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*  Saposin protein domain
All mammalian saposins are synthesized as a single precursor molecule (prosaposin) which contains four Saposin-B domains, ... In molecular biology a saposin protein domain is a region of the saposin protein that has a certain conserved sequence or ... Ponting CP (1994). "Acid sphingomyelinase possesses a domain homologous to its activator proteins: saposins B and D". Protein ... The Saposin-B domains also occur in other proteins, many of them active in the lysis of membranes. Below is a schematic diagram ...
*  Signal peptide peptidase
Bacteria produce a number of protein precursors that undergo post-translational methylation and proteolysis prior to secretion ... In molecular biology, the Signal Peptide Peptidase (SPP) is a type of protein that specifically cleaves parts of other proteins ... SPP also plays a pathophysiological role; it cleaves the structural nucleocapsid protein (also known as core protein) of the ... In mice, a nonamer peptide originating from the SPP protein serves as minor histocompatibility antigen HM13 that plays a role ...
*  Amyloid beta
... and β-secretases which generate Aβ from its precursor protein, APP (amyloid precursor protein). Aβ circulates in plasma, ... The peptides derive from the amyloid precursor protein (APP), which is cleaved by beta secretase and gamma secretase to yield A ... The gene for the amyloid precursor protein is located on chromosome 21, and accordingly people with Down syndrome have a very ... Hiltunen M, van Groen T, Jolkkonen J (2009). "Functional roles of amyloid-beta protein precursor and amyloid-beta peptides: ...
*  Amyloid precursor protein
... (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses of ... "Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein". Proceedings ... a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein". The Journal of Biological ... enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism". The Journal of Biological ...
*  Alzheimer's disease research
... amyloid protein precursor (APP) was found to be indirectly related based on network analysis. Aβ (one of the diagnostic ... Functional protein sequence alignments (e.g. ClustalW, MUSCLE) and phylogenetic analysis (e.g. Phylip, Mega) demonstrate that ... EGFR is a transmembrane protein and a member of the HER/ErbB receptor family that share a common pathway with insulin receptors ... Gamma secretase is a protein complex thought to be a fundamental building block in the development of the amyloid beta peptide ...
*  Protein primary structure
Proteins are often synthesized in an inactive precursor form; typically, an N-terminal or C-terminal segment blocks the active ... Protein primary structure is the linear sequence of amino acids in a peptide or protein. By convention, the primary structure ... The protein is activated by cleaving off the inhibitory peptide. Some proteins even have the power to cleave themselves. ... The colloidal protein hypothesis stated that proteins were colloidal assemblies of smaller molecules. This hypothesis was ...
*  Protein precursor
A protein precursor, also called a pro-protein or pro-peptide, is an inactive protein (or peptide) that can be turned into an ... Protein precursors are often used by an organism when the subsequent protein is potentially harmful, but needs to be available ... Some protein precursors are secreted from the cell. Many of these are synthesized with an N-terminal signal peptide that ... Like other proteins that contain a signal peptide, their name is prefixed by pre. They are thus called pre-pro-proteins or pre- ...
*  Amyloid precursor protein secretase
Among other roles in the cell, secretases act on the amyloid precursor protein (APP) to cleave the protein into three fragments ... BACE is a transmembrane protein with an extracellular aspartic acid protease domain. γ-secretase is actually a protein complex ... If α-secretase acts on APP first instead of BACE, no amyloid-β is formed because α-secretase recognizes a target protein ... Besides their involvement in the pathogenesis of Alzheimer's, these proteins also have other functional roles in the cell. γ- ...
*  TIP39
"Entrez Gene: TIP39 tuberoinfundibular 39 residue protein precursor". Weaver RE, Mobarec JC, Wigglesworth MJ, Reynolds CA, ... TIP39 is related to parathyroid hormone (PTH; MIM 168450) and PTH-related protein (PTHRP; MIM 168470) and is a ligand for PTH ... Tuberoinfundibular peptide of 39 residues is a protein that in humans is encoded by the PTH2 gene. ...
*  Transforming growth factor beta
They are all encoded as large protein precursors; TGF-β1 contains 390 amino acids and TGF-β2 and TGF-β3 each contain 412 amino ... The mature TGF-β protein dimerizes to produce a 25 KDa active protein with many conserved structural motifs. TGF-β has nine ... TGF-β causes synthesis of p15 and p21 proteins, which block the cyclin:CDK complex responsible for retinoblastoma protein (Rb) ... Protein Lefty-2; Protein Lefty-A) The peptide structures of the TGF-β isoforms are highly similar (homologies on the order of ...
*  CCL25
Human CCL25 is produced as a protein precursor containing 151 amino acids. The gene for CCL25 (scya25) is located on human ...
*  Christine Van Broeckhoven
Amyloid beta protein precursor gene and hereditary cerebral hemorrhage with amyloidosis, Science. 1990 June 1;248(4959):1120-2 ... in 1993 she and three other scientists were awarded the American Potamkin Prize for their work on the amyloid precursor protein ...
*  CCL2
The CCL2 protein precursor contains a signal peptide of 23 amino acids. In turn, the mature CCL2 is 76 amino acids long. The ... "Expression of monocyte chemoattractant protein-1 and macrophage inflammatory protein-1 after focal cerebral ischemia in the rat ... The protein expression of TNF-α, IL-1β was also decreased and IL-10 increased with melatonin treatment. Exogenous ... Xu LL, Warren MK, Rose WL, Gong W, Wang JM (Sep 1996). "Human recombinant monocyte chemotactic protein and other C-C chemokines ...
*  Preproenzyme
Protein precursor Zymogen Braun P, de Groot A, Bitter W, Tommassen J. 1998. Secretion of elastinolytic enzymes and their ...
