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*  List of MeSH codes (D12.776)
... proto-oncogene protein c-ets-1 MeSH D12.776.624.664.700.175.200 - proto-oncogene protein c-ets-2 MeSH D12.776.624.664.700.175. ... proto-oncogene proteins c-crk MeSH D12.776.624.664.700.175 - proto-oncogene proteins c-ets MeSH D12.776.624.664.700.175.100 - ... proto-oncogene proteins c-abl MeSH D12.776.624.664.700.168 - proto-oncogene proteins c-akt MeSH D12.776.624.664.700.169 - proto ... proto-oncogene proteins c-fes MeSH D12.776.624.664.700.179 - proto-oncogene proteins c-fos MeSH D12.776.624.664.700.180 - proto ...
*  Transmembrane protein 268
REL is associated to be a proto-oncogene that is from a family of transcription factors. It is associated with B-cell ... citation needed] The protein was found to be expressed in numerous different tissues. The ETS Profile for TMEM268 indicates the ... Transmembrane protein 268 is a protein that in humans is encoded by TMEM268 gene. The protein is a transmembrane protein of 342 ... The protein has been identified in organisms from the common fruit fly to primates. To date, there has been no protein ...
*  FLI1
... which is a proto-oncogene. Fli-1 is a member of the ETS transcription factor family that was first identified in ... 1998). "Erg proteins, transcription factors of the Ets family, form homo, heterodimers and ternary complexes via two distinct ... Oncogene. 8 (8): 2167-73. PMID 8336942. Ohno T, Rao VN, Reddy ES (December 1993). "EWS/Fli-1 chimeric protein is a ... "Analysis of the DNA-binding and transcriptional activation functions of human Fli-1 protein". Oncogene. 8 (8): 2167-73. PMID ...
*  PAK1
B-Raf proto-oncogene, casein kinase 2-interacting protein 1, and filamin A. Functions of PAK1 are regulated by its ability to ... binding protein 1-T60-S246, integrin-linked kinase 1-T173-S246, epithelium-specific Ets transcription factor 1-S207, ErbB3 ... ARG-binding protein 2γ, hepatitis B virus X protein, STE20-related kinase adaptor protein α, RhoI, Klotho, N-acetylglucosaminyl ... These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of ...
*  ELK4
ETS domain-containing protein Elk-4 is a protein that in humans is encoded by the ELK4 gene. This gene is a member of the Ets ... complex by binding to the serum response factor and the serum response element in the promoter of the c-fos proto-oncogene. The ... "Entrez Gene: ELK4 ELK4, ETS-domain protein (SRF accessory protein 1)". Chai Y, Chipitsyna G, Cui J, Liao B, Liu S, Aysola K, ... "Id helix-loop-helix proteins inhibit nucleoprotein complex formation by the TCF ETS-domain transcription factors". EMBO J. 18 ( ...
*  ELK1
The downstream target of Elk1 is the serum response element (SRE) of the c-fos proto-oncogene. To produce c-fos, a protein ... Elk1 can, thus, independently interact with an ETS binding site, as in the case of the lck proto-oncogene in Figure 2. Moreover ... ETS domain-containing protein Elk-1 is a protein that in humans is encoded by the ELK1 gene. Elk-1 functions as a transcription ... The binding of Elk1 to SRF happens due to protein-protein interaction between the B domain of Elk1 and SRF and the protein-DNA ...
*  List of MeSH codes (D12.776.260)
... oncogene protein v-maf MeSH D12.776.260.108.500.061.750 -- proto-oncogene proteins c-maf MeSH D12.776.260.108.500.500 -- maf ... ets-domain protein elk-1 MeSH D12.776.260.665.600.300 -- ets-domain protein elk-4 MeSH D12.776.260.713.500.100 -- smad1 protein ... ccaat-enhancer-binding protein-alpha MeSH D12.776.260.108.124.750 -- ccaat-enhancer-binding protein-beta MeSH D12.776.260.108. ... smad5 protein MeSH D12.776.260.713.500.800 -- smad8 protein MeSH D12.776.260.775.875.374 -- transcription factor tfiia MeSH ...
*  List of MeSH codes (D12.776.930)
... oncogene protein v-maf MeSH D12.776.930.127.500.061.750 -- proto-oncogene proteins c-maf MeSH D12.776.930.127.500.500 -- maf ... ets-domain protein elk-1 MeSH D12.776.930.635.600.300 -- ets-domain protein elk-4 MeSH D12.776.930.675.500.500 -- retinoid X ... smad1 protein MeSH D12.776.930.806.500.200 -- smad2 protein MeSH D12.776.930.806.500.300 -- smad3 protein MeSH D12.776.930.806. ... CCAAT-enhancer-binding protein-alpha MeSH D12.776.930.127.124.750 -- CCAAT-enhancer-binding protein-beta MeSH D12.776.930.127. ...
