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*  Alpha-1 antitrypsin
A protease inhibitor, it is also known as alpha1-proteinase inhibitor (A1PI) or alpha1-antiproteinase (A1AP) because it ... Like all serine protease inhibitors, A1AT has a characteristic secondary structure of beta sheets and alpha helices. Mutations ... In blood test results, the IEF results are notated as in PiMM, where Pi stands for protease inhibitor and "MM" is the banding ... A1PI is both an endogenous protease inhibitor and an exogenous one used as medication. The pharmaceutical form is purified from ...
*  PEDF
They found that PEDF was a previously uncharacterized protein and a member of the serpin (serine protease inhibitor) family. ... which is normally involved in serine protease inhibitor activity; however, in PEDF this region does not retain the inhibitory ... neurotrophic activity and identification as a member of the serine protease inhibitor gene family". Proceedings of the National ... "Entrez Gene: SERPINF1 serpin peptidase inhibitor, clade F (alpha-2 antiplasmin, pigment epithelium derived factor), member 1". ...
*  Cysteine protease
Protease inhibitor (biology) TopFIND - database of protease specificity, substrates, products and inhibitors MEROPS - Database ... Protease inhibitors are usually proteins with domains that enter or block a protease active site to prevent substrate access. ... Examples of protease inhibitors include: Serpins Stefins IAPs Currently there is no widespread use of cysteine proteases as ... Cysteine proteases, also known as thiol proteases, are enzymes that degrade proteins. These proteases share a common catalytic ...
*  Protein primary structure
All glycosylation can be blocked with certain inhibitors, such as tunicamycin. deamidation (succinimide formation) In this ... which cannot be cleaved by most proteases. Additionally, proline can form stable trans-isomers at the peptide bond. Finally, ... by chemical hydrolysis or by proteases). Proteins are often synthesized in an inactive precursor form; typically, an N-terminal ...
*  SLPI
Human seminal inhibitor I (HUSI-I), antileukoprotease (ALP), secretory leukocyte protease inhibitor (SLPI)". Biological ... and complete amino acid sequence of human secretory leukocyte protease inhibitor, a potent inhibitor of leukocyte elastase". ... "Location of the protease-inhibitory region of secretory leukocyte protease inhibitor". The Journal of Biological Chemistry. 265 ... Clauss A, Lilja H, Lundwall A (Nov 2002). "A locus on human chromosome 20 contains several genes expressing protease inhibitor ...
*  Protease inhibitor
... can refer to: Protease inhibitor (pharmacology): a class of medication that inhibits viral protease Protease ...
*  Protease inhibitor (biology)
Classes of proteases are: Aspartic protease inhibitors Cysteine protease inhibitors Metalloprotease inhibitors Serine protease ... inhibitors Threonine protease inhibitors Trypsin inhibitors Kunitz STI protease inhibitor Classes of inhibitor mechanisms of ... Many naturally occurring protease inhibitors are proteins. In medicine, protease inhibitor is often used interchangeably with ... Suicide inhibitor Transition state inhibitor Protein protease inhibitor (see serpins) Chelating agents This is a family of ...
*  Protease inhibitor (pharmacology)
Protease inhibitors prevent viral replication by selectively binding to viral proteases (e.g. HIV-1 protease) and blocking ... A cysteine protease inhibitor drug was found to cure Chagas disease in mice. Researchers are investigating whether protease ... Protease inhibitors that have been developed and are currently used in clinical practice include: Antiretroviral HIV-1 protease ... Tanomastat is one of the matrix metalloproteinase inhibitors that can be used to treat cancer. Protease inhibitors can cause a ...
*  SSI protease inhibitor
This is a protease inhibitor. These are often synthesised as part of a larger precursor protein, either as a prepropeptide. The ... SSI is a protease inhibitor, it prevents enzymes from acting on a substrate. Some SSI's also inhibit trypsin, chymotrypsin and ... In molecular biology the protein SSI is a Subtilisin inhibitor-like which stands for Streptomyces subtilisin inhibitor. ... Protease binding induces the widening of a channel-like structure, in which hydrophobic side-chains are sandwiched between 2 ...
