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*  Protein primary structure
Some proteins even have the power to cleave themselves. Typically, the hydroxyl group of a serine (rarely, threonine) or the ... Such reactions are catalyzed by kinases and the reverse reaction is catalyzed by phosphatases. The phosphorylated tyrosines are ... A phosphate group can be attached to the sidechain hydroxyl group of serine, threonine and tyrosine residues, adding a negative ... Protein primary structure is the linear sequence of amino acids in a peptide or protein. By convention, the primary structure ...
*  Protein kinase C
Serine/threonine-specific protein kinase Signal transduction Yasutomi Nishizuka, discovered protein kinase C Wilson CH, Ali ES ... membrane-bound receptor for activated protein kinase C proteins). The protein kinase C enzymes are known for their long-term ... Protein kinase C, commonly abbreviated to PKC (EC 2.7.11.13), is a family of protein kinase enzymes that are involved in ... The consensus sequence of protein kinase C enzymes is similar to that of protein kinase A, since it contains basic amino acids ...
*  Receptor protein serine/threonine kinase
... receptor type I serine/threonine protein kinase, receptor type II serine/threonine protein kinase, STK13, TGF-beta kinase, and ... In enzymology, a receptor protein serine/threonine kinase (EC 2.7.11.30) is an enzyme that catalyzes the chemical reaction ATP ... to be specific those transferring phosphorus-containing groups protein-serine/threonine kinases. The systematic name of this ... receptor serine/threonine protein kinase. This enzyme participates in 7 metabolic pathways: MAPK signaling pathway, cytokine- ...
*  Serine/threonine-specific protein kinase
A serine/threonine protein kinase (EC 2.7.11.1) is a kinase enzyme that phosphorylates the OH group of serine or threonine ( ... Serine/threonine kinase (STK) expression is altered in many types of cancer. Serine/threonine protein kinase p90-kDa ribosomal ... specifically protein-serine/threonine kinases. These enzymes transfer phosphates to the oxygen atom of a serine or threonine ... At least 125 of the 500+ human protein kinases are serine/threonine kinases (STK). In enzymology, the term non-specific serine/ ...
*  Phosphoinositide 3-kinase
DNA-dependent protein kinase (DNA-PK) and mammalian target of rapamycin (mTOR). They are protein serine/threonine kinases. The ... Many of the PI 3-kinases appear to have a serine/threonine kinase activity in vitro; however, it is unclear whether this has ... Full activation of AKT occurs upon phosphorylation of serine 473 by the TORC2 complex of the mTOR protein kinase. The "PI3-k/ ... Many of these functions relate to the ability of class I PI 3-kinases to activate protein kinase B (PKB, aka Akt) as in the ...
*  BMPR1A
Wu X, Robinson CE, Fong HW, Gimble JM (1996). "Analysis of the native murine bone morphogenetic protein serine threonine kinase ... receptors are a family of transmembrane serine/threonine kinases that include the type I receptors BMPR1A (this protein) and ... "Activin receptor-like kinases: a novel subclass of cell-surface receptors with predicted serine/threonine kinase activity". ... "Identification of type I and type II serine/threonine kinase receptors for growth/differentiation factor-5". J. Biol. Chem. 271 ...
*  RAF kinase
... a major tyrosine kinase target protein, is a mitogen-activated serine/threonine protein kinase". Proc Natl Acad Sci USA. 86 (18 ... RAF kinases are a family of three serine/threonine-specific protein kinases that are related to retroviral oncogenes. The mouse ... Roskoski R (August 2010). "RAF protein-serine/threonine kinases: structure and regulation" (PDF). Biochem. Biophys. Res. Commun ... "Direct activation of mitogen-activated protein kinase kinase kinase MEKK1 by the Ste20p homologue GCK and the adapter protein ...
*  PKM2
"Regulation of glycolysis by Raf protein serine/threonine kinases". Advances in Enzyme Regulation. 42: 317-32. doi:10.1016/S0065 ... Gupta V, Bamezai RN (Nov 2010). "Human pyruvate kinase M2: a multifunctional protein". Protein Science. 19 (11): 2031-44. doi: ... Pyruvate kinase isozymes M1/M2 (PKM1/M2), also known as pyruvate kinase muscle isozyme (PKM), pyruvate kinase type K, cytosolic ... "Use of a novel method to find substrates of protein kinase C delta identifies M2 pyruvate kinase". The International Journal of ...
*  MELK
... is a serine/threonine kinase belonging to the family of AMPK/snf1 protein kinases. MELK was first identified present as ... "Maternal embryonic leucine zipper kinase/murine protein serine-threonine kinase 38 is a promising therapeutic target for ... by murine protein serine/threonine kinase 38 (MPK38)". The Biochemical Journal. 361 (Pt 3): 597-604. doi:10.1042/0264-6021: ... "Cloning and expression of a cDNA encoding a novel protein serine/threonine kinase predominantly expressed in hematopoietic ...
