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*  Factor X
It acts by cleaving prothrombin in two places (an arg-thr and then an arg-ile bond), which yields the active thrombin. This ... Factor Xa is the prime component of the prothrombinase complex which converts large amounts of prothrombin-the "thrombin burst ... These agents, so-called vitamin K antagonists (VKA), inhibit the vitamin K-dependent carboxylation of Factors II (prothrombin ... from prothrombin (Factor II). A new model, the cell-based model of anticoagulation appears to explain more fully the steps in ...
*  Scott syndrome
Impaired factor X and prothrombin activation associated with decreased phospholipid exposure in platelets from a patient with a ... where it provides a binding site for plasma protein complexes that are involved in the conversion of prothrombin to thrombin, ...
*  Factor V Leiden
Prothrombin G20210A De Stefano V, Leone G (1995). "Resistance to activated protein C due to mutated factor V as a novel cause ... In the normal person, factor V functions as a cofactor to allow factor Xa to activate prothrombin, resulting in the enzyme ... Andreassi MG, Botto N, Maffei S (2006). "Factor V Leiden, prothrombin G20210A substitution and hormone therapy: indications for ...
*  Thrombophilia
Two years later, the same group described a common mutation in the prothrombin gene that caused elevation of prothrombin levels ... untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous ... The prothrombin mutation occurs at rates of 1-4% in the general population, 5-10% of people with thrombosis, and 15% of people ... The most common ones are factor V Leiden (a mutation in the F5 gene at position 1691) and prothrombin G20210A, a mutation in ...
*  Discovery and development of direct Xa inhibitors
Modelling both prothrombin and FXa makes it possible to deduct the difference and identify the amino acids at each binding site ... Factor Xa is an activated serine protease that occupies a key role in the blood coagulation pathway by converting prothrombin ... Direct Xa inhibitors are a class of relatively new oral anticoagulant drugs that inhibit factor Xa in splitting prothrombin ... which were thought to be necessary as mimics for an arginine residue in prothrombin, the natural substrate of factor Xa. ...
*  Matrix gla protein
This process also occurs with a number of proteins involved in coagulation: prothrombin, factor VII, factor IX and factor X, ...
*  Thrombin
Prothrombin G20210A is congenital. Prothrombin G20210A is not usually accompanied by other factor mutations (i.e., the most ... Prothrombin complex concentrate and fresh frozen plasma are prothrombin-rich coagulation factor preparations that can be used ... Activation of prothrombin is crucial in physiological and pathological coagulation. Various rare diseases involving prothrombin ... The molecular weight of prothrombin is approximately 72,000 Da. The catalytic domain is released from prothrombin fragment 1.2 ...
*  Protein C
Factor Va binds to prothrombin and Factor Xa, increasing the rate at which thrombin is produced by four orders of magnitude ( ... Factor VIII, on the other hand, is a cofactor in production of activated Factor X, which in turn converts prothrombin into ... Mammen EF, Thomas WR, Seegers WH (December 1960). "Activation of purified prothrombin to autoprothrombin I or autoprothrombin ... such as prothrombin, Factor VII, Factor IX and Factor X. Protein C synthesis occurs in the liver and begins with a single-chain ...
*  Warfarin necrosis
Notably, the prothrombin time (or international normalized ratio, INR) used to test the effect of warfarin is highly dependent ...
*  Mixing study
Mixing studies take advantage of the fact that factor levels that are 50 percent of normal should give a normal Prothrombin ... If the patient has a high titer antibody against factor VIII, try porcine factor VIII or prothrombin complex concentrates to ...
*  Prothrombin time
The prothrombin ratio (aka international normalized ratio) is the prothrombin time for a patient sample divided by the result ... The prothrombin time (PT)-along with its derived measures of prothrombin ratio (PR) and international normalized ratio (INR)- ... The INR is the ratio of a patient's prothrombin time to a normal (control) sample, raised to the power of the ISI value for the ... "Test ID: PT Prothrombin Time, Plasma". Della Valle P, Crippa L, Garlando AM, et al. (December 1999). "Interference of lupus ...
*  Prothrombin G20210A
Individuals who carry the condition have the prothrombin mutation which can be inherited by offspring. Having the prothrombin ... untranslated region of the prothrombin gene is associated with elevated plasma prothrombin levels and an increase in venous ... Because prothrombin is also known as factor II, the mutation is also sometimes referred to as the factor II mutation or simply ... Prothrombin G20210A (a.k.a. rs1799963) refers to condition in which a specific gene mutation increases the risk of blood clots ...