*  ERG (gene)
"Human ERG-2 protein is a phosphorylated DNA-binding protein--a distinct member of the ets family". Oncogene. 8 (6): 1559-66. ... This gene can be classified as a proto-oncogene. During chromosomal translocations that occur in cell division, ERG can ... ERG (ETS-related gene) is an oncogene. ERG is a member of the ETS (erythroblast transformation-specific) family of ... The ERG gene encodes for a protein, also called ERG, that functions as a transcriptional regulator. Genes in the ETS family ...
*  ETV6
The human ETV6 protein is a member of the ETS transcription factor family; however, it more often acts to inhibit than ... ETV6 is a clinically significant proto-oncogene in that it can fuse with other genes to drive the development and/or ... and ETV6-PER1 fusion genes produce chimeric proteins which lack ETV6 protein's gene-suppressing activity. The chimeric protein ... This creates a fusion gene of the oncogene category which encodes a chimeric protein that promotes the malignant growth of its ...
*  SPI1
"Functional and physical interactions between AML1 proteins and an ETS protein, MEF: implications for the pathogenesis of t(8;21 ... "The human homologue of the putative proto-oncogene Spi-1: characterization and expression in tumors". Oncogene. 5 (5): 663-8. ... Transcription factor PU.1 is a protein that in humans is encoded by the SPI1 gene. This gene encodes an ETS-domain ... Bassuk AG, Anandappa RT, Leiden JM (1997). "Physical interactions between Ets and NF-kappaB/NFAT proteins play an important ...
*  ETS2
Protein C-ets-2 is a protein that in humans is encoded by the ETS2 gene. The protein encoded by this gene belongs to the ETS ... "Characterization and localization of the products of the human homologs of the v-ets oncogene". Oncogene. 2 (2): 99-103. PMID ... "Regulation of transcription of the human presenilin-1 gene by ets transcription factors and the p53 protooncogene". The Journal ... "Mammalian ets-1 and ets-2 genes encode highly conserved proteins". Proceedings of the National Academy of Sciences of the ...
*  Cyclin D1
Mulcahy LS, Smith MR, Stacey DW (1985). "Requirement for ras proto-oncogene function during serum-stimulated growth of NIH 3T3 ... This protein has been shown to interact with tumor suppressor protein Rb and the expression of this gene is regulated ... "Transforming p21ras mutants and c-Ets-2 activate the cyclin D1 promoter through distinguishable regions". J Biol Chem. 270: ... Motokura T, Arnold A (1993). "PRAD1/cyclin D1 proto-oncogene: genomic organization, 5' DNA sequence, and sequence of a tumor- ...
*  ETS1
Li R, Pei H, Watson DK (2000). "Regulation of Ets function by protein - protein interactions". Oncogene. 19 (55): 6514-23. doi: ... Reddy ES, Rao VN (1988). "Structure, expression and alternative splicing of the human c-ets-1 proto-oncogene". Oncogene ... Protein C-ets-1 is a protein that in humans is encoded by the ETS1 gene. The protein encoded by this gene belongs to the ETS ... In particular, ETS1 protein interacts with several DNA repair proteins. ETS1 binds with DNA-dependent protein kinase (DNA-PK) [ ...
*  C-Met
Proto-Oncogene Proteins c-met at the US National Library of Medicine Medical Subject Headings (MeSH) UniProtKB/Swiss-Prot entry ... MET promoter has four putative binding sites for Ets, a family of transcription factors that control several invasive growth ... MET proto-oncogene (GeneID: 4233) has a total length of 125,982 bp, and it is located in the 7q31 locus of chromosome 7. MET is ... "Entrez Gene: MET met proto-oncogene (hepatocyte growth factor receptor)". Dean M, Park M, Le Beau MM, Robins TS, Diaz MO, ...
*  Tyrosine-protein kinase BLK
"The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the ... 2004). "Isoforms of the Ets transcription factor NERF/ELF-2 physically interact with AML1 and mediate opposing effects on AML1- ... Oncogene. 10 (3): 477-86. PMID 7845672. "Entrez Gene: BLK B lymphoid tyrosine kinase". Oda H, Kumar S, Howley PM (August 1999 ... microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase". Mol. Cell. Biol. 13 (9): ...
