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*  Protein primary structure
"Normalization of nomenclature for peptide motifs as ligands of modular protein domains". FEBS Letters. 513 (1): 141-144. doi: ... additional molecular interactions may render the amide form less stable; the amino group is expelled instead, resulting in an ... Protein primary structure is the linear sequence of amino acids in a peptide or protein. By convention, the primary structure ... The protein is activated by cleaving off the inhibitory peptide. Some proteins even have the power to cleave themselves. ...
*  BTB/POZ domain
Bardwell VJ, Treisman R (July 1994). "The POZ domain: a conserved protein-protein interaction motif". Genes Dev. 8 (14): 1664- ... domain is present near the N-terminus of a fraction of zinc finger proteins and in proteins that contain the Kelch motif and a ... The BTB/POZ domain is a common structural domain contained within some proteins. The BTB (for BR-C, ttk and bab) or POZ (for ... BTB/POZ domains from several zinc finger proteins have been shown to mediate transcriptional repression and to interact with ...
*  Zinc finger and BTB domain-containing protein 16
1996). "Amino-terminal protein-protein interaction motif (POZ-domain) is responsible for activities of the promyelocytic ... Zinc finger and BTB domain-containing protein 16 is a protein that in humans is encoded by the ZBTB16 gene. This gene is a ... Zinc finger and BTB domain-containing protein 16 has been shown to interact with: Angiotensin II receptor type 1, BCL6, BMI1, ... Tsuzuki S, Enver T. "Interactions of GATA-2 with the promyelocytic leukemia zinc finger (PLZF) protein, its homologue FAZF, and ...
*  Kruppel-like factors
... which allow for similar function due to similar protein interaction motifs at the N-terminal domains. The C-terminal end is ... KLFs 15 and 17 are distantly related without any defined protein interaction motifs. The proliferation of KLF genes, presumably ... are repressors via interaction with the C-terminal Binding Protein 1 and 2 (CtBP1 and CtBP2). Group 2 (KLFs 1,2,4,5,6, and 7) ... in endothelial cells and cGMP-dependent protein kinase 1α/protein kinase G 1α (PKG 1α) in VSMCs. PKG 1α is activated by NO and ...
*  LDB3
ZASP is a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino ... "Protein-protein interaction of zinc finger LIM domains with protein kinase C". The Journal of Biological Chemistry. 271 (49): ... LIM domain binding 3 (LDB3), also known as Z-band alternatively spliced PDZ-motif (ZASP), is a protein which in humans is ... The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also ...
*  BCAR1
... multiple protein interaction domains and phosphorylation motifs through which Cas family members can recruit effector proteins ... of adaptor proteins which is characterized by the presence of multiple conserved motifs for protein-protein interactions, and ... This acts as a protein-interaction motif, similar to those found in other adhesion-related proteins such as focal adhesion ... domain, followed by a proline-rich domain (PRR) and a substrate domain (SD). The substrate domain consists of 15 repeats of the ...
*  Power graph analysis
Network compression, a new measure derived from Power Graphs, has been proposed as a quality measure for protein interaction ... domain-peptide binding motifs, Gene regulatory networks and Homology/Paralogy networks. Also a network of significant disease- ... has been shown to be useful for the analysis of several types of biological networks such as Protein-protein interaction ... This transformation changes the point of view from time domain to frequency domain and enables many interesting applications in ...
*  MED26
"A sequence motif conserved in diverse nuclear proteins identifies a protein interaction domain utilised for nuclear targeting ... The 80 or so N-terminal residues form a protein interaction domain containing a conserved motif, which has been called the LW ... This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which ... PIBP, a small hypothetical protein that could be a phosphoinositide binding protein. IWS1, which is thought to function in both ...
*  DISC1
The presence or absence of certain protein interaction domains or targeting motifs may confer specific functions and influence ... This data suggests a direct DISC1 GSK3/β-catenin interaction. DISC1 functions through a rich protein-protein interaction ... The protein encoded by this gene is predicted to contain a coiled coil motif rich C-terminal domain, and a N-terminal globular ... and two leucine zippers that may mediate protein-protein interactions. The protein locates to the nucleus, centrosome, ...
