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*  Factor V Leiden
Prothrombin G20210A De Stefano V, Leone G (1995). "Resistance to activated protein C due to mutated factor V as a novel cause ... In both methods, the time it takes for blood to clot is decreased in the presence of the factor V Leiden mutation. This is done ... People who inherit two copies of the mutation (homozygous), one from each parent, may have up to 80 times the usual risk of ... Most laboratories screen 'at risk' patients with either a snake venom (e.g. dilute Russell's viper venom time) based test or an ...
*  Thrombophilia
... prothrombin time, partial thromboplastin time, thrombodynamics test, thrombin time and reptilase time, lupus anticoagulant, ... Two years later, the same group described a common mutation in the prothrombin gene that caused elevation of prothrombin levels ... and hence the investigations are usually not performed at the time when thrombosis is diagnosed but at a later time. In ... untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous ...
*  Discovery and development of direct Xa inhibitors
At the same time, Glu-15 located outside the reactive site of antistasin fits to positively charged residues on the surface of ... Modelling both prothrombin and FXa makes it possible to deduct the difference and identify the amino acids at each binding site ... Factor Xa is an activated serine protease that occupies a key role in the blood coagulation pathway by converting prothrombin ... Direct Xa inhibitors are a class of relatively new oral anticoagulant drugs that inhibit factor Xa in splitting prothrombin ...
*  Thrombin
Prothrombin G20210A is congenital. Prothrombin G20210A is not usually accompanied by other factor mutations (i.e., the most ... Wu H, Zhang Z, Li Y, Zhao R, Li H, Song Y, Qi J, Wang J (October 2010). "Time course of upregulation of inflammatory mediators ... Prothrombin complex concentrate and fresh frozen plasma are prothrombin-rich coagulation factor preparations that can be used ... Activation of prothrombin is crucial in physiological and pathological coagulation. Various rare diseases involving prothrombin ...
*  Disseminated intravascular coagulation
Prolongation of the prothrombin time (PT) and the activated partial thromboplastin time (aPTT) reflect the underlying ... At the same time, thrombocytopenia occurs and this has been attributed to the entrapment and consumption of platelets. Clotting ...
*  Warfarin necrosis
Notably, the prothrombin time (or international normalized ratio, INR) used to test the effect of warfarin is highly dependent ...
*  Mixing study
... studies take advantage of the fact that factor levels that are 50 percent of normal should give a normal Prothrombin time (PT) ... Some inhibitors are time dependent. In other words, it takes time for the antibody to react with and inactivate the added ... Performing a thrombin time on the test plasma can provide useful additional information for the interpretation of mixing tests ... Prednisone will often lower the titer over time. Intravenous immunoglobulin has been reported to also help but it does not seem ...
*  Prothrombin time
The prothrombin ratio (aka international normalized ratio) is the prothrombin time for a patient sample divided by the result ... The prothrombin time (PT)-along with its derived measures of prothrombin ratio (PR) and international normalized ratio (INR)- ... Jackson CM, Esnouf MP (March 2005). "Has the time arrived to replace the quick prothrombin time test for monitoring oral ... Partial thromboplastin time (PTT), or activated partial thromboplastin time (aPTT or APTT) Thrombin time (TT) ...
*  Vitamin K
... status can be assessed by: The prothrombin time (PT) test measures the time required for blood to clot. A blood ... Undercarboxylated prothrombin (PIVKA-II); in a study of 53 newborns, found "PT (prothrombin time) is a less sensitive marker ... "Prothrombin Time". WebMD. Dituri, F.; Buonocore, G.; Pietravalle, A.; Naddeo, F.; Cortesi, M; Pasqualetti, P; Tataranno M. L.; ... At this time[update], 17 human proteins with Gla domains have been discovered, and they play key roles in the regulation of ...
*  Prothrombin complex concentrate
... prolonged prothrombin time). It is also used when such a patient must undergo an emergency operation treatment. Other ... Prothrombin complex concentrate (PCC), also known as factor IX complex, is a medication made up of blood clotting factors II, ... Prothrombin complex concentrate came into medical use in the 1960s. It is on the World Health Organization's List of Essential ... Bruce, D.; Nokes, T. J. (2008). "Prothrombin complex concentrate (Beriplex P/N) in severe bleeding: Experience in a large ...
*  Fenoprofen
Anticoagulants: Coadministration may prolong prothrombin time. Aspirin: Fenoprofen Cl may be increased; coadministration is not ...
*  Zileuton
This can lead to an increase in prothrombin time. Zileuton is an active oral inhibitor of the enzyme 5-lipoxygenase, which ... although significant increase in prothrombin time is not obvious. It is advised that the doses of each medication be monitored ... The recommended dose of ZYFLO is one 600 mg tablet, four times per day. The tablets may be split in half to make them easier to ... Following oral administration zileuton is rapidly absorbed with a mean time to peak blood serum concentration of 1.7 hours and ...
