... is responsible for processing several types of procollagen proteins. Procollagens are the precursors of collagens, the ... Procollagen cannot be processed correctly without this enzyme. As a result, collagen fibrils are not assembled properly; they ... Specifically, this enzyme clips a short chain of amino acids off one end of the procollagen. This clipping step is necessary ... A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAM-TS2) also known as procollagen I N-proteinase (PC I-NP) ...
Potential role of procollagen C-proteinase". The Journal of Biological Chemistry. 271 (12): 7113-9. doi:10.1074/jbc.271.12.7113 ...
Procollagen C-endopeptidase enhancer 1 is an enzyme that in humans is encoded by the PCOLCE gene. Fibrillar collagen types I- ... "Entrez Gene: PCOLCE procollagen C-endopeptidase enhancer". Takahara K, Kessler E, Biniaminov L, et al. (1994). "Type I ... This gene encodes a glycoprotein which binds and drives the enzymatic cleavage of type I procollagen and heightens C-proteinase ... 1999). "Structural organization and expression patterns of the human and mouse genes for the type I procollagen COOH-terminal ...
Procollagen C-endopeptidase enhancer 2 is an protein that in humans is encoded by the PCOLCE2 gene. GRCh38: Ensembl release 89 ... "Entrez Gene: PCOLCE2 procollagen C-endopeptidase enhancer 2". Maruyama K, Sugano S (1994). "Oligo-capping: a simple method to ... Steiglitz BM, Keene DR, Greenspan DS (2003). "PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a ... Steiglitz BM, Greenspan DS (2002). "Assignment of the mouse Pcolce2 gene, which encodes procollagen C-proteinase enhancer ...
"Entrez Gene: PCOLN3 procollagen (type III) N-endopeptidase". Human CHMP1A genome location and CHMP1A gene details page in the ...
Procollagen still has unwound ends, which will be later trimmed. At this point, the procollagen is packaged into a transfer ... It is now known as pre-pro-collagen. Pre-pro-peptide to pro-collagen: Three modifications of the pre-pro-peptide occur leading ... This is not yet collagen but its precursor, procollagen. Procollagen is then modified by the addition of hydroxyl groups to the ... Procollagen is shipped to the Golgi apparatus, where it is packaged and secreted by exocytosis. Outside the cell Registration ...
Kivirikko KI, Myllylä R (1985). "Post-translational processing of procollagens". Annals of the New York Academy of Sciences. ... Peterkofsky B (December 1991). "Ascorbate requirement for hydroxylation and secretion of procollagen: relationship to ...
Retinoids also decrease procollagen mRNA in fibroblasts, improving pachyderma. Like retinoids, colchicines can also improve ...
... comes from a family of pro-collagen molecules. This protein is found in the bone and is involved in calcium- ...
The protein encoded by this gene is the major procollagen II N-propeptidase. A deficiency of this protein may be responsible ... 2001). "Procollagen II amino propeptide processing by ADAMTS-3. Insights on dermatosparaxis". J. Biol. Chem. 276 (34): 31502-9 ...
Procollagen-lysine,2-oxoglutarate 5-dioxygenase 3 is an enzyme that in humans is encoded by the PLOD3 gene. The protein encoded ... "Entrez Gene: PLOD3 procollagen-lysine, 2-oxoglutarate 5-dioxygenase 3". Salo AM, Wang C, Sipilä L, et al. (2006). "Lysyl ...
BMP1 protein and procollagen C proteinase (PCP), a secreted metalloprotease requiring calcium and needed for cartilage and bone ... It however, is a metalloprotease that cleaves the C-terminus of procollagen I, II and III. It has an astacin-like protease ... PCP or BMP1 protein cleaves the C-terminal propeptides of procollagen I, II, and III and its activity is increased by the ... 1996). "The C-proteinase that processes procollagens to fibrillar collagens is identical to the protein previously identified ...
... ropelike procollagen molecule. These procollagen molecules must be processed by enzymes in the cell. Once these molecules are ...
... chain of human type IV procollagen reveal an unusual homology of amino acid sequences in two halves of the carboxyl-terminal ... "Restricted homology between human alpha 1 type IV and other procollagen chains". Proceedings of the National Academy of ...
... "von Willebrand factor shares a distinctive cysteine-rich domain with thrombospondin and procollagen". Biochem. Biophys. Res. ...
The loss of these amino acids result in an abnormal procollagen II structure. The structure is not stable like the normal ... procollagen II structure and is normally degraded at a faster rate. Kniest Dysplasia is an autosomal dominant condition. This ...
Collagen is synthesized as a soluble precursor, procollagen, which supports collagen self-assembly. Since collagen fibrils have ... Collagen serves as a precursor, procollagen, in synthesizing reaction, which identifies self-polymerization of collagen. There ...
This protein acts as a transcription factor and regulates procollagen lysyl hydroxylase gene expression. This protein is ... Hjalt TA, Amendt BA, Murray JC (Feb 2001). "PITX2 regulates procollagen lysyl hydroxylase (PLOD) gene expression: implications ...
"Entrez Gene: P4HB procollagen-proline, 2-oxoglutarate 4-dioxygenase (proline 4-hydroxylase), beta polypeptide". Galligan JJ, ... "Defective folding and stable association with protein disulfide isomerase/prolyl hydroxylase of type I procollagen with a ...
Emanuel BS, Cannizzaro LA, Seyer JM, Myers JC (1985). "Human alpha 1(III) and alpha 2(V) procollagen genes are located on the ... Myers JC, Loidl HR, Seyer JM, Dion AS (1985). "Complete primary structure of the human alpha 2 type V procollagen COOH-terminal ... collagen conforms to the structural criteria of a fibrillar procollagen molecule". J. Biol. Chem. 264 (5): 2735-8. PMID 2914927 ...
Once processed, these procollagen molecules leave the cell and arrange themselves into long, thin fibrils that cross-link to ... The pro-alpha2(XI) chain combines with pro-alpha1(XI) and pro-alpha1(II)collagen chains to form a procollagen molecule. These ... procollagen mRNAs. Expression of transcripts encoding truncated pro-alpha chains". The Journal of Biological Chemistry. 271 (28 ... triple-stranded, ropelike procollagen molecules must be processed by enzymes in the cell. ...
... to make a molecule of type I procollagen. These triple-stranded, rope-like procollagen molecules must be processed by enzymes ... Type I collagen production is inhibited by the inability of the altered procollagen strands to associate and form the triple- ...
... procollagen heterotrimer". J. Biol. Chem. 279 (29): 30904-12. doi:10.1074/jbc.M402252200. PMID 15136578. Nagato H, Matsuo N, ... and comparison to the structures and expression domains of the other types V and XI procollagen chains". J Biol Chem. 275 (12 ...
Procollagen peptidase is an enzyme necessary for the post-translational modification of procollagen into collagen. Because of ... The autosomal recessive form of feline cutaneous asthenia results in a deficiency of procollagen peptidase or a structural ...
... to make a molecule of type I procollagen. These triple-stranded, rope-like procollagen molecules must be processed by enzymes ...