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*  Prostaglandin D2
Pettipher R, Hansel TT (2008). "Antagonists of the prostaglandin D2 receptor CRTH2". Drug News & Perspectives. 21 (6): 317-22. ... Prostaglandin D2 (or PGD2) is a prostaglandin that binds to the receptor PTGDR (DP1), as well as CRTH2 (DP2). It is a major ... 2012-03-21). "Prostaglandin D2 Inhibits Hair Growth and Is Elevated in Bald Scalp of Men with Androgenetic Alopecia". Science ... 2012-05-21). "Prostaglandin D2, a cerebral sleep-inducing substance in monkeys". Proceedings of the National Academy of ...
*  PTGS1
Cyclooxygenase 1 (COX-1), also known as prostaglandin G/H synthase 1, prostaglandin-endoperoxide synthase 1 or prostaglandin H2 ... "Death of cultured human neuroblastoma cells induced by HIV-1 gp120 is prevented by NMDA receptor antagonists and inhibitors of ... Prostaglandin-endoperoxide synthase (PTGS), also known as cyclooxygenase (COX), is the key enzyme in prostaglandin biosynthesis ... "Entrez Gene: PTGS1 prostaglandin-endoperoxide synthase 1 (prostaglandin G/H synthase and cyclooxygenase)". Chandrasekharan NV, ...
*  Prostaglandin EP1 receptor
EP1 receptor antagonists have been studied clinically primarily to treat hyperalgesia. Numerous EP antagonists have been ... Prostaglandin receptors Prostanoid receptors Prostaglandin E2 receptor 2 (EP2) Prostaglandin E2 receptor 3 (EP3) Prostaglandin ... Prostaglandin E2 receptor 1 (EP1) is a 42kDa prostaglandin receptor encoded by the PTGER1 gene. EP1 is one of four identified ... "Combined effects of prostaglandin E receptor subtype EP1 and subtype EP4 antagonists on intestinal tumorigenesis in adenomatous ...
*  Prostaglandin
... prostaglandin E2 (PGE2), and prostaglandin F2α (PGF2α). Examples of prostaglandin antagonists are: NSAIDs (inhibit ... Prostaglandin E2 (PGE2) is generated from the action of prostaglandin E synthases on prostaglandin H2 (prostaglandin H2, PGH2 ... "Prostaglandin F2alpha formation from prostaglandin H2 by Prostaglandin-F synthase (PGFS): crystal structure of PGFS containing ... The name prostaglandin derives from the prostate gland. When prostaglandin was first isolated from seminal fluid in 1935 by the ...
*  Prostaglandin antagonist
A Prostaglandin antagonist is a hormone antagonist acting upon prostaglandin. NSAIDs inhibit cyclooxygenase and reduce ... Prostaglandin antagonists at the US National Library of Medicine Medical Subject Headings (MeSH). ... prostaglandin synthesis. Corticosteroids inhibit phospholipase A2 production by boosting production of lipocortin, an inhibitor ...
*  Niacin
... by taking one tablet of ibuprofen per day or by co-administering the prostaglandin receptor antagonist laropiprant. Taking ... "Suppression of niacin-induced vasodilation with an antagonist to prostaglandin D2 receptor subtype 1". Clinical pharmacology ... Laropiprant is a prostaglandin D2 binding drug shown to reduce vasodilatation and flushing up to 73%. The HPS2-THRIVE study, a ... Prostaglandin (PGD2) is the primary cause of the flushing reaction, with serotonin appearing to have a secondary role in this ...
*  Laropiprant
... acts as a selective DP1 receptor antagonist to inhibit the vasodilation of prostaglandin D2-induced activation of ... June 2007). "Suppression of niacin-induced vasodilation with an antagonist to prostaglandin D2 receptor subtype 1". Clin. ... PGD2 dilates the blood vessels via activation of the prostaglandin D2 receptor subtype DP1, increasing blood flow and thus ... Niacin in cholesterol lowering doses (500-2000 mg per day) causes facial flushes by stimulating biosynthesis of prostaglandin ...
*  Prostaglandin EP4 receptor
... and selective prostaglandin EP4 receptor antagonist". Bioorganic & Medicinal Chemistry Letters. 27 (5): 1186-1192. doi:10.1016/ ... Prostaglandin E2 receptor 4 (EP4) is a prostaglandin receptor for prostaglandin E2 (PGE2) encoded by the PTGER4 gene in humans ... Prostaglandin E2 receptor 1 (EP1) Prostaglandin E2 receptor 2 (EP2) Prostaglandin E2 receptor 3 (EP3) Eicosanoid receptor ... Prostaglandin E1 (PGE1), which has one less double bond than PGE2, has the same binding affinity and potency for EP4, both PGs ...