*  Thrombosis prevention
These same herbal supplements taken with warfarin increased prothrombin time. By containing significant content of vitamin K, ... When sitting for long periods of time, such as when traveling for more than four hours: Get up and walk around every 2 to 3 ... Dong quai, garlic, ginger, Ginkgo biloba, bilberry and feverfew can increase bleeding time. ...
*  Malabsorption
Prolonged prothrombin time can be caused by vitamin K deficiency. Serological studies. Specific tests are carried out to ...
*  Paracentesis
The risk of bleeding may be increased if: prothrombin time > 21 seconds international normalized ratio > 1.6 platelet count < ...
*  Theiler's disease
The prothrombin time (PT) and partial thromboplastin time (PTT) is often prolonged. Subclinical horses may only show elevated ... Decreases in the SDH and prothrombin time along with improvement in appetite are the best positive predictive indicators of ...
*  Niacin
Side effects of heart arrhythmias have also been reported.[page needed] Increased prothrombin time and decreased platelet count ... For the first time, niacin was extracted by Casimir Funk, but he thought that it was thiamine and due to the discovered amine ... The time-release form has a lower therapeutic index for lowering serum lipids relative to this form of toxicity. The high doses ... Particularly the time-release variety, at extremely high doses, can cause acute toxic reactions. Extremely high doses of niacin ...
*  Tinzaparin sodium
Tinzaparin does not affect the international normalized ratio (INR), prothrombin time (PT).[citation needed] Anti-factor Xa ...
*  Factor XII deficiency
Specifically prothrombin time (PT) or activated partial thromboplastin time(aPTT) are prolonged. The diagnosis is confirmed by ...
*  Anti-thrombin aptamers
As a result, TBA prolongs the prothrombin time when interacting with prothrombin. TBA entered the phase I clinical trial for ... In addition, the TBA-HD22 avidity can be examined by ecarin clotting time. Ecarin activates prothrombin and accordingly ... shows significant improvement both in the assay of activated partial thromboplastin time, clotting time and thrombin-induced ... As a result, TBA-HD22 construct cannot improve the ecarin clotting time, which further demonstrates the improvement of aptamer ...
*  Fluorouracil
It may also increase the INR and prothrombin times in patients on warfarin. Fluorouracil's efficacy is decreased when used ...
*  Celecoxib
... does not usually affect prothrombin time, partial thromboplastin time or platelet counts; it does not inhibit ... Use the lowest effective dose for the shortest duration of time, consistent with individual patient goals, to reduce risk of GI ... Use the lowest effective dose for the shortest duration of time, consistent with individual patient goals, to reduce risk of ... Celecoxib is approximately 10-20 times more selective for COX-2 inhibition over COX-1. It binds with its polar sulfonamide side ...
*  Fingerstick
CBC Prothrombin time Fingersticks are routine for hardy[citation needed] adults, but are generally performed on children and ... Whole Blood Prothrombin Time". Arch Intern Med. American Medical Association. 149 (11): 2509-11. doi:10.1001/archinte. ...
*  Waldenström's macroglobulinemia
Prothrombin time, activated partial thromboplastin time, thrombin time, and fibrinogen tests should be performed. Platelet ... For a time, WM was considered to be related to multiple myeloma because of the presence of monoclonal gammopathy and ... At times, patients with Waldenström's macroglobulinemia may exhibit more than one M protein. Plasma viscosity must be measured ... Older diagnosis and treatments resulted in published reports of median survival of approximately 5 years from time of diagnosis ...
*  Liver function tests
Prothrombin time (PT) and its derived measures of prothrombin ratio (PR) and international normalized ratio (INR) are measures ... These tests include prothrombin time (PT/INR), aPTT, albumin, bilirubin (direct and indirect), and others. Liver transaminases ... When AST and ALT are greater than three times normal but not greater than 1000 IU/L, the differential can include alcohol ... In the third trimester of pregnancy, ALP is about two to three times higher. Biliary tract disease produces relatively greater ...
*  Pericardial heart valves
... haemorrhage was extremely rarely reported because few patients received prothrombin depressants for long periods of time ( ... For the time being, one has to accept that most of the aspects of the present are accessible only to Prophesy, about the future ... The time-frame of their usage also varies. Surgical techniques and experience in general have evolved over the past 40 years. ... One of the not so rare causes is allowing the cusps of the valve to become dry - to look like parchment - during the time of ...
*  Liver disease
... prothrombin time, partial thromboplastin time. Imaging tests such as transient elastography, ultrasound and magnetic resonance ... By the time accumulating epigenetic and mutational changes eventually cause hepatocellular carcinoma, epigenetic alterations ...