*  Zinc finger protein 208
A conserved protein motif, termed the Kruppel-associated box (KRAB) domain, mediates protein-protein interactions (Eichler et ... Zinc finger protein 208 is a protein that in humans is encoded by the ZNF208 gene. Zinc finger proteins (ZNFs), such as ZNF208 ... This article incorporates text from the United States National Library of Medicine, which is in the public domain.. ... Most ZNFs contain conserved C2H2 motifs and are classified as Kruppel-type zinc fingers. ...
*  Death fold
This motif is commonly found in domains that participate in protein-protein interactions leading to the formation of large ... In these interactions death-folds bind to another death-fold containing domain through the same type of protein interaction ... Examples of death fold domains include the death domain (DD), death effector domain (DED), Caspase Recruitment Domain (CARD), ... The motifs consist of several defined protein interactions with other suspected apoptotic roles (Lahm). Caspase recruitment ...
*  Ankyrin repeat
Domains consisting of ankyrin repeats mediate protein-protein interactions and are among the most common structural motifs in ... These domains are one of the most common protein-protein interaction platforms in nature. They occur in a large number of ... and involved mainly in mediating protein-protein interactions. An artificial protein design based on a consensus sequence ... Ankyrin repeat proteins, though absent in most viruses, are common among poxviruses. Most proteins that contain the motif have ...
*  Short linear motif
... finding short linear motifs on domain interaction interfaces in Protein Data Bank". Bioinformatics. 26 (8): 1036-1042. doi: ... Linear Motifs or minimotifs) are short stretches of protein sequence that mediate protein protein interaction. The first ... Linear motif mediated protein-protein interactions have shown promise in recent years as novel drug targets. Success stories ... A protein-protein interaction database for PDZ-domains". Bioinformatics. 21 (6): 827-828. doi:10.1093/bioinformatics/bti098. ...
*  ADAMTS7
... type 1 motifs, one cysteine-rich and spacer domain, and other domains specific to certain ADAMTS proteins. ADAMTS7 in ... particular possesses 8 TSP type 1 motifs which, together with its spacer domain, participate in the protein's tight interaction ... As an ADAMTS protein, ADAMTS7 contains a shared proteinase domain and an ancillary domain. The proteinase domain can be further ... Unlike the proteinase domain, the ancillary domain varies by ADAMTS protein and includes any number of thrombospondin (TSP) ...
*  EIF2C2
"A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain". Nat. ... The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with Dicer1 and play a role ... 2004). "Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer". EMBO Rep. 5 (2): 189-94. ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. doi:10.1038 ...
*  TNRC6B
"A conserved motif in Argonaute-interacting proteins mediates functional interactions through the Argonaute PIWI domain". Nat. ... Trinucleotide repeat-containing gene 6B protein is a protein that in humans is encoded by the TNRC6B gene. TNRC6B has been ... It is also known to associate with argonaute proteins and has been shown to be required for miRNA-guided gene silencing in HeLa ... The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro". DNA Res. 6 (3): 197-205. doi: ...
*  NDH-2
... with the characteristic GxGxxG motif present. The third domain, C-terminal, is responsible for the protein-membrane interaction ... The structure/fold from these proteins may be divided into three domains: first dinucleotide binding domain (green in the ... figure), second dinucleotide binding domain (orange in the figure) and C-terminal domain (blue in the figure). The first domain ... The third domain, together with part of the first domain, is also partially responsible for the binding of the electron ...
*  Synaptotagmin 1
... synaptic protein interaction) motif of the pore-forming subunit of voltage-gated calcium channels. The C2B domain regulates ... Ca2+-binding alters the protein-protein interactions of synaptotagmin such as increasing the affinity of synaptotagmin for ... Ca2+-independent is the interaction between the C2B domain and SNAP-25, and between the C2B domain and the "synprint" ( ... The C2 domain is a widely occurring conserved sequence motif of 130-140 amino acid residues, which was first defined as the ...
*  Epstein-Barr virus latent membrane protein 2
The 119 amino-terminal cytoplasmic domain of LMP2A has several motifs that mediate interactions between proteins, including ... "The Epstein-Barr virus latent membrane protein 2A PY motif recruits WW domain-containing ubiquitin-protein ligases". Virology. ... Epstein-Barr virus (EBV) latent membrane protein 2 (LMP2) are two viral proteins of the Epstein-Barr virus. LMP2A/LMP2B are ... The N-terminus domain of LMP2A is tyrosine phosphorylated and associates with Src family protein tyrosine kinases (PTKs) as ...
