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*  Tyrosine-protein kinase BLK
... also known as B lymphocyte kinase is an enzyme that in humans is encoded by the BLK gene. The ... BLK B lymphoid tyrosine kinase". Oda H, Kumar S, Howley PM (August 1999). "Regulation of the Src family tyrosine kinase Blk ... microtubule-associated protein kinase, GTPase-activating protein, and phosphatidylinositol 3-kinase". Mol. Cell. Biol. 13 (9): ... 1993). "Mapping of sites on the Src family protein tyrosine kinases p55blk, p59fyn, and p56lyn which interact with the effector ...
*  Tyrosine-protein kinase CSK
... also known as C-terminal Src kinase is an enzyme that, in humans, is encoded by the CSK gene. This ... Universal protein resource accession number P41240 for "Tyrosine-protein kinase CSK" at UniProt. Bräuninger A, Holtrich U, ... This Non-receptor tyrosine-protein kinase plays an important role in the regulation of cell growth, differentiation, migration ... CSK tyrosine-protein kinase at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and Cellular ...
*  Proto-oncogene tyrosine-protein kinase Src
A number of tyrosine kinase inhibitors that target c-Src tyrosine kinase (as well as related tyrosine kinases) have been ... Proto-oncogene tyrosine-protein kinase Src, also known as proto-oncogene c-Src or simply c-Src , is a non-receptor tyrosine ... The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by CSK. ... c-Src can be activated by many transmembrane proteins that include: adhesion receptors, receptor tyrosine kinases, G-protein ...
*  Feline sarcoma oncogene
"The Fes protein-tyrosine kinase phosphorylates a subset of macrophage proteins that are involved in cell adhesion and cell-cell ... "Tyrosine phosphorylation of BCR by FPS/FES protein-tyrosine kinases induces association of BCR with GRB-2/SOS". Molecular and ... Tyrosine-protein kinase Fes/Fps also known as proto-oncogene c-Fes/Fps is an enzyme that in humans is encoded by the FES gene. ... The gene product has tyrosine-specific protein kinase activity and that activity is required for maintenance of cellular ...
*  BYKdb
The Bacterial protein tyrosine-kinase database (BYKdb) is a specialized database of computer-annotated bacterial tyrosine- ... the Bacterial protein tYrosine Kinase database". Nucleic Acids Res. England. 40 (Database issue): D321-4. doi:10.1093/nar/ ... kinases that share no resemblance with their eukaryotic counterparts tyrosine-kinases Jadeau, Fanny; Grangeasse Christophe; Shi ...
*  TYRO3
Tyrosine-protein kinase receptor TYRO3 is an enzyme that in humans is encoded by the TYRO3 gene. TYRO3 has been shown to ... Crosier PS, Freeman SA, Orlic D, Bodine DM, Crosier KE (1996). "The Dtk receptor tyrosine kinase, which binds protein S, is ... "Entrez Gene: TYRO3 TYRO3 protein tyrosine kinase". Mark MR, Chen J, Hammonds RG, Sadick M, Godowsk PJ (April 1996). " ... "The Ran binding protein RanBPM interacts with Axl and Sky receptor tyrosine kinases". Int. J. Biochem. Cell Biol. 37 (11): 2344 ...
*  Signal transduction
Receptor tyrosine kinases (RTKs) are transmembrane proteins with an intracellular kinase domain and an extracellular domain ... Histidine-specific protein kinases are structurally distinct from other protein kinases and are found in prokaryotes, fungi, ... cAMP-dependent pathway: In humans, cAMP works by activating protein kinase A (PKA, cAMP-dependent protein kinase) (see picture ... most commonly protein phosphorylation catalysed by protein kinases, which ultimately results in a cellular response. Proteins ...
*  PTK7
Tyrosine-protein kinase-like 7 also known as colon carcinoma kinase 4 (CCK4) is a receptor tyrosine kinase that in humans is ... Receptor protein tyrosine kinases transduce extracellular signals across the cell membrane. A subgroup of these kinases lack ... The protein encoded by this gene an intracellular domain with tyrosine kinase homology and may function as a cell adhesion ... Banga SS, Ozer HL, Park SK, Lee ST (1997). "Assignment of PTK7 encoding a receptor protein tyrosine kinase-like molecule to ...
*  ERBB3
Receptor tyrosine-protein kinase erbB-3, also known as HER3 (human epidermal growth factor receptor 3), is a membrane bound ... Roskoski R (2014). "The ErbB/HER family of protein-tyrosine kinases and cancer". Pharmacol. Res. 79: 34-74. doi:10.1016/j.phrs. ... ErbB3 is a member of the epidermal growth factor receptor (EGFR/ERBB) family of receptor tyrosine kinases. The kinase-impaired ... "Escape from HER-family tyrosine kinase inhibitor therapy by the kinase-inactive HER3". Nature. 445 (7126): 437-41. doi:10.1038/ ...
