"In vitro differentiation of endothelial cells from AC133-positive progenitor cells". Blood. 95 (10): 3106-12. doi:10.1182/blood ... stem cell factor and rhIL-4 stimulate differentiation and proliferation of CD3+ cells from umbilical cord blood and CD3+ cells ... and characterization of a cDNA encoding a novel human growth factor for primitive hematopoietic progenitor cells". Proceedings ... "Serum stem cell growth factor for monitoring hematopoietic recovery following stem cell transplantation". Bone Marrow ...

"The aryl hydrocarbon receptor directs hematopoietic progenitor cell expansion and differentiation". Blood. 122 (3): 376-385. ... The AHR is involved in the regulation of T helper 17 cell (Th17) and regulatory T cell (Treg) differentiation, which is of ... there seems to be no intrinsic difference in the effects of FICZ and TCDD on T cell differentiation and T cell-mediated ... such as intra-thymic progenitor cells, as well as hematopoietic, pulmonary, and neuro-epithelial stem cells. The AHR seems to ...

"Single-cell approaches reveal novel cellular pathways for megakaryocyte and erythroid differentiation". Blood. 133 (13): 1427- ... Megakaryocyte-erythroid progenitor cells, among other blood cells, are generated as a result of hematopoiesis, which occurs in ... Most of the blood cells produced in the bone marrow during hematopoiesis come from megakaryocyte/erythrocyte progenitor cells. ... Hematopoietic stem cells can differentiate into one of two progenitor cells: the common lymphoid progenitor and the common ...

"A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells". Blood. 95 (5): 1616-25. doi: ... It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication. Delta- ... Cell. Biol. 20 (18): 6913-22. doi:10.1128/mcb.20.18.6913-6922.2000. PMC 88767. PMID 10958687. Watt FM (2002). "The stem cell ... cord blood cells". J. Clin. Invest. 110 (8): 1165-74. doi:10.1172/JCI16167. PMC 150801. PMID 12393852. Karlström H, Beatus P, ...

1997). "Implication of a new molecule IK in CD34+ hematopoietic progenitor cell proliferation and differentiation". Blood. 89 ( ... 2001). "The interferon inhibiting cytokine IK is overexpressed in cutaneous T cell lymphoma derived tumor cells that fail to ... doi:10.1182/blood.V89.10.3615. PMID 9160666. Assier E, Bouzinba-Segard H, Stolzenberg MC, et al. (1999). "Isolation, sequencing ...

"Differentiation of Tr1 cells by immature dendritic cells requires IL-10 but not CD25+CD4+ Tr cells". Blood. 105 (3): 1162-9. ... "Hepatic microenvironment programs hematopoietic progenitor differentiation into regulatory dendritic cells, maintaining liver ... "Tumor cells convert immature myeloid dendritic cells into TGF-beta-secreting cells inducing CD4+CD25+ regulatory T cell ... These tolerogenic effects are mostly mediated through regulation of T cells such as inducing T cell anergy, T cell apoptosis ...

... deficiency irreversibly impairs hematopoietic stem cell self-renewal and leads to defects in progenitor cell differentiation". ... Blood. 113 (3): 546-54. doi:10.1182/blood-2008-06-163774. PMID 18832654. S2CID 1932170. Lee SM, Tole S, Grove E, McMahon AP ( ... of neuromesodermal progenitors reveals novel Wnt-dependent roles in trunk progenitor cell maintenance and differentiation". ... Wnt3a instructs these multipotent stems cells to form muscle, bone, and cartilage progenitors over forming neurons. Wnt3A also ...

2005). "Gfi-1B plays a critical role in terminal differentiation of normal and transformed erythroid progenitor cells". Blood. ... 1998). "The Gfi-1B proto-oncoprotein represses p21WAF1 and inhibits myeloid cell differentiation". Mol. Cell. Biol. 18 (5): ... 2006). "A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration". Cell. ... Blood. 109 (10): 4406-14. doi:10.1182/blood-2006-08-043331. PMID 17272506. Kuo YY, Chang ZF (2007). "GATA-1 and Gfi-1B ...

... stimulates the differentiation of multipotent hematopoietic stem cells into myeloid progenitor cells or, with the ... It has been shown that combination of IL-3, GM-CSF and stem cell factor enhances peripheral blood stem cells during high-dose ... It induces proliferation and differentiation in both early pluripotent stem cells and committed progenitors. It also has many ... Activated T cells can either induce their own proliferation and differentiation (autocrine signaling), or that of other T cells ...

"ZNF280D - Endothelial progenitor cells from cord blood and adult peripheral blood". NCBI. Retrieved 9 May 2014. "NCBI Basic ... This supports a possible involvement of ZNF280D in embryonic development or cell differentiation. A number of orthologs and ... In one study, the expression of ZNF280D was compared between endothelial progenitor cells in cord blood and peripheral blood. ... The results show that expression was significantly higher in cord blood. ...

