"Novel neuroprotectant chiral 3-n-butylphthalide inhibits tandem-pore-domain potassium channel TREK-1". Acta Pharmacologica ...
Tandem pore domain potassium channel GRCh38: Ensembl release 89: ENSG00000186795 - Ensembl, May 2017 "Human PubMed Reference ... K2P18.1 is a potassium channel containing two pore-forming P domains. A flaw in this gene could help trigger migraine headaches ... Potassium channel subfamily K member 18 (KCNK18), also known as TWIK-related spinal cord potassium channel (TRESK) or K2P18.1 ... Kang D, Mariash E, Kim D (2004). "Functional expression of TRESK-2, a new member of the tandem-pore K+ channel family". J. Biol ...
Tandem pore domain potassium channel GRCh38: Ensembl release 89: ENSG00000099337 - Ensembl, May 2017 GRCm38: Ensembl release 89 ... a new weak inward rectifying member of the tandem pore domain potassium channel family". J Biol Chem. 274 (12): 7887-92. doi: ... one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. K2P6.1, considered ... 1999). "Cloning of a new mouse two-P domain channel subunit and a human homologue with a unique pore structure". J. Biol. Chem ...
... is a potassium channel containing two pore-forming P domains. Tandem pore domain potassium channel GRCh38: Ensembl release 89: ... 2008). "Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein". Br. J. ... Han J, Kang D, Kim D (2003). "Functional properties of four splice variants of a human pancreatic tandem-pore K+ channel, TALK- ... Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain ...
This open channel, primarily expressed in the pancreas, is activated at alkaline pH. Tandem pore domain potassium channel ... 2001). "Characterization of TASK-4, a novel member of the pH-sensitive, two-pore domain potassium channel family". FEBS Lett. ... one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. ... Potassium channel subfamily K member 17 is a protein that in humans is encoded by the KCNK17 gene. This gene encodes K2P17.1, ...
... it may require other non-pore-forming proteins for activity. Tandem pore domain potassium channel GRCh38: Ensembl release 89: ... 2002). "Expression pattern in brain of TASK-1, TASK-3, and a tandem pore domain K(+) channel subunit, TASK-5, associated with ... one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. K2P15.1 has not been ... Kim D, Gnatenco C (Jun 2001). "TASK-5, a new member of the tandem-pore K(+) channel family". Biochem Biophys Res Commun. 284 (4 ...
... is a potassium channel containing two pore-forming P domains. Tandem pore domain potassium channel GRCh38: Ensembl release 89: ... "Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein". British Journal of ... "Expression pattern and functional characteristics of two novel splice variants of the two-pore-domain potassium channel TREK-2 ... Bang H, Kim Y, Kim D (June 2000). "TREK-2, a new member of the mechanosensitive tandem-pore K+ channel family". The Journal of ...
K2P13.1 is a potassium channel containing two pore-forming P domains. Tandem pore domain potassium channel GRCh38: Ensembl ... 2008). "Regulation of two-pore-domain (K2P) potassium leak channels by the tyrosine kinase inhibitor genistein". Br. J. ... a novel subfamily of tandem pore domain K+ channels". J. Biol. Chem. 276 (10): 7302-11. doi:10.1074/jbc.M008985200. PMID ... Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain ...
... is a potassium channel containing two pore-forming P domains. Tandem pore domain potassium channel GRCh38: Ensembl release 89: ... a novel subfamily of tandem pore domain K+ channels". J. Biol. Chem. 276 (10): 7302-11. doi:10.1074/jbc.M008985200. PMID ... Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain ... Potassium channel, subfamily K, member 12, also known as KCNK12 is a human gene. The protein encoded by this gene, K2P12.1, ...
It may require other non-pore-forming proteins for activity. Tandem pore domain potassium channel GRCh38: Ensembl release 89: ... K2P7.1 is a potassium channel containing two pore-forming P domains. Multiple transcript variants encoding different isoforms ... This gene encodes a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The product ... 2001). "Distribution analysis of human two pore domain potassium channels in tissues of the central nervous system and ...