*  Poziotinib
Roskoski R, Jr (September 2014). "ErbB/HER protein-tyrosine kinases: Structures and small molecule inhibitors". Pharmacological ...
*  Tyrosine kinase 2
This gene encodes a member of the tyrosine kinase and, to be more specific, the Janus kinases (JAKs) protein families. This ... Non-receptor tyrosine-protein kinase TYK2 is an enzyme that in humans is encoded by the TYK2 gene. Tyk2 was the first member of ... Velazquez L, Fellous M, Stark GR, Pellegrini S (July 1992). "A protein tyrosine kinase in the interferon alpha/beta signaling ... 1996). "Interaction of the c-cbl proto-oncogene product with the Tyk-2 protein tyrosine kinase". Biochem. Biophys. Res. Commun ...
*  Biochemical cascade
These proteins activate protein tyrosine kinase (PTK) that phosphorylates various proteins important for capacitation and ... Mitogen-Activated Protein Kinase/Extracellular Signal-Regulated Kinase) regulates gene transcription through successive kinase ... So, ZP3 can activate G protein coupled receptors and tyrosine kinase receptors, that leads to production of PLC. PLC cleaves ... McGinnis, LK; Carroll, DJ; Kinsey, WH (Oct-Nov 2011). "Protein tyrosine kinase signaling during oocyte maturation and ...
*  ABL (gene)
"A C-terminal protein-binding domain in the retinoblastoma protein regulates nuclear c-Abl tyrosine kinase in the cell cycle". ... "Cytoskeletal protein PSTPIP1 directs the PEST-type protein tyrosine phosphatase to the c-Abl kinase to mediate Abl ... Cao C, Leng Y, Li C, Kufe D (April 2003). "Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the ... Ren R, Ye ZS, Baltimore D (April 1994). "Abl protein-tyrosine kinase selects the Crk adapter as a substrate using SH3-binding ...
*  AXL receptor tyrosine kinase
Tyrosine-protein kinase receptor UFO is an enzyme that in humans is encoded by the AXL gene. The gene was initially designated ... The protein encoded by this gene is a member of the receptor tyrosine kinase subfamily. Although it is similar to other ... Lee ST, Strunk KM, Spritz RA (Dec 1993). "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes". ... AXL is a cell surface receptor tyrosine kinase, part of the TAM family of kinases including TYRO3 and MERTK. The Axl gene is ...
*  Related to receptor tyrosine kinase
The protein encoded by this gene is an atypical member of the family of growth factor receptor protein tyrosine kinases, ... "Localization of two mouse genes encoding the protein tyrosine kinase receptor-related protein RYK". Mamm. Genome. 6 (4): 255-6 ... RYK RYK receptor-like tyrosine kinase". Hovens, CM, Stacker, SA (1992). "RYK, a receptor tyrosine kinase-related molecule with ... Lee ST, Strunk KM, Spritz RA (1993). "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes". ...
*  ABL2
Tyrosine-protein kinase ABL2 also known as Abelson-related gene (Arg) is an enzyme that in humans is encoded by the ABL2 gene. ... Cao C, Leng Y, Li C, Kufe D (April 2003). "Functional interaction between the c-Abl and Arg protein-tyrosine kinases in the ... ABL2 is a cytoplasmic tyrosine kinase which is closely related to but distinct from ABL1. The similarity of the proteins ... Wang B, Kruh GD (1996). "Subcellular localization of the Arg protein tyrosine kinase". Oncogene. 13 (1): 193-7. PMID 8700546. ...
*  NMDA receptor
Yu XM, Askalan R, Keil GJ, Salter MW (January 1997). "NMDA channel regulation by channel-associated protein tyrosine kinase Src ... which contain residues that can be directly modified by a series of protein kinases and protein phosphatases, as well as ... Neuroscience portal Calcium/calmodulin-dependent protein kinases Laube B, Hirai H, Sturgess M, Betz H, Kuhse J (1997). " ... Reelin modulates NMDA function through Src family kinases and DAB1. significantly enhancing LTP in the hippocampus. Src kinase ...
