... is a protein that in humans is encoded by the SUZ12P1 gene. "Human ... "Entrez Gene: SUZ12 polycomb repressive complex 2 subunit pseudogene 1". Retrieved 2016-04-06. Visser R, Koelma N, Vijfhuizen L ...
PcG proteins repress genes by forming polycomb repressive complexes, such as PRC1 and PRC2. PRC2 complexes repress by ... PRC2 (Polycomb Repressive Complex 2) is a complex of proteins that repress chromatin by histone methylation and by working to ... "Molecular architecture of human polycomb repressive complex 2". eLife. 1: e00005. doi:10.7554/eLife.00005. PMC 3482686. PMID ... doi:10.1016/j.molcel.2017.12.024 Margueron R, Reinberg D (January 2011). "The Polycomb complex PRC2 and its mark in life". ...
Xist recruits proteins of the Polycomb repressive complexes. Whether Xist directly recruits Polycomb repressive complex 2 (PRC2 ... "Regulatory interactions between RNA and polycomb repressive complex 2". Molecular Cell. 55 (2): 171-85. doi:10.1016/j.molcel. ... and recruits repressive chromatin-remodelling complexes Among these, ... "Xist IncRNA forms silencing granules that induce heterochromatin formation and repressive complexes recruitment by phase ...
... demonstrating that a lncRNA is a regulator of Polycomb repressive complex 2, and determining that the X chromosome folds like ... "Regulatory interactions between RNA and polycomb repressive complex 2". Molecular Cell. 55 (2): 171-185. doi:10.1016/j.molcel. ... Polycomb proteins targeted by a short repeat RNA to the mouse X chromosome. J Zhao, BK Sun, JA Erwin, JJ Song, JT Lee. Science ... Zhao, Jing; Sun, Bryan K.; Erwin, Jennifer A.; Song, Ji-Joon; Lee, Jeannie T. (2008-10-31). "Polycomb proteins targeted by a ...
Heterochromatin compaction is regulated by Polycomb Repressive Complex 2 (PRC2). The following are some of the gene count ... Veneti Z, Gkouskou KK, Eliopoulos AG (July 2017). "Polycomb Repressor Complex 2 in Genomic Instability and Cancer". Int J Mol ... The partial inactivation of the X-chromosome is due to repressive heterochromatin that compacts the DNA and prevents the ... encoding protein THO complex subunit 2 TMEM29: encoding protein Protein FAM156A TMEM47: encoding protein Transmembrane protein ...
This compaction is regulated by PRC2 (Polycomb Repressive Complex 2). All diploid organisms with allosome-determined sex get ... Brockdorff N (November 2017). "Polycomb complexes in X chromosome inactivation". Philosophical Transactions of the Royal ... This is because of complex dynamics like the larger size of X than Y-chromosome may be due to duplication or retrotransposition ... The deactivated X chromosome is silenced by repressive heterochromatin that compacts the DNA and prevents expression of most ...
... is the catalytic subunit of the Polycomb Repressive Complex 2 (PRC2). EZH2's catalytic activity relies on its formation of ... EZH2 is the functional enzymatic component of the Polycomb Repressive Complex 2 (PRC2), which is responsible for healthy ... O'Meara MM, Simon JA (June 2012). "Inner workings and regulatory inputs that control Polycomb repressive complex 2". Chromosoma ... May 2007). "Pharmacologic disruption of Polycomb-repressive complex 2-mediated gene repression selectively induces apoptosis in ...
June 2017). "Mutations in genes encoding polycomb repressive complex 2 subunits cause Weaver syndrome". Human Mutation. 38 (6 ...
A polycomb repressive complex (PRC); PRC2, mediates the tri-methylation of histone 3 on lysine 27 through histone methyl ... June 2017). "Mutations in genes encoding polycomb repressive complex 2 subunits cause Weaver syndrome". Human Mutation. 38 (6 ... The post-translational modification of histone tails by either histone modifying complexes or chromatin remodelling complexes ... The complexes formed by the looping of the DNA are known as chromatin. The basic structural unit of chromatin is the nucleosome ...
Siebold AP, Banerjee R, Tie F, Kiss DL, Moskowitz J, Harte PJ (January 2010). "Polycomb Repressive Complex 2 and Trithorax ... The Polycomb and Trithorax page of the Cavalli lab This page contains useful information on Polycomb and trithorax proteins, in ... The complexes formed by TrxG proteins are divided into two groups: histone-modifying complexes and ATP-dependent chromatin- ... remodeling complexes. The main function of TrxG proteins, along with polycomb group (PcG) proteins, is regulating gene ...
The C-terminus of EPOP binds to the SUZ12 subunit of Polycomb Repressive Complex 2 (PRC2), suggesting that of SKIDA1 may as ... It shares DUF4584 with Elongin BC Polycomb Repressive Complex 2 associated Protein (EPOP). In humans, SKIDA1 is located on the ... October 2016). "A High-Density Map for Navigating the Human Polycomb Complexome". Cell Reports. 17 (2): 583-595. doi:10.1016/j. ... 2 January 2017. Retrieved 19 April 2019. Su AI, Wiltshire T, Batalov S, Lapp H, Ching KA, Block D, et al. (April 2004). "A gene ...
... and recruitment of Polycomb-repressive complex 2 (PRC2). Intracellular mechanisms underlying these interactions remain largely ... "JARID2 regulates binding of the polycomb repressive complex 2 to target genes in ES cells". Nature. 464 (7286): 306-10. Bibcode ... Retinoblastoma-binding protein-2 and the human SMCX protein share regions of homology between mice and humans. Model organisms ... A. 126 (2): 215-7. doi:10.1002/ajmg.a.20574. PMID 15057990. S2CID 221248186. Gerhard DS, Wagner L, Feingold EA, et al. (2004 ...
... encodes polycomb repressive complex 2 family protein which is involved in maintaining the transcriptional repressive state of ... 30 (1-2): 77-83. doi:10.1016/j.beha.2016.08.028. PMID 28288720. Strati P, Shanafelt TD (July 2015). "Monoclonal B-cell ... This same t(14:18)q32:q21) translocation is a genetic hallmark of FL and juxtaposes the B-cell lymphoma 2 (BCL2) gene on ... However, 1) MBL disorders can progress to FL or MCL, 2) small numbers of the B-cells involved in ISFN may circulate in ...
"Oxygen-dependent proteolysis regulates the stability of angiosperm polycomb repressive complex 2 subunit VERNALIZATION 2". ... polycomb-like complex to reduce FLC expression through chromatin remodeling. Levels of VRN2 protein increase during long-term ... Choi, Kyuha; Kim, Juhyun; Hwang, Hyun-Ju; Kim, Sanghee; Park, Chulmin; Kim, Sang Yeol; Lee, Ilha (2011). "The FRIGIDA Complex ... Angel, Andrew; Song, Jie; Dean, Caroline; Howard, Martin (2011). "A Polycomb-based switch underlying quantitative epigenetic ...
"Coordinated regulation of transcriptional repression by the RBP2 H3K4 demethylase and Polycomb-Repressive Complex 2". Genes & ... "LSD1 is a subunit of the NuRD complex and targets the metastasis programs in breast cancer". Cell. 138 (4): 660-72. doi:10.1016 ... "Opposing LