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*  CRKL
"The BCR/ABL oncogene alters interaction of the adapter proteins CRKL and CRK with cellular proteins". Leukemia. 11 (3): 376-85 ... Lin H, Martelli MP, Bierer BE (January 2001). "The involvement of the proto-oncogene p120 c-Cbl and ZAP-70 in CD2-mediated T ... Crk-like protein is a protein that in humans is encoded by the CRKL gene. v-CRK avian sarcoma virus CT10-homolog-like contains ... Shi CS, Tuscano J, Kehrl JH (February 2000). "Adaptor proteins CRK and CRKL associate with the serine/threonine protein kinase ...
*  Proto-oncogene tyrosine-protein kinase Src
... , also known as proto-oncogene c-Src or simply c-Src , is a non-receptor tyrosine ... This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this ... Src (pronounced "sarc" as it is short for sarcoma) is a proto-oncogene encoding a tyrosine kinase originally discovered by J. ... This protein phosphorylates specific tyrosine residues in other proteins. An elevated level of activity of c-Src tyrosine ...
*  DEK (gene)
Alexiadis V, Waldmann T, Andersen J, Mann M, Knippers R, Gruss C (2000). "The protein encoded by the proto-oncogene DEK changes ... Kappes F, Burger K, Baack M, Fackelmayer FO, Gruss C (2001). "Subcellular localization of the human proto-oncogene protein DEK ... The human DEK gene encodes the DEK protein. This gene encodes a protein with one SAP domain. The protein binds to cruciform and ... Forero L, Zwirner NW, Fink CW, Fernández-Viña MA, Stastny P (1998). "Juvenile arthritis, HLA-A2 and binding of DEK oncogene- ...
*  Metencephalon
Wnt1 is a proto-oncogene protein (Wingless-type MMTV integration site family, member 1). This gene was originally thought to ... Fgf8 is also known as Fibroblast Growth Factor 8. It is a protein that is widely thought to be the most important organizing ...
*  MYB (gene)
Myb proto-oncogene protein also known as transcriptional activator Myb is a protein that in humans is encoded by the MYB gene. ... Myb proto-oncogene protein is a member of the MYB (myeloblastosis) family of transcription factors. The protein contains three ... Jacobs SM, Gorse KM, Westin EH (1994). "Identification of a second promoter in the human c-myb proto-oncogene". Oncogene. 9 (1 ... MYB protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) Drosophila Myb oncogene-like - The ...
*  WNT1
Proto-oncogene protein Wnt-1 is a protein that in humans is encoded by the WNT1 gene. The WNT gene family consists of ... "Entrez Gene: WNT1 wingless-type MMTV integration site family, member 1". McMahon AP, Moon RT (1990). "int-1--a proto-oncogene ... Thomas KR, Capecchi MR (1990). "Targeted disruption of the murine int-1 proto-oncogene resulting in severe abnormalities in ... It is very conserved in evolution, and the protein encoded by this gene is known to be 98% identical to the mouse Wnt1 protein ...
*  WNT3
Proto-oncogene protein Wnt-3 is a protein that in humans is encoded by the WNT3 gene. The WNT gene family consists of ... It encodes a protein showing 98% amino acid identity to mouse Wnt3 protein, and 84% to human WNT3A protein, another WNT gene ... These proteins have been implicated in oncogenesis and in several developmental processes, including regulation of cell fate ... Smolich BD, McMahon JA, McMahon AP, Papkoff J (1994). "Wnt family proteins are secreted and associated with the cell surface". ...
*  MYCL1
L-myc-1 proto-oncogene protein is a protein that in humans is encoded by the MYCL1 gene. MYCL1 is a bHLH (basic helix-loop- ... Atchley WR, Fitch WM (1995). "Myc and Max: molecular evolution of a family of proto-oncogene products and their dimerization ... "Amplification and overexpression of the L-MYC proto-oncogene in ovarian carcinomas". Am. J. Pathol. 162 (5): 1603-10. doi: ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-1178. doi:10.1038/ ...
*  Adapter molecule crk
... also known as proto-oncogene c-Crk or p38 is a protein that in humans is encoded by the CRK gene. The CRK ... Crk Info with links in the Cell Migration Gateway Proto-Oncogene Proteins c-crk at the US National Library of Medicine Medical ... Koval AP, Karas M, Zick Y, LeRoith D (1998). "Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth ... 1993). "CRK proto-oncogene maps to human chromosome band 17p13". Oncogene. 8 (10): 2853-5. PMID 8378094. Smit L, van der Horst ...
*  IRS4
Koval, A P; Karas M; Zick Y; LeRoith D (Jun 1998). "Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like ... Koval AP, Karas M, Zick Y, LeRoith D (1998). "Interplay of the proto-oncogene proteins CrkL and CrkII in insulin-like growth ... The IRS4 protein is phosphorylated by the insulin receptor tyrosine kinase upon receptor stimulation. IRS4 has been shown to ... Tyrosine-phosphorylated IRS4 protein has been shown to associate with cytoplasmic signalling molecules that contain SH2 domains ...
