*  CRKL
Lin H, Martelli MP, Bierer BE (January 2001). "The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T ... "The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins". Leukemia. 11 (3): 376-85 ... Crk-like protein is a protein that in humans is encoded by the CRKL gene. v-CRK avian sarcoma virus CT10-homolog-like contains ... Shi CS, Tuscano J, Kehrl JH (February 2000). "Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase ...
*  List of MeSH codes (D08)
... proto-oncogene proteins c-cbl MeSH D08.811.464.938.750.562 --- proto-oncogene proteins c-mdm2 MeSH D08.811.464.938.750.750 --- ... proto-oncogene proteins c-bcr MeSH D08.811.913.696.620.682.700.776 --- proto-oncogene proteins c-pim-1 MeSH D08.811.913.696. ... proto-oncogene proteins c-kit MeSH D08.811.913.696.620.682.725.400.075 --- proto-oncogene proteins c-met MeSH D08.811.913.696. ... proto-oncogene proteins c-fyn MeSH D08.811.913.696.620.682.725.800.590 --- proto-oncogene proteins c-hck MeSH D08.811.913.696. ...
*  PIK3CG
... "p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl". Exp. ... "The SH2-containing adapter protein GRB10 interacts with BCR-ABL". Oncogene. 17 (8): 941-8. doi:10.1038/sj.onc.1202024. PMID ... This gene encodes a protein that belongs to the pi3/pi4-kinase family of proteins. The gene product is an enzyme that ... In addition to its role in promoting assembly of adherens junctions, the protein is thought to play a pivotal role in the ...
*  BCR (gene)
... "p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl". Exp. ... "Regulation of Bcr-Abl-induced SAP kinase activity and transformation by the SHPTP1 protein tyrosine phosphatase". Oncogene. 17 ... The breakpoint cluster region protein (BCR) also known as renal carcinoma antigen NY-REN-26 is a protein that in humans is ... BCR protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) Human BCR genome location and BCR ...
*  Paxillin
... "p210BCR/ABL induces formation of complexes containing focal adhesion proteins and the protooncogene product p120c-Cbl". ... "p130CAS forms a signaling complex with the adapter protein CRKL in hematopoietic cells transformed by the BCR/ABL oncogene". ... The N-terminal region of paxillin is rich in protein-protein interaction sites. The proteins that bind to paxillin are diverse ... "Protein sequence of human PXN (Uniprot ID: P49023)". Cardiac Organellar Protein Atlas Knowledgebase (COPaKB). Retrieved 13 July ...
*  Tyrosine kinase 2
1996). "Interaction of the c-cbl proto-oncogene product with the Tyk-2 protein tyrosine kinase". Biochem. Biophys. Res. Commun ... "The WD motif-containing protein RACK-1 functions as a scaffold protein within the type I IFN receptor-signaling complex". J. ... Non-receptor tyrosine-protein kinase TYK2 is an enzyme that in humans is encoded by the TYK2 gene. Tyk2 was the first member of ... This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by ...
*  List of MeSH codes (D12.776)
... proto-oncogene proteins c-bcr MeSH D12.776.624.664.700.172 - proto-oncogene proteins c-cbl MeSH D12.776.624.664.700.174 - proto ... proto-oncogene proteins c-abl MeSH D12.776.624.664.700.168 - proto-oncogene proteins c-akt MeSH D12.776.624.664.700.169 - proto ... proto-oncogene proteins c-fes MeSH D12.776.624.664.700.179 - proto-oncogene proteins c-fos MeSH D12.776.624.664.700.180 - proto ... proto-oncogene proteins c-hck MeSH D12.776.624.664.700.182 - proto-oncogene proteins c-jun MeSH D12.776.624.664.700.183 - proto ...
*  CBLB (gene)
"Cloning and characterization of cbl-b: a SH3 binding protein with homology to the c-cbl proto-oncogene". Oncogene. 10 (12): ... 1997). "Cbl-b, a member of the Sli-1/c-Cbl protein family, inhibits Vav-mediated c-Jun N-terminal kinase activation". Oncogene ... CBL-B is an E3 ubiquitin-protein ligase that in humans is encoded by the CBLB gene. CBLB is a member of the CBL gene family. ... 2002). "Differential expression and signaling of CBL and CBL-B in BCR/ABL transformed cells". Oncogene. 21 (9): 1423-33. doi: ...
*  CBL (gene)
"The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase". Biochem. Biophys. Res. Commun. 257 ... Cbl (named after Casitas B-lineage Lymphoma) is a mammalian gene encoding the protein CBL which is an E3 ubiquitin-protein ... "The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src ... "The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the ...