*  ABCA1
The ABCA1 c-terminus contains a PDZ domain, responsible for mediating protein-protein interactions, as well as a VFVNFA motif ... "Molecular and functional interaction of the ATP-binding cassette transporter A1 with Fas-associated death domain protein". J. ... Since this protein is needed throughout the body it is expressed ubiquitously as a 220-kDa protein. It is present in higher ... also known as the cholesterol efflux regulatory protein (CERP) is a protein which in humans is encoded by the ABCA1 gene. This ...
*  NEDD4
The WW domains interact with proline rich PPxY motifs in target proteins to mediate interactions with substrates and adaptors. ... 3-4 WW protein-protein interaction domains, and a carboxyl-terminal catalytic HECT ubiquitin ligase domain. The C2 domain ... The NDFIP1 and NDFIP2 proteins function as adaptor proteins that can facilitate NEDD4 binding to substrates that lack PY motifs ... all of which vary in the C2 domain but share 100% identity from the first WW domain through to the end of the protein. The ...
*  Myogenic regulatory factors
These proteins contain a conserved basic DNA binding domain that binds the E box DNA motif. They dimerize with other HLH ... containing proteins through an HLH-HLH interaction. Perry R, Rudnick M (2000). "Molecular mechanisms regulating myogenic ... Barndt R, Zhuang Y (1999). "Controlling lymphopoiesis with a combinatorial E-protein code". Cold Spring Harb Symp Quant Biol. ...
*  STIM2
EF-hand Ca2+-binding motif discovered recently and a sterile a-motif (SAM) domain, a well-known protein-protein interaction ... domain that contains two coiled-coil domains. The coiled-coil domains mediate interactions between STIM proteins, allowing them ... "SAM as a protein interaction domain involved in developmental regulation". Protein Science. 6 (1): 249-53. doi:10.1002/pro. ... No additional STIM-like proteins have been identified until now in vertebrates. STIM2 protein is a type I transmembrane protein ...
*  GPRC5A
... characterized by the signature 7-transmembrane domain motif. The encoded protein may be involved in interaction between ... Retinoic acid-induced protein 3 is a protein that in humans is encoded by the GPRC5A gene. This gene encodes a member of the ... "Entrez Gene: GPRC5A G protein-coupled receptor, family C, group 5, member A". Zhou H, Rigoutsos I (2014). "MiR-103a-3p targets ... Tao Q, Cheng Y, Clifford J, Lotan R (2004). "Characterization of the murine orphan G-protein-coupled receptor gene Rai3 and its ...
*  Sorting nexin
... a phospholipid-binding motif) or through protein-protein interactions with membrane-associated protein complexes Some members ... BAR_3_WASP_bdg: WASP-binding domain of Sorting nexin protein, Pfam PF10456 PXA: PXA domain, Pfam PF02194 MIT: MIT (microtubule ... N-terminal domain PX domain CTD - C-terminal BAR domain Bravo J, Karathanassis D, Pacold CM, et al. (October 2001). "The ... domain, Pfam PF00788 FERM_M: FERM central domain, Pfam PF00373 SMAD_FHA: SMAD/FHA domain, InterPro: IPR008984 Sorting Nexins at ...
*  Phage display
... is a laboratory technique for the study of protein-protein, protein-peptide, and protein-DNA interactions that ... The N2 domain binds to the F pilus during virion infection freeing the N1 domain which then interacts with a TolA protein on ... "Comparison of bacterial and phage display peptide libraries in search of target-binding motif". Appl. Biochem. Biotechnol. 127 ... characterize small molecules-protein interactions and map protein-protein interactions. Users can use three dimensional ...
*  Cingulin
Most of cingulin protein interactions are through the globular head domain. Cingulin interacts with ZO-1 through an N-terminal ... ZO-1 interacting motif (ZIM) in its head region. The rod domain is involved in dimerization and interaction with the RhoA ... and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization". ... domain, a long α-helical coiled-coil "rod" domain and a small globular C-terminal "tail" region. This organization is highly ...