... p38 mitogen-activated protein kinases, cytosolic Phospholipase A2, PI3K/Akt, protein kinase C beta (PKCβ), and/or (PKCε). Most ... alpha subunit-linked G protein-coupled receptor based on the ability of 5-oxo-ETE to activate this class of membrane G proteins ... and hematopoietic cytokines cooperate in stimulating neutrophil function and the mitogen-activated protein kinase pathway". The ... and found it coupled with and activated the G protein complex composed of the Gi alpha subunit (Gαi) and G beta-gamma complex ( ...
"Scaffold proteins may biphasically affect the levels of mitogen-activated protein kinase signaling and reduce its threshold ... WormBase provides: a genome browser, genome, gene and protein sets for searches on sequence similarities and gene and protein ... They also discovered that let-23 kinase function in at least 5 different tissues. "The lin-15 locus encodes two negative ... "Multiple functions of let-23, a caenorhabditis elegans receptor tyrosine kinase gene required for vulval induction"(1991) Let- ...
"Tumor necrosis factor-induced activation and increased tyrosine phosphorylation of mitogen-activated protein (MAP) kinase in ... led to the discovery of novel genes and proteins, and helped to identify signaling pathways. Over the span of his career, ... At the time, interferon was still a poorly defined protein studied by only a handful of scientists across the world. In 1964, ... Lee, T.H.; Wisniewski, H.-G.; Vilcek, J. (1992). "A novel secretory tumor necrosis factor-inducible protein (TSG-6) is a member ...
... mitogen-activated protein kinase pathway". J. Biol. Chem. 271 (19): 11272-9. doi:10.1074/jbc.271.19.11272. PMID 8626678. " ... All the intracellular functions occur via the interaction with Gαi and Gαo: these two proteins recruit other proteins for ... The main functions of S1P-S1PR1 system are as follows: The phosphatidylinositol 3-kinase (PI3K) and the lipid dependent protein ... is a protein that in humans is encoded by the S1PR1 gene. S1PR1 is a G-protein-coupled receptor which binds the bioactive ...
"Cell type-specific inhibition of the ETS transcription factor ER81 by mitogen-activated protein kinase-activated protein kinase ... "Specificities of protein-protein and protein-DNA interaction of GABP alpha and two newly defined ets-related proteins". Genes ... and stress-activated protein kinase 1 (MSK1)". Oncogene. 22 (5): 746-55. doi:10.1038/sj.onc.1206185. PMID 12569367. S2CID ... "Regulation of the ETS transcription factor ER81 by the 90-kDa ribosomal S6 kinase 1 and protein kinase A". The Journal of ...
"Entrez Gene: MAPKAP1 mitogen-activated protein kinase associated protein 1". Colicelli J, Nicolette C, Birchmeier C, et al. ( ... "The human stress-activated protein kinase-interacting 1 gene encodes JNK-binding proteins". Cell. Signal. 17 (6): 761-7. doi: ... This gene encodes a protein that is highly similar to the yeast SIN1 protein, a stress-activated protein kinase. Alternatively ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ...
"Phosphorylation of PHAS-I by mitogen-activated protein (MAP) kinase. Identification of a site phosphorylated by MAP kinase in ... This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic ... a novel protein kinase regulated by the p38 MAP kinase". EMBO J. 17 (12): 3372-3384. doi:10.1093/emboj/17.12.3372. PMC 1170675 ... "Phosphorylation of the cap-binding protein eukaryotic translation initiation factor 4E by protein kinase Mnk1 in vivo". Mol. ...
... human myosatellite cell proliferation in vitro is mediated through the phosphorylation of the mitogen-activated protein kinases ... HMB produces these effects in part by stimulating the production of proteins and inhibiting the breakdown of proteins in muscle ... the p70S6 kinase and the translation repressor protein 4EBP1). Supplementation with HMB in several non-human animal species has ... a serine/threonine-specific protein kinase. The free acid (HMB-FA) and monohydrated calcium salt (HMB-Ca) forms of HMB have ...
Navas TA, Baldwin DT, Stewart TA (November 1999). "RIP2 is a Raf1-activated mitogen-activated protein kinase kinase". The ... Many of these stimuli activate the c-Jun N-terminal kinases (JNKs) leading to the phosphorylation of Jun proteins and enhanced ... of mitogen-activated protein kinase and NF-kappaB pathways by a Kaposi's sarcoma-associated herpesvirus K15 membrane protein". ... "Human cytomegalovirus IE1 protein activates AP-1 through a cellular protein kinase(s)". The Journal of General Virology. 80 ( ...
... synaptic NMDA excitation caused a decrease in the intracellular concentration of p38 mitogen-activated protein kinase (p38MAPK ... The receptor is a highly complex and dynamic heteromeric protein that interacts with a multitude of intracellular proteins via ... which contain residues that can be directly modified by a series of protein kinases and protein phosphatases, as well as ... Calcium/calmodulin-dependent protein kinases Laube B, Hirai H, Sturgess M, Betz H, Kuhse J (March 1997). "Molecular ...
