A protein isoform, or "protein variant", is a member of a set of highly similar proteins that originate from a single gene or ... While many perform the same or similar biological roles, some isoforms have unique functions. A set of protein isoforms may be ... MeSH entry protein isoforms Definitions Isoform (CS1 errors: missing periodical, Articles with short description, Short ... isoforms represent functional protein products, and the structure of most isoforms in the human proteome has been predicted by ...

... is a protein that in humans is encoded by the RPS4X gene. Ribosomes, organelles that ... This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein ... Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. This gene is not subject to X-inactivation. It has been ... and Y-encoded isoforms of ribosomal protein S4 consistent with a role in Turner syndrome". Nat. Genet. 4 (3): 268-271. doi: ...

... is a protein that in humans is encoded by the RPS4Y1 gene. Cytoplasmic ribosomes, ... This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein ... Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. It has been suggested that haploinsufficiency of the ... and Y-encoded isoforms of ribosomal protein S4 consistent with a role in Turner syndrome". Nat. Genet. 4 (3): 268-71. doi: ...

This gene encodes ribosomal protein S4, a component of the 40S subunit. Ribosomal protein S4 is the only ribosomal protein ... Ribosomal protein S4, Y-linked 2 also known as RPS4Y2 is a protein which in humans is encoded by the RPS4Y2 gene which resides ... Ribosomal protein S4 belongs to the S4E family of ribosomal proteins. It has been suggested that haploinsufficiency of the ... "Entrez Gene: RPS4Y2 ribosomal protein S4, Y-linked 2". Andrés O, Kellermann T, López-Giráldez F, Rozas J, Domingo-Roura X, ...

Isoforms harboring changes in the CDS have been the most thoroughly characterized because they commonly give rise to proteins ... Protein isoform Mitchell PJ, Tjian R (July 1989). "Transcriptional regulation in mammalian cells by sequence-specific DNA ... Four Atf3 isoforms were identified in dorsal root ganglia (DRG) so far. These four isoforms differ in TSS, and one differs in ... UTR compared to the conventional Pten isoform expressed within neurons. The truncated CDS encodes a protein that lacks a ...

... each encoding a protein isoform. Isoform 1, the canonical sequence, has 7 exons. The remaining isoforms are missing various ... NCBI (National Center for Biotechnology Information) Protein entry on Uncharacterized Protein CXorf38 Isoform 1 [1] Wen G, ... "Protein BLAST: search protein databases using a protein query". blast.ncbi.nlm.nih.gov. Retrieved 2019-05-02. "TimeTree: The ... The DUF covers nearly the entire protein. About two-thirds of the secondary protein structure is predicted to consist of alpha ...

The protein has a molecular mass of 32,142 Daltons. There are four protein isoforms. The primary isoform (X1) is 287 amino ... Uncharacterized protein C2orf73 is a protein that in humans is encoded by the C2orf73 gene. The protein is predicted to be ... The PELE tool on Biology Workbench predicts three likely α-helices and one β-strand in the protein. The GPS, NetPhos, MyHits ... Three proteins have been experimentally determined to interact with C2orf73 through Yeast Two-Hybrid experiments. FCH and ...

The c14orf93 protein has 9 isoforms. The most common and largest isoform has 538 AAs, a molecular weight of 58.7 kdal, and a ... C14orf93 is a protein that is encoded in humans by the C14orf93 gene. It is a globular protein with a conserved C-terminus that ... PTP1, tyrosine-protein phosphatase 1, is a protein found in yeast, but there is an ortholog in humans. PTP1 may be responsible ... This protein may be involved in senescence, cell growth, and immortalization. There is a human ortholog to mouse Set protein ( ...

