A protein precursor, also called a pro-protein or pro-peptide, is an inactive protein (or peptide) that can be turned into an ... Protein precursors are often used by an organism when the subsequent protein is potentially harmful, but needs to be available ... Some protein precursors are secreted from the cell. Many of these are synthesized with an N-terminal signal peptide that ... Media related to Precursor proteins at Wikimedia Commons v t e (Articles with short description, Short description matches ...
... is an ancient and highly conserved protein. In humans, the gene APP is located on chromosome 21 ... Amyloid-beta precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses ... "Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein". Proceedings ... a novel protein that binds to the carboxyl-terminal region of the amyloid precursor protein". The Journal of Biological ...
Among other roles in the cell, secretases act on the amyloid-beta precursor protein (APP) to cleave the protein into three ... BACE is a transmembrane protein with an extracellular aspartic acid protease domain. γ-secretase is actually a protein complex ... Besides their involvement in the pathogenesis of Alzheimer's, these proteins also have other functional roles in the cell. γ- ... Secretases are enzymes that "snip" pieces off a longer protein that is embedded in the cell membrane. ...
"MicroRNA-153 negatively regulates the expression of amyloid precursor protein and amyloid precursor-like protein 2". Brain ... Delay C, Calon F, Mathews P, Hébert SS (October 2011). "Alzheimer-specific variants in the 3'UTR of Amyloid precursor protein ... Page for mir-153 microRNA precursor family at Rfam v t e (Rfam pages needing a picture, MicroRNA, MicroRNA precursor families, ... "MicroRNA-153 physiologically inhibits expression of amyloid-β precursor protein in cultured human fetal brain cells and is ...
Liu W, Liu C, Zhu J, Shu P, Yin B, Gong Y, Qiang B, Yuan J, Peng X (2010). "MicroRNA-16 targets amyloid precursor protein to ... The miR-16 microRNA precursor family is a group of related small non-coding RNA genes that regulates gene expression. miR-16, ... Metzler M, Wilda M, Busch K, Viehmann S, Borkhardt A (2004). "High expression of precursor microRNA-155/BIC RNA in children ... Page for mir-16 microRNA precursor family at Rfam miRBase family MIPF0000006 Baudry A, Mouillet-Richard S, Schneider B, Launay ...
... , also known as NPPC, is a protein that in humans is encoded by the NPPC gene. The precursor ... "Entrez Gene: NPPC natriuretic peptide precursor C". Kaneko T, Shirakami G, Nakao K, Nagata I, Nakagawa O, Hama N, Suga S, ... Tawaragi Y, Fuchimura K, Tanaka S, Minamino N, Kangawa K, Matsuo H (March 1991). "Gene and precursor structures of human C-type ... "CNP production in the kidney and effects of protein intake restriction in nephrotic syndrome". American Journal of Physiology. ...
Pardee, A. B. (1954). "Nucleic acid precursors and protein synthesis". Proceedings of the National Academy of Sciences of the ... He named this DNA-protein interaction as the "diamond code." Although Gamow's premise that DNA directly synthesized proteins ... Crick, Francis: From DNA to protein On degenerate templates and the adapter hypothesis: a note for the RNA Tie Club, 1955. ... Based on the Watson-Crick model, he proposed the "direct DNA template hypothesis" that states that proteins are directly ...
Pardee AB (May 1954). "Nucleic Acid Precursors and Protein Synthesis". Proceedings of the National Academy of Sciences of the ... binding protein. eIF-4E and eIF-4G block the decapping enzyme (DCP2), and poly(A)-binding protein blocks the exosome complex, ... Proteins that are needed in a particular region of the cell can also be translated there; in such a case, the 3' UTR may ... Proteins that bind to either the 3' or 5' UTR may affect translation by influencing the ribosome's ability to bind to the mRNA ...
Pardee, A. B. (1954). "Nucleic acid precursors and protein synthesis". Proceedings of the National Academy of Sciences of the ... On Protein Synthesis A soluble ribonucleic acid intermediate in protein synthesis Archived 2007-09-29 at the Wayback Machine ( ... He even speculated that "insulin, for example, are probably RNA-made proteins. Perhaps a special class of DNA-made proteins ... In fact, they are much larger, having a more complex role to play in protein synthesis, and are closer to 100 nucleotides in ...
... s are precursor proteins that are modified into tachykinin peptides. Via alternative splicing and post- ...
Protein precursor Zymogen Braun P, de Groot A, Bitter W, Tommassen J (1988). "Secretion of elastinolytic enzymes and their ...