*  Bowman-Birk protease inhibitor
In molecular biology, the Bowman-Birk protease inhibitor family of proteins consist of eukaryotic proteinase inhibitors, ... Proteins of the Bowman-Birk inhibitor family of serine proteinase inhibitors interact with the enzymes they inhibit via an ... Birk, Y (February 1985). "The Bowman-Birk inhibitor. Trypsin- and chymotrypsin-inhibitor from soybeans". International journal ... These inhibitors are primarily found in plants and in particular in the seeds of legumes, as well as in cereal grains. In ...
*  Kunitz STI protease inhibitor
Kunitz soybean trypsin inhibitor is a type of protein contained in legume seeds which functions as a protease inhibitor. Kunitz ... "Kunitz STI inhibitors". A web/HMMer based tool to study Kunitz protease inhibitors. Federal University of São Paulo. Retrieved ... Two types of trypsin inhibitors are found in soy: the Kunitz trypsin inhibitor (KTI) and the Bowman-Birk inhibitor (BBI). KTI ... Soybean Protease Inhibitors in Foods], DiPietro CM, Liener IE, 1989. J Food Sci. Murzin AG, Lesk AM, Chothia C (January 1992 ...
*  Protein Z-related protease inhibitor
Protein Z-dependent protease inhibitor is a protein circulating in the blood which inhibits factors Xa and XIa of the ... It is a member of the class of the serine protease inhibitors (serpins). Its name implies that it requires protein Z, another ... Isolation of protein Z-dependent plasma protease inhibitor. Proc Natl Acad Sci U S A 1998;95:9250-5. Fulltext. PMID 9689066. ... Characterization of the protein Z-dependent protease inhibitor. Blood 2000;96:3049-55. Fulltext. PMID 11049983. The MEROPS ...
*  Discovery and development of HIV-protease inhibitors
In 2009, ten protease inhibitors have reached the market for treatment against HIV but one protease inhibitor, amprenavir, was ... All the FDA approved protease inhibitors are listed below. All the HIV protease inhibitors on the market contain a central core ... Tipranavir is a nonpeptidic HIV-1 protease inhibitor and reached the market in 2005. Unlike other HIV protease inhibitors on ... HIV protease inhibitors fit the active site of the HIV aspartic protease and were rationally designed utilizing knowledge of ...
*  Protease accumulated by inhibitors
... (PABI) is a protein participating in eukaryotic translation, by making interaction between ... "Isolation and characterization of a novel large protease accumulated in mammalian cells in the presence of inhibitors". J. Biol ...
*  Antiviral drug
Improved protease inhibitors are now in development. Protease inhibitors have also been seen in nature. A protease inhibitor ... "protease inhibitors" to attack HIV at that phase of its life cycle. Protease inhibitors became available in the 1990s and have ... Anderson J, Schiffer C, Lee SK, Swanstrom R (2009). "Viral protease inhibitors". Handb Exp Pharmacol. Handbook of Experimental ... "The Role of Protease Inhibitors in the Pathogenesis of HIV-Associated Lipodystrophy: Cellular Mechanisms and Clinical ...
*  Atazanavir
It is of the protease inhibitor (PI) class and works by blocking HIV protease. Atazanavir was approved for medical use in the ... Lv, Z; Chu, Y; Wang, Y (2015). "HIV protease inhibitors: a review of molecular selectivity and toxicity. ". HIV/AIDS - Research ... PMC 4396582 . Graziani, Amy L (June 17, 2014). "HIV protease inhibitors". UpToDate. Bold, G; Fässler, A; Capraro, HG; Cozens, R ... "New Aza-Dipeptide Analogues as Potent and Orally Absorbed HIV-1 Protease Inhibitors: Candidates for Clinical Development". ...
*  Simvastatin
HIV protease inhibitors; the antidepressant nefazodone; the cardiovascular drug gemfibrozil; the immunosuppressant ciclosporin ... Tobert JA (2003). "Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors". Nat Rev Drug Discov. 2 (7): 517-26 ... This discovery encouraged scientists worldwide to find an effective inhibitor of this enzyme.[citation needed] By 1976, Akira ... While developing and researching lovastatin, Merck scientists synthetically derived a more potent HMG-CoA reductase inhibitor ...