Ochs MJ, Suess B, Steinhilber D (2014). "5-lipoxygenase mRNA and protein isoforms". Basic & Clinical Pharmacology & Toxicology ... ALOX5 binds with the F actin-binding protein, coactin-like protein. Based on in vitro studies, this protein binding serves to ... protein kinase A (PKA), protein kinase C, Cdc2, and/or a Ca2+/calmodulin-dependent protein kinase; b) moves to bind with ... Coactin-like protein (COL1), and Dicer protein A PLAT domain within its C2-like domain; this domain, by analogy to other PLAT ...

"Entrez Gene: ACTA1 actin, alpha 1, skeletal muscle". Bandman E (December 1992). "Contractile protein isoforms in muscle ... Actin, alpha skeletal muscle is a protein that in humans is encoded by the ACTA1 gene. Actin alpha 1 which is expressed in ... Bretscher A, Weber K (July 1980). "Villin is a major protein of the microvillus cytoskeleton which binds both G and F actin in ... SRF may bring a number of other proteins to the promoter of skeletal actin, such as androgen receptor, and thereby contribute ...

Four transcript variants encoding different isoforms have been found for this gene. The protein Numb is coded for by the gene, ... Protein numb homolog is a protein that in humans is encoded by the NUMB gene. The protein encoded by this gene plays a role in ... Numb has demonstrated protein-protein interactions with adaptor-related protein complex 2, alpha 1, Mdm2, L1, DPYSL2, SIAH1, ... The encoded protein, whose degradation is induced in a proteasome-dependent manner by MDM2, is a membrane-bound protein that ...

... has two different isoforms, isoform 1 and 2. These two isoforms encode the same protein. Isoform 2 uses an alternate in- ... The LSMEM2 protein has two isoforms. Isoform 1 has an alanine added after amino acid 57, otherwise the two isoforms are ... "leucine-rich single-pass membrane protein 2 isoform 1 [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2020-04 ... "leucine-rich single-pass membrane protein 2 isoform 2 [Homo sapiens] - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2020-04 ...

There are 2 protein isoforms for FAM155B. Isoform 1 is 340 amino acids long while isoform 2 is composed of 292 amino acids. ... The FAM155B gene has 2 known isoforms. The transcript of isoform 1 is 4685 bp long with a coding sequence of 1022 bp. It has a ... The transcript of isoform 2 is much shorter at 975 bp with a coding sequence of 878 bp. It also has a 5' UTR of 79 bp, but the ... The protein sequence of FAM155B is 472 amino acids long. The molecular weight is predicted to be 52.5 kDa and the isoelectric ...

The protein is expressed as different isoforms. AKNA is known to upregulate expression of the receptor CD40 and its ligand ... AKNA is a protein that in humans is encoded by the AKNA gene. The protein is an AT-hook transcription factor which contains an ... "AKNA - Microtubule organization protein AKNA - Homo sapiens (Human) - AKNA gene & protein". www.uniprot.org. Retrieved 2020-05- ... "AKNA protein expression summary - The Human Protein Atlas". www.proteinatlas.org. Retrieved 2020-05-01. "AKNA Gene - GeneCards ...

Weide T, Teuber J, Bayer M, Barnekow A (Jun 2003). "MICAL-1 isoforms, novel rab1 interacting proteins". Biochemical and ... Ras-related protein Rab-1A is a protein that in humans is encoded by the RAB1A gene. RAB1A has been shown to interact with: ... Weide T, Teuber J, Bayer M, Barnekow A (Jun 2003). "MICAL-1 isoforms, novel rab1 interacting proteins". Biochemical and ... "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome ...

Weide T, Teuber J, Bayer M, Barnekow A (Jun 2003). "MICAL-1 isoforms, novel rab1 interacting proteins". Biochemical and ... The golgins are a family of proteins, of which the protein encoded by this gene is a member, that are localized to the Golgi. ... Golgin subfamily A member 2, also known as 130 kDa cis-Golgi matrix protein 1 (GM130) is a protein that in humans is encoded by ... "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode:2005Natur. ...