They are all encoded as large protein precursors; TGF-β1 contains 390 amino acids and TGF-β2 and TGF-β3 each contain 412 amino ... The mature TGF-β protein dimerizes to produce a 25 KDa active protein with many conserved structural motifs. TGF-β has nine ... TGF-β causes synthesis of p15 and p21 proteins, which block the cyclin:CDK complex responsible for retinoblastoma protein (Rb) ... Protein Lefty-2; Protein Lefty-A). A fourth member of the subfamily, TGFB4, has been identified in birds and a fifth, TGFB5, ...
... skeletal muscle-specific Ca2+/calmodulin-dependent protein kinase; Akt; Beta-amyloid precursor protein (betaAPP); Huntingtin. ... For example, GAPDH interactions with beta-amyloid precursor protein (betaAPP) could interfere with its function regarding the ... GAPDH participates in a number of biological functions through its protein-protein interactions with: tubulin to facilitate ... where it ubiquitinates and degrades nuclear proteins during nitrosative stress conditions; GAPDH's competitor of Siah protein ...
Hevein on Pubchem (Precursor proteins). ... They correspond to the full Pro-Havein protein, the matur ... Hevein is the main IgE-binding epitope of the major latex allergen prohevein as are hevein-like protein domains in fruit class ... Gidrol X, Chrestin H, Tan HL, Kush A (Mar 1994). "Hevein, a lectin-like protein from Hevea brasiliensis (rubber tree) is ... Pro-hevein (Alternative name: Major hevein, gene name: HEV1) is a wound-induced and a lectin-like protein from Hevea ...
ISBN 1-4160-2328-3. "Protein" thyroglobulin precursor [Homo sapiens]". National Center for Biotechnology Information, U.S. ... Refolding of colloidal thyroglobulin by protein disulfide isomerase and immunoglobulin heavy chain-binding protein". The ... Metabolism of thyroglobulin occurs in the liver via thyroid gland recycling of the protein. Circulating thyroglobulin has a ... Thyroglobulin has been shown to interact with Binding immunoglobulin protein. GRCh38: Ensembl release 89: ENSG00000042832 - ...
"uncharacterized protein C4orf29 precursor [Homo sapiens]". NCBI Protein. "NetOGlyc4.0 C4orf29". CBS Prediction Servers. " ... The domain of unknown function, DUF2048, is found from amino acid residues 25 to 414 in the precursor C4orf29 protein. This ... In humans, the protein is found at high levels the digestive tract and parathyroid gland. The homologous mouse protein ... "NP_001034806". NCBI Protein BLAST. Kelley, LA; Sternberg, MJE. "Protein structure prediction on the web: a case study using the ...
Protein precursors include immunoglobulin-derived light chains and transthyretin mutations. The misfolding of the protein ... The general cause of cardiac amyloidosis is the misfolding of a specific protein precursor depending on the amyloidosis type. ... Cardiac amyloidosis is a subcategory of amyloidosis where there is depositing of the protein amyloid in the cardiac muscle and ... Amyloid, a misfolded and insoluble protein, can become a deposit in the heart's atria, valves, or ventricles. These deposits ...
This protein domain provides the precursors necessary for DNA synthesis. It catalyses the biosynthesis of DNA from RNA. This ... The Stirrup protein domain is found in prokaryotic protein ribonucleotide reductases. It obtains its name due to its ... In molecular biology, the protein domain Stirrup is a domain, found only in found in the domain, archaea. ...
Chen Y, Bodles AM (2007). "Amyloid precursor protein modulates beta-catenin degradation". Journal of Neuroinflammation. 4: 29. ... Beta-catenin-interacting protein 1 is a protein that is encoded in humans by the CTNNBIP1 gene. The protein encoded by this ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Mol. Syst. Biol. 3 (1): 89. doi: ... CTNNBIP1+protein,+human at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Human CTNNBIP1 genome location ...
"Conserved domains on uncharacterized protein precursor C1orf127". National Center for Biotechnology Information. "PSORT II". ... The protein also appears to have a cleavable signal peptide from Met1 to Pro18. The protein C1orf127 is suggested to be ... Uncharactarized protein C1orf127 is a protein that in humans is encoded by the C1orf127 gene, the structure and function of ... C1orf127's protein product is a member of the Ensembl protein family TF607005. The primary assembly weighs 89 kDa with an ...
... is a protein that in humans is encoded by the GRN gene. Each granulin protein is cleaved from the precursor ... The structure of the granulin protein is similar to the structure of proteins from protein families that consist of hormones, ... Progranulin is the precursor protein for granulin. Cleavage of progranulin produces a variety of active 6 kDa granulin peptides ... "The epithelin precursor encodes two proteins with opposing activities on epithelial cell growth". The Journal of Biological ...