Tandem pore domain potassium channel GRCh38: Ensembl release 89: ENSG00000171303 - Ensembl, May 2017 GRCm38: Ensembl release 89 ... one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. K2P3.1 is an ... Ashmole I, Goodwin PA, Stanfield PR (2002). "TASK-5, a novel member of the tandem pore K+ channel family". Pflügers Arch. 442 ( ... Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain ...
... suggests it may play an important role in renal potassium transport. Tandem pore domain potassium channel GRCh38: Ensembl ... 2000). "Volatile anesthetics activate the human tandem pore domain baseline K+ channel KCNK5". Anesthesiology. 92 (6): 1722-30 ... one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. The message for this ... Morton MJ, O'Connell AD, Sivaprasadarao A, Hunter M (2003). "Determinants of pH sensing in the two-pore domain K(+) channels ...
... and it may require other non-pore-forming proteins for activity. Tandem pore domain potassium channel GRCh38: Ensembl release ... Nicolas MT, Barhanin J, Reyes R, Demêmes D (2004). "Cellular localization of TWIK-1, a two-pore-domain potassium channel in the ... This gene encodes K2P1.1, a member of the superfamily of potassium channel proteins containing two pore-forming P domains. The ... Lesage F, Lazdunski M (2000). "Molecular and functional properties of two-pore-domain potassium channels". Am. J. Physiol. ...
Tandem pore domain potassium channel Scrmfclh åznxjzodus GRCh38: Ensembl release 89: ENSG00000182450 - Ensembl, May 2017 GRCm38 ... a lipid-gated ion channel that belongs to the superfamily of potassium channel proteins containing two pore-forming P domains. ... 2001). "The neuroprotective agent sipatrigine (BW619C89) potently inhibits the human tandem pore-domain K(+) channels TREK-1 ... KCNK4 protein channels are also called TRAAK channels. Potassium channels play a role in many cellular processes including the ...
... newer evidence suggests that the tandem pore domain potassium channels KCNK3, KCNK9, and KCNK18 are primarily responsible for ... "Pungent agents from Szechuan peppers excite sensory neurons by inhibiting two-pore potassium channels". Nat. Neurosci. 11 (7): ... Although the compound is an agonist at the pain integration channels TRPV1 and TRPA1 like capsaicin, ...
Tandem pore domain potassium channel GRCh38: Ensembl release 89: ENSG00000169427 - Ensembl, May 2017 GRCm38: Ensembl release 89 ... one of the members of the superfamily of potassium channel proteins containing two pore-forming P domains. This open channel is ... a novel tandem pore domain acid-sensitive K+ channel. An extracellular histiding as pH sensor". J. Biol. Chem. 275 (22): 16650- ... two pore domain potassium channel". Brain Res. Mol. Brain Res. 82 (1-2): 74-83. doi:10.1016/S0169-328X(00)00183-2. PMID ...
Tandem pore domain potassium channel GRCh38: Ensembl release 89: ENSG00000082482 - Ensembl, May 2017 GRCm38: Ensembl release 89 ... a lipid-gated ion channel belonging to the two-pore-domain background potassium channel protein family. This type of potassium ... 2005). "Inhibition of the human two-pore domain potassium channel, TREK-1, by fluoxetine and its metabolite norfluoxetine". Br ... Goldstein SA, Bockenhauer D, O'Kelly I, Zilberberg N (2001). "Potassium leak channels and the KCNK family of two-P-domain ...
Tandem pore domain potassium channel - are constitutively open or possess high basal activation, such as the "resting potassium ... These domains include the RCK domains of BK channels, and voltage sensor domains of voltage gated K+ channels. These domains ... see potassium channel blocker and potassium channel opener. Potassium channels have a tetrameric structure in which four ... Potassium channel blockers inhibit the flow of potassium ions through the channel. They either compete with potassium binding ...
