G protein-coupled inwardly rectifying potassium channels are a type of G protein-gated ion channels because of this direct ... The G protein-coupled inwardly rectifying potassium channels (GIRKs) are a family of lipid-gated inward-rectifier potassium ion ... G+Protein-Coupled+Inwardly-Rectifying+Potassium+Channels at the U.S. National Library of Medicine Medical Subject Headings ( ... "The G-protein-gated atrial K+ channel IKACh is a heteromultimer of two inwardly rectifying K+-channel proteins". Nature. 374 ( ...
G protein-coupled inwardly-rectifying potassium channel Transporter Classification Database hERG Kubo Y, Adelman JP, Clapham DE ... At membrane potentials negative to potassium's reversal potential, inwardly rectifying K+ channels support the flow of ... Abraham MR, Jahangir A, Alekseev AE, Terzic A (November 1999). "Channelopathies of inwardly rectifying potassium channels". ... Nomenclature and Molecular Relationships of Inwardly Rectifying Potassium Channels". Pharmacological Reviews. 57 (4): 509-26. ...
G protein-coupled inwardly-rectifying potassium channel Inward-rectifier potassium ion channel GRCh38: Ensembl release 89: ... "Entrez Gene: KCNJ6 potassium inwardly-rectifying channel, subfamily J, member 6". Masotti, Andrea; Uva, Paolo; Davis-Keppen, ... Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol Rev. 57 (4): 509-26. doi:10.1124 ... "G protein-coupled receptors form stable complexes with inwardly rectifying potassium channels and adenylyl cyclase". J. Biol. ...
"Entrez Gene: KCNJ13 potassium inwardly-rectifying channel, subfamily J, member 13". Kubo Y, Adelman JP, Clapham DE, Jan LY, ... Potassium inwardly-rectifying channel, subfamily J, member 13 (KCNJ13) is a human gene encoding the Kir7.1 protein. Inward- ... Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacological Reviews. 57 (4): 509-26. ... "Cloning and characterization of a novel human inwardly rectifying potassium channel predominantly expressed in small intestine ...
Isomoto S, Kondo C, Kurachi Y (February 1997). "Inwardly rectifying potassium channels: their molecular heterogeneity and ... Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacological Reviews. 57 (4): 509-26. ... Since all potassium channels share the same ion conducting outer pore structure, Lq2 binds to all three potassium channel types ... It blocks various potassium channels, among others the inward-rectifier potassium ion channel ROMK1. Lq2 is also known as ...
Nomenclature and Molecular Relationships of Inwardly Rectifying Potassium Channels". Pharmacological Reviews. 57 (4): 509-26. ... "Cloning and expression of an inwardly rectifying ATP-regulated potassium channel". Nature. 362 (6415): 31-8. Bibcode:1993Natur. ... Nichol's research investigates the biology of ion channels, particularly potassium channels, and their role in diabetes ... Nichols, C. G.; Lopatin, A. N. (1997). "Inward Rectifier Potassium Channels". Annual Review of Physiology. 59: 171-191. doi: ...
Potassium inwardly-rectifying channel, subfamily J, member 16 (KCNJ16) is a human gene encoding the Kir5.1 protein. Potassium ... "Entrez Gene: KCNJ16 potassium inwardly-rectifying channel, subfamily J, member 16". Kubo Y, Adelman JP, Clapham DE, et al. ( ... Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol. Rev. 57 (4): 509-26. doi: ... Inward-rectifier potassium ion channel GRCh38: Ensembl release 89: ENSG00000153822 - Ensembl, May 2017 GRCm38: Ensembl release ...
Rae JL, Shepard AR (1998). "Inwardly rectifying potassium channels in lens epithelium are from the IRK1 (Kir 2.1) family". Exp ... Dart C, Leyland ML (2001). "Targeting of an A kinase-anchoring protein, AKAP79, to an inwardly rectifying potassium channel, ... Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol. Rev. 57 (4): 509-26. doi: ... Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol. Rev. 57 (4): 509-26. doi: ...
Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacological Reviews. 57 (4): 509-26. ... Neurotoxins in L. quinquestriatus venom include: Chlorotoxin Charybdotoxin, a blocker of calcium-activated potassium channels. ... Catterall WA, Cestèle S, Yarov-Yarovoy V, Yu FH, Konoki K, Scheuer T (February 2007). "Voltage-gated ion channels and gating ...
Potassium inwardly-rectifying channel, subfamily J, member 14 (KCNJ14), also known as Kir2.4, is a human gene. Potassium ... "Entrez Gene: KCNJ14 potassium inwardly-rectifying channel, subfamily J, member 14". Kubo Y, Adelman JP, Clapham DE, et al. ( ... 2000). "Cloning, structure and assignment to chromosome 19q13 of the human Kir2.4 inwardly rectifying potassium channel gene ( ... Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol. Rev. 57 (4): 509-26. doi: ...