"Irisin stimulates browning of white adipocytes through mitogen-activated protein kinase p38 MAP kinase and ERK MAP kinase ... It appears that these proteins are connected and related to each other in terms of cardiovascular/metabolic diseases, such as ... Fibronectin domain-containing protein 5 is a membrane protein comprising a short cytoplasmic domain, a transmembrane segment, ... potentially generating a protein that begins at methionine-76 (Met-76). A protein initiated at Met-76 would be missing the ...
... which then activates the downstream kinases, Jun-N-terminal kinase (JNK) and p38 mitogen-activated protein kinase (p38 MAPK), ... proteins in the ER activates the integrated stress response through protein kinase RNA-like endoplasmic reticulum kinase (PERK ... Those processes are mainly regulated by three factors: protein kinase RNA-like endoplasmic reticulum kinase (PERK), activating ... double-stranded RNA-activated protein kinase (PKR) iron deficiency through heme-regulated inhibitor kinase (HRI) stress from ...
1997). "Cripto enhances the tyrosine phosphorylation of Shc and activates mitogen-activated protein kinase (MAPK) in mammary ... 2001). "The orphan receptor ALK7 and the Activin receptor ALK4 mediate signaling by Nodal proteins during vertebrate ... The protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and ... 1999). "Cripto-1 induces phosphatidylinositol 3'-kinase-dependent phosphorylation of AKT and glycogen synthase kinase 3beta in ...
... mitogen-activated protein kinase) proteins ERK, JNK, and p38 with specificity distinct from that of individual MKP proteins. ... a novel cytosolic protein-tyrosine phosphatase that exemplifies a new class of mitogen-activated protein kinase phosphatase". J ... 2004). "Identification of protein tyrosine phosphatases with specificity for the ligand-activated growth hormone receptor". Mol ... Dual specificity protein phosphatase 7 is an enzyme that in humans is encoded by the DUSP7 gene. Dual-specificity phosphatases ...
The anti-inflammatory effects of CO are attributed to activation of the p38 mitogen-activated protein kinase (MAPK) pathway. ... CO may have an inhibitory effect on numerous proteins including cytochrome P450 and cytochrome c oxidase. CO has approximately ... HMOX is a heme-containing member of the heat shock protein (HSP) family identified as HSP32. Three isoforms of HMOX have been ... While CO commonly interacts with the ferrous iron atom of heme in a hemoprotein, it has been demonstrated that CO activates ...
1999). "KSR-1 binds to G-protein betagamma subunits and inhibits beta gamma-induced mitogen-activated protein kinase activation ... 2003). "Activation of heterotrimeric G proteins by a high energy phosphate transfer via nucleoside diphosphate kinase (NDPK) B ... Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-3 is a protein that in humans is encoded by the GNG3 gene. G ... "Entrez Gene: GNG3 guanine nucleotide binding protein (G protein), gamma 3". Wedegaertner PB, Wilson PT, Bourne HR (1995). " ...
"T cell activation through the CD43 molecule leads to Vav tyrosine phosphorylation and mitogen-activated protein kinase pathway ... Yonemura S, Hirao M, Doi Y, Takahashi N, Kondo T, Tsukita S, Tsukita S (February 1998). "Ezrin/radixin/moesin (ERM) proteins ... Leukosialin also known as sialophorin or CD43 (cluster of differentiation 43) is a transmembrane cell surface protein that in ... 1998). "Ezrin/radixin/moesin (ERM) proteins bind to a positively charged amino acid cluster in the juxta-membrane cytoplasmic ...
"The JIP group of mitogen-activated protein kinase scaffold proteins". Mol. Cell. Biol. 19 (10): 7245-54. doi:10.1128/mcb.19.10. ... Mitogen-activated protein kinase kinase kinase 11 is an enzyme that in humans is encoded by the MAP3K11 gene. The protein ... "Direct Activation of Mitogen-Activated Protein Kinase Kinase Kinase MEKK1 by the Ste20p Homologue GCK and the Adapter Protein ... "Entrez Gene: MAP3K11 mitogen-activated protein kinase kinase kinase 11". Barthwal MK, Sathyanarayana P, Kundu CN, Rana B, ...
CB1 receptors are coupled through Gi/o proteins and inhibit adenylyl cyclase and activate mitogen-activated protein (MAP) ... kinase. In addition, CB1 receptors inhibit presynaptic N- and P/Q-type calcium channels and activate inwardly rectifying ... Both receptors are 7-transmembrane G-protein coupled receptors (GPCRs) which inhibit the accumulation of cyclic adenosine ...
"The JIP group of mitogen-activated protein kinase scaffold proteins". Mol. Cell. Biol. 19 (10): 7245-54. doi:10.1128/mcb.19.10. ... Mitogen-activated protein kinase kinase kinase 10 is an enzyme that in humans is encoded by the MAP3K10 gene. The protein ... "Entrez Gene: MAP3K10 mitogen-activated protein kinase kinase kinase 10". Nagata Ki, Puls A, Futter C, Aspenstrom P, Schaefer E ... directly phosphorylates and activates SEK1, an activator of c-Jun N-terminal kinase/stress-activated protein kinase". J. Biol. ...