"Mannose-binding protein C precursor [Homo sapiens]". Retrieved 2012-01-03. Jensen PH, Laursen I, Matthiesen F, Højrup P (2007 ... the MASP protein functions to cleave the blood protein C4 into C4a and C4b. The C4b fragments can then bind to the surface of ... It is produced in the liver as a response to infection, and is part of many other factors termed acute phase proteins. ... Guo N, Mogues T, Weremowicz S, Morton CC, Sastry KN (March 1998). "The human ortholog of rhesus mannose-binding protein-A gene ...
... or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of ... "A myristoylated calcium-binding protein that preferentially interacts with the Alzheimer's disease presenilin 2 protein". J. ... Presenilin-2 is a protein that (in humans) is encoded by the PSEN2 gene. Alzheimer's disease (AD) patients with an inherited ... APH-1 interacts with presenilin and nicastrin and is required for intramembrane proteolysis of amyloid-beta precursor protein ...
The amyloid-beta precursor protein (APP) is a transmembrane protein whose proteolysis produces the amyloid beta peptides. ... O'Brien, Richard J.; Wong, Philip C. (2011). "Amyloid Precursor Protein Processing and Alzheimer's Disease". Annual Review of ... Tau PET detects the abnormal accumulation of tau protein, which is also a hallmark of AD. It is not commonly used in medical ... The Apolipoprotein E (APOE) is a protein involved in transportation of fats, like cholesterol, in the bloodstream. APOE comes ...
Lengths shown are for the precursor proteins. SLC46A3 is an integral membrane protein 461 amino acids (aa) of length with a ... S-palmitoylation can also modulate protein-protein interactions of SLC46A3 by changing the affinity of the protein for lipid ... The protein contains a C-(X)2-C motif (CLLC), which is mostly present in metal-binding proteins and oxidoreductases. A sorting- ... Short for non-structural protein 2, NSP2 is one of the many non-structural proteins encoded in the orf1ab polyprotein. NSP2 ...
Selkoe DJ (1994). "Cell biology of the amyloid beta-protein precursor and the mechanism of Alzheimer's disease". Annu. Rev. ... Pitsi D, Octave JN (June 2004). "Presenilin 1 stabilizes the C-terminal fragment of the amyloid precursor protein independently ... Levesque G (1999). "Presenilins interact with armadillo proteins including neural-specific plakophilin-related protein and beta ... or the amyloid precursor protein (APP). These disease-linked mutations result in increased production of the longer form of ...
Farnesyl and geranyl pyrophosphate also serve as precursors for prenylated proteins. Prenylation is a common type of covalent ... a 10 carbon precursor) and isopentenyl diphosphate (a 5 carbon precursor) whereas its two products are diphosphate and trans, ... A notable example of the former is the farnesylation of small G-proteins including Ras, CDC42, Rho, and Rac. The attachment of ... Ericsson J, Jackson SM, Edwards PA (Oct 1996). "Synergistic binding of sterol regulatory element-binding protein and NF-Y to ...
... mitochondrial protein precursor-processing proteinase, matrix peptidase, matrix processing peptidase, matrix processing ... Mitochondria import the majority of their proteins from the cell cytosol. In order to achieve this, many mitochondrial proteins ... This enzyme catalyses the following chemical reaction Release of N-terminal targeting peptides from precursor proteins imported ... "Uniform nomenclature for the mitochondrial peptidases cleaving precursors of mitochondrial proteins". Trends Biochem. Sci. 18 ( ...
CE precursor proteins are cross-linked by transglutaminases. The ratio of CE precursor proteins varies from tissue to tissue. ... the cornified envelope precursor family, the S100 protein family and the S100 fused type protein (SFTP) family. It has been ... As its name implies, the cornified envelope (CE) precursor family includes genes that encode the proteins forming the CE. The ... The proteins encoded by EDC genes are closely related in terms of function, and evolutionarily they belong to three distinct ...
It is also a precursor protein for bradykinin. Low-molecular-weight-kininogen (LK) is mainly a precursor protein for kallidin. ... Kininogens are precursor proteins for kinins, biologically active polypeptides involved in blood coagulation, vasodilation, ... T-kininogen (TK) is only found in rats and a protein whose function is still being researched. TK is believed to be a ... Structural relationship of kininogens with major acute phase protein and alpha 1-cysteine proteinase inhibitor". The Journal of ...