IQ calmodulin-binding motif-containing protein 1 is a protein that in humans is encoded by the IQCB1 gene. GRCh38: Ensembl ... 2002). "The gene mutated in juvenile nephronophthisis type 4 encodes a novel protein that interacts with nephrocystin". Nat. ... Proteins. 59 (2): 347-55. doi:10.1002/prot.20344. PMID 15723349. Luo X, He Q, Huang Y, Sheikh MS (2006). "Cloning and ... a ciliary IQ domain protein, is mutated in Senior-Loken syndrome and interacts with RPGR and calmodulin". Nat Genet. 37 (3): ...
A version of the plot (CPint) has also been built and made available to probe similar errors in protein-protein interfaces. ... is an advanced graphical tool in structural validation of atomic models for both folded globular proteins and protein-protein ... can potentially signal unbalanced partial charges within protein interiors. It is useful in homology modeling and protein ... The Complementarity Plot for Protein-Protein Interface. J Bioinforma Intell Control 3:309-314 . doi: 10.1166/jbic.2014.1103 ...
... which run weekly against newly solved protein structures deposited in the Protein Data Bank, CAFASP generates much less data, ... CAFASP, or the Critical Assessment of Fully Automated Structure Prediction, is a large-scale blind experiment in protein ... Proteins. Suppl 3: 209-217. doi:10.1002/(SICI)1097-0134(1999)37:3+. 3.0.CO;2-Y. PMID 10526371. Bourne, P. E. (2003). "CASP and ... and ab initio prediction of protein tertiary structures based only on amino acid sequence. The experiment runs once every two ...
Proteins. 72: 1084-1088. doi:10.1002/prot.22098. PMID 18491386. 7-cyano-7-deazaguanine synthase at the US National Library of ...
Methods not available anymore: Ferron F, Longhi S, Canard B, Karlin D (October 2006). "A practical overview of protein disorder ... Kozlowski, L. P.; Bujnicki, J. M. (2012). "MetaDisorder: A meta-server for the prediction of intrinsic disorder in proteins". ... Computational methods exploit the sequence signatures of disorder to predict whether a protein is disordered, given its amino ... Peng Z, Mizianty MJ, Kurgan L (Jan 2014). "Genome-scale prediction of proteins with long intrinsically disordered regions". ...
"Prediction of EF-hand calcium-binding proteins and analysis of bacterial EF-hand proteins". Proteins. 65 (3): 643-55. doi: ... Notably, the protein contains three EF hand motifs that function as binding sites for Ca2+ ions. The protein is a member of the ... In the animals, the protein occurs together with the Green fluorescent protein to produce green light by resonant energy ... Since then, the protein has been widely used as reported in many model biological systems, including zebrafish, rats, mice, and ...
One of these small proteins, Ptu1, blocks reversibly the N-type calcium channels, but at the same time is less specific for the ... Insect toxins are various protein toxins produced by insect species. Assassin bugs, sometimes known as kissing bugs, are one of ... Proteins. 54 (2): 195-205. doi:10.1002/prot.10513. PMID 14696181. Nakajima T, Corzo G, Nagao T, Kusui Y, Adachi-Akahane S (2001 ...
The rest of the genome encodes structural proteins at the 5' end and non-structural proteins at the 3' end in a single ... The 1A, 1B, 1C, and 1D proteins are the capsid proteins VP4, VP2, VP3, and VP1, respectively.Virus-coded proteases perform the ... VPg may also play an important role in specific recognition of viral genome by movement protein (MP). Movement proteins are non ... Precursor proteins also have an effect on VPg-CRE specificity and stability. The upper RNA stem loop, to which VPg binds, has a ...
Doig, AJ; MacArthur MW (1997). "Structures of N-termini of helices in proteins". Protein Science. 6 (1): 147-155. doi:10.1002/ ... Leader, DP; Milner-White EJ (2009). "Motivated Proteins: A web application for studying small three-dimensional protein motifs ... Two websites are available for finding and examining ST motifs in proteins, Motivated Proteins: [1] and PDBeMotif [2]. When one ... The ST motif is a commonly occurring feature in proteins and polypeptides. It consists of four or five amino acid residues with ...
C-type lectin domain family 7 member A or Dectin-1 is a protein that in humans is encoded by the CLEC7A gene. CLEC7A is a ... Dectin-1 is a transmembrane protein containing an immunoreceptor tyrosine-based activation (ITAM)-like motif in its ... Proteins. 53 (1): 44-55. doi:10.1002/prot.10440. PMID 12945048. Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen ... Protein Sci. 16 (6): 1042-52. doi:10.1110/ps.072791207. PMC 2206667 . PMID 17473009. Taylor PR, Brown GD, Reid DM, Willment JA ...
Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and ... Protein phosphatase 2A (PP2A) is a major intracellular protein phosphatase that regulates multiple aspects of cell growth and ... 2009). "The structure of the PP2A regulatory subunit B56 gamma: the remaining piece of the PP2A jigsaw puzzle". Proteins. 74 (1 ... 2010). "Nuclear export and centrosome targeting of the protein phosphatase 2A subunit B56alpha: role of B56alpha in nuclear ...