*  Prothrombin activator
... is a complex of a dozen blood coagulation factors that functions in catalyzing prothrombin into thrombin ... Prothrombin activator is released in the body by a cascade of chemical reactions in response to damage in a blood vessel. ...
*  Prothrombin complex concentrate
... (PCC), also known as factor IX complex, is a medication made up of blood clotting factors II, ... Prothrombin complex concentrate came into medical use in the 1960s. It is on the World Health Organization's List of Essential ... Bruce, D.; Nokes, T. J. (2008). "Prothrombin complex concentrate (Beriplex P/N) in severe bleeding: Experience in a large ... prolonged prothrombin time). It is also used when such a patient must undergo an emergency operation treatment. Other ...
*  Vitamin K
Undercarboxylated prothrombin (PIVKA-II); in a study of 53 newborns, found "PT (prothrombin time) is a less sensitive marker ... "Prothrombin Time". WebMD. Dituri, F.; Buonocore, G.; Pietravalle, A.; Naddeo, F.; Cortesi, M; Pasqualetti, P; Tataranno M. L.; ... Vitamin K status can be assessed by: The prothrombin time (PT) test measures the time required for blood to clot. A blood ... This test is insensitive to mild deficiency, as the values do not change until the concentration of prothrombin in the blood ...
*  Antithrombin
Seegers WH, Johnson JF, Fell C (1954). "An antithrombin reaction to prothrombin activation". Am. J. Physiol. 176 (1): 97-103. ...
*  Fenoprofen
Anticoagulants: Coadministration may prolong prothrombin time. Aspirin: Fenoprofen Cl may be increased; coadministration is not ...
*  Hypoprothrombinemia
... essentially decreasing prothrombin production. This is associated with bleeding from birth. Here, plasma levels of prothrombin ... Prothrombin is a glycoprotein that occurs in blood plasma and functions as a precursor to the enzyme, thrombin, which acts to ... Prothrombin Blood Test: Determines if patient has deficient or low levels of Factor II. Vitamin K1 Test: Performed to evaluate ... Prothrombin is a critical protein that is involved in the process of hemostasis, as well as illustrating procoagulant ...
*  Anti-thrombin aptamers
As a result, TBA prolongs the prothrombin time when interacting with prothrombin. TBA entered the phase I clinical trial for ... Ecarin activates prothrombin and accordingly produces meizothrombin. The exosite II is not accessible in meizothrombin, so thus ... Furthermore, TBA recognizes and inhibits prothrombin with similar affinity against alpha-thrombin. ... binds exosite 1 on prothrombin with high affinity and inhibits its activation by prothrombinase. The Journal of Biological ...
*  Johan Stenflo
In 1975, he published a classic paper on the biosynthesis of prothrombin. Kresge N, Simoni RD, Hill RL (May 2009). "The Finding ... Fernlund P, Stenflo J, Roepstorff P, Thomsen J (August 1975). "Vitamin K and the biosynthesis of prothrombin. V. Gamma- ... carboxyglutamic acids, the vitamin K-dependent structures in prothrombin". J. Biol. Chem. 250 (15): 6125-33. PMID 50323. ... That Prothrombin Contains γ-Carboxyglutamic Acid: the Work of Johan Stenflo". Journal of Biological Chemistry. 284 (18): e1. " ...
*  Coagulase
... reacts with prothrombin in the blood. The resulting complex is called staphylothrombin, which enables the enzyme ...
*  Zileuton
This can lead to an increase in prothrombin time. Zileuton is an active oral inhibitor of the enzyme 5-lipoxygenase, which ... although significant increase in prothrombin time is not obvious. It is advised that the doses of each medication be monitored ...
*  Thrombosis prevention
These same herbal supplements taken with warfarin increased prothrombin time. By containing significant content of vitamin K, ...
*  Warfarin
It is recommended that the effects of warfarin typically be monitored by checking prothrombin time (INR) every one to four ... Chai-Adisaksopha, C; Hillis, C; Siegal, DM; Movilla, R; Heddle, N; Iorio, A; Crowther, M (4 August 2016). "Prothrombin complex ... The effects of warfarin may be reversed with phytonadione (vitamin K1), fresh frozen plasma, or prothrombin complex concentrate ... prothrombin complex concentrate (PCC), or fresh frozen plasma (FFP) in addition to intravenous vitamin K. Blood products should ...
*  Malabsorption
Prolonged prothrombin time can be caused by vitamin K deficiency. Serological studies. Specific tests are carried out to ...