*  Prostaglandin DP2 receptor
"On the mechanism of interaction of potent surmountable and insurmountable antagonists with the prostaglandin D2 receptor CRTH2 ... DP2 along with Prostaglandin DP1 receptor are receptors for prostaglandin D2 (PGD2). Activation of DP2 by PGD2 or other cognate ... Prostaglandin DP1 receptor Prostaglandin receptors Prostanoid receptors Eicosanoid receptor GRCh38: Ensembl release 89: ... Prostaglandins & Other Lipid Mediators. 75 (1-4): 153-67. doi:10.1016/j.prostaglandins.2004.11.003. PMID 15789622. Hata AN, ...
*  Ramatroban
September 2008). "A novel antagonist of prostaglandin D2 blocks the locomotion of eosinophils and basophils". Eur. J. Clin. ... April 2003). "An orally bioavailable small molecule antagonist of CRTH2, ramatroban (BAY u3405), inhibits prostaglandin D2- ... Ramatroban (INN) is a thromboxane receptor antagonist. It is also a DP2 receptor antagonist. It is indicated for the treatment ... Fiedler VB, Seuter F, Perzborn E (December 1990). "Effects of the novel thromboxane antagonist Bay U 3405 on experimental ...
*  Fevipiprant
2016). "Fevipiprant, a prostaglandin D2 receptor 2 antagonist, in patients with persistent eosinophilic asthma: a single-centre ... orally available antagonist of the prostaglandin D2 receptor 2 (DP2 or CRTh2). As of 2016[update], it is in Phase III clinical ... Prostaglandin DP2 receptor Setipiprant Erpenbeck VJ, Vets E, Gheyle L, Osuntokun W, Larbig M, Neelakantham S, et al. (2016). " ... 2016). "The oral CRTh2 antagonist QAW039 (fevipiprant): A phase II study in uncontrolled allergic asthma". Pulm Pharmacol Ther ...
*  Pharmaceutical drug
H2-receptor antagonists, cytoprotectants, prostaglandin analogues Lower digestive tract: laxatives, antispasmodics, ... dopamine antagonists, antihistamines, cholinergics, anticholinergics, emetics, cannabinoids, and 5-HT (serotonin) antagonists. ... prostaglandin agonists/prostaglandin inhibitors. nitroglycerin Antibiotics, sympathomimetics, antihistamines, anticholinergics ... Leukotriene antagonists androgens, antiandrogens, estrogens, gonadotropin, corticosteroids, human growth hormone, insulin, ...
*  Prostaglandin E2
"A live imaging cell motility screen identifies prostaglandin E2 as a T cell stop signal antagonist". Journal of Immunology. 187 ... Prostaglandin E2 works as well as prostaglandin E1 in babies; however, it is much less expensive. It has important effects in ... Prostaglandin E2 (PGE2), also known as dinoprostone, is a naturally occurring prostaglandin which is used as a medication. As a ... Prostaglandin E2 is in the oxytocics family of medications. It works by binding and activating the prostaglandin E2 receptor ...
*  Sérgio Henrique Ferreira
II-Prostaglandins hyperalgesia: the peripheral analgesic activity of morphine, enkephalins and opioid antagonists. ... In this area he described an antagonist of IL-1 that is now being developed as a model for a new class of analgesics. ... Prostaglandins, aspirin-like drugs and analgesia. Nature New Biology. vol. 240, p. 200-203. Ferreira, S. H. and Nakamura, M. ... Prostaglandins. vol. 18, p. 191-200. Ferreira, S. H., et al. 1988. Interleukin-1b as a potent hyperalgesic agent antagonized by ...
*  Ménétrier's disease
Such medications include: anticholinergic agents, prostaglandins, proton pump inhibitors, prednisone, and H2 receptor ... antagonists. Anticholinergics decrease protein loss. A high-protein diet should be recommended to replace protein loss in ...
*  Setipiprant
... orally available antagonist of the prostaglandin D2 receptor 2 (DP2). It was initially researched as a treatment for allergies ... Prostaglandin DP2 receptor Fevipiprant Ramatroban Fretz H, Valdenaire A, Pothier J, Hilpert K, Gnerre C, Peter O, Leroy X, ... Prostaglandin D2 inhibits hair growth and is elevated in bald scalp of men with androgenetic alopecia. Science Translational ... However, following the discovery in 2012 that the prostaglandin D2 receptor (DP/PGD2) is expressed at high levels in the scalp ...
*  Prostaglandin DP1 receptor
Asapiprant (S-555739) and Laropiprant are selective receptor antagonists of DP1 whereas Vidupiprant is a receptor antagonist ... Prostaglandin receptors Prostanoid receptors Prostaglandin DP2 receptor Eicosanoid receptor GRCh38: Ensembl release 89: ... is primarily a receptor for prostaglandin D2 (PGD2). The receptor is a member of the Prostaglandin receptors belonging to the ... Prostaglandins & Other Lipid Mediators. 107: 48-55. doi:10.1016/j.prostaglandins.2013.07.001. PMID 23850788. Ferré S (2015). " ...
*  Prostaglandin F receptor
Currently, there are no selective receptor antagonists for FP. FP is classified as a contractile type of prostenoid receptor ... Prostaglandin F receptor (FP) is a receptor belonging to the prostaglandin (PG) group of receptors. FP binds to and mediates ... 1995). "Cloning of the rat and human prostaglandin F2 alpha receptors and the expression of the rat prostaglandin F2 alpha ... Prostaglandin F2 alpha Prostaglandin receptors Eicosanoid receptor GRCh38: Ensembl release 89: ENSG00000122420 - Ensembl, May ...