Currently, there are 21 proteins that are predicted to interact with uncharacterized protein C14orf80. These 21 proteins were ... Uncharacterized protein C14orf80 is a protein which in humans is encoded by the chromosome 14 open reading frame 80, C14orf80, ... Uncharacterized protein C14orf80 is not predicted to be a transmembrane protein. It is mainly localized to the golgi apparatus ... 2015). STRING v10: protein-protein interaction networks, integrated over the tree of life. Nuc. Acids Res. 43, D447-D452. ...
Proteins. 38 (4): 441-9. doi:10.1002/(SICI)1097-0134(20000301)38:4. 3.0.CO;2-L. PMID 10707030. Rogowski RS, Collins JH, O'Neill ...
Osteoglycin (also called mimecan), encoded by the OGN gene, is a human protein. This gene encodes a protein which induces ... 2001). "Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs ... This protein is a small proteoglycan which contains tandem leucine-rich repeats (LRR). The gene expresses three transcript ... Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci ...
Proteins. 53 (1): 44-55. doi:10.1002/prot.10440. PMID 12945048. Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, ...
Proteins. 72 (3): 1089-95. doi:10.1002/prot.22101. PMID 18491387. O'Connor RJ, Halvorson H (March 1961). "The substrate ... Proteins. 72 (3): 1089-95. doi:10.1002/prot.22101. PMID 18491387. Molecular and Cellular Biology portal. ...
For instance, two protein sequences may be relatively similar however, may differ at certain intervals as one protein may have ... the result is an extension of the protein sequence that may also have implications on protein function. The use of alignment in ... When comparing proteins, one uses a similarity matrix which assigns a score to each possible residue. The score should be ... In alignments gaps are represented as contiguous dashes on a protein/DNA sequence alignment. The scoring that occurs in Gap ...
Class II proteins contain four conserved disulphide bridges and two conserved calcium-binding sites. Class III consists of the ... Class III proteins are also monomeric glycoproteins, containing four conserved disulphide bridges and two calcium ions, ... The crystal structures of a number of these proteins show that they share the same architecture - two all-alpha domains between ... Proteins. 69 (2): 223-33. doi:10.1002/prot.21550. PMID 17654545. This article incorporates text from the public domain Pfam and ...
The protein encoded by this gene is a member of the PTP family and PTPN14 subfamily of tyrosine protein phosphatases. PTPs are ... "Entrez Gene: PTPN14 protein tyrosine phosphatase, non-receptor type 14". Wadham C, Gamble JR, Vadas MA, Khew-Goodall Y (Jun ... Tyrosine-protein phosphatase non-receptor type 14 is an enzyme that in humans is encoded by the PTPN14 gene. ... Wadham C, Gamble JR, Vadas MA, Khew-Goodall Y (Jun 2003). "The protein tyrosine phosphatase Pez is a major phosphatase of ...
... ɑ-helices in proteins: Results from Analysis of Protein Structures". Proteins: Structure, Function, and Bioinformatics. 59 (4 ... Proteins perform extremely specific functions which are dependent on their structure. Proteins that do not fold correctly are ... Proteins. 54 (3): 513-25. doi:10.1002/prot.10595. PMID 14747999. Stefani, Massimo (August 6, 2004). "Protein misfolding and ... implications for protein folding". Protein Science. 6 (10): 2134-42. doi:10.1002/pro.5560061008. PMC 2143565 . PMID 9336836. ...
It aims to achieve an optimized conformation for both the protein and ligand and relative orientation between protein and ... docking Molecular mechanics Protein structure Protein design Software for molecular mechanics modeling List of protein-ligand ... orientation of a ligand that binds to a particular protein of interest. However, since both the ligand and the protein are ... and are usually scalable to even protein-protein interactions. They are also much more amenable to pharmacophore based ...
The proteins three-dimensional structure has been reconstructed using nuclear magnetic resonance techniques. Lq2 interacts with ... March 1999). "Solution structure of potassium channel-inhibiting scorpion toxin Lq2". Proteins. 34 (4): 417-26. doi:10.1002/( ...
A potentially much larger percentage of proteins could be made druggable if protein-protein interactions could be disrupted by ... A protein is predicted to be "druggable" if it is a member of a protein family for which other members of the family are known ... This is an increasingly popular approach in addressing the druggability of protein-protein interactions. As well as using 3D ... Morelli X, Bourgeas R, Roche P (August 2011). "Chemical and structural lessons from recent successes in protein-protein ...
Richardson, J.S. (1981). "Anatomy and Taxonomy of Protein Structures". Advances in Protein Chemistry. Advances in Protein ... Richardson, J.S. (1981). "Anatomy and Taxonomy of Protein Structures". Advances in Protein Chemistry. Advances in Protein ... Ramachandran, G.N.; Sasiskharan, V. (1968). "Conformation of polypeptides and proteins". Advances in Protein Chemistry. ... For the first two protein side-chain dihedral angles a similar plot is the Janin Plot. Ramachandran plot for the general case; ...
2002). "Shotgun identification of protein modifications from protein complexes and lens tissue". Proc. Natl. Acad. Sci. U.S.A. ... Seven protein regions exist in crystallins: four homologous motifs, a connecting peptide, and N- and C-terminal extensions. ... Gamma-crystallin B is a protein that in humans is encoded by the CRYGB gene. Crystallins are separated into two classes: taxon- ... The latter class constitutes the major proteins of vertebrate eye lens and maintains the transparency and refractive index of ...