... by changing the turnover kinetics of the focal adhesion proteins. The relationship between forces on focal adhesions and their ... MBInfo - Focal Adhesion MBInfo - Focal Adhesion Assembly MBInfo - Regulation of Focal Adhesion Assembly AdhesomeFAnetwork ... However, some focal complexes mature into larger and stable focal adhesions, and recruit many more proteins such as zyxin. ... both the composition and the morphology of the focal adhesion change. Initially, small (0.25μm²) focal adhesions called focal ...

... where he continued to work on focal adhesions. He discovered talin (protein) as another focal adhesion protein and then, in ... His research on focal adhesions includes the discovery of many adhesion proteins including vinculin, talin and paxillin, and ... Focal adhesions as production sites of intracellular signals Geiger B (September 1979). "A 130K protein from chicken gizzard: ... Since these regions would several years later be named focal adhesions, α-actinin was the first protein found to be ...

Focal adhesion targeting (FAT) domain The FAT-like C-terminal domain is highly conserved in focal adhesion proteins, and ... Hayashi I, Vuori K, Liddington RC (2002). "The focal adhesion targeting (FAT) region of focal adhesion kinase is a four-helix ... In interphase cells, the majority of NEDD9 localizes to focal adhesions. However, some of the protein is also cytoplasmic, and ... Integrins are transmembrane proteins that nucleate focal adhesions, structures that provide bi-directional signaling between ...

Caltagarone J, Jing Z, Bowser R (Apr 2007). "Focal adhesions regulate Abeta signaling and cell death in Alzheimer's disease". ... Amyloid-beta precursor protein is an ancient and highly conserved protein. In humans, the gene APP is located on chromosome 21 ... Amyloid-beta precursor protein (APP) is an integral membrane protein expressed in many tissues and concentrated in the synapses ... Chauhan VP, Ray I, Chauhan A, Wisniewski HM (May 1999). "Binding of gelsolin, a secretory protein, to amyloid beta-protein". ...

A protein tyrosine kinase called pp125, also referred to as focal adhesion kinase (FAK) is likely at hand in the influence of ... Tyrosine Phosphate ATP Protein tyrosine kinase proteins contain a Protein kinase domain, which consists of an N-terminal lobe ... cellular focal adhesions, as indicated by an immunofluorescent localization of FAK. Focal adhesions are macromolecular ... "pp125FAK a structurally distinctive protein-tyrosine kinase associated with focal adhesions". Proceedings of the National ...

November 1997). "Fluid shear stress activation of focal adhesion kinase. Linking to mitogen-activated protein kinases". The ... Genetic analysis indicated that CDC25 is essential for activation of RAS proteins. In Drosophila, the protein encoded by the ' ... Oneyama C, Nakano H, Sharma SV (March 2002). "UCS15A, a novel small molecule, SH3 domain-mediated protein-protein interaction ... the guanine nucleotide exchange protein Sos and a 75-kDa protein that is a substrate for T cell antigen receptor-activated ...

These interactions allow DLC1 to co-localize along with these proteins to focal adhesions at the periphery of the cell, where ... The activity of RhoA regulates the formation of actin stress fibers and focal adhesions - complexes of many proteins located at ... DLC1 is also involved in the formation of focal adhesions, so loss of DLC1 leads to reduced cell adhesion and increased ... dephosphorylation of FAK ultimately leads to an increase in focal adhesion turnover and cellular adhesion, and inhibition of ...

... a focal adhesion protein phosphorylated by P210BCR/ABL". The Journal of Biological Chemistry. 270 (10): 5039-47. doi:10.1074/ ... "Interaction of focal adhesion kinase with cytoskeletal protein talin". The Journal of Biological Chemistry. 270 (28): 16995-9. ... and to focal adhesions in smooth muscle and non-muscle cells. Talin-1 functions to mediate cell-cell adhesion via the linkage ... "Monocyte cells and cancer cells express novel paxillin isoforms with different binding properties to focal adhesion proteins". ...

"Interaction of focal adhesion kinase with cytoskeletal protein talin". The Journal of Biological Chemistry. 270 (28): 16995-9. ... It belongs to the talin protein family. This gene encodes a protein related to talin 1, a cytoskeletal protein that plays a ... "Differential regulation of Pyk2 and focal adhesion kinase (FAK). The C-terminal domain of FAK confers response to cell adhesion ... Shoeman RL, Hartig R, Hauses C, Traub P (2002). "Organization of focal adhesion plaques is disrupted by action of the HIV-1 ...

