DDB1 forms a complex with DDB2 that functions as a DNA damage-binding protein. Furthermore, cereblon and DDB2 bind to DDB1 in a ... Cereblon is a protein that in humans is encoded by the CRBN gene. The gene that encodes the cereblon protein is found on the ... "Thalidomide binding protein revealed". Chemistry World. Royal Society of Chemistry. 2010-03-11. Retrieved 2010-03-11. Moisse K ... Cereblon forms an E3 ubiquitin ligase complex with damaged DNA binding protein 1 (DDB1), Cullin-4A (CUL4A), and regulator of ...
In: Drug-protein binding. New York: Praeger, 1986; p. 11. Corbella i Corbella J. Antoni Esteve i Subirana, semblança biogràfica ...
Maltose Binding Protein is located at the N-Terminal ● Another protein is located at the C-Terminal ● Expression of a fusion ... "Maltose Binding Protein Expression , NEB". www.neb.com. Retrieved 2016-02-26. Sharone Tayar, Nurit Kleinberger-Doron; Hebrew ... This makes it suitable for high-efficiency protein production of a recombinant protein. The strong repression of expression in ... Maltose-Binding Protein at N-terminal and maltose having expressed at C-terminal. Transformation can take place inside ...
A tropomyosin-binding protein". J Biol Chem. 267 (4): 2616-21. PMID 1370827. Sung LA, Fan Y, Lin CC (Dec 1996). "Gene ... 2000). "Tropomodulin-binding site mapped to residues 7-14 at the N-terminal heptad repeats of tropomyosin isoform 5". Arch. ... Sung LA, Lin JJ (1994). "Erythrocyte tropomodulin binds to the N-terminus of hTM5, a tropomyosin isoform encoded by the gamma- ... Vera C, Lao J, Hamelberg D, Sung LA (2006). "Mapping the tropomyosin isoform 5 binding site on human erythrocyte tropomodulin: ...
MIS18 binding protein 1 is a protein that in humans is encoded by the MIS18BP1 gene. The gene is also known as LKNL2, M18BP1, ... "MIS18 binding protein 1". Retrieved 2011-12-04. Maddox PS, Hyndman F, Monen J, Oegema K, Desai A (Mar 2007). "Functional ... "Functional genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin". J. Cell Biol ... genomics identifies a Myb domain-containing protein family required for assembly of CENP-A chromatin". J Cell Biol. 176 (6): ...
FK506 binding protein 7 is a protein that in humans is encoded by the FKBP7 gene. The gene is also known as FKBP23 and PPIase. ... a Novel FK506-Binding Protein with Ca2+-Binding Ability". Genomics. 54 (1): 89-98. doi:10.1006/geno.1998.5571. PMID 9806833. " ... The orthologous protein in mouse is located in the endoplasmic reticulum and binds calcium. Model organisms have been used in ... "FK506 binding protein 7". Retrieved 2011-12-06. Nakamura, T.; Yabe, D.; Kanazawa, N.; Tashiro, K.; Sasayama, S.; Honjo, T. ( ...
Morse, D.; Pappenheimer, A.M.; Jr.; Hastings, J.W. (1989). "Role of a luciferin-binding protein in the circadian bioluminescent ... Morse, D.; Mittag, M. (2000). "Dinoflagellate luciferin-binding protein". Methods Enzymol. 305: 258-276. doi:10.1016/s0076-6879 ... Li, L. (2000). "Gonyaulax luciferase: gene structure, protein expression, and purification from recombinant sources". Methods ... hnu Dinoflagellate luciferase is a single protein with three luciferase domains. Dunlap, J.C.; Hastings, J.W. (1981). "The ...
... single stranded DNA binding protein, ribosome recycling factor, peptidyl tRNA hydrolase, pantothenate kinase and DNA binding ... "Snapshots of RecA protein involving movement of the C-domain and different conformations of the DNA-binding loops: ... side chain conformation in proteins and additional binding sites in lysozyme. Vijayan has published more than 260 peer reviewed ... "Structure of Mycobacterium tuberculosis single-stranded DNA-binding protein. Variability in quaternary structure and its ...
Cortajarena AL, Regan L (May 2006). "Ligand binding by TPR domains". Protein Science. 15 (5): 1193-8. doi:10.1110/ps.062092506 ... The PEX5 protein is a receptor for PTS1 (peroxisomal targeting signal tripeptide which directs proteins into peroxisomes). It ... It is found in tandem arrays of 3-16 motifs, which form scaffolds to mediate protein-protein interactions and often the ... hsp90-binding immunophilins, transcription factors, the PKR protein kinase inhibitor, the major receptor for peroxisomal matrix ...
Plasma protein binding is 88%. Bimatoprost is metabolized by oxidation, N-deethylation and glucuronidation, forming a variety ...
"Identification and characterization of proteins that selectively interact with isoforms of the mRNA binding protein AUF1 (hnRNP ... "Identification and characterization of proteins that selectively interact with isoforms of the mRNA binding protein AUF1 (hnRNP ... Kim JH, Paek KY, Ha SH, Cho S, Choi K, Kim CS, Ryu SH, Jang SK (September 2004). "A cellular RNA-binding protein enhances ... Lau PP, Chang BH, Chan L (April 2001). "Two-hybrid cloning identifies an RNA-binding protein, GRY-RBP, as a component of apobec ...