*  Tyrosine-protein kinase BLK
"The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the ... Oncogene. 10 (3): 477-86. PMID 7845672. "Entrez Gene: BLK B lymphoid tyrosine kinase". Oda H, Kumar S, Howley PM (August 1999 ... microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase". Mol. Cell. Biol. 13 (9): ... Tyrosine-protein kinase BLK also known as B lymphocyte kinase is an enzyme that in humans is encoded by the BLK gene. The ...
*  HCK
"The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase". Biochemical and Biophysical ... "Membrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular transformation". Oncogene. 21 (11): 1707-16. doi ... Tyrosine-protein kinase HCK is an enzyme that in humans is encoded by the HCK gene. The protein encoded by this gene is a ... Wiskott-Aldrich syndrome protein (WASP), WASP-interacting protein (WIP), and ELMO1". The Journal of Biological Chemistry. 277 ( ...
*  GRB2
"The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the ... RET proto-oncogene, SH2B1, SH3KBP1, SHC1, SOS1, Src, Syk, TNK2, TrkA, VAV1, VAV2, VAV3, and Wiskott-Aldrich syndrome protein. ... "SETA is a multifunctional adapter protein with three SH3 domains that binds Grb2, Cbl, and the novel SB1 proteins". Cellular ... SH3 domain-mediated protein-protein interaction blocking drug". Oncogene. 21 (13): 2037-50. doi:10.1038/sj.onc.1205271. PMID ...
*  NCK1
"Physical association between Src homology 3 elements and the protein product of the c-cbl proto-oncogene". J. Biol. Chem. 269 ( ... "The Nck SH2/SH3 adaptor protein is present in the nucleus and associates with the nuclear protein SAM68". Oncogene. 14 (2): 223 ... "The Nck SH2/SH3 adaptor protein is present in the nucleus and associates with the nuclear protein SAM68". Oncogene. 14 (2): 223 ... "Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth ...
*  VAV1
Proto-oncogene vav is a protein that in humans is encoded by the VAV1 gene. The protein encoded by this proto-oncogene is a ... "Proto-oncoprotein Vav interacts with c-Cbl in activated thymocytes and peripheral T cells". J. Immunol. 159 (1): 70-6. PMID ... Shigematsu H, Iwasaki H, Otsuka T, Ohno Y, Arima F, Niho Y (May 1997). "Role of the vav proto-oncogene product (Vav) in ... Adams JM, Houston H, Allen J, Lints T, Harvey R (1992). "The hematopoietically expressed vav proto-oncogene shares homology ...
*  Adapter molecule crk
... also known as proto-oncogene c-Crk or p38 is a protein that in humans is encoded by the CRK gene. The CRK ... c-Cbl, PI 3-kinase, Crk-II and Grb2". Oncogene. 14 (19): 2331-8. doi:10.1038/sj.onc.1201074. PMID 9178909. Matsuda M, Ota S, ... Crk Info with links in the Cell Migration Gateway Proto-Oncogene Proteins c-crk at the US National Library of Medicine Medical ... Koval AP, Karas M, Zick Y, LeRoith D (1998). "Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth ...
*  FYN
Proto-oncogene tyrosine-protein kinase Fyn (p59-FYN, Slk, Syn, MGC45350, Gene ID 2534) is an enzyme that in humans is encoded ... "Molecular cloning and characterization of a novel cbl-family gene, cbl-c". Gene. 239 (1): 145-54. doi:10.1016/s0378-1119(99) ... By definition as a proto-oncogene, Fyn codes for proteins that help regulate cell growth. Changes in its DNA sequence transform ... SH3 domain-mediated protein-protein interaction blocking drug". Oncogene. 21 (13): 2037-50. doi:10.1038/sj.onc.1205271. PMID ...
*  PIK3R1
Shigematsu H, Iwasaki H, Otsuka T, Ohno Y, Arima F, Niho Y (1997). "Role of the vav proto-oncogene product (Vav) in ... Lavagna-Sévenier C, Marchetto S, Birnbaum D, Rosnet O (1998). "The CBL-related protein CBLB participates in FLT3 and ... "Tyrosine phosphorylation and complex formation of Cbl-b upon T cell receptor stimulation". Oncogene. 18 (5): 1147-56. doi: ... tyrosine kinase receptors and Src homology 3 domain proteins". Oncogene. 10 (8): 1475-83. PMID 7537362. Kapeller R, Toker A, ...
*  PIK3R2
Lin H, Martelli MP, Bierer BE (Jan 2001). "The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T cell ... Pandey A, Lazar DF, Saltiel AR, Dixit VM (Dec 1994). "Activation of the Eck receptor protein tyrosine kinase stimulates ... "Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl". ... "Specific association of the beta isoform of the p85 subunit of phosphatidylinositol-3 kinase with the proto-oncogene c-cbl". ...