The following proteins have been used in split protein PCAs: Beta-lactamase Dihydrofolate reductase (DHFR) Focal adhesion ... Ma Y, Nagamune T, Kawahara M (September 2014). "Split focal adhesion kinase for probing protein-protein interactions". ... since the bait protein can be used to identify a prey protein, see figure). The protein that produces a detectable readout is ... "Genome-wide protein-protein interaction screening by protein-fragment complementation assay (PCA) in living cells". Journal of ...

... form focal adhesions with the substratum, linking them to the cell surface. Many types of migrating cells display ... A study deploying protein imaging of adult mice showed that filopodia in the explored regions were by an order of magnitude ... Khurana S, George SP (September 2011). "The role of actin bundling proteins in the assembly of filopodia in epithelial cells". ... Rho activity also results in activation by phosphorylation of ezrin-moesin-radixin family proteins that link actin filaments to ...

So the focal adhesions contain integrin ligand, integrin molecule, and associate plaque proteins. Binding is propelled by ... Focal adhesions are large molecular complexes, which are generated following interaction of integrins with ECM, then their ... In a reverse direction, when a receptor tyrosine kinase is activated, integrins co-localise at focal adhesion with the receptor ... These act by regulating kinases such as FAK (focal adhesion kinase) and Src kinase family members to phosphorylate substrates ...

It disrupts focal adhesions in fibroblasts. It also regulates the proliferation of some cells, especially endothelial cells, ... Osteonectin (ON) also known as secreted protein acidic and rich in cysteine (SPARC) or basement-membrane protein 40 (BM-40) is ... Extracellular matrix proteins, Matricellular proteins, Genes mutated in mice). ... This protein is synthesized by macrophages at sites of wound repair and platelet degranulation, so it may play an important ...

... the focal adhesion targeting domain is a conserved protein domain that was first identified in focal adhesion kinase (FAK), ... Hayashi I, Vuori K, Liddington RC (February 2002). "The focal adhesion targeting (FAT) region of focal adhesion kinase is a ... also known as PTK2 protein tyrosine kinase 2 (PTK2). Focal adhesions are multi-protein intracellular signalling complexes that ... Focal adhesions form and dissipate as cells attach and detach from matrix during cell adhesion and cell migration. The FAK ...

"A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading". The Journal ... Zhang Y, Chen K, Guo L, Wu C (October 2002). "Characterization of PINCH-2, a new focal adhesion protein that regulates the ... In mammals ILK lacks catalytic activity but supports scaffolding protein functions for focal adhesions. In plants, ILKs signal ... Velyvis A, Yang Y, Wu C, Qin J (February 2001). "Solution structure of the focal adhesion adaptor PINCH LIM1 domain and ...

Kuo, J. C.; Han, X.; Yates Jr, 3rd; Waterman, C. M. (2012-01-01). Shimaoka, Motomu (ed.). Isolation of Focal Adhesion Proteins ... "Analysis of the myosin-II-responsive focal adhesion proteome reveals a role for β-Pix in negative regulation of focal adhesion ... they localize to a cell adhesion structure such as focal adhesion or adherens junction. 2. they directly interact with one of ... which mediate specific protein-protein binding. The literature-based adhesome contains enzymes, such as protein tyrosine and ...

"Regulation of focal adhesion kinase by a novel protein inhibitor FIP200". Molecular Biology of the Cell. 13 (9): 3178-91. doi: ... RB1-inducible coiled-coil protein 1 is a protein that in humans is encoded by the RB1CC1 gene. RB1CC1 has been shown to ... "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3 (1): 89. doi: ... Hara T, Takamura A, Kishi C, Iemura S, Natsume T, Guan JL, Mizushima N (May 2008). "FIP200, a ULK-interacting protein, is ...

... also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by the PTK2 gene. PTK2 is a focal adhesion- ... a tyrosine phosphorylated focal adhesion-associated protein binds to the carboxyl terminal domain of focal adhesion kinase". ... Lineage for Protein: Focal adhesion kinase 1 Q00944 "Entrez Gene: PTK2 PTK2 protein tyrosine kinase 2". Guan JL, Shalloway D ( ... within focal adhesions-but not in the cytoplasm-and therefore is thought to require interaction with focal adhesion proteins, ...

Lavelin I, Geiger B (Feb 2005). "Characterization of a novel GTPase-activating protein associated with focal adhesions and the ... "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs". Genome ... Rho GTPase-activating protein 24 is an enzyme that in humans is encoded by the ARHGAP24 gene. GRCh38: Ensembl release 89: ... "Entrez Gene: ARHGAP24 Rho GTPase activating protein 24". Human ARHGAP24 genome location and ARHGAP24 gene details page in the ...

Normal FAK is a tyrosine kinase that gets recruited to focal adhesion sites and plays a key role in directed cell movement. ... The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. ... This family also includes Abl, Src, focal adhesion kinase and Janus kinase.) Fyn is located downstream of several cell surface ... Tyrosine phosphorylation of target proteins by Fyn serves to either regulate target protein activity, and/or to generate a ...