*  Non-receptor tyrosine kinase
... to tyrosine residues in proteins. Non-receptor tyrosine kinases are a subgroup of protein family tyrosine kinases, enzymes that ... Unlike the receptor tyrosine kinases (RTKs), the second subgroup of tyrosine kinases, the non-receptor tyrosine kinases are ... Non-receptor tyrosine kinases do not contain only a tyrosine kinase domain, nRTKs also possess domains that mediate protein- ... protein, protein-lipid, and protein-DNA interactions. One of the protein-protein interaction domains in nRTKs are the Src ...
*  YES1
The encoded protein has tyrosine kinase activity and belongs to the src family of proteins. This gene lies in close proximity ... Proto-oncogene tyrosine-protein kinase Yes is an enzyme that in humans is encoded by the YES1 gene. This gene is the cellular ... Non-receptor type protein-tyrosine kinases closely related to src and yes compose a multigene family". Int. Symp. Princess ... 1991). "Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human ...
*  Phosphorylation
Protein kinase B) as part of the insulin signaling pathway. Phosphorylation of src tyrosine kinase (pronounced "sarc") by C- ... Cole PA, Shen K, Qiao Y, Wang D (October 2003). "Protein tyrosine kinases Src and Csk: a tail's tale". Curr Opin Chem Biol. 7 ( ... Kinases phosphorylate proteins and phosphatases dephosphorylate proteins. Many enzymes and receptors are switched "on" or "off ... However, since tyrosine phosphorylated proteins are relatively easy to purify using antibodies, tyrosine phosphorylation sites ...
*  TYROBP
TYRO protein tyrosine kinase-binding protein is an adapter protein that in humans is encoded by the TYROBP gene. This gene ... This protein may bind zeta-chain (TCR) associated protein kinase 70kDa (ZAP-70) and spleen tyrosine kinase (SYK) and play a ... "Entrez Gene: TYROBP TYRO protein tyrosine kinase binding protein". Dietrich J, Cella M, Seiffert M, Bühring HJ, Colonna M ( ... The encoded protein may associate with the killer cell immunoglobulin-like receptor (KIR) family of membrane glycoproteins and ...
*  FYN
... is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been ... Fyn is a tyrosine-specific phospho-transferase that is a member of the Src family of non-receptor tyrosine protein kinases. ( ... "Protein-tyrosine kinase Pyk2 is involved in interleukin-2 production by Jurkat T cells via its tyrosine 402". J. Biol. Chem. ... a novel protein that associates with the protein tyrosine kinase p59fyn in human T-lymphocytes". J. Biol. Chem. 272 (26): 16077 ...
*  Ephrin receptor
Easty DJ, Herlyn M, Bennett DC (January 1995). "Abnormal protein tyrosine kinase gene expression during melanoma progression ... an EPH family receptor protein tyrosine kinase, in various human tumors". Cancer Res. 54 (14): 3645-50. PMID 8033077. ... George SE, Simokat K, Hardin J, Chisholm AD (Mar 1998). "The VAB-1 Eph receptor tyrosine kinase functions in neural and ... The Eph receptors were initially identified in 1987 following a search for tyrosine kinases with possible roles in cancer, ...
*  CBL (gene)
Howlett CJ, Robbins SM (March 2002). "Membrane-anchored Cbl suppresses Hck protein-tyrosine kinase mediated cellular ... N-terminal tyrosine kinase binding domain (TKB domain): determines the protein which it can bind to RING finger domain motif: ... is a downstream substrate of the Hck protein-tyrosine kinase". Biochem. Biophys. Res. Commun. 257 (1): 129-38. doi:10.1006/bbrc ... "The Cbl proteins are binding partners for the Cool/Pix family of p21-activated kinase-binding proteins". FEBS Lett. 550 (1-3): ...
*  MST1R
Lee ST, Strunk KM, Spritz RA (1993). "A survey of protein tyrosine kinase mRNAs expressed in normal human melanocytes". ... 1997). "Role of macrophage-stimulating protein and its receptor, RON tyrosine kinase, in ciliary motility". J. Clin. Invest. 99 ... "A novel putative receptor protein tyrosine kinase of the met family". Oncogene. 8 (5): 1195-202. PMID 8386824. "Entrez Gene: ... It is related to the c-MET receptor tyrosine kinase. MST1R has been shown to interact with Grb2. GRCh38: Ensembl release 89: ...
*  MAPK8IP3
"A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine- ... "A scaffold protein in the c-Jun N-terminal kinase signaling pathway is associated with focal adhesion kinase and tyrosine- ... C-jun-amino-terminal kinase-interacting protein 3 is an enzyme that in humans is encoded by the MAPK8IP3 gene. The protein ... "Entrez Gene: MAPK8IP3 mitogen-activated protein kinase 8 interacting protein 3". Matsuura, Hiroshi; Nishitoh Hideki; Takeda ...