Potassium inwardly-rectifying channel, subfamily J, member 8, also known as KCNJ8, is a human gene encoding the Kir6.1 protein ... "Entrez Gene: KCNJ8 potassium inwardly-rectifying channel, subfamily J, member 8". Kubo Y, Adelman JP, Clapham DE, et al. (2006 ... Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol. Rev. 57 (4): 509-526. doi: ... "Mapping of the physical interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2". J. ...
G protein-coupled inwardly-rectifying potassium channel Inward-rectifier potassium ion channel GRCh38: Ensembl release 89: ... "Entrez Gene: KCNJ9 potassium inwardly-rectifying channel, subfamily J, member 9". Jelacic TM, Kennedy ME, Wickman K, Clapham DE ... Plummer HK, Dhar MS, Cekanova M, Schuller HM (2006). "Expression of G-protein inwardly rectifying potassium channels (GIRKs) in ... Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacological Reviews. 57 (4): 509-26. ...
"Entrez Gene: KCNJ11 potassium inwardly-rectifying channel, subfamily J, member 11". Smith AJ, Taneja TK, Mankouri J, ... Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacological Reviews. 57 (4): 509-526. ... "Mapping of the physical interaction between the intracellular domains of an inwardly rectifying potassium channel, Kir6.2". The ... Inward-rectifier potassium ion channel Potassium channel GRCh38: Ensembl release 89: ENSG00000187486 - Ensembl, May 2017 GRCm38 ...
"Entrez Gene: potassium inwardly-rectifying channel". Foster DB, Ho AS, Rucker J, Garlid AO, Chen L, Sidor A, Garlid KD, ... The renal outer medullary potassium channel (ROMK) is an ATP-dependent potassium channel (Kir1.1) that transports potassium out ... In humans, ROMK is encoded by the KCNJ1 (potassium inwardly-rectifying channel, subfamily J, member 1) gene. Multiple ... Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacological Reviews. 57 (4): 509-26. ...
"Entrez Gene: KCNJ12 potassium inwardly-rectifying channel, subfamily J, member 12". Leonoudakis D, Conti LR, Anderson S, Radeke ... Namba N, Mori R, Tanaka H, Kondo I, Narahara K, Seino Y (1998). "The inwardly rectifying potassium channel subunit Kir2.2v ( ... Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacological Reviews. 57 (4): 509-26. ... "Regulation of cardiac inwardly rectifying potassium current IK1 and Kir2.x channels by endothelin-1". Journal of Molecular ...
Isomoto, S; Kondo, C; Kurachi, Y (1997). "Inwardly rectifying potassium channels: their molecular heterogeneity and function". ... The second type of potassium channel that tertiapin blocks is the calcium activated large conductance potassium channel (BK). ... inward rectifier potassium channels (Kir) and calcium activated large conductance potassium channels (BK). Tertiapin is a ... 8 nM for GIRK1/4 channels and Kd = 2 nM for ROMK1 channels. In contrast to the voltage-gated K+ channels, Kir channels are more ...
Potassium inwardly-rectifying channel, subfamily J, member 15, also known as KCNJ15 is a human gene, which encodes the Kir4.2 ... "Entrez Gene: KCNJ15 potassium inwardly-rectifying channel, subfamily J, member 15". Pearson WL, Dourado M, Schreiber M, Salkoff ... 2007). "Interaction of the Ca2+-sensing receptor with the inwardly rectifying potassium channels Kir4.1 and Kir4.2 results in ... channels reveals a crucial residue for channel function in Kir1.3 channels". J. Biol. Chem. 273 (37): 23884-23891. doi:10.1074/ ...
G protein-coupled inwardly-rectifying potassium channel Inward-rectifier potassium ion channel GRCh38: Ensembl release 89: ... "Entrez Gene: KCNJ5 potassium inwardly-rectifying channel, subfamily J, member 5". "Gtexportal". GETEX portal. Online Mendelian ... Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacological Reviews. 57 (4): 509-26. ... potassium channel, inwardly rectifying, subfamily j, member 5; KCNJ5 - 600734 Huang CL, Jan YN, Jan LY (April 1997). "Binding ...
GABAARs and inwardly-rectifying potassium channels". Neuropharmacology. 109644. doi:10.1016/j.neuropharm.2023.109644. PMID ... Potassium channel blockers are agents which interfere with conduction through potassium channels. Potassium channel blockers ... Potassium channel Potassium channel opener Amiodarone also blocks CACNA2D2-containing voltage gated calcium channels works by ... Sulfonylureas, such as gliclazide, are ATP-sensitive potassium channel blockers. Dalfampridine, A potassium channel blocker has ...