... of salicylate in the blood is bound to albumin protein, while the rest remains in the active, ionized state; protein binding is ... Aspirin is known to displace a number of drugs from protein-binding sites in the blood, including the antidiabetic drugs ... Acetylation of cellular proteins is a well-established phenomenon in the regulation of protein function at the post- ... Saturation of binding sites leads to more free salicylate and increased toxicity. The volume of distribution is 0.1-0.2 L/kg. ...
Plasma protein binding is 99%. The substance is metabolized by many CYP enzymes (percentages in vitro, at higher than clinical ... At therapeutic concentrations, ixazomib selectively and reversibly inhibits the protein proteasome subunit beta type-5 (PSMB5) ... liver enzymes and transporter proteins. The only relevant finding in studies was a reduction of ixazomib blood levels when ...
It is a binding protein; that is, it binds itself to promicin in the body and neutralizes it. However, if there is no promicin ... for it to bind to, it remains in the body. Eventually, it builds up to toxic levels in the lymph nodes, damaging the immune ...
In clinical trials plasma protein binding has been shown to be high (~94,5%). Most COL-3 binds to serum albumin. MMP activity ... They are secreted proteins of low-molecular weight. TIMPs bind noncovalently to the active site of MMPs. Changes of TIMP levels ... Its volume of distribution is 50-80 L (0,7 L/kg). Protein binding is 82-93 %. It is excreted in urine and in feces. Doxycycline ... This binding forms a 5-members chelate ring that looks similar to the binding of hydroxamic acid. The amide bond of the ...
Retinol-binding protein 3, interstitial (RBP3), also known as IRBP is a protein that in humans is encoded by the RBP3 gene. ... The inter-photoreceptor retinoid-binding protein is a large glycoprotein known to bind retinoids and found primarily in the ... Shaw NS, Noy N (Feb 2001). "Interphotoreceptor retinoid-binding protein contains three retinoid binding sites". Experimental ... Liou GI, Ma DP, Yang YW, Geng L, Zhu C, Baehr W (May 1989). "Human interstitial retinoid-binding protein. Gene structure and ...
Plasma protein binding is 68%. It is metabolised in the liver, mainly via the enzyme CYP3A4, but to a minor extent via CYP1A2 ...
... binds to the messenger RNA coding for apolipoprotein B-100 (ApoB-100), a protein that is the main component of low- ... Protein binding is over 90%. The molecule is slowly broken up by endonucleases and subsequently by exonucleases. After 24 hours ...
The protein binding is 40%. The volume of distribution may increase in neonates and those suffering from cirrhosis or ... which codes for the protein collagen. It has been shown that theophylline may reverse the clinical observations of steroid ... DNA is repackaged so that the promoter regions of inflammatory genes are unavailable for binding of transcription factors such ...
Plasma protein binding is 60%. Oral bioavailability is 80%. Elimination half-life is 6 hours. Volume of distribution is 4-5 L/ ... "Differential analysis of the frequency-dependent effects of class 1 antiarrhythmic drugs according to periodical ligand binding ...
... which then can allow the heavy chain to bind to a heavy-chain binding protein. There are five types of mammalian immunoglobulin ... Haas, Ingrid G.; Wabl, Matthias (1983). "Immunoglobulin heavy chain binding protein". Nature. 306 (5941): 387-9. Bibcode: ... If the heavy chain is able to bind to a surrogate light chain and move to the plasma membrane, then the developing B cell can ... The heavy chain doesn't always have to bind to a light chain. Pre-B lymphocytes can synthesize heavy chain in the absence of ...
Plasma protein binding is 40%. The major route of metabolism is by its target enzymes via cholinesterase-mediated hydrolysis. ...
Aux/IAA proteins can bind ARF proteins sitting on gene promoters and prevent them from doing their job. TIR1 proteins are F-box ... so TIR1 proteins are auxin receptors), and Aux/IAA proteins (via a degron domain). Upon binding of auxin, a TIR1 protein's ... Another protein, auxin-binding protein 1 (ABP1), is a putative receptor for a different signaling pathway, but its role is as ... ARF proteins have DNA binding domains and can bind promoter regions of genes and activate or repress gene expression. ...
Peterson, Lr; Gerding, Dn (Aug 1978). "Protein binding and antibiotic concentrations". Lancet. 2 (8085): 376. doi:10.1016/S0140 ...
Stoddart RW, Kiernan, JA (1973). "Aprotinin, a carbohydrate-binding protein". Histochemie. 34 (4): 275-280. doi:10.1007/ ... Richardson, J.S. (1981). "Anatomy and Taxonomy of Protein Structure". Advances in Protein Chemistry. Advances in Protein ... It was one of the earliest protein crystal structures solved, in 1970 in the laboratory of Robert Huber, and was the first ... Because it is a small, stable protein whose structure had been determined at high resolution by 1975, it was the first ...
RNA polymerase II regulatory region sequence-specific DNA binding. • DNA binding. • sequence-specific DNA binding. • ... Homeobox protein Hox-D8 is a protein that in humans is encoded by the HOXD8 gene.[5][6][7] ... 1989). "Complementary homeo protein gradients in developing limb buds". Genes Dev. 3 (5): 641-50. doi:10.1101/gad.3.5.641. PMID ... HOXD8+protein,+human at the US National Library of Medicine Medical Subject Headings (MeSH) ...