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*  INPP5D
... an inositol phosphatase domain, and two C-terminal protein interaction domains. Expression of this protein is restricted to ... This gene is a member of the inositol polyphosphate-5-phosphatase (INPP5) family and encodes a protein with an N-terminal SH2 ... Leitges M, Gimborn K, Elis W, Kalesnikoff J, Hughes MR, Krystal G, Huber M (June 2002). "Protein kinase C-delta is a negative ... "Entrez Gene: INPP5D inositol polyphosphate-5-phosphatase, 145kDa". Cui B, Chen L, Zhang S, Mraz M, Fecteau JF, Yu J, Ghia EM, ...
*  Calcineurin
... (CaN) is a calcium and calmodulin dependent serine/threonine protein phosphatase (also known as protein phosphatase ... "Association of protein kinase A and protein phosphatase 2B with a common anchoring protein". Science. 267 (5194): 108-11. doi: ... Giri PR, Higuchi S, Kincaid RL (1991). "Chromosomal mapping of the human genes for the calmodulin-dependent protein phosphatase ... "Molecular cloning of a full-length cDNA encoding the catalytic subunit of human calmodulin-dependent protein phosphatase ( ...
*  Glucose 6-phosphatase
Glucose-6-phosphatase is a complex of multiple component proteins, including transporters for G6P, glucose, and phosphate. The ... Mutations of the glucose-6-phosphatase system, to be specific the glucose-6-phosphatase-α subunit (glucose-6-phosphatase-α), ... and glucose-6-phosphatase-β, encoded by G6PC3. Glucose-6-phosphatase-α and glucose-6-phosphatase-β are both functional ... Glucose-6-phosphatase-β is a ubiquitously expressed, 346-amino acid membrane protein that shares 36% sequence identity with ...
*  Protein primary structure
Such reactions are catalyzed by kinases and the reverse reaction is catalyzed by phosphatases. The phosphorylated tyrosines are ... Protein primary structure is the linear sequence of amino acids in a peptide or protein. By convention, the primary structure ... The protein is activated by cleaving off the inhibitory peptide. Some proteins even have the power to cleave themselves. ... The colloidal protein hypothesis stated that proteins were colloidal assemblies of smaller molecules. This hypothesis was ...
*  Protein phosphatase 2
The PP2A heterotrimeric protein phosphatase is ubiquitously expressed, accounting for a large fraction of phosphatase activity ... Protein phosphatase 2 (PP2), also known as PP2A, is an enzyme that in humans is encoded by the PPP2CA gene. ... Groves MR, Hanlon N, Turowski P, Hemmings BA, Barford D (January 1999). "The structure of the protein phosphatase 2A PR65/A ... Ory S, Zhou M, Conrads TP, Veenstra TD, Morrison DK (August 2003). "Protein phosphatase 2A positively regulates Ras signaling ...
*  ANP32E
In brain tissue, ANP32E together with Cpd1 regulate protein phosphatase 2A activity at synapses during synaptogenesis and has ... Santa-Coloma TA (2003). "Anp32e (Cpd1) and related protein phosphatase 2 inhibitors". Cerebellum. 2 (4): 310-20. doi:10.1080/ ... "Anp32e/Cpd1 regulates protein phosphatase 2A activity at synapses during synaptogenesis". Eur. J. Neurosci. 23 (2): 309-24. doi ... Acidic leucine-rich nuclear phosphoprotein 32 family member E is a protein that in humans is encoded by the ANP32E gene. The ...
*  Ceramide
... s cause endothelial dysfunction by activating protein phosphatase 2 (PP2A). In mitochondria, ceramide suppresses the ... This leads to the egress of proteins from the intermembrane space. Ceramides may be found as ingredients of some topical skin ... Ceramide is subsequently transported to the Golgi apparatus by either vesicular trafficking or the ceramide transfer protein ... "Ceramide-activated phosphatase mediates fatty acid-induced endothelial VEGF resistance and impaired angiogenesis". The American ...
*  PPP2R5D
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell ... "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Lett. 401 (2-3): 197-201. doi: ... Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform is an enzyme that in humans is encoded by the ... "Entrez Gene: PPP2R5D protein phosphatase 2, regulatory subunit B', delta isoform". Firulli BA, Howard MJ, McDaid JR, McIlreavey ...
*  PPP2R1B
"HRX leukemic fusion proteins form a heterocomplex with the leukemia-associated protein SET and protein phosphatase 2A". The ... "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Letters. 401 (2-3): 197-201. doi: ... Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A beta isoform is an enzyme that in humans is encoded by the ... "Entrez Gene: PPP2R1B protein phosphatase 2 (formerly 2A), regulatory subunit A, beta isoform". Zhou J, Pham HT, Ruediger R, ...