*  Protein kinase B
Proto-Oncogene Proteins c-akt at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular ... Protein kinase B (PKB), also known as Akt, is a serine/threonine-specific protein kinase that plays a key role in multiple ... Franke TF, Kaplan DR, Cantley LC, Toker A (January 1997). "Direct regulation of the Akt proto-oncogene product by ... Akt1 is also able to induce protein synthesis pathways, and is therefore a key signaling protein in the cellular pathways that ...
*  FGF3
INT-2 proto-oncogene protein also known as FGF-3 is a protein that in humans is encoded by the FGF3 gene. FGF-3 is a member of ... Represa J, León Y, Miner C, Giraldez F (1991). "The int-2 proto-oncogene is responsible for induction of the inner ear". Nature ... The FGF3 gene was identified by its similarity with mouse fgf3/int-2, a proto-oncogene activated in virally induced mammary ... Mansour SL, Goddard JM, Capecchi MR (1993). "Mice homozygous for a targeted disruption of the proto-oncogene int-2 have ...
*  MAS1 oncogene
IUPHAR GPCR Database - MAS1 IUPHAR GPCR Database - MAS1L proto-oncogene proteins c-mas-1 at the US National Library of Medicine ... The MAS1 oncogene is a G protein-coupled receptor which binds the angiotensin-II metabolite Angiotensin (1-7). The MAS1 ... "Isolation and characterization of a new cellular oncogene encoding a protein with multiple potential transmembrane domains". ... is an endogenous ligand for the G protein-coupled receptor Mas". Proc. Natl. Acad. Sci. U.S.A. 100 (14): 8258-63. doi:10.1073/ ...
*  Geoffrey M. Cooper
More specifically, he focuses on "the roles of proto-oncogene proteins as elements of signal transduction pathways that control ... Identification of COUP-TF as a transcriptional repressor of the c-mos proto-oncogene. J. Biol. Chem. 274:36796-36800. Erhardt, ... Regulation of neuronal survival by the Ser/Thr protein kinase Akt. Science 275:661-665. Erhardt, P., Tomaselli, K.J., and ... Direct binding and activation of STAT transcription factors by the herpesvirus saimiri protein Tip. J. Biol. Chem. 275:16925- ...
*  Platelet-derived growth factor
Proto-Oncogene Proteins c-sis at the US National Library of Medicine Medical Subject Headings (MeSH) McKinnon RD, Matsui T, ... McClintock JT, Chan IJ, Thaker SR, Katial A, Taub FE, Aotaki-Keen AE, Hjelmeland LM (1992). "Detection of c-sis proto-oncogene ... The "c-Sis" oncogene is derived from PDGF. Age related downregulation of the PDGF receptor on islet beta cells has been ... It has been shown that the sis oncogene is derived from the PDGF B-chain gene. PDGF-BB is the highest-affinity ligand for the ...
*  Tim Hunt
Nebreda, A.R.; Hunt, T. (1993). "The c-mos proto-oncogene protein kinase turns on and maintains the activity of MAP kinase, but ... Distinguished for his studies of the control of protein synthesis in animal cells and for the discovery of cyclin, a protein ... "The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2". EMBO ... Cyclins are proteins that play a key role in regulating the cell-division cycle. Hunt found that cyclins begin to be ...
*  RET proto-oncogene
GeneReviews/NCBI/NIH/UW entry on Multiple Endocrine Neoplasia Type 2 ret Proto-Oncogene Proteins at the US National Library of ... 1993). "Characterization of the ret proto-oncogene products expressed in mouse L cells". Oncogene. 8 (11): 2925-2929. PMID ... "Characterization of RET proto-oncogene 3' splicing variants and polyadenylation sites: a novel C-terminus for RET". Oncogene. ... RET proto-oncogene has been shown to interact with: DOK1, DOK5, GDNF family receptor alpha 1, GRB10, GRB7, Grb2, SHC1, and ...
*  N-Myc
... proto-oncogene protein also known as N-Myc or basic helix-loop-helix protein 37 (bHLHe37), is a protein that in humans is ... Ramsay G, Stanton L, Schwab M, Bishop JM (1987). "Human proto-oncogene N-myc encodes nuclear proteins that bind DNA". Mol. Cell ... This protein is located in the cell nucleus and must dimerize with another bHLH protein in order to bind DNA. N-Myc is highly ... "Identification and characterization of the protein encoded by the human N-myc oncogene". Science. 232 (4751): 768-72. doi: ...