*  Fusion gene
Alternatively, a proto-oncogene is fused to a strong promoter, and thereby the oncogenic function is set to function by an ... For example, by creating a fusion gene of a protein of interest and green fluorescent protein, the protein of interest may be ... In the case of TMPRSS2-ERG, by disrupting androgen receptor (AR) signaling and inhibiting AR expression by oncogenic ETS ... ChiPPI: The Server Protein-Protein Interaction of Chimeric Proteins. ChimerDB 2.0: a knowledgebase for fusion genes updated. ...
*  EP300
"Regulation of transcription of the human presenilin-1 gene by ets transcription factors and the p53 protooncogene". J. Biol. ... Na SY, Choi JE, Kim HJ, Jhun BH, Lee YC, Lee JW (October 1999). "Bcl3, an IkappaB protein, stimulates activating protein-1 ... Oncogene. 22 (1): 151-6. doi:10.1038/sj.onc.1206067. PMID 12527917. Yamamoto N, Yamamoto S, Inagaki F, Kawaichi M, Fukamizu A, ... Ko L, Cardona GR, Chin WW (May 2000). "Thyroid hormone receptor-binding protein, an LXXLL motif-containing protein, functions ...
*  C-jun
... is a proto-oncogene (its protein is Jun) and is the cellular homolog of the viral oncoprotein v-jun. Jun is the first ... "The Ets transcription factors interact with each other and with the c-Fos/c-Jun complex via distinct protein domains in a DNA- ... "Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1 ... Angel P, Hattori K, Smeal T, Karin M (December 1988). "The jun proto-oncogene is positively autoregulated by its product, Jun/ ...
*  TP53
Some oncogenes can also stimulate the transcription of proteins that bind to MDM2 and inhibit its activity. If the TP53 gene is ... "Regulation of transcription of the human presenilin-1 gene by ets transcription factors and the p53 protooncogene". The Journal ... Oncogenes also stimulate p53 activation, mediated by the protein p14ARF. In unstressed cells, p53 levels are kept low through a ... Finlay, C. A.; Hinds, P. W.; Levine, A. J. (1989-06-30). "The p53 proto-oncogene can act as a suppressor of transformation". ...
*  AP-1 transcription factor
Dimerization happens between the products of the c-jun and c-fos protooncogenes, and is required for DNA-binding. Jun proteins ... Wai PY, Mi Z, Gao C, Guo H, Marroquin C, Kuo PC (July 2006). "Ets-1 and runx2 regulate transcription of a metastatic gene, ... Fos was first isolated as the cellular homologue of two viral v-fos oncogenes, both of which induce osteosarcoma in mice and ... April 1999). "Human cytomegalovirus IE1 protein activates AP-1 through a cellular protein kinase(s)". J. Gen. Virol. 80 (4): ...
*  PAX5
"Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas". Nature. 412 (6844): 341-6. doi:10.1038/ ... Paired box protein Pax-5 is a protein that in humans is encoded by the PAX5 gene. The PAX5 gene is a member of the paired box ( ... "The highly conserved beta-hairpin of the paired DNA-binding domain is required for assembly of Pax-Ets ternary complexes". ... The PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to ...
*  Cancer epigenetics
June 2006). "Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in ... HMGA2 protein specifically targets the promoter of ERCC1, thus reducing expression of this DNA repair gene. ERCC1 protein ... Oncogene. 22 (46): 7243-6. doi:10.1038/sj.onc.1206977. PMID 14562054. Bi FF, Li D, Yang Q (2013). "Hypomethylation of ETS ... HGMA proteins are polypeptides of ~100 amino acid residues characterized by a modular sequence organization. These proteins ...
*  Transcription factor
Many transcription factors, especially some that are proto-oncogenes or tumor suppressors, help regulate the cell cycle and as ... Cdx protein family DNA-binding protein Inhibitor of DNA-binding protein Nuclear receptor, a class of ligand activated ... Ets-type 3.5.3 Family: Interferon regulatory factors 3.6 Class: TEA ( transcriptional enhancer factor) domain 3.6.1 Family: TEA ... TAD is domain of the transcription factor that binds other proteins such as transcription coregulators. Proteins containing ...
*  SIN3A
Paired amphipathic helix protein Sin3a is a protein that in humans is encoded by the SIN3A gene. The protein encoded by this ... Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, Herr W, Cleary ML (July 2004). "Leukemia proto-oncoprotein ... Oncogene. 16 (19): 2549-56. doi:10.1038/sj.onc.1202043. PMID 9627120. Ward JO, McConnell MJ, Carlile GW, Pandolfi PP, Licht JD ... ets-related gene)-associated histone methyltransferase interacts with histone deacetylases 1/2 and transcription co-repressors ...