*  PPP2R1A
Lubert EJ, Hong Y, Sarge KD (2001). "Interaction between protein phosphatase 5 and the A subunit of protein phosphatase 2A: ... 1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Lett. 401 (2-3): 197-201 ... Serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform is an enzyme that in humans is encoded by the ... "Entrez Gene: PPP2R1A protein phosphatase 2 (formerly 2A), regulatory subunit A , alpha isoform". Goudreault M, D'Ambrosio LM, ...
*  PPP2R3C
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma is an enzyme that in humans is encoded by the ... "Entrez Gene: PPP2R3C protein phosphatase 2 (formerly 2A), regulatory subunit B'', gamma". Kamnasaran D, Chen CP, Devriendt K, ... Xing Y, Igarashi H, Wang X, Sakaguchi N (Sep 2005). "Protein phosphatase subunit G5PR is needed for inhibition of B cell ... "MCM3-binding GANP DNA-primase is associated with a novel phosphatase component G5PR". Genes Cells. 7 (8): 821-34. doi:10.1046/j ...
*  PPP2R2C
"Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Letters. 401 (2-3): 197-201. doi: ... Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell ... Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B gamma isoform is an enzyme that in humans is encoded by the ... "Entrez Gene: PPP2R2C protein phosphatase 2 (formerly 2A), regulatory subunit B, gamma isoform". Zolnierowicz S (Oct 2000). " ...
*  PPP1R9B
2001). "The human tumor suppressor arf interacts with spinophilin/neurabin II, a type 1 protein-phosphatase-binding protein". J ... 1999). "Characterization of the neuronal targeting protein spinophilin and its interactions with protein phosphatase-1". ... a novel protein phosphatase 1 binding protein localized to dendritic spines". Proc Natl Acad Sci U S A. 94 (18): 9956-61. doi: ... a type 1 protein-phosphatase-binding protein". J. Biol. Chem. United States. 276 (17): 14161-9. doi:10.1074/jbc.M006845200. ...
*  PPP2R2B
The product of this gene belongs to the phosphatase 2regulatory subunit B family. Protein phosphatase 2 is one of the four ... 1997). "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Lett. 401 (2-3): 197-201 ... "Regulation of protein kinase cascades by protein phosphatase 2A". Trends Biochem. Sci. 24 (5): 186-91. doi:10.1016/S0968-0004( ... Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B beta isoform is an enzyme that in humans is encoded by the ...
*  LMTK2
... protein phosphatase-1 (PP1C), p35, and myosin VI. It phosphorylates other proteins, and is itself also phosphorylated when ... Wang H, Brautigan DL (Dec 2002). "A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2". ... Wang H, Brautigan DL (Dec 2002). "A novel transmembrane Ser/Thr kinase complexes with protein phosphatase-1 and inhibitor-2". ... This protein interacts with several other proteins, such as androgen receptor, inhibitor-2 (Inh2), ...
*  Tim Hunt
"Greatwall phosphorylates an inhibitor of protein phosphatase 2Α that is essential for mitosis". Science. 330 (6011): 1670-1673 ... Distinguished for his studies of the control of protein synthesis in animal cells and for the discovery of cyclin, a protein ... "The cdc2-related protein p40MO15 is the catalytic subunit of a protein kinase that can activate p33cdk2 and p34cdc2". EMBO ... Cyclins are proteins that play a key role in regulating the cell-division cycle. Hunt found that cyclins begin to be ...
*  PPP1R2
Agarwal-Mawal A, Paudel HK (2001). "Neuronal Cdc2-like protein kinase (Cdk5/p25) is associated with protein phosphatase 1 and ... Protein phosphatase inhibitor 2 is an enzyme that in humans is encoded by the PPP1R2 gene. PPP1R2 has been shown to interact ... "Entrez Gene: PPP1R2 protein phosphatase 1, regulatory (inhibitor) subunit 2". Wang, Hong; Brautigan David L (Dec 2002). "A ... 2003). "Neurabins recruit protein phosphatase-1 and inhibitor-2 to the actin cytoskeleton". J. Biol. Chem. 277 (48): 46535-43. ...