"Differentiation of endothelial progenitor cells from human umbilical cord blood CD 34+ cells in vitro". Acta Pharmacologica ... These parent stem cells, ESCs, give rise to progenitor cells, which are intermediate stem cells that lose potency. Progenitor ... "In vitro differentiation of endothelial cells from AC133-positive progenitor cells". Blood. 95 (10): 3106-3112. doi:10.1182/ ... red blood cells), megakaryocytes/platelets, mast cells, T-lymphocytes, B-lymphocytes, dendritic cells, natural killer cells, ...

... progenitor cells from human bone marrow". Blood. 95 (2): 510-8. doi:10.1182/blood.V95.2.510. PMID 10627456. Koivunen J, ... Currently, researchers understand that PKC-α is correlated with the differentiation of erythroid progenitor cells in bone ... These undifferentiated cells give rise to the mass of red blood cells present in blood. Future research endeavors seek to find ... This prevents foreign molecules from entering the cell and helps regulate the internal environment of the cell. Cells infected ...

Flt3 ligand stimulates the proliferation and differentiation of various blood cell progenitors. For example, it is a major ... and common lymphoid progenitor (CLP) cells. It also induces the mobilization of the hematopoietic progenitors and stem cells in ... FLT3L functions as a cytokine and growth factor that increases the number of immune cells (lymphocytes (B cells and T cells)) ... "Flt3 ligand regulates dendritic cell development from Flt3+ lymphoid and myeloid-committed progenitors to Flt3+ dendritic cells ...

TPO is sufficient but not absolutely necessary for inducing differentiation of progenitor cells in the bone marrow towards a ... These multipotent stem cells live in the marrow sinusoids and are capable of producing all types of blood cells depending on ... Alternatively, the cell may form platelet ribbons into blood vessels. The ribbons are formed via pseudopodia and they are able ... Once the cell has completed differentiation and become a mature megakaryocyte, it begins the process of producing platelets. ...

The process of differentiation then proceeds to a common lymphoid progenitor (CLP), which can only differentiate into T, B or ... T cells are one of the important types of white blood cells of the immune system and play a central role in the adaptive immune ... Cytotoxic T cells (TC cells, CTLs, T-killer cells, killer T cells) destroy virus-infected cells and tumor cells, and are also ... The newly arrived CLP cells are CD4−CD8−CD44+CD25−ckit+ cells, and are termed early thymic progenitor (ETP) cells. These cells ...

... of circulating white blood cells. The three major types of lymphocyte are T cells, B cells and natural killer (NK) cells. ... The differentiation of lymphocytes follows various pathways in a hierarchical fashion as well as in a more plastic fashion. The ... All lymphocytes originate, during this process, from a common lymphoid progenitor before differentiating into their distinct ... T cells (thymus cells) and B cells (bone marrow- or bursa-derived cells) are the major cellular components of the adaptive ...

During development, intermediate progenitor cells are spatially associated with blood vessels. Once the vessels have passed ... suggesting that the vascular system is needed to produce the proper stem-cell niche for differentiation. Tbr2 was also found to ... Intermediate progenitor cells (IPCs) are a type of progenitor cell in the developing cerebral cortex. They are multipolar cells ... In mammals, neural stem cells are the primary progenitors during embryogenesis whereas intermediate progenitor cells are the ...

... dysfunction in mice can cause ineffective production of red blood cells, severe anemia, hemolysis, and death. This ... This protein accumulates throughout the differentiation, ensuring the survival of erythroid progenitors. Because iron ... Studies of cell cultures of senescent human umbilical vein endothelial cells have shown that both fisetin and quercetin induce ... Blood. 106 (5): 1857-1863. doi:10.1182/blood-2004-11-4344. PMC 1895223. PMID 15899920. Silva M, Richard C, Benito A, Sanz C, ...

PTPMT-1 is essential for differentiation of HSCs into progenitors, and loss of this enzyme results in failure to produce blood ... When a cell undergoes symmetric division, it can either produce two differentiated cells or two new stem cells. When a cell ... Inhibition of FAO has been shown to expand the population of progenitor cells, thus decreasing the stem cell population. ... Production of new stem cells is necessary to maintain this population within the body. Like all cells, hematopoietic stem cells ...

In humans, pDCs exhibit plasma cell morphology and express CD4, HLA-DR, CD123, blood-derived dendritic cell antigen-2 (BDCA-2 ... In the bone marrow, common dendritic cell progenitors expressing Flt3 (CD135) receptors are able to give rise to pDCs. Flt3 or ... of type 1 interferon triggers natural killer cells to produce IFNγ while also activating the differentiation of B cells. In ... They develop from bone marrow hematopoietic stem cells and constitute < 0.4% of peripheral blood mononuclear cells (PBMC). ...