*  DORN1
Plant perception (physiology) Receptor protein serine/threonine kinase Choi, J.; Tanaka, K.; Cao, Y.; Qi, Y.; Qiu, J.; Liang, Y ... In contrast to animal purinergic receptors (which are G protein-coupled receptors), DORN1 is a lectin receptor kinase (LecRK), ... several mutants lacking the DORN1 receptors are unable to phosphorylate mitogen-activated protein kinases after ATP stimulation ... resulting in several cellular responses such as mitogen-activated protein kinase activation, increased cytosolic calcium ...
*  PLK3
Ouyang B, Pan H, Lu L, Li J, Stambrook P, Li B, Dai W (1997). "Human Prk is a conserved protein serine/threonine kinase ... Cytokine-inducible kinase is a putative serine/threonine kinase. CNK contains both a catalytic domain and a putative regulatory ... a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas". J ... a cytokine-inducible human protein serine/threonine kinase whose expression appears to be down-regulated in lung carcinomas". J ...
*  Cyclin-dependent kinase 10
... a novel putative member of the cdk family of protein serine/threonine kinases". Oncogene. 9 (10): 3037-41. PMID 8084611. " ... Cell division protein kinase 10 is an enzyme that in humans is encoded by the CDK10 gene. The protein encoded by this gene ... "Entrez Gene: CDK10 cyclin-dependent kinase (CDC2-like) 10". Kasten M, Giordano A (Apr 2001). "Cdk10, a Cdc2-related kinase, ... "Chromosomal mapping of members of the cdc2 family of protein kinases, cdk3, cdk6, PISSLRE, and PITALRE, and a cdk inhibitor, ...
*  PIM1
Proto-oncogene serine/threonine-protein kinase Pim-1 is an enzyme that in humans is encoded by the PIM1 gene. Pim-1 is a proto- ... Saris CJ, Domen J, Berns A (March 1991). "The pim-1 oncogene encodes two related protein-serine/threonine kinases by ... "Complementary functions of the antiapoptotic protein A1 and serine/threonine kinase pim-1 in the BCR/ABL-mediated ... Bachmann M, Möröy T (April 2005). "The serine/threonine kinase Pim-1". The International Journal of Biochemistry & Cell Biology ...
*  Rosalind A Segal
"Regulation of neuronal survival by the serine-threonine protein kinase Akt." Science 275, no. 5300 (1997): 661-665. Ma, Qing, ... Segal defined the motif within Hedgehog proteins critical for binding to proteoglycans, defined the nature of the proteoglycan ...
*  ROCK1
... is a protein serine/threonine kinase also known as rho-associated, coiled-coil-containing protein kinase 1. Other common ... ROCK1 is also the name of the gene that encodes the protein ROCK1, a serine/threonine kinase. ROCK1 is activated when bound to ... two isoforms of Rho-associated coiled-coil forming protein serine/threonine kinase in mice". FEBS Letters. 392 (2): 189-93. doi ... The ROCK1 structure is a serine/threonine kinase with molecular weight of 158kDa. It is a homodimer composed of a catalytic ...
*  Fas-activated serine/threonine kinase
Fas-activated serine/threonine protein] ⇌ {\displaystyle \rightleftharpoons } ADP + [Fas-activated serine/threonine ... specifically those transferring phosphorus-containing groups protein-serine/threonine kinases. The systematic name of this ... In enzymology, a Fas-activated serine/threonine kinase (EC 2.7.11.8) is an enzyme that catalyzes the chemical reaction ATP + [ ... Tian Q, Taupin J, Elledge S, Robertson M, Anderson P (1995). "Fas-activated serine/threonine kinase (FAST) phosphorylates TIA-1 ...
*  SGK2
Serine/threonine-protein kinase Sgk2 is an enzyme that in humans is encoded by the SGK2 gene. This gene encodes a serine/ ... threonine protein kinase. Although this gene product is similar to serum- and glucocorticoid-induced protein kinase (SGK), this ... 2003). "The serine/threonine kinases SGK2 and SGK3 are potent stimulators of the epithelial Na+ channel alpha,beta,gamma-ENaC ... 2003). "K+ channel activation by all three isoforms of serum- and glucocorticoid-dependent protein kinase SGK". Pflugers Arch. ...