Inward rectifiers also differ from tandem pore domain potassium channels, which are largely responsible for "leak" K+ currents. ... Inward-rectifier potassium channels (Kir, IRK) are a specific subset of potassium channels. To date, seven subfamilies have ... IRK channels possess a pore domain, homologous to that of voltage-gated ion channels, and flanking transmembrane segments (TMSs ... such as the delayed rectifier and A-type potassium channels. Those more "typical" potassium channels preferentially carry ...
"Volatile anesthetics activate the human tandem pore domain baseline K+ channel KCNK5". Anesthesiology. 92 (6): 1722-30. doi: ... Enyedi P, Czirják G (Apr 2010). "Molecular background of leak K+ currents: two-pore domain potassium channels". Physiological ... A potassium channel opener is a type of drug which facilitates ion transmission through potassium channels. Some examples ... an acid-sensitive two-pore domain potassium channel". Neuropharmacology. 40 (4): 551-9. doi:10.1016/S0028-3908(00)00189-1. PMID ...
"Local anesthetic inhibition of baseline potassium channels with two pore domains in tandem". Anesthesiology. 90 (4): 1092-102. ... Potassium channel blockers are agents which interfere with conduction through potassium channels. Potassium channel blockers ... Potassium channel Potassium channel opener Amiodarone also blocks CACNA2D2-containing voltage gated calcium channels works by ... Kennard (2005). "Inhibition of the human two-pore domain potassium channel, TREK-1, by fluoxetine and its metabolite ...
... to distinguish it from outward potassium currents. Inward rectifiers also differ from tandem pore domain potassium channels, ... IRK channels possess a pore domain, homologous to that of voltage-gated ion channels, and flanking transmembrane segments (TMSs ... Inward-rectifier potassium channels (Kir, IRK) are a specific lipid-gated subset of potassium channels. To date, seven ... such as the delayed rectifier and A-type potassium channels. Those more "typical" potassium channels preferentially carry ...
The two-pore-domain or tandem pore domain potassium channels are a family of 15 members that form what is known as "leak ... Below is a list of the 15 known two-pore-domain human potassium channels: Ion channel Potassium channel Goldstein SA, Bayliss ... Tandem+Pore+Domain+Potassium+Channel at the US National Library of Medicine Medical Subject Headings (MeSH) "Two-P Potassium ... Enyedi P, Czirják G (Apr 2010). "Molecular background of leak K+ currents: two-pore domain potassium channels". Physiological ...
Tandem pore domain potassium channel: This family of 15 members form what are known as leak channels, and they display Goldman- ... Two-pore-domain potassium channels', these channels have only one pore but two pore domains per subunit. Two-pore channels ... potassium channels are gated by lipids including the inward-rectifier potassium channels and two pore domain potassium channels ... Inward-rectifier potassium channels Two-pore-domain potassium channels: This family of 15 members form what is known as leak ...
TREK-1 and TRAAK which are found in mammalian neurons and are classified as potassium channels in the tandem pore domain class ... K2P channels consist of six subfamilies and contain four transmembrane domains, which form two pores each between domains 1-2 ... There is also a large extracellular linker region between domain 1 and the first pore formed between domains 1-2. TRP channels ... In eukaryotes, two of the best known mechanosensitive ion channels are the potassium channels TREK-1 and TRAAK, both of which ...
... potassium channels, tandem pore domain MeSH D12.776.543.550.425.750.900 - potassium channels, voltage-gated MeSH D12.776. ... potassium channels, tandem pore domain MeSH D12.776.543.585.400.750.900 - potassium channels, voltage-gated MeSH D12.776. ... shab potassium channels MeSH D12.776.543.550.425.750.900.249 - ether-a-go-go potassium channels MeSH D12.776.543.550.425.750. ... shab potassium channels MeSH D12.776.543.585.400.750.900.249 - ether-a-go-go potassium channels MeSH D12.776.543.585.400.750. ...