... and Mitogen-activated Protein Kinase Can Regulate Epithelial Cell Proliferation". Mol. Biol. Cell. 10 (2): 259-70. doi:10.1091/ ... "HIV-protein-mediated alterations in T cell interactions with the extracellular matrix proteins and endothelium". Arch. Immunol ... The protein encoded by this gene is the alpha-3 chain of laminin 5, which is a complex glycoprotein composed of three subunits ... Laminin subunit alpha-3 is a protein that in humans is encoded by the LAMA3 gene. Laminins are basement membrane components ...
The RAS pathway can couple with the mitogen-activated protein kinase pathway or a number of other possible effectors. The PI3K/ ... Activation of the receptor tyrosine kinases generates a signaling cascade where the Ras GTPase proteins are activated to a GTP- ... that activates the further process of transphosphorylation of the specific tyrosine kinases in the kinase domain of ErbB's ... The ErbB family of proteins contains four receptor tyrosine kinases, structurally related to the epidermal growth factor ...
Van Golen KL, Bao LW, Pan Q, Miller FR, Wu ZF, Merajver SD (2002). "Mitogen Activated Protein Kinase Pathway Is Involved in ... Rho proteins promote reorganization of the actin cytoskeleton and regulate cell shape and motility. RhoC can activate formins ... 2002). "Mitogen activated protein kinase pathway is involved in RhoC GTPase induced motility, invasion and angiogenesis in ... 1999). "Signaling from Rho to the actin cytoskeleton through protein kinases ROCK and LIM-kinase". Science. 285 (5429): 895-8. ...
... is an orally available inhibitor of mitogen-activated protein kinase kinase (MEK), or more specifically, a MAP2K ... Inhibition of MEK1/2 prevents the activation of MEK1/2 dependent effector proteins and transcription factors, which may result ... MEK1/2 are dual-specificity threonine/tyrosine kinases that play key roles in the activation of the RAS/RAF/MEK/ERK pathway and ... Binimetinib, uncompetitive with ATP, binds to and inhibits the activity of MEK1/2 kinase, which has been shown to regulate ...
Mitogen-activated protein kinase kinase kinase 15 is a protein that in humans is encoded by the MAP3K15 gene. The protein ... Human proteins, Genetics, Genes). ... "Entrez Gene: Mitogen-activated protein kinase kinase kinase 15 ... where an activated MAPK kinase kinase (MAP3K) phosphorylates and activates a specific MAPK kinase (MAP2K), which then activates ... encoded by this gene is a member of the mitogen-activated protein kinase (MAPK) family. These family members function in a ...
2005). "Phosphorylation of Ser28 in histone H3 mediated by mixed lineage kinase-like mitogen-activated protein triple kinase ... 2001). "Methylation of histone H3 lysine 9 creates a binding site for HP1 proteins". Nature. 410 (6824): 116-20. Bibcode: ... Dai J, Sultan S, Taylor SS, Higgins JM (2005). "The kinase haspin is required for mitotic histone H3 Thr 3 phosphorylation and ... "Novel mitosis-specific phosphorylation of histone H3 at Thr11 mediated by Dlk/ZIP kinase". Nucleic Acids Res. 31 (3): 878-85. ...
"Gi-mediated activation of the p21ras-mitogen-activated protein kinase pathway by alpha 2-adrenergic receptors expressed in ... Prezeau L, Richman JG, Edwards SW, Limbird LE (May 1999). "The zeta isoform of 14-3-3 proteins interacts with the third ... "Analysis of the relative interactions between the alpha 2C10 adrenoceptor and the guanine-nucleotide-binding proteins G(o)1 ... "Four consecutive serines in the third intracellular loop are the sites for beta-adrenergic receptor kinase-mediated ...
Interaction between CD86 and CD28 activates mitogen-activated protein kinase and transcription factor nf-κB in the T-cell. ... These proteins up-regulate production of CD40L (used in B-cell activation), IL-21 and IL-21R (used for division/proliferation ... At the protein level, CD86 shares 25% identity with CD80 and both are coded on human chromosome 3q13.33q21. CD86 and CD80 bind ... This protein interaction is also essential for T lymphocytes to receive the full activation signal, which in turn leads to T ...
"Human mitogen-activated protein kinase kinase kinase mediates the stress-induced activation of mitogen-activated protein kinase ... Takekawa M, Saito H (1998). "A family of stress-inducible GADD45-like proteins mediate activation of the stress-responsive MTK1 ... Mitogen-activated protein kinase kinase kinase 4 is an enzyme that in humans is encoded by the MAP3K4 gene. The central core of ... each mitogen-activated protein kinase (MAPK) pathway is a conserved cascade of 3 protein kinases: an activated MAPK kinase ...
"Stimulation of the mitogen-activated protein kinase cascade and tyrosine phosphorylation of the epidermal growth factor ... This protein interacts with Mia40 during the import of intermembrane space proteins including the small Tim proteins Cox17 and ... The structure of the protein is a homodimer which has been found to be fairly similar to the scERV1 protein of yeast. The gene ... the second encodes the bulk of the protein; and the third the remainder. Proteins of the ERV1/ALR family are encoded by all ...