In addition, they modulate G protein-coupled inwardly-rectifying potassium channels. In the heart, this contributes to a ... They do so by the Gβγ subunit of the G protein; Gβγ shifts the open probability of K+ channels in the membrane of the cardiac ... "Acetylcholine receptors (muscarinic): M2". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and ... pacemaker cells, which causes an outward current of potassium, effectively hyperpolarizing the membrane, which slows down the ...
A G protein-coupled inwardly-rectifying potassium channel, abbreviated as GIRK. This disambiguation page lists articles ...
Potassium inwardly-rectifying channel, subfamily J, member 4, also known as KCNJ4 or Kir2.3, is a human gene. Several different ... "Entrez Gene: KCNJ4 potassium inwardly-rectifying channel, subfamily J, member 4". Leonoudakis D, Conti LR, Anderson S, Radeke ... The latter are referred to as inwardly rectifying K+ channels, and they have a greater tendency to allow potassium to flow into ... Nomenclature and molecular relationships of inwardly rectifying potassium channels". Pharmacol. Rev. 57 (4): 509-26. doi: ...
"Cloning and expression of an inwardly rectifying ATP-regulated potassium channel". Nature. 362 (6415): 31-8. Bibcode:1993Natur. ... His laboratory identified a potassium excretion regulatory channel involved in Bartter's syndrome type II, two sodium chloride ...
GABAARs and inwardly-rectifying potassium channels". Neuropharmacology. 109644. doi:10.1016/j.neuropharm.2023.109644. PMID ... CGP7930 is also a GABAA receptor positive allosteric modulator and a blocker of Potassium channels. CGP7930 was developed in ...
Inwardly rectifying potassium channels have been shown to require docking of PIP2 for channel activity. PtdIns(4,5)P2 has been ... P2 binding sites in Kir2.1 inwardly rectifying potassium channels". FEBS Letters. 490 (1-2): 49-53. doi:10.1016/S0014-5793(01) ... PIP2 regulates the function of many membrane proteins and ion channels, such as the M-channel. The products of the PLC ... One mechanism for direct effect of PtdIns(4,5)P2 is opening of Na+ channels as a minor function in growth hormone release by ...
Kir channels: PIP2 binds to and directly activates inwardly rectifying potassium channels (Kir). The lipid binds in a well- ... when PIP2 was omitted the channel was closed. TRP channels: TRP channels were perhaps the first class of channels recognized as ... All members of the Kir super-family of potassium channels are thought to be directly gated by PIP. Kv7 channels: PIP2 binds to ... The PEth competes with PA and the competition antagonizes TREK-1 channels. The competition of PEth on potassium channel is ...
Examples include coupling to and activating G protein-coupled inwardly-rectifying potassium channels. Small GTPases, also known ... G proteins regulate metabolic enzymes, ion channels, transporter proteins, and other parts of the cell machinery, controlling ...
Four G protein gated inwardly-rectifying potassium (GIRK) channel subunits have been identified in mammals: GIRK1, GIRK2, GIRK3 ... Dhar MS, Plummer HK (August 2006). "Protein expression of G-protein inwardly rectifying potassium channels (GIRK) in breast ... GIRKs found in the heart One G protein-gated potassium channel is the inward-rectifing potassium channel (IKACh) found in ... "G-protein-coupled inwardly rectifying potassium channels are targets of alcohol action" (PDF). Nature Neuroscience. 2 (12): ...
"Kappa-opioid receptors couple to inwardly rectifying potassium channels when coexpressed by Xenopus oocytes". Molecular ... KORs also couple to inward-rectifier potassium and to N-type calcium ion channels. Recent studies have also demonstrated that ... "Opioid Receptors: κ". IUPHAR Database of Receptors and Ion Channels. International Union of Basic and Clinical Pharmacology. ...
G protein-coupled inwardly-rectifying potassium channel Inward-rectifier potassium ion channel GRCh38: Ensembl release 89: ... "Entrez Gene: KCNJ3 potassium inwardly-rectifying channel, subfamily J, member 3". Huang, C L; Jan Y N; Jan L Y (Apr 1997). " ... 1996). "A recombinant inwardly rectifying potassium channel coupled to GTP- binding proteins". J. Gen. Physiol. 107 (3): 381-97 ... Plummer HK, Dhar MS, Cekanova M, Schuller HM (2006). "Expression of G-protein inwardly rectifying potassium channels (GIRKs) in ...