyrosine phosphatase SHP-2 by Gi protein-coupled receptors in ... These data suggests that Shp2 may be a proto-oncogene. However, it has been reported that PTPN11/Shp2 can act as either tumor ... "Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth ... PTPN11 is a protein tyrosine phosphatase (PTP) Shp2. PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. PTPs ...
*  Syk
"Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product". Immunity. 5 (6): 591-604. doi: ... Without Syk, the protein it makes, and genetic disruption in a panel of 55 genes thought also to be controlled by Syk, breast ... Syk has been shown to interact with: Cbl gene CRKL, FCGR2A, FYN, Grb2, Lck, LYN, PTK2, PTPN6, and VAV1. GRCh38: Ensembl release ... Deckert M, Elly C, Altman A, Liu YC (April 1998). "Coordinated regulation of the tyrosine phosphorylation of Cbl by Fyn and Syk ...
*  GRB2
RET proto-oncogene, SH2B1, SH3KBP1, SHC1, SOS1, Src, Syk, TNK2, TrkA, VAV1, VAV2, VAV3, and Wiskott-Aldrich syndrome protein. ... "Fyn kinase-directed activation of SH2 domain-containing protein-tyrosine phosphatase SHP-2 by Gi protein-coupled receptors in ... "The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the ... SH3 domain-mediated protein-protein interaction blocking drug". Oncogene. 21 (13): 2037-50. doi:10.1038/sj.onc.1205271. PMID ...
*  C-Raf
RAF proto-oncogene serine/threonine-protein kinase, also known as proto-oncogene c-RAF or simply c-Raf or even Raf-1, is an ... C-Raf has been shown to interact with: AKT1, ASK1, BAG1, BRAF, Bcl-2, CDC25A, CFLAR, FYN, GRB10, HRAS, HSP90AA1, KRAS, MAP2K1, ... "The small GTP-binding protein, Rhes, regulates signal transduction from G protein-coupled receptors". Oncogene. 23 (2): 559-68 ... 14-3-3 proteins also contribute to the autoinhibition. As 14-3-3 proteins are all known to form constitutive dimers, their ...
*  Beta-catenin
SH3 domain-mediated protein-protein interaction blocking drug". Oncogene. 21 (13): 2037-50. doi:10.1038/sj.onc.1205271. PMID ... Beta-catenin is a proto-oncogene. Mutations of this gene are commonly found in a variety of cancers: in primary hepatocellular ... "p120 Catenin-associated Fer and Fyn tyrosine kinases regulate beta-catenin Tyr-142 phosphorylation and beta-catenin-alpha- ... DIX domains are unique: the only other proteins known to have a DIX domain are Dishevelled and DIXDC1. (The single Dsh protein ...
*  Colony stimulating factor 1 receptor
"Nucleotide sequence and structural organization of the human FMS proto-oncogene". Oncogene Res. 4 (1): 9-17. PMID 2524025. ... The encoded protein is a single pass type I membrane protein and acts as the receptor for colony stimulating factor 1, a ... Colony stimulating factor 1 receptor has been shown to interact with: Cbl gene, FYN, Grb2, Suppressor of cytokine signaling 1, ... Sherr CJ, Rettenmier CW, Sacca R, Roussel MF, Look AT, Stanley ER (July 1985). "The c-fms proto-oncogene product is related to ...
*  NCK1
"Physical association between Src homology 3 elements and the protein product of the c-cbl proto-oncogene". J. Biol. Chem. 269 ( ... "Fyn-binding protein (Fyb)/SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the ... "The Nck SH2/SH3 adaptor protein is present in the nucleus and associates with the nuclear protein SAM68". Oncogene. 14 (2): 223 ... "The Nck SH2/SH3 adaptor protein is present in the nucleus and associates with the nuclear protein SAM68". Oncogene. 14 (2): 223 ...
*  Janus kinase 2
Shigematsu H, Iwasaki H, Otsuka T, Ohno Y, Arima F, Niho Y (May 1997). "Role of the vav proto-oncogene product (Vav) in ... "The human homologue of the yeast proteins Skb1 and Hsl7p interacts with Jak kinases and contains protein methyltransferase ... Janus kinase 2 has been shown to interact with: DNAJA3, EGFR, EPOR, FYN, Grb2, GHR, IRS1, IL12RB2, IL5RA, PIK3R1, PPP2R4, PTK2 ... Sarkar S, Pollack BP, Lin KT, Kotenko SV, Cook JR, Lewis A, Pestka S (December 2001). "hTid-1, a human DnaJ protein, modulates ...
*  Tyrosine kinase 2
1996). "Interaction of the c-cbl proto-oncogene product with the Tyk-2 protein tyrosine kinase". Biochem. Biophys. Res. Commun ... Tyrosine kinase 2 has been shown to interact with FYN, PTPN6, IFNAR1, Ku80 and GNB2L1. GRCh38: Ensembl release 89: ... "The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex". J. ... Non-receptor tyrosine-protein kinase TYK2 is an enzyme that in humans is encoded by the TYK2 gene. Tyk2 was the first member of ...