*  Inter-alpha-trypsin inhibitor
They function as protease inhibitors. IαI form complexes with hyaluronan (HA), generating a serum-derived hyaluronan-associated ... Inter-alpha-trypsin inhibitors (IαI) are plasma proteins consisting of three of four heavy chains selected from the group ITIH1 ... Inter-alpha-inhibitor at the US National Library of Medicine Medical Subject Headings (MeSH). ... Zhuo L, Hascall VC, Kimata K (September 2004). "Inter-alpha-trypsin inhibitor, a covalent protein-glycosaminoglycan-protein ...
*  Vertex Pharmaceuticals
Telaprevir is a protease inhibitor. In 2012 ivacaftor, was designated as an orphan drug, identifying cystic fibrosis as ...
*  Streptomyces violascens
Jönsson, A. G.; Torstensson, N. T. L. (1972). "Protease inhibitors from Streptomyces violascens". Archiv für Mikrobiologie. 83 ... Proteinase Inhibitors Proceedings of the 2nd International Research Conference. Berlin, Heidelberg: Springer Berlin Heidelberg ...
*  How to Survive a Plague
In 1996, Protease inhibitors were released. These consist of a combination of drugs which lower the HIV viral load in patients ...
*  Lopinavir/ritonavir
... like several HIV protease inhibitors, its blood levels are greatly increased by low doses of ritonavir, a potent inhibitor of ... researchers found the points of attack of the HIV protease inhibitors - agents that block the breakdown of proteins. Protease ... Both medications are HIV protease inhibitors. Ritonavir functions by slowing down the breakdown of lopinavir. Lopinavir/ ... 1998) ABT-378, a highly potent inhibitor of the human immunodeficiency virus protease. Antimicrob. Agents Chemother. 42: 3218- ...
*  Caspase 8
Ye S, Goldsmith EJ (2002). "Serpins and other covalent protease inhibitors". Curr. Opin. Struct. Biol. 11 (6): 740-5. doi: ... the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases". Proc. ... Caspases exist as inactive proenzymes composed of a prodomain, a large protease subunit, and a small protease subunit. ... Biochemically, caspase-8 was found to enter the complex of the inhibitor of NF-κB kinase (IKK) with the upstream Bcl10-MALT1 ( ...
*  Nelfinavir
... is a protease inhibitor: it inhibits HIV-1 and HIV-2 proteases. HIV protease is an aspartate protease which splits ... All protease inhibitors bind to the protease, the precise mode of binding determines how the molecule inhibits the protease. ... Pyrko P, Kardosh A, Wang W, Xiong W, Schönthal AH, Chen TC (2007). "HIV-1 protease inhibitors nelfinavir and atazanavir induce ... Nelfinavir's interaction profile is similar to that of other protease inhibitors. Most interactions occur at the level of the ...
*  Alpha-2-Macroglobulin
aM protease inhibitors inhibit by steric hindrance. The mechanism involves protease cleavage of the bait region, a segment of ... These protease inhibitors share several defining properties, which include (i) the ability to inhibit proteases from all ... In addition to tetrameric forms of alpha-2-macroglobulin, dimeric, and more recently monomeric aM protease inhibitors have been ... The alpha-macroglobulin (aM) family of proteins includes protease inhibitors, typified by the human tetrameric alpha-2- ...
*  Norovirus
Lundborg M, Ali E, Widmalm G (2013). "An in silico virtual screening study for the design of norovirus inhibitors: fragment- ... by the viral 3C-like protease (NS6), a major structural protein (VP1) of about 58~60 kDa and a minor capsid protein (VP2). The ...
*  Inhibitor cystine knot
Plant ICK proteins are often protease inhibitors. Because of their stability, ICK motifs are being developed as possible ... An inhibitor cystine knot (aka ICK or Knottin) is a protein structural motif containing three disulfide bridges. Three types of ... The motif is also found in some inhibitor proteins found in plants, but the plant and animal motifs are thought to be a product ... "Novel Inhibitor Cystine Knot Peptides from Momordica charantia". PLoS ONE. 8 (10): e75334. doi:10.1371/journal.pone.0075334. ...