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*  Coagulation factor II receptor
... receptor is a protein that in humans is encoded by the F2R gene. PAR1 is a G protein-coupled receptor involved in the ... Offermanns S, Laugwitz KL, Spicher K, Schultz G (Jan 1994). "G proteins of the G12 family are activated via thromboxane A2 and ... Ogino Y, Tanaka K, Shimizu N (Nov 1996). "Direct evidence for two distinct G proteins coupling with thrombin receptors in human ... A novel mechanism for resensitization of a G protein-coupled receptor". The Journal of Biological Chemistry. 269 (44): 27719-26 ...
*  Factor X
Contributions of protein-protein and protein-membrane interactions toward complex formation". The Journal of Biological ... The affinity of this protein for factor Xa is increased 1000-fold by the presence of protein Z, while it does not require ... Defects in protein Z lead to increased factor Xa activity and a propensity for thrombosis. The half life of factor X is 40-45 ... In stage 1, Factor VII binds to the transmembrane protein TF on the surface of cells and is converted to Factor VIIa. The ...
*  Scott syndrome
A candidate protein, scramblase, that may be involved in this process appears to be normal in Scott syndrome platelets. Other ... Thromb Haemost 2001; 86:266-275 Zhou Q, Sims PJ, Wiedmer T. Expression of proteins controlling transbilayer movement of plasma ... A novel missense mutation in ABCA1 results in altered protein trafficking and reduced phosphatidylserine translocation in a ... Scott syndrome erythrocytes contain a membrane protein capable of mediating Ca2+-dependent transbilayer migration of membrane ...
*  Factor V Leiden
Activated protein C (aPC) is a natural anticoagulant that acts to limit the extent of clotting by cleaving and degrading factor ... This is done by running two tests simultaneously; one test is run in the presence of activated protein C (APC) and the other, ... The condition results in a factor V variant that cannot be as easily degraded by aPC (activated Protein C). The gene that codes ... As a missense substitution of base G to base A, it changes the protein's amino acid from arginine to glutamine. Depending on ...
*  Thrombophilia
... protein C (which inhibits factors Va and VIIIa in the presence of protein S), and protein Z (which inhibits factor Xa). In ... of people with protein C deficiency and about a third of those with protein S deficiency. People with activated protein C ... Protein C and protein S deficiency have also been associated with an increased risk of skin necrosis on commencing ... The main ones are antithrombin III deficiency, protein C deficiency and protein S deficiency. Milder rare congenital ...
*  Discovery and development of direct thrombin inhibitors
... such as requiring intravenous administration and having a variable dose-response curve due to substantial protein binding. In ...
*  Discovery and development of direct Xa inhibitors
Antistasin is a protein made up of 119 amino acid residues, of which 20 are cysteines involved in 10 disulfide bonds. It acts ... Andexanet alfa from Portola Pharmaceuticals is a recombinant protein that is given intravenously. It should work as an antidote ... These two proteins were mostly used to validate factor Xa as a drug target. Animal studies suggested direct Xa-inhibition to be ... "Using Molecular Genetics to Improve the Production of Recombinant Proteins by the Yeast Saccharomyces cerevisiae". Annals of ...
*  Matrix gla protein
... protein C, protein S and protein Z. Abnormalities in the MGP gene have been linked with Keutel syndrome, a rare condition ... Gla-containing proteins. MGP has a high affinity binding to calcium ions, similar to other Gla-containing proteins. The protein ... Pinto JP, Conceição N, Gavaia PJ, Cancela ML (2003). "Matrix Gla protein gene expression and protein accumulation colocalize ... It is present in bone together with the related vitamin K2-dependent protein osteocalcin. In bone, its production is increased ...
*  Thrombin
Activated protein C inactivates factors Va and VIIIa. Binding of activated protein C to protein S leads to a modest increase in ... Thrombin bound to thrombomodulin activates protein C, an inhibitor of the coagulation cascade. The activation of protein C is ... The thrombin cleavage site (Leu-Val-Pro-Arg-Gly-Ser) is commonly included in linker regions of recombinant fusion protein ... Following purification of the fusion protein, thrombin can be used to selectively cleave between the Arginine and Glycine ...