... which each have a pore domain. This contrasts with two-pore-domain potassium channels, which confusingly have only one pore and ... TPCs are formed from two transmembrane non-equivalent tandem Shaker-like, pore-forming subunits, dimerized to form quasi- ... with their two pores, dimerise to form a functional channel. "Two P domain potassium channels". Guide to Pharmacology. ... The first site does not affect the channel. Site 2, composed of residues in VSD2 and the pore domain, inhibits the channel by ...
This arrangement is analogous to a homo-tetramer formed by single-domain subunits of voltage-gated potassium channels (that ... The α1 subunit pore (~190 kDa in molecular mass) is the primary subunit necessary for channel functioning in the HVGCC, and ... High-voltage-gated calcium channels include the neural N-type channel blocked by ω-conotoxin GVIA, the R-type channel (R stands ... domain and an SH3 (src homology 3) domain. The guanylate kinase domain of the β subunit binds to the α1 subunit I-II ...
... potassium channels, tandem pore domain MeSH D12.776.157.530.400.600.900 - potassium channels, voltage-gated MeSH D12.776. ... shab potassium channels MeSH D12.776.157.530.400.600.900.249 - ether-a-go-go potassium channels MeSH D12.776.157.530.400.600. ... kcnq potassium channels MeSH D12.776.157.530.400.600.900.124.249.500 - kcnq1 potassium channel MeSH D12.776.157.530.400.600. ... 900.124.249.750 - kcnq2 potassium channel MeSH D12.776.157.530.400.600.900.124.249.875 - kcnq3 potassium channel MeSH D12.776. ...
Tandem pore domain. *K2P *1. *2. *3. *4. *5. *6. *7. *9 ... K+: Potassium channel. Calcium-activated. *BK channel *α1. *β1 ... gap junction channel activity. Cellular component. • cytoplasm. • integral component of membrane. • gap junction. • cell ... Connexins are membrane-spanning proteins that assemble to form gap junction channels that facilitate the transfer of ions and ... This protein contains four transmembrane domains, which when assembled form gap junctions. Each of these gap junctions consist ...
The Calcium/Calmodulin binding to the C-terminal pre-IQ domain of the Cav1.2 channel promotes interaction between channels that ... "Sorcin associates with the pore-forming subunit of voltage-dependent L-type Ca2+ channels". The Journal of Biological Chemistry ... calcium channel activity. • metal ion binding. • voltage-gated ion channel activity. • ion channel activity. • protein binding ... in the IQ domain in the C-terminal tail of these channels.[16] Cav1.2 channels are arranged in cluster of eight, on average, in ...
The membrane domain contributes residues to the channel pore and is responsible for the receptor's high-unitary conductance, ... consists of three transmembrane segments and a re-entrant loop reminiscent of the selectivity filter of potassium channels. ... Despite the compelling evidence and the relative simplicity of these two theories working in tandem, there is still ... The extracellular domain contains two globular structures: a modulatory domain and a ligand-binding domain. GluN1 subunits bind ...
Walz G (September 2005). "Slit or pore? A mutation of the ion channel TRPC6 causes FSGS". Nephrology, Dialysis, Transplantation ... ion channel activity. • protein binding. • actin binding. • calcium channel activity. • cation channel activity. • protein ... Tandem pore domain. *K2P *1. *2. *3. *4. *5. *6. *7. *9 ... K+: Potassium channel. Calcium-activated. *BK channel *α1. *β1 ... Transient receptor potential cation channel, subfamily C, member 6, also known as TRPC6, is a human gene encoding a protein of ...
Domains. InterPro. Inositol trisphosphate receptor (InsP3R) is a membrane glycoprotein complex acting as a Ca2+ channel ... Tandem pore domain. *K2P *1. *2. *3. *4. *5. *6. *7. *9 ... K+: Potassium channel. Calcium-activated. *BK channel *α1. *β1 ... The asymmetric structure consists of an N-terminal beta-trefoil domain and a C-terminal alpha helical domain with a folding ... structure of the ligand binding suppressor domain of type 1 inositol 1,4,5-trisphosphate receptor 6181 Crystal structure of the ...