There are two isoforms of the protein. Confusingly, it is also sometimes referred to as SMAD8 in the literature. The SMAD ... proteins are homologs of both the drosophila protein, mothers against decapentaplegic (MAD) and the C. elegans protein SMA. The ... Developmental genes and proteins, MH1 domain, MH2 domain, R-SMAD, Transcription factors, Human proteins, All stub articles, ... Mothers against decapentaplegic homolog 9 also known as SMAD9, SMAD8, and MADH6 is a protein that in humans is encoded by the ...

Weide T, Teuber J, Bayer M, Barnekow A (2003). "MICAL-1 isoforms, novel rab1 interacting proteins". Biochem. Biophys. Res. ... NEDD9-interacting protein with calponin homology and LIM domains is a protein that in humans is encoded by the MICAL1 gene. ... "MICAL-1 isoforms, novel rab1 interacting proteins". Biochem. Biophys. Res. Commun. United States. 306 (1): 79-86. doi:10.1016/ ... Fischer J, Weide T, Barnekow A (2005). "The MICAL proteins and rab1: a possible link to the cytoskeleton?". Biochem. Biophys. ...

Weide T, Teuber J, Bayer M, Barnekow A (2003). "MICAL-1 isoforms, novel rab1 interacting proteins". Biochem. Biophys. Res. ... 2004). "Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation ...

Alternative splicing results in two protein isoforms. DIAPH2 has been shown to interact with RhoD. GRCh38: Ensembl release 89: ... Protein diaphanous homolog 2 is a protein that in humans is encoded by the DIAPH2 gene. This gene may play a role in the ... Satoh S, Tominaga T (2001). "mDia-interacting protein acts downstream of Rho-mDia and modifies Src activation and stress fiber ... Eisenmann KM, Harris ES, Kitchen SM, Holman HA, Higgs HN, Alberts AS (2007). "Dia-interacting protein modulates formin-mediated ...

There are two isoforms of the CCDC138 protein. The primary isoform has 665 amino acids while the secondary isoform has 577 ... Figure shows the pairwise sequence alignment comparing the primary isoform (Isoform 1) to the secondary isoform (Isoform 2). A ... The CCDC138 protein has been found to interact with ubiquitin C, a protein involved in ubiquination and eventually protein ... Coiled-coil domain-containing protein 138, also known as CCDC138, is a human protein encoded by the CCDC138 gene. The exact ...

... isoform 2, containing 5 exons and encoding a shorter protein (468 amino acids in length); and isoform 3, containing 6 exons and ... allowing the CAS protein to function as a scaffold for other proteins including CRK proteins and C3G, a guanine nucleotide ... There are three protein isoforms of human Efs. hEfs1 and hEfs2 were identified by Ishino et al. hEFS1 (561 aa) represents the ... In humans, the 561 amino acid EFS protein acts as a scaffolding protein for cell signaling based on interactions with SRC, FAK ...

Also present are three protein isoforms of transferrin; transferrin binds serum iron (Fe3+), which makes the environment less ... These proteins are directly toxic on muscle tissue due to their sheer volume in the venom, and are destructive to cell ... The venom has multiple proteins with antibiotic activity, including two L-amino-acid oxidases (LAO1 and LAO2) that exhibit ... Pseudechetoxin and pseudecin are two proteins that block cyclic nucleotide-gated ion channels, including those present in ...

There are two known isoforms of this protein. The SMAD proteins are homologs of both the drosophila protein, mothers against ... SMAD family member 6, also known as SMAD6, is a protein that in humans is encoded by the SMAD6 gene. SMAD6 is a protein that, ... Developmental genes and proteins, MH1 domain, MH2 domain, Human proteins, All stub articles, Human chromosome 15 gene stubs, ... It acts as a regulator of TGFβ family (such as bone morphogenetic proteins) activity by competing with SMAD4 and preventing the ...