*  Protein C
In addition, Protein C is inhibited by protein C inhibitor. Protein C is a major component in anticoagulation in the human body ... The protein C zymogen is activated when it binds to thrombin, another protein heavily involved in coagulation, and protein C's ... Walker FJ (June 1980). "Regulation of activated protein C by a new protein. A possible function for bovine protein S". The ... "Product Information: Human Activated Protein C - Bovine Activated Protein C - Mouse Activated Protein C". Haematologic ...
*  Disseminated intravascular coagulation
Recombinant human activated protein C was previously recommended in those with severe sepsis and DIC, but drotrecogin alfa has ... Smith, OP (1997). "Use of protein-C concentrate, heparin, and haemodiafiltration in meningococcus-induced purpura fulminans". ...
*  CD93
Molecular characterization of CD93 revealed that this protein is identical with C1qRp, a human protein identified as a putative ... a protein known to play a role in linking transmembrane proteins to the cytoskeleton and in the remodelling of the cytoskeleton ... CD93 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) Human CD93 genome location and CD93 ... CD93 (Cluster of Differentiation 93) is a protein that in humans is encoded by the CD93 gene. CD93 is a C-type lectin ...
*  Protein
ISBN 0-8053-3931-0. The Protein Naming Utility NCBI Entrez Protein database NCBI Protein Structure database Human Protein ... fibrous proteins, and membrane proteins. Almost all globular proteins are soluble and many are enzymes. Fibrous proteins are ... DNA-binding protein Macromolecule Intein List of proteins Proteopathy Proteopedia Proteolysis Protein sequence space Protein ... Proteins can bind to other proteins as well as to small-molecule substrates. When proteins bind specifically to other copies of ...
*  VISTA (protein)
2005). "Towards a proteome-scale map of the human protein-protein interaction network". Nature. 437 (7062): 1173-8. doi:10.1038 ... V-domain Ig suppressor of T cell activation (VISTA) is a type I transmembrane protein that functions as an immune checkpoint ... Zhang Z, Henzel WJ (2005). "Signal peptide prediction based on analysis of experimentally verified cleavage sites". Protein Sci ... "The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane ...
*  Protein & Cell
... is a monthly peer-reviewed open access journal covering protein and cell biology. It was established in 2010 and ... "Protein & Cell". 2013 Journal Citation Reports. Web of Science (Science ed.). Thomson Reuters. 2014. Liang, Puping; Xu, Yanwen ... Protein & Cell. 6: 363-72. doi:10.1007/s13238-015-0153-5. PMC 4417674 . PMID 25894090. Kolata, Gina (23 April 2015). "Chinese ...
*  Cerberus (protein)
Cerberus inhibits the proteins bone morphogenetic protein 4 (BMP4), Xnr1, and Xwnt8. This gene encodes a cytokine member of the ... Cerberus also known as CER1 is a protein that in humans is encoded by the CER1 gene. Cerberus is an inhibitor in the TGF beta ... The proteins that Cerberus inhibits (BMP4, Xnr1, Xwnt8) concentrations were increased also. It was also shown that just the ... CER1 protein, human at the US National Library of Medicine Medical Subject Headings (MeSH) This article incorporates text from ...
*  Protein deacetylase
... ; any enzyme that removes acetyl groups from lysine amino acids in proteins. The main ones are histone ... Because histone proteins were the first known substrate for protein deacetylases the later all tend to be called HDACs of one ... Human protein deacetylase enzymes have been categorized into Class I (HDAC1,2,3,8); Class II (HDAC4,5,6,7,9,10), Class III ( ... SIRT1,2,3,5,6), Class IV (HDAC11 and its related enzymes). Class III are the NAD+-dependent protein deacetylases.. ...