*  NEK2
... a cell-cycle-regulated protein kinase localized to centrosomes, is complexed to protein phosphatase 1". Biochem. J. 349 (Pt 2 ... a novel centrosomal coiled-coil protein and candidate substrate of the cell cycle-regulated protein kinase Nek2". J. Cell Biol ... Serine/threonine-protein kinase Nek2 is an enzyme that in humans is encoded by the NEK2 gene. NEK2 has been shown to interact ... Protein kinase which is involved in the control of centrosome separation and bipolar spindle formation in mitotic cells and ...
*  Signum Biosciences
Protein Phosphatases in Parkinson's Disease. Chapter 7 in Emerging Drugs and Targets for Parkinson's Disease, Volume 34 of RSC ... on compounds that can modulate protein phosphatase 2 (PP2). Gregory Stock, Stock's brother, served as the first CEO. In 2008 ... EHT is derived from coffee and inhibits demethylaton of the enzyme protein phosphatase 2 (PPP2CA; PP2A). EHT has shown ... reported to occur at IC50 3.9µM." Taymans JM, Baekelandt V. Phosphatases of α-synuclein, LRRK2, and tau: important players in ...
*  PPP2R5A
Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell ... "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Letters. 401 (2-3): 197-201. doi: ... "The B56alpha regulatory subunit of protein phosphatase 2A is a target for regulation by double-stranded RNA-dependent protein ... Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform is an enzyme that in humans is encoded by the ...
*  Myosin-light-chain phosphatase
Somlyo, Andrew P.; Somlyo, Avril V. (November 10, 1999). "Signal Transduction by G-Proteins, Rho-Kinase and Protein Phosphatase ... Because it is so important to basic cellular functions, and because there are far fewer protein phosphatases than kinases in ... While it is known that myosin phosphatase is regulated by rho-associated protein kinases, there is current debate about whether ... The enzyme is composed of three subunits: the catalytic region (protein phosphatase 1, or PP1), the myosin binding subunit ( ...
*  Exon junction complex
Faulkner, N.E.; Hilfinger, J.M.; Markovitz, D.M. (2001). "Protein phosphatase 2A activates the HIV-2 promoter through enhancer ... These proteins are the most important components of the NMD mechanism. The EJC protein MAGOH, Y14 and eIF4AIII provide a ... EJC also interacts with a large number of additional proteins; most notably SR proteins. These interactions are suggested to be ... as well as the additional proteins Magoh and Y14.The binding of these proteins to nuclear speckled domains has been measured ...
*  Cantharidic acid
... is a selective inhibitor of PP2A (protein phosphatase 2) and PP1 (protein phosphatase 1). It is the hydrolysis ...
*  REC8
Prior to anaphase, Rec8 is protected from phosphorylation by Protein Phosphatase 2 (PP2A-B56) in mouse. PP2A is recruited to ... Meiotic recombination protein REC8 homolog is a protein that in humans is encoded by the REC8 gene. Rec8 is a meiosis-specific ... The protein localizes to the axial elements of chromosomes during meiosis in both oocytes and spermatocytes. REC8 protein ... Rec8 remains in complex with SMC proteins until anaphase, where it is degraded by Separase once the spindle assembly checkpoint ...
*  PPP2CB
This gene encodes the phosphatase 2A catalytic subunit. Protein phosphatase 2A is one of the four major Ser/Thr phosphatases, ... "A protein phosphatase methylesterase (PME-1) is one of several novel proteins stably associating with two inactive mutants of ... "Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr". FEBS Letters. 401 (2-3): 197-201. doi: ... "p42 MAP kinase phosphorylation sites in microtubule-associated protein tau are dephosphorylated by protein phosphatase 2A1. ...
*  Prokaryotic DNA replication
... which contains multiple binding sites for the initiator protein DnaA (a highly homologous protein amongst bacterial kingdom). ... by inorganic phosphatase) into two phosphates. This hydrolysis drives DNA synthesis to completion. Furthermore, DNA polymerase ... In E. coli these proteins include DiaA, SeqA, IciA, HU, and ArcA-P, but they vary across other bacterial species. A few other ... Meanwhile, several other proteins interact directly with the oriC sequence to regulate initiation, usually by inhibition. ...
*  PPP2R3B
Protein phosphatase 2 (formerly named type 2A) is one of the four major Ser/Thr phosphatases and is implicated in the negative ... Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit beta is an enzyme that in humans is encoded by the ... "Entrez Gene: PPP2R3B protein phosphatase 2 (formerly 2A), regulatory subunit B, beta". Zhou J, Pham HT, Ruediger R, Walter G ( ... Protein phosphatase 2 holoenzymes are heterotrimeric proteins composed of a structural subunit A, a catalytic subunit C, and a ...