*  ABL (gene)
The ABL1 proto-oncogene encodes a cytoplasmic and nuclear protein tyrosine kinase that has been implicated in processes of cell ... Abl gene has been shown to interact with: ABI1, ABI2, ABL2, ATM, BCAR1, BCR, BRCA1, CAT, CBL, CRKL, DOK1, EPHB2, GPX1, GRB10, ... Activity of ABL1 protein is negatively regulated by its SH3 domain, and deletion of the SH3 domain turns ABL1 into an oncogene ... Abelson murine leukemia viral oncogene homolog 1 also known as ABL1 is a protein that, in humans, is encoded by the ABL1 gene ( ...
*  MST1R
2000). "Cross-talk between the proto-oncogenes Met and Ron". Oncogene. 19 (27): 3041-9. doi:10.1038/sj.onc.1203620. PMID ... Penengo L, Rubin C, Yarden Y, Gaudino G (2003). "c-Cbl is a critical modulator of the Ron tyrosine kinase receptor". Oncogene. ... Macrophage-stimulating protein receptor is a protein that in humans is encoded by the MST1R gene. MST1R is also known as RON ( ... 2003). "The Ron proto-oncogene product is a phenotypic marker of renal oncocytoma". Am. J. Surg. Pathol. 27 (6): 779-85. doi: ...
*  C-Met
Proto-Oncogene Proteins c-met at the US National Library of Medicine Medical Subject Headings (MeSH) UniProtKB/Swiss-Prot entry ... "Mutation of the c-Cbl TKB domain binding site on the Met receptor tyrosine kinase converts it into a transforming protein". Mol ... MET proto-oncogene (GeneID: 4233) has a total length of 125,982 bp, and it is located in the 7q31 locus of chromosome 7. MET is ... "Entrez Gene: MET met proto-oncogene (hepatocyte growth factor receptor)". Dean M, Park M, Le Beau MM, Robins TS, Diaz MO, ...
*  PTPN11
These data suggests that Shp2 may be a proto-oncogene. However, it has been reported that PTPN11/Shp2 can act as either tumor ... "Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth ... Tanaka Y, Tanaka N, Saeki Y, Tanaka K, Murakami M, Hirano T, Ishii N, Sugamura K (Aug 2008). "c-Cbl-dependent ... PTPN11 is a protein tyrosine phosphatase (PTP) Shp2. PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. PTPs ...
*  CD117
... c-kit proto-oncogene product) in normal human bone marrow". Blood. 78 (1): 30-7. PMID 1712644. Proto-Oncogene Proteins c-kit at ... CBL)". J. Biol. Chem. 272 (15): 10248-53. doi:10.1074/jbc.272.15.10248. PMID 9092574. Liang X, Wisniewski D, Strife A, Clarkson ... also known as proto-oncogene c-Kit or tyrosine-protein kinase Kit or CD117, is a receptor tyrosine kinase protein that in ... CD117 is a proto-oncogene, meaning that overexpression or mutations of this protein can lead to cancer. Seminomas, a subtype of ...
*  Erythropoietin receptor
Shigematsu H, Iwasaki H, Otsuka T, Ohno Y, Arima F, Niho Y (May 1997). "Role of the vav proto-oncogene product (Vav) in ... Feng GS, Ouyang YB, Hu DP, Shi ZQ, Gentz R, Ni J (May 1996). "Grap is a novel SH3-SH2-SH3 adaptor protein that couples tyrosine ... and Cbl in hematopoietic cells". Biochemical and Biophysical Research Communications. 239 (2): 412-7. doi:10.1006/bbrc. ... The erythropoietin receptor (EpoR) is a protein that in humans is encoded by the EPOR gene. EpoR is a 52kDa peptide with a ...
*  Syk
"Functional and physical interactions of Syk family kinases with the Vav proto-oncogene product". Immunity. 5 (6): 591-604. doi: ... Without Syk, the protein it makes, and genetic disruption in a panel of 55 genes thought also to be controlled by Syk, breast ... Melander F, Andersson T, Dib K (March 2003). "Fgr but not Syk tyrosine kinase is a target for beta 2 integrin-induced c-Cbl- ... Syk has been shown to interact with: Cbl gene CRKL, FCGR2A, FYN, Grb2, Lck, LYN, PTK2, PTPN6, and VAV1. GRCh38: Ensembl release ...
*  Lck
Protein kinase C, ITK, PLC, SHC, RasGAP, Cbl, Vav1, and PI3K. In resting T cells, Lck is constitutively inhibited by Csk ... and the proto oncogene product p56lck important?". Medical Hypotheses. 38 (4): 322-4. doi:10.1016/0306-9877(92)90025-8. PMID ... Lck is a 56-kilodalton protein. The N-terminal tail of Lck is myristoylated and palmitoylated, which tethers the protein to the ... Lck (or lymphocyte-specific protein tyrosine kinase) is a 56 kDa protein that is found inside specialized cells of the immune ...