"Cell-cycle-dependent association of protein phosphatase 1 and focal adhesion kinase". Biochem. J. 358 (Pt 2): 407-14. doi: ... The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/ ... 2001). "Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs ... "The human SNF5/INI1 protein facilitates the function of the growth arrest and DNA damage-inducible protein (GADD34) and ...

This protein localizes to focal adhesion sites and along actin stress fibers. Recruitment of this protein to the plasma ... "A nuclear isoform of the focal adhesion LIM-domain protein Trip6 integrates activating and repressing signals at AP-1- and NF- ... "The zyxin-related protein TRIP6 interacts with PDZ motifs in the adaptor protein RIL and the protein tyrosine phosphatase PTP- ... Thyroid receptor-interacting protein 6 is a protein that in humans is encoded by the TRIP6 gene. This gene is a member of the ...

January 1998). "Cell adhesion kinase beta forms a complex with a new member, Hic-5, of proteins localized at focal adhesions". ... Thomas SM, Hagel M, Turner CE (January 1999). "Characterization of a focal adhesion protein, Hic-5, that shares extensive ... Thomas SM, Hagel M, Turner CE (January 1999). "Characterization of a focal adhesion protein, Hic-5, that shares extensive ... Thomas SM, Hagel M, Turner CE (January 1999). "Characterization of a focal adhesion protein, Hic-5, that shares extensive ...

... focal adhesions are quite more than simple anchors - their proteins have many roles in signaling. These proteins, such as focal ... a reduction in focal adhesion tension by transferring cells to softer ECM or by inhibiting ROCK results in focal adhesion ... The focal adhesion proteins (FAK/paxillin/vinculin) - and their phosphorylation-dependent interactions as well as their ... The site of cellular contact with the extracellular matrix is the focal adhesion, a large, dynamic protein complex that ...

Degenhardt YY, Silverstein S (2001). "Interaction of Zyxin, a Focal Adhesion Protein, with the E6 Protein from Human ... and characterization of a zyxin-related protein that binds the focal adhesion and microfilament protein VASP (vasodilator- ... Zyxin is a protein that in humans is encoded by the ZYX gene. Focal adhesions are actin-rich structures that enable cells to ... "Regulation of human endothelial cell focal adhesion sites and migration by cGMP-dependent protein kinase I". J. Biol. Chem. 275 ...

"Protein tyrosine phosphatase-PEST regulates focal adhesion disassembly, migration, and cytokinesis in fibroblasts". J. Cell ... "Stromal cell-derived factor-1alpha stimulates tyrosine phosphorylation of multiple focal adhesion proteins and induces ... Calalb MB, Polte TR, Hanks SK (1995). "Tyrosine phosphorylation of focal adhesion kinase at sites in the catalytic domain ... Adapter molecule crk also known as proto-oncogene c-Crk is a protein that in humans is encoded by the CRK gene. The CRK protein ...

Coutts AS, MacKenzie E, Griffith E, Black DM (March 2003). "TES is a novel focal adhesion protein with a role in cell spreading ... Protein enabled homolog is a protein that in humans is encoded by the ENAH gene. ENAH has been shown to interact with ABI1, ZYX ... April 2003). "The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions". The Journal of ... SLP-76-associated protein (SLAP), Ena/vasodilator-stimulated phosphoprotein (VASP) proteins and the Arp2/3 complex link T cell ...

Zhang Y, Chen K, Tu Y, Wu C (2004). "Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins ... Olski TM, Noegel AA, Korenbaum E (Feb 2001). "Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily ... "Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans". Gene. 279 (1 ... Members of the parvin family, including PARVB, PARVA and PARVG, are actin-binding proteins associated with focal contacts.[ ...

2001). "A new focal adhesion protein that interacts with integrin-linked kinase and regulates cell adhesion and spreading". J. ... a new focal adhesion protein that binds paxillin LD motifs and actin and regulates cell adhesion". J. Cell Biol. 151 (7): 1435- ... Zhang Y, Chen K, Tu Y, Wu C (2004). "Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins ... Olski TM, Noegel AA, Korenbaum E (Feb 2001). "Parvin, a 42 kDa focal adhesion protein, related to the alpha-actinin superfamily ...

Coutts AS, MacKenzie E, Griffith E, Black DM (2003). "TES is a novel focal adhesion protein with a role in cell spreading". J. ... Actin-like protein 7A is a protein that in humans is encoded by the ACTL7A gene. The protein encoded by this gene is a member ... 2003). "The conformational state of Tes regulates its zyxin-dependent recruitment to focal adhesions". J. Cell Biol. 161 (1): ... 2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. Bibcode: ...