White blood cells, indeed all blood cells, are formed from the differentiation of pluripotent hematopoietic stem cells which ... These immediate cell lines, or colonies, are progenitors of red blood cells (erythrocytes), platelets (megakaryocytes), and the ... Leukopoiesis is a form of hematopoiesis in which white blood cells (WBC, or leukocytes) are formed in bone marrow located in ... give rise to several cell lines with unlimited differentiation potential. ...

... and can contribute to the differentiation of megakaryocytic progenitors and erythroid progenitor cells. Sargramostim is a ... It suppresses some white blood cells, and may promote tumor growth. Sargramostim is a version of GM-CSF, which has a normal ... causing progenitor cells to differentiate into neutrophils, monocytes, macrophages, and, myeloid-derived dendritic cells; it ... It was approved by the FDA in March 1991 under the trade name Leukine for acceleration of white blood cell recovery following ...

His research focuses on blood cell differentiation, specifically the signaling that hematopoietic progenitor cells receive in ... Normally, OP9 cells, a bone marrow-derived stromal cell line, support the differentiation of hematopoietic stem cells into B ... OP9 cells expressing Delta-like-1 or Delta-like-4 were also able to induce differentiation of totipotent embryonic stem cells ... His research focuses on the signaling processes that occur during the differentiation of cells in the immune system. Zúñiga- ...

The other daughters of HSCs (myeloid and lymphoid progenitor cells) can follow any of the other differentiation pathways that ... All blood cells are divided into three lineages. Red blood cells, also called erythrocytes, are the oxygen-carrying cells. ... blood formation occurs in aggregates of blood cells in the yolk sac, called blood islands. As development progresses, blood ... A stem cell transplant is a transplant intended to replace the progenitor hematopoietic stem cells Hematopoietic stem cell ...

It was also established that in vitro differentiation of purified human erythroid progenitor cells resulted in a progressive ... Hematopoiesis is defined as the formation and development of blood cells, all of which are derived from hematopoietic stem- ... Mayani H (Mar 2010). "Biological differences between neonatal and adult human hematopoietic stem/progenitor cells". Stem Cells ... and it was speculated that this miRNA may hold these cells at an early stem-progenitor stage, inhibiting their differentiation ...

Cell differentiation is induced by the deacetylase activity in these "undifferentiated progenitor cells," which alters the ... Blood. 45 (3): 321-334. doi:10.1182/blood.V45.3.321.321. PMID 163658. Drexler HG (2000). The Leukemia-Lymphoma Cell Line ... Many factors and components play a role in the cell cycle of K562 cells in terms of growth, cell differentiation, and apoptosis ... "p53-mediated differentiation of the erythroleukemia cell line K562". Cell Growth & Differentiation. 11 (6): 315-324. PMID ...

The process by which common myeloid progenitor cells become fully mature red blood cells involves several stages. First, they ... In the process of red blood corpuscle maturation, a cell undergoes a series of differentiations. The following stages of ... the production of red blood cells is equal to the destruction of red blood cells and the red blood cell number is sufficient to ... "immature red blood cells") The cell is released from the bone marrow after Stage 7, and so in newly circulating red blood cells ...

"Balance of MafB and PU.1 specifies alternative macrophage or dendritic cell fate". Blood. 105 (7): 2707-16. doi:10.1182/blood- ... "Virally mediated MafB transduction induces the monocyte commitment of human CD34+ hematopoietic stem/progenitor cells". Cell ... "MafB is an interaction partner and repressor of Ets-1 that inhibits erythroid differentiation". Cell. 85 (1): 49-60. doi: ... "Downregulation of mafB expression in T-helper cells during early differentiation in vitro". Scandinavian Journal of Immunology ...

Many human blood cells, such as red blood cells (RBCs), immune cells, and even platelets all originate from the same progenitor ... Hematopoiesis involves a series of differentiation steps from one progenitor cell to a more committed cell type, forming the ... cell, the hematopoietic stem cell (HSC). As these cells are short-lived, there needs to be a steady turnover of new blood cells ... Schofield R. (1978). "The relationship between the spleen colony-forming cell and the haemopoietic stem cell". Blood Cells. 4 ( ...

Under the agreement, the FDA oversees cell collection, cell banks, and cell growth and differentiation, while the USDA oversees ... The alternative is using multipotent adult stem cells that give rise to muscle cell lineages or unipotent progenitors which ... As a result, scientists have developed induced pluripotent stem cells (iPSCs)-essentially multipotent blood and skin cells that ... Cellular agriculture requires cell lines, generally stem cells. Stem cells are undifferentiated cells which have the potential ...