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*  List of MeSH codes (D12.776)
... proto-oncogene proteins c-abl MeSH D12.776.624.664.700.168 - proto-oncogene proteins c-akt MeSH D12.776.624.664.700.169 - proto ... proto-oncogene proteins c-bcr MeSH D12.776.624.664.700.172 - proto-oncogene proteins c-cbl MeSH D12.776.624.664.700.174 - proto ... proto-oncogene proteins c-fes MeSH D12.776.624.664.700.179 - proto-oncogene proteins c-fos MeSH D12.776.624.664.700.180 - proto ... proto-oncogene proteins c-hck MeSH D12.776.624.664.700.182 - proto-oncogene proteins c-jun MeSH D12.776.624.664.700.183 - proto ...
*  Proto-oncogene tyrosine-protein kinase Src
Src (gene) has been shown to interact with the following signaling pathways: PI3K Akt IKK NFkB Caspase 9 STAT3 p38 MAPK VEGF IL ... Proto-oncogene tyrosine-protein kinase Src, also known as proto-oncogene c-Src or simply c-Src , is a non-receptor tyrosine ... This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this ... Src (pronounced "sarc" as it is short for sarcoma) is a proto-oncogene encoding a tyrosine kinase originally discovered by J. ...
*  Protein kinase B
Proto-Oncogene Proteins c-akt at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular ... Protein kinase B (PKB), also known as Akt, is a serine/threonine-specific protein kinase that plays a key role in multiple ... Franke TF, Kaplan DR, Cantley LC, Toker A (January 1997). "Direct regulation of the Akt proto-oncogene product by ... If Akt is not phosphorylated at this position, Akt does not fold in the right way. The T450-non-phosphorylated misfolded Akt is ...
*  TCL1 MTCP1 protein domain
Laine J, Künstle G, Obata T, Sha M, Noguchi M (2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol Cell. 6 (2): ... They are, T-cell leukemia/lymphoma protein 1A TCL1A encoded by oncogene TCL-1 SWISSPROT and Protein p13 MTCP-1 encoded by MTCP- ... In molecular biology, TCL-1/MTCP-1 is a protein domain found in proteins encoded for by two related protooncogenes, other words ... This protein exists as a homodimer. It interacts with AKT1, AKT2 and AKT3 via the PH protein domain. It interacts with PNPT1; ...
*  Alectinib
... and the RET proto-oncogene. The active metabolite M4 has similar activity against ALK. Inhibition of ALK subsequently blocks ... Plasma protein binding of alectinib and M4 is over 99%. The enzyme mainly responsible for alectinib metabolism is CYP3A4; other ... cell signalling pathways, including STAT3 and the PI3K/AKT/mTOR pathway, and induces death (apoptosis) of tumour cells. When ... Interactions via other CYP enzymes and transporter proteins cannot be excluded but are unlikely to be of clinical significance ...
*  Imatinib
... is specific for the TK domain in abl (the Abelson proto-oncogene), c-kit and PDGF-R (platelet-derived growth factor ... The PI/PI3K/AKT/BCL-2 pathway is also affected. BCL-2 is responsible for keeping the mitochondria stable; this suppresses cell ... Imatinib is highly plasma protein-bound: dialysis is unlikely to be helpful removing imatinib. Imatinib is a 2-phenyl amino ... 23 Feb 2012, 5:00 PST NCI Drug Information Summary for Patients Imatinib bound to proteins in the PDB Pharmacy and pharmacology ...
*  Platelet-derived growth factor
Proto-Oncogene Proteins c-sis at the US National Library of Medicine Medical Subject Headings (MeSH) McKinnon RD, Matsui T, ... Song G, Ouyang G, Bao S (2005). "The activation of Akt/PKB signaling pathway and cell survival". J. Cell. Mol. Med. 9 (1): 59- ... McClintock JT, Chan IJ, Thaker SR, Katial A, Taub FE, Aotaki-Keen AE, Hjelmeland LM (1992). "Detection of c-sis proto-oncogene ... The "c-Sis" oncogene is derived from PDGF. Age related downregulation of the PDGF receptor on islet beta cells has been ...
*  CBL (gene)
"The proto-oncogene p120(Cbl) is a downstream substrate of the Hck protein-tyrosine kinase". Biochem. Biophys. Res. Commun. 257 ... "FGFR2-Cbl interaction in lipid rafts triggers attenuation of PI3K/Akt signaling and osteoblast survival". Bone. 42 (6): 1032-9 ... "The adapter type protein CMS/CD2AP binds to the proto-oncogenic protein c-Cbl through a tyrosine phosphorylation-regulated Src ... "The protein product of the c-cbl protooncogene is the 120-kDa tyrosine-phosphorylated protein in Jurkat cells activated via the ...
*  Beta-catenin
SH3 domain-mediated protein-protein interaction blocking drug". Oncogene. 21 (13): 2037-50. doi:10.1038/sj.onc.1205271. PMID ... Beta-catenin is a proto-oncogene. Mutations of this gene are commonly found in a variety of cancers: in primary hepatocellular ... These changes were coordinate with Akt activation and glycogen synthase kinase 3β inhibition, suggesting once again that the ... DIX domains are unique: the only other proteins known to have a DIX domain are Dishevelled and DIXDC1. (The single Dsh protein ...
*  Geoffrey M. Cooper
More specifically, he focuses on "the roles of proto-oncogene proteins as elements of signal transduction pathways that control ... Regulation of neuronal survival by the Ser/Thr protein kinase Akt. Science 275:661-665. Erhardt, P., Tomaselli, K.J., and ... Identification of COUP-TF as a transcriptional repressor of the c-mos proto-oncogene. J. Biol. Chem. 274:36796-36800. Erhardt, ... Role of translation initiation factor 2B in control of cell survival by the phosphatidylinositol 3-kinase/Akt/glycogen synthase ...
*  AKT2
This gene is a putative oncogene encoding a protein belonging to the AKT subfamily of serine/threonine kinases that contain SH2 ... Laine J, Künstle G, Obata T, Sha M, Noguchi M (August 2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol. Cell. ... The encoded protein is a general protein kinase capable of phosphorylating several known proteins. The gene was shown to be ... Laine J, Künstle G, Obata T, Sha M, Noguchi M (2000). "The protooncogene TCL1 is an Akt kinase coactivator". Mol. Cell. 6 (2): ...
*  FYN
Proto-oncogene tyrosine-protein kinase Fyn (p59-FYN, Slk, Syn, MGC45350, Gene ID 2534) is an enzyme that in humans is encoded ... Yadav, Vipin; Denning, Mitchell F. (2011-05-01). "Fyn is induced by Ras/PI3K/Akt signaling and is required for enhanced ... By definition as a proto-oncogene, Fyn codes for proteins that help regulate cell growth. Changes in its DNA sequence transform ... SH3 domain-mediated protein-protein interaction blocking drug". Oncogene. 21 (13): 2037-50. doi:10.1038/sj.onc.1205271. PMID ...
*  PIK3R1
Shigematsu H, Iwasaki H, Otsuka T, Ohno Y, Arima F, Niho Y (1997). "Role of the vav proto-oncogene product (Vav) in ... tyrosine kinase receptors and Src homology 3 domain proteins". Oncogene. 10 (8): 1475-83. PMID 7537362. Kapeller R, Toker A, ... Hellyer NJ, Kim MS, Koland JG (2001). "Heregulin-dependent activation of phosphoinositide 3-kinase and Akt via the ErbB2/ErbB3 ... Protein Pept. Sci. 5 (1): 1-8. doi:10.2174/1389203043486955. PMID 14965316. Joseph AM, Kumar M, Mitra D (2005). "Nef: " ...
*  Phosphoinositide 3-kinase
Franke TF, Kaplan DR, Cantley LC, Toker A (January 1997). "Direct regulation of the Akt proto-oncogene product by ... Full activation of AKT occurs upon phosphorylation of serine 473 by the TORC2 complex of the mTOR protein kinase. The "PI3-k/ ... Many of these functions relate to the ability of class I PI 3-kinases to activate protein kinase B (PKB, aka Akt) as in the ... The interaction of activated PDK1 and AKT allows AKT to become phosphorylated by PDK1 on threonine 308, leading to partial ...
*  Nerve growth factor
Crowder RJ, Freeman RS (Apr 1998). "Phosphatidylinositol 3-kinase and Akt protein kinase are necessary and sufficient for the ... "Tyrosine phosphorylation and tyrosine kinase activity of the trk proto-oncogene product induced by NGF". Nature. 350 (6314): ... Both Akt and RSK, components of the PI3K-Akt and MAPK pathways respectively, act to phosphorylate the cyclic AMP response ... The active Ras protein phosphorylates several proteins, along with the serine/threonine kinase, Raf. Raf in turn activates the ...
*  C-Met
Proto-Oncogene Proteins c-met at the US National Library of Medicine Medical Subject Headings (MeSH) UniProtKB/Swiss-Prot entry ... PI3K activation also triggers a survival signal due to activation of the AKT pathway. The STAT pathway, together with the ... MET proto-oncogene (GeneID: 4233) has a total length of 125,982 bp, and it is located in the 7q31 locus of chromosome 7. MET is ... "Entrez Gene: MET met proto-oncogene (hepatocyte growth factor receptor)". Dean M, Park M, Le Beau MM, Robins TS, Diaz MO, ...
*  MAP3K8
Aoki M, Hamada F, Sugimoto T, Sumida S, Akiyama T, Toyoshima K (Oct 1993). "The human cot proto-oncogene encodes two protein ... Kane LP, Mollenauer MN, Xu Z, Turck CW, Weiss A (Aug 2002). "Akt-dependent phosphorylation specifically regulates Cot induction ... "Identification and characterization of protein products of the cot oncogene with serine kinase activity". Oncogene. 6 (9): 1515 ... Lin X, Cunningham ET, Mu Y, Geleziunas R, Greene WC (Feb 1999). "The proto-oncogene Cot kinase participates in CD3/CD28 ...