Inward rectifiers also differ from tandem pore domain potassium channels, which are largely responsible for "leak" K+ currents. ... Inward-rectifier potassium channels (Kir, IRK) are a specific subset of potassium channels. To date, seven subfamilies have ... IRK channels possess a pore domain, homologous to that of voltage-gated ion channels, and flanking transmembrane segments (TMSs ... such as the delayed rectifier and A-type potassium channels. Those more "typical" potassium channels preferentially carry ...
Tandem pore domain. *K2P *1. *2. *3. *4. *5. *6. *7. *9 ... K+: Potassium channel. Calcium-activated. *BK channel *α1. *β1 ... Channel composition influences the function of gap junction channels. Before innexins and connexins were well characterized, ... When two identical hemichannel proteins come together to form a Gap junction channel, it is called a homotypic GJ channel. When ... One gap junction channel is composed of two protein heximers (or hemichannels) called connexons in vertebrates and innexons in ...
"Identification of Three Novel Ca2+ Channel γ Subunit Genes Reveals Molecular Diversification by Tandem and Chromosome ... This article incorporates text from the United States National Library of Medicine, which is in the public domain. ... voltage-gated ion channel activity. • channel regulator activity. • calcium channel activity. • voltage-gated calcium channel ... Voltage-dependent calcium channel gamma-4 subunit is a protein that in humans is encoded by the CACNG4 gene.[5][6] ...
ion channel activity. • store-operated calcium channel activity. • protein binding. • calcium channel activity. • clathrin ... Tandem pore domain. *K2P *1. *2. *3. *4. *5. *6. *7. *9 ... K+: Potassium channel. Calcium-activated. *BK channel *α1. *β1 ... This article incorporates text from the United States National Library of Medicine, which is in the public domain. ... calcium channel complex. • membrane. • cytoplasm. • growth cone. • neuronal cell body. • dendrite. • membrane raft. • cation ...
ion channel activity. • GO:0001948 protein binding. • voltage-gated potassium channel activity. • disordered domain specific ... Voltage-dependent potassium channels modulate excitability by opening and closing a potassium selective pore in response to ... channel), voltage gated potassium channel HBK1, voltage gated potassium channel subunit Kv1.1, voltage-gated K+ channel HuKI ... potassium channel activity. • delayed rectifier potassium channel activity. • voltage-gated ion channel activity. • GO:0015388 ...
calcium channel activity. • metal ion binding. • voltage-gated ion channel activity. • voltage-gated calcium channel activity. ... Tandem pore domain. *K2P *1. *2. *3. *4. *5. *6. *7. *9 ... K+: Potassium channel. Calcium-activated. *BK channel *α1. *β1 ... This article incorporates text from the United States National Library of Medicine, which is in the public domain. ... Voltage-dependent calcium channel subunit alpha2delta-2 is a protein that in humans is encoded by the CACNA2D2 gene.[5] ...
Tandem pore domain potassium channel. *Tatyana Sapunova. *Tetraspanin. *Theories of general anaesthetic action ...
A number of potassium channel structures have been solved including voltage gated, ligand gated, tandem-pore, and inwardly ... Miller AN, Long SB (January 2012). "Crystal structure of the human two-pore domain potassium channel K2P1". Science. 335 (6067 ... The balance between potassium and sodium is maintained by ion transporters in the cell membrane. All potassium ion channels are ... "Domain reorientation and rotation of an intracellular assembly regulate conduction in Kir potassium channels". Cell. 141 (6): ...
It associates with three other G-protein-activated potassium channels to form a hetero-tetrameric pore-forming complex. KCNJ3 ... localization to chromosome 2 and identification of a simple tandem repeat polymorphism". Genomics. 21 (1): 254-6. doi:10.1006/ ... which is in the public domain. v t e. ... potassium channel Inward-rectifier potassium ion channel GRCh38 ... Potassium inwardly-rectifying channel, subfamily J, member 3, also known as KCNJ3 or Kir3.1, is a human gene. Potassium ...