*  Src family kinase
Molecular and Cellular Biology portal Proto-oncogene_tyrosine-protein_kinase_Src. ... Src family kinases interact with many cellular cytosolic, nuclear and membrane proteins, modifying these proteins by ... Parsons SJ, Parsons JT (October 2004). "Src family kinases, key regulators of signal transduction". Oncogene. 23 (48): 7906-9. ...
*  List of MeSH codes (D12.776)
... proto-oncogene proteins c-abl MeSH D12.776.624.664.700.168 - proto-oncogene proteins c-akt MeSH D12.776.624.664.700.169 - proto ... proto-oncogene proteins c-bcr MeSH D12.776.624.664.700.172 - proto-oncogene proteins c-cbl MeSH D12.776.624.664.700.174 - proto ... proto-oncogene proteins c-fes MeSH D12.776.624.664.700.179 - proto-oncogene proteins c-fos MeSH D12.776.624.664.700.180 - proto ... proto-oncogene proteins c-hck MeSH D12.776.624.664.700.182 - proto-oncogene proteins c-jun MeSH D12.776.624.664.700.183 - proto ...
*  C-Met
Proto-Oncogene Proteins c-met at the US National Library of Medicine Medical Subject Headings (MeSH) UniProtKB/Swiss-Prot entry ... MET proto-oncogene (GeneID: 4233) has a total length of 125,982 bp, and it is located in the 7q31 locus of chromosome 7. MET is ... "Entrez Gene: MET met proto-oncogene (hepatocyte growth factor receptor)". Dean M, Park M, Le Beau MM, Robins TS, Diaz MO, ... The protein possesses tyrosine kinase activity. The primary single chain precursor protein is post-translationally cleaved to ...
*  CD117
... c-kit proto-oncogene product) in normal human bone marrow". Blood. 78 (1): 30-7. PMID 1712644. Proto-Oncogene Proteins c-kit at ... also known as proto-oncogene c-Kit or tyrosine-protein kinase Kit or CD117, is a receptor tyrosine kinase protein that in ... CD117 is a proto-oncogene, meaning that overexpression or mutations of this protein can lead to cancer. Seminomas, a subtype of ... proto-oncogene". Oncogene. 7 (11): 2207-17. PMID 1279499. Spritz RA, Droetto S, Fukushima Y (1992). "Deletion of the KIT and ...
*  List of MeSH codes (D12.776.157)
... oncogene protein p21(ras) MeSH D12.776.157.325.515.500.600 -- proto-oncogene proteins p21(ras) MeSH D12.776.157.325.515.700 -- ... smad1 protein MeSH D12.776.157.057.170.500.200 -- smad2 protein MeSH D12.776.157.057.170.500.300 -- smad3 protein MeSH D12.776. ... smad proteins, inhibitory MeSH D12.776.157.057.170.249.600 -- smad6 protein MeSH D12.776.157.057.170.249.700 -- smad7 protein ... gtp-binding protein alpha subunits, g12-g13 MeSH D12.776.157.325.332.100.200 -- gtp-binding protein alpha subunits, gi-go MeSH ...
*  Met
... gene for c-Met proto-oncogene protein Met, hypermethioninemia Mesenchymal-epithelial transition Exercise parameter "metabolic ...
*  Myc
The Myc Protein NCBI Human Myc protein Myc cancer gene myc Proto-Oncogene Proteins at the US National Library of Medicine ... "The proto-oncogene c-myc in hematopoietic development and leukemogenesis". Oncogene. 21 (21): 3414-21. doi:10.1038/sj.onc. ... Myc is a very strong proto-oncogene and it is very often found to be upregulated in many types of cancers. Myc overexpression ... Enhancers that normally drive expression of immunoglobin genes now lead to overexpression of Myc proto-oncogene in lymphoma ...
*  PSMD7
... as well as a number of proto-oncogenes (Raf, Myc, Myb, Rel, Src, Mos, Abl). The UPS is also involved in the regulation of ... To recognize protein as designated substrate, 19S complex has subunits that are capable to recognize proteins with a special ... Accordingly, misfolded proteins and damaged protein need to be continuously removed to recycle amino acids for new synthesis; ... The 19S regulatory particles can recognize ubiquitin-labeled protein as degradation substrate, unfold the protein to linear, ...
*  List of MeSH codes (D12.776.930)
... oncogene protein v-maf MeSH D12.776.930.127.500.061.750 -- proto-oncogene proteins c-maf MeSH D12.776.930.127.500.500 -- maf ... smad1 protein MeSH D12.776.930.806.500.200 -- smad2 protein MeSH D12.776.930.806.500.300 -- smad3 protein MeSH D12.776.930.806. ... ets-domain protein elk-1 MeSH D12.776.930.635.600.300 -- ets-domain protein elk-4 MeSH D12.776.930.675.500.500 -- retinoid X ... CCAAT-enhancer-binding protein-alpha MeSH D12.776.930.127.124.750 -- CCAAT-enhancer-binding protein-beta MeSH D12.776.930.127. ...