*  PAK1
B-Raf proto-oncogene, casein kinase 2-interacting protein 1, and filamin A. Functions of PAK1 are regulated by its ability to ... Zhou GL, Zhuo Y, King CC, Fryer BH, Bokoch GM, Field J (November 2003). "Akt phosphorylation of serine 21 on Pak1 modulates Nck ... ARG-binding protein 2γ, hepatitis B virus X protein, STE20-related kinase adaptor protein α, RhoI, Klotho, N-acetylglucosaminyl ... These proteins serve as targets for the small GTP binding proteins Cdc42 and Rac and have been implicated in a wide range of ...
*  HER2/neu
Receptor tyrosine-protein kinase erbB-2, also known as CD340 (cluster of differentiation 340), proto-oncogene Neu, Erbb2 ( ... Signaling pathways activated by HER2 include: mitogen-activated protein kinase (MAPK) phosphoinositide 3-kinase (PI3K/Akt) ... which is a proto-oncogene associated with breast, testicular germ cell, gastric, and eosophageal tumours. HER2 proteins have ... ERBB2, a known proto-oncogene, is located at the long arm of human chromosome 17 (17q12). The ErbB family consists of four ...
*  PSMD2
... as well as a number of proto-oncogenes (Raf, Myc, Myb, Rel, Src, Mos, Abl). The UPS is also involved in the regulation of ... To recognize protein as designated substrate, 19S complex has subunits that are capable to recognize proteins with a special ... These effects of siRNA-mediated PSMD2 inhibition were associated with changes in the balance between phosphorylated AKT and p38 ... Accordingly, misfolded proteins and damaged protein need to be continuously removed to recycle amino acids for new synthesis; ...
*  CENTG1
"PIKE-A is a proto-oncogene promoting cell growth, transformation and invasion". Oncogene. 26 (34): 4918-27. doi:10.1038/sj.onc. ... Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 2 is a protein that in humans is encoded by the AGAP2 gene. ... Knobbe CB, Trampe-Kieslich A, Reifenberger G (2005). "Genetic alteration and expression of the phosphoinositol-3-kinase/Akt ... Werden SJ, Barrett JW, Wang G, Stanford MM, McFadden G (2007). "M-T5, the ankyrin repeat, host range protein of myxoma virus, ...
*  ETS2
... "ets-2 is a target for an akt (Protein kinase B)/jun N-terminal kinase signaling pathway in macrophages of motheaten-viable ... "Characterization and localization of the products of the human homologs of the v-ets oncogene". Oncogene. 2 (2): 99-103. PMID ... "Regulation of transcription of the human presenilin-1 gene by ets transcription factors and the p53 protooncogene". The Journal ... Protein C-ets-2 is a protein that in humans is encoded by the ETS2 gene. The protein encoded by this gene belongs to the ETS ...
*  PTPN11
These data suggests that Shp2 may be a proto-oncogene. However, it has been reported that PTPN11/Shp2 can act as either tumor ... Akt PLCG2, PTK2B, Ras SLAMF1, SOCS3, SOS1, STAT3, STAT5A, and STAT5B. CagA is a protein and virulence factor inserted by ... "Induced direct binding of the adapter protein Nck to the GTPase-activating protein-associated protein p62 by epidermal growth ... PTPN11 is a protein tyrosine phosphatase (PTP) Shp2. PTPN11 is a member of the protein tyrosine phosphatase (PTP) family. PTPs ...
*  Myc
The Myc Protein NCBI Human Myc protein Myc cancer gene myc Proto-Oncogene Proteins at the US National Library of Medicine ... Also, Less TOR, AKT, S6K and other changes in energy and metabolic pathways (such as AMPK, more oxygen consumption, more body ... "The proto-oncogene c-myc in hematopoietic development and leukemogenesis". Oncogene. 21 (21): 3414-21. doi:10.1038/sj.onc. ... Myc is a very strong proto-oncogene and it is very often found to be upregulated in many types of cancers. Myc overexpression ...
*  Fibroblast growth factor receptor 1
Phospholipase C/PI3K/AKT, b) Ras subfamily/ERK, c) Protein kinase C, d) IP3-induced raising of cytosolic Ca2+, and e) Ca2+/ ... they are therefore classified as proto-oncogenes. FGFR1 is a member of the fibroblast growth factor receptor (FGFR) family, ... These proteins have continuously active FGFR1-derived tyrosine kinase and thereby continuously stimulated the cell growth and ... FGF-induced activation of FGFR1 also stimulates the activation of sprouty proteins SPRY1, SPRY2, SPRY3, and/or SPRY4 which in ...
*  MECOM
EVI1 is a proto-oncogene conserved across humans, mice, and rats, sharing 91% homology in nucleotide sequence and 94% homology ... MDS1 and EVI1 complex locus protein EVI1 (MECOM) also known as ecotropic virus integration site 1 protein homolog (EVI-1) or ... and taxol-mediated cell death via PI3K/AKT". Oncogene. 25 (25): 3565-75. doi:10.1038/sj.onc.1209403. PMID 16462766. Alliston T ... EVI1 has been described as a proto-oncogene since its first discovery in 1988. Overexpression and aberrant expression of EVI1 ...