Bruikman CS, Zhang H, Kemper AM, van Gils JM (2019-02-24). "Netrin Family: Role for Protein Isoforms in Cancer". Journal of ... Netrin-5 (NTN5), also known as netrin-1-like protein, is a protein that in humans is encoded by the NTN5 gene. Netrin-5 is ... included in the family of secreted laminin-related proteins. Netrin-5 functions are not fully clarified. However, it is ...

Table 3. Table of WDCP protein Isoforms and Protein Information. The secondary structure of WDCP Protein Isoform 1 consists of ... Protein sequence of WDCP protein isoform 1. Compositional analysis of WDCP Isoform 1 shows no extremely high or low levels of ... The protein sequence for WDCP Protein Isoform 1 is shown below. 1 MELGKGKLLR TGLNALHQAV HPIHGLAWTD GNQVVLTDLR LHSGEVKFGD ... Close orthologs of WDCP Isoform 1 have shown similar results for orthologous proteins, where the protein is most likely located ...

Ziat, Esma; Bertrand, Anne T. (2015-01-01). "FHL1 protein isoforms in Emery-Dreifuss muscular dystrophy". Orphanet Journal of ... Protein structures Protein LMNA Protein EMD Protein FHL1 Genetic mutations causing EDMD affect proteins comprising the nuclear ... Each gene implicated in EDMD provides instructions for making a protein that is associated with the nuclear envelope, which ... Possibly, in all EDMD subtypes there is impaired protein importation into the nucleus. Another possibility is that in all ...

... has three known protein isoforms (Table 2). Isoform 1 is the largest and most abundant. Isoforms of NOXRED1. ... "NADP-dependent oxidoreductase domain-containing protein 1 isoform X2 [ - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022- ... "NADP-dependent oxidoreductase domain-containing protein 1 isoform X3 [ - Protein - NCBI". www.ncbi.nlm.nih.gov. Retrieved 2022- ... The primary isoform is 2324 bases in length and is composed of 6 exons. Isoform 2 and Isoform 3 are 1773 and 1770 nucleotides ...

... the proteins they interact with in a specific area of the nucleus, or the specific PML protein isoforms of which they are ... yielding more than 15 known PML protein isoforms. While the isoforms vary at their C-terminal domain, they all contain a ... is the protein product of the PML gene. PML protein is a tumor suppressor protein required for the assembly of a number of ... Jensen K, Shiels C, Freemont PS (October 2001). "PML protein isoforms and the RBCC/TRIM motif". Oncogene. 20 (49): 7223-33. doi ...

There are three isoforms of the FGFR1OP2 protein. Transcript variant 1 consists of 253 amino acids and weighs 29.4 kilodaltons ... The table below shows the protein orthologs to the Homo sapiens FGFR1OP2 protein. FGFR1OP2 is conserved in all clades of the ... No structural models for the Homo sapiens FGFR1OP2 protein could be found, but the Mus musculus FGFR1OP2 protein's structure ... Ortholog mRNA and protein sequences were found using NCBI's BLAST and UCSC's BLAT Tool. The accession numbers, as well as the ...

Chemical optimization and detection of distinct protein isoforms". Analytical Chemistry. 81 (9): 3314-20. doi:10.1021/ac802513n ... Affimer proteins display two peptide loops that can all be randomized to bind to desired target proteins, in a similar manner ... Affimers that inhibit protein-protein interactions can be produced with the potential to express these inhibitors in mammalian ... Affimer molecules are small proteins that bind to target proteins with affinity in the nanomolar range. These engineered non- ...

Three isoforms of desmocollin proteins have been identified. Desmocollin-1, coded by the DSC1 gene Desmocollin-2, coded by the ... The '2' and '3' isoforms of desmocollin and desmoglein are expressed in the lower epidermal layers, and the '1' proteins and ... Different isoforms are located in the same individual cells, and single desmosomes contain more than one isoform of both ... Bank, RCSB Protein Data. "RCSB PDB - 5IRY: Crystal structure of human Desmocollin-1 ectodomain". www.rcsb.org. Retrieved 2020- ...