*  PRB1
Chan M, Bennick A (2001). "Proteolytic processing of a human salivary proline-rich protein precursor by proprotein convertases ... Basic salivary proline-rich protein 1 is a protein that in humans is encoded by the PRB1 gene. The protein encoded by this gene ... complete covalent structure of protein IB-9 and partial structure of protein IB-6, members of a polymorphic pair". Biochemistry ... This gene and five other genes that also encode salivary proline-rich proteins (PRPs), as well as a gene encoding a lacrimal ...
*  PRB4
Chan M, Bennick A (2001). "Proteolytic processing of a human salivary proline-rich protein precursor by proprotein convertases ... Basic salivary proline-rich protein 4 is a protein that in humans is encoded by the PRB4 gene. The protein encoded by this gene ... PRB4 is post-translationally cleaved into three different mature peptides: Protein N1 Glycosylated protein A Peptide P-D (also ... PRB4 proline-rich protein BstNI subfamily 4". Azen EA, Maeda N (1988). "Molecular genetics of human salivary proteins and their ...
*  PSEN1
Selkoe DJ (1994). "Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease". Annu. Rev. ... Pitsi D, Octave JN (June 2004). "Presenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently ... Levesque G (1999). "Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta ... or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of ...
*  Filaggrin
... monomers are tandemly clustered into a large, 350kDa protein precursor known as profilaggrin. In the epidermis, these ... Ten to twelve filaggrin units are post-translationally hydrolized from a large profilaggrin precursor protein during terminal ... Filaggrin (filament aggregating protein) is a filament-associated protein that binds to keratin fibers in epithelial cells. ... cornified envelope precursors, S100 proteins and the 'fused genes' family". Experimental Dermatology. 21 (9): 643-649. doi: ...
*  CLSTN1
... enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism". The Journal of Biological ... Nakayama M, Kikuno R, Ohara O (Nov 2002). "Protein-protein interactions between large proteins: two-hybrid screening using a ... enhance the X11-like protein-mediated stabilization of amyloid beta-protein precursor metabolism". The Journal of Biological ... CLSTN1 has been shown to interact with APBA2 and Amyloid precursor protein. GRCh38: Ensembl release 89: ENSG00000171603 - ...
*  Glyceraldehyde 3-phosphate dehydrogenase
... skeletal muscle-specific Ca2+/calmodulin-dependent protein kinase; Akt; Beta-amyloid precursor protein (betaAPP); Huntingtin. ... For example, GAPDH interactions with beta-amyloid precursor protein (betaAPP) could interfere with its function regarding the ... GAPDH participates in a number of biological functions through its protein-protein interactions with: tubulin to facilitate ... where it ubiquitinates and degrades nuclear proteins during nitrosative stress conditions; GAPDH's competitor of Siah protein ...
*  CoRR hypothesis
There they code for protein precursors that are made in the cytosol for subsequent import into the organelles. Why do ... Most genes for proteins of chloroplasts and mitochondria are, however, now located on chromosomes in the nuclei of eukaryotic ... Different products of protein synthesis in isolated chloroplasts and mitochondria are obtained in the presence of redox ... We cannot think of compelling reasons why the proteins made in mitochondria and chloroplasts should be made there rather than ...
*  Nesfatin-1
... is a polypeptide encoded in the N-terminal region of the protein precursor, Nucleobindin2 (NUCB2). Recombinant human ... In addition, the protein stimulated insulin secretion from the pancreatic beta cells of both rats and mice. ... It is needed to fully activate AKT and consists of two discrete protein complexes, TORC1 and TORC2, only one of which, TORC1, ... It was found that central nesfatin-1 resulted in a marked suppression of hepatic PEPCK mRNA and protein levels in both standard ...
*  CTNNBIP1
Chen Y, Bodles AM (2007). "Amyloid precursor protein modulates beta-catenin degradation". Journal of Neuroinflammation. 4: 29. ... Beta-catenin-interacting protein 1 is a protein that is encoded in humans by the CTNNBIP1 gene. The protein encoded by this ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: ... CTNNBIP1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) Human CTNNBIP1 genome location ...
*  PSEN2
... or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of ... "A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 protein". J. ... Presenilin-2 is a protein that in humans is encoded by the PSEN2 gene. Alzheimer's disease (AD) patients with an inherited form ... APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein ...
*  Thermoplasma volcanium
... especially those proteins mediating certain metabolic pathways. For example, in most hyperthermophiles, the protein precursors ... Thus, further investigation of this protein offers insight into the evolutionary relatedness seen between protein-DNA ... "A PPM-family protein phosphatase from the thermoacidophile Thermoplasma volcanium hydrolyzes protein-bound phosphotyrosine". ... These two members of the genus Thermoplasma are highly motile, lack a cell wall, and have homologous histone-like proteins ...
*  Prostaglandin-endoperoxide synthase 2
Picot D, Loll PJ, Garavito RM (January 1994). "The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1 ... It is involved in the conversion of arachidonic acid to prostaglandin H2, an important precursor of prostacyclin, among others ... PTGS (COX, which can be confused with "cytochrome oxidase") enzymes are monotopic membrane proteins; the membrane-binding ... of the protein. The catalytic domain is homologous to mammalian peroxidases such as myeloperoxidase. It has been found that ...
*  Histidinol dehydrogenase
... and in plants it is expressed as a nuclear encoded protein precursor which is exported to the chloroplast. Histodinol ... Adams E (1955). "L-Histidinal, a biosynthetic precursor of histidine". J. Biol. Chem. 217 (1): 325-344. PMID 13271397. Yourno J ...