*  Antifreeze protein
Antifreeze proteins (AFPs) or ice structuring proteins (ISPs) refer to a class of polypeptides produced by certain vertebrates ... They are alpha helical proteins rich in glutamate and glutamine. This protein is approximately 12KDa in size and consists of a ... Jorov A, Zhorov BS, Yang DS (June 2004). "Study of interaction of winter flounder antifreeze protein with ice". Protein Sci. 13 ... Recent attempts have been made to relabel antifreeze proteins as ice structuring proteins to more accurately represent their ...
*  CD5 (protein)
... such as bacterial proteins) and not by normal tissue proteins. CD5 was used as a T-cell marker until monoclonal antibodies ... Protein Eng. 11 (10): 847-53. doi:10.1093/protein/11.10.847. PMID 9862202. Perez-Villar JJ, Whitney GS, Bowen MA, Hewgill DH, ... Van de Velde H, von Hoegen I, Luo W, Parnes JR, Thielemans K (1991). "The B-cell surface protein CD72/Lyb-2 is the ligand for ... Raab M, Yamamoto M, Rudd CE (1994). "The T-cell antigen CD5 acts as a receptor and substrate for the protein-tyrosine kinase ...
*  G protein
... turning the G protein on). RGS proteins stimulate GTP hydrolysis (creating GDP, thus turning the G protein off). G protein can ... G proteins, also known as guanine nucleotide-binding proteins, are a family of proteins that act as molecular switches inside ... Whereas G proteins are activated by G protein-coupled receptors, they are inactivated by RGS proteins (for "Regulator of G ... A group of proteins called Regulator of G protein signalling (RGSs), act as GTPase-activating proteins (GAPs), are specific for ...
*  Retinoblastoma protein
The retinoblastoma protein (protein name abbreviated pRb; gene name abbreviated RB or RB1) is a tumor suppressor protein that ... ESF-1 to ESF-5 are known to associate with proteins in the pRb-family of proteins while ESF-6 and ESF-7 are independent of pRb ... RB/E2F-family proteins repress transcription. Rb is a multifunctional protein with many binding and phosphorylation sites. ... Buyse IM, Shao G, Huang S (May 1995). "The retinoblastoma protein binds to RIZ, a zinc-finger protein that shares an epitope ...
*  Antiviral protein
Antiviral proteins are proteins that are induced by human or animal cells to interfere with viral replication. These proteins ... The Pokeweed antiviral protein and the Zinc-Finger antiviral protein are two major antiviral proteins that have undergone ... The Zinc finger Antiviral Protein (ZAP) is a specific antiviral protein that aids in the destruction of virus particles, ... Studies and experiments have shown that a specific protein, the Pokeweed Antiviral Protein (PAP), could possibly be used ...
*  Protein sequencing
Although proteins ionize less well than the peptides derived from them, a protein in solution may be able to be subjected to ... Protein sequencing is the practical process of determining the amino acid sequence of all or part of a protein or peptide. This ... A protein sequenator is a machine that performs Edman degradation in an automated manner. A sample of the protein or peptide is ... Protein identification is the process of assigning a name to a protein of interest (POI), based on its amino-acid sequence. ...
*  Soy protein
... and soy protein concentrates. Soy protein isolate is a highly refined or purified form of soy protein with a minimum protein ... Soybean protein is a "complete protein" since it provides all of the essential amino acids for human nutrition. Soybean protein ... Soy protein is generally regarded as stored protein held in discrete particles called "protein bodies" estimated to contain at ... Based on this method, soy protein is considered to have a similar equivalent in protein quality to animal proteins. Egg white ...
*  Membrane protein
Membrane proteins are a common type of proteins along with soluble globular proteins, fibrous proteins, and disordered proteins ... A large fraction of all proteins are thought to be membrane proteins. For instance, about 1000 of the ~4200 proteins of E. coli ... proteins arranged in the lipid bilayer Protein Data Bank of Transmembrane Proteins 3D models of all transmembrane proteins ... "transmembrane proteins", are integral membrane proteins that span across the membrane at least once. These proteins may have ...