*  Nonclassic eicosanoid
Prostaglandins Other Lipid Mediat. 73 (3-4): 155-72. doi:10.1016/j.prostaglandins.2004.03.005. PMID 15290791. Anderle P, Farmer ... 1999). "In vitro and in vivo pharmacological characterization of SB 201993, an eicosanoid-like LTB4 receptor antagonist with ... "Prostaglandins and Leukotrienes: Advances in Eicosanoid Biology". Science. 294 (5548): 1871-1875. doi:10.1126/science.294.5548. ... and three types of prostanoids-prostaglandins (PG) prostacyclins (PGI), and thromboxanes (TX). However, several other classes ...
*  12-Hydroxyeicosatetraenoic acid
... an eicosanoid-like LTB4 receptor antagonist with anti-inflammatory activity". Prostaglandins, leukotrienes, and essential fatty ... 12(S)-HETE and 12(R)-HETE bind to and act as Competitive antagonists of the Thromboxane receptor which mediates the actions of ... Based on the effects of LTB4 receptor antagonists, for example, leukotriene B4 receptor 2 mediates: the rise in cytosolic Ca2+ ... Yoshimoto, T; Takahashi, Y (2002). "Arachidonate 12-lipoxygenases". Prostaglandins & other lipid mediators. 68-69: 245-62. doi: ...
*  List of MeSH codes (D16)
... leukotriene antagonists MeSH D27.505.696.399.450.710 --- prostaglandin antagonists MeSH D27.505.696.399.472 --- hormones MeSH ... histamine h1 antagonists MeSH D27.505.519.625.375.425.400.500 --- histamine h1 antagonists, non-sedating MeSH D27.505.519.625. ... histamine h1 antagonists MeSH D27.505.696.577.375.425.400.500 --- histamine h1 antagonists, non-sedating MeSH D27.505.696.577. ... adrenergic alpha-antagonists MeSH D27.505.519.625.050.200.200 --- adrenergic beta-antagonists MeSH D27.505.519.625.050.601 --- ...
*  Panadol night
The main belief is that it reduces the production of prostaglandins in the brain and spinal cord. Diphenhydramine is a sedating ... H1 antagonist. Diphenhydramine works by blocking the effects of histamine and causes drowsiness. The combination of the active ...
*  Israpafant
... (Y-24180) is a drug which acts as a selective antagonist for the platelet-activating factor receptor, and was ... Interactions with PAF and benzodiazepine receptors". Prostaglandins. 40 (6): 571-583. doi:10.1016/0090-6980(90)90002-D. Komatsu ... Hozawa, S (1995). "Effects of a PAF antagonist, Y-24180, on bronchial hyperresponsiveness in patients with asthma". American ... Takehara, S. (1990). "Pharmacological actions of Y-24180, a new specific antagonist of Platelet Activating Factor (PAF): II. ...
*  Sulprostone
... synthetic EP3 receptor antagonists have the realized or potential ability to promote the beneficial effects of prostaglandin ... prostaglandin EP3 receptor, and prostaglandin EP4 receptor. Sulprosotone binds to and activates the prostaglandin EP3 receptor ... It is listed as a comparatively weak receptor agonist of the prostaglandin EP1 receptor. In all events, this as well as other ... Sulprostone is an analogue of prostaglandin E2 (PGE2) that has oxytocic activity in assays of rat kidney cells and tissues. ...
*  Antiprogestogen
... and the silent antagonist aglepristone. For medical abortion, mifepristone is combined with a prostaglandin (e.g., gemeprost). ... Antiprogestogens, or antiprogestins, also known as progesterone antagonists or progesterone blockers, are a class of drugs ... Antiprogestogens are one of three types of sex hormone antagonists, the others being antiestrogens and antiandrogens. ... Oct 2006). "Progesterone receptor antagonists". Curr Opin Investig Drugs. 7 (10): 882-90. PMID 17086932. Tang, OS.; Ho, PC. ( ...
*  Effects of cannabis
Prostaglandins and Other Lipid Mediators. 122: 28-36. doi:10.1016/j.prostaglandins.2015.11.002. Fride, Ester (2004). "The ... but it is only found in small amounts and is a cannabinoid antagonist. There are also similar compounds contained in cannabis ...
*  Peptic ulcer disease
H2 antagonists or proton-pump inhibitors decrease the amount of acid in the stomach, helping with healing of ulcers. When H. ... NSAIDs block the function of cyclooxygenase 1 (COX-1), which is essential for the production of these prostaglandins. COX-2 ... People who are taking nonsteroidal anti-inflammatories (NSAIDs) may also be prescribed a prostaglandin analogue (misoprostol) ... Younger people with ulcer-like symptoms are often treated with antacids or H2 antagonists before endoscopy is undertaken. ...