*  MAP3K8
The encoded protein is a member of the serine/threonine protein kinase family. This kinase can activate both the ERK1/2 and p38 ... MAP3K8 mitogen-activated protein kinase kinase kinase 8". Arthur JS, Ley SC (Sep 2013). "Mitogen-activated protein kinases in ... Mitogen-activated protein kinase kinase kinase 8 is an enzyme that in humans is encoded by the MAP3K8 gene. This gene was ... "The human cot proto-oncogene encodes two protein serine/threonine kinases with different transforming activities by alternative ...
*  George Yancopoulos
May 1991). "ERKs: a family of protein-serine/threonine kinases that are activated and tyrosine phosphorylated in response to ... May 1996). "The receptor tyrosine kinase MuSK is required for neuromuscular junction formation in vivo". Cell. 85 (4): 501-12. ... March 2000). "Ror2, encoding a receptor-like tyrosine kinase, is required for cartilage and growth plate development". Nature ... November 1994). "Ligands for EPH-related receptor tyrosine kinases that require membrane attachment or clustering for activity ...
*  PTPRJ
"The receptor-like protein-tyrosine phosphatase DEP-1 is constitutively associated with a 64-kDa protein serine/threonine kinase ... The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling ... "Entrez Gene: PTPRJ protein tyrosine phosphatase, receptor type, J". Holsinger LJ, Ward K, Duffield B, Zachwieja J, Jallal B ( ... Receptor-type tyrosine-protein phosphatase eta is an enzyme that in humans is encoded by the PTPRJ gene. ...
*  MST4
Serine/threonine protein kinase MST4, also known as mammalian STE20-like protein kinase 4 (MST-4), is a protein that in humans ... RP6-213H19.1 serine/threonine protein kinase MST4". Goudreault M, D'Ambrosio LM, Kean MJ, Mullin MJ, Larsen BG, Sanchez A, ... The protein kinase localizes to the Golgi apparatus and is specifically activated by binding to the Golgi matrix protein GM130 ... which are a subset of the Ste20-like kinases. The encoded protein contains an amino-terminal kinase domain, and a carboxy- ...
*  TGF beta receptor 1
The encoded protein is a serine/threonine protein kinase. Mutations in this gene have been associated with Loeys-Dietz aortic ... Kawabata M, Chytil A, Moses HL (March 1995). "Cloning of a novel type II serine/threonine kinase receptor through interaction ... Transforming growth factor beta receptor I (activin A receptor type II-like kinase, 53kDa) is a membrane-bound receptor protein ... The protein encoded by this gene forms a heteromeric complex with type II TGF-β receptors when bound to TGF-β, transducing the ...
*  MAPK6
MAP Kinase Resource . Boulton TG, Nye SH, Robbins DJ, et al. (1991). "ERKs: a family of protein-serine/threonine kinases that ... MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein ... The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen- ... Mitogen-activated protein kinase 6 is an enzyme that in humans is encoded by the MAPK6 gene. ...
*  AKT2
RAC-beta serine/threonine-protein kinase is an enzyme that in humans is encoded by the AKT2 gene. This gene is a putative ... OH kinase-dependent regulation of glycogen synthase kinase 3 and protein kinase B/AKT by the integrin-linked kinase". Proc. ... The encoded protein is a general protein kinase capable of phosphorylating several known proteins. The gene was shown to be ... a putative oncogene encoding a member of a subfamily of protein-serine/threonine kinases, is amplified in human ovarian ...
*  Neurotrophic factors
They signal through receptor tyrosine kinases and serine/threonine protein kinases. Several other biomolecules that have ... Whereas neurotrophic factors within the neurotrophin family commonly have a protein tyrosine kinase receptor (Trk), ... Most NTFs exert their trophic effects on neurons by signaling through tyrosine kinases, usually a receptor tyrosine kinase. In ... The NT-3 protein is found within the thymus, spleen, intestinal epithelium but its role in the function of each organ is still ...
*  NOL1
"The receptor-like protein-tyrosine phosphatase DEP-1 is constitutively associated with a 64-kDa protein serine/threonine kinase ... Ren Y, Busch RK, Perlaky L, Busch H (May 1998). "The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with ... Ren Y, Busch RK, Perlaky L, Busch H (1998). "The 58-kDa microspherule protein (MSP58), a nucleolar protein, interacts with ... "Identification of the nuclear and nucleolar localization signals of the protein p120. Interaction with translocation protein ...
*  Sequestosome 1
"The receptor-like protein-tyrosine phosphatase DEP-1 is constitutively associated with a 64-kDa protein serine/threonine kinase ... Geetha T, Wooten MW (February 2003). "Association of the atypical protein kinase C-interacting protein p62/ZIP with nerve ... Also known as the ubiquitin-binding protein p62, it is an autophagosome cargo protein that targets other proteins that bind to ... "The atypical protein kinase C-interacting protein p62 is a scaffold for NF-kappaB activation by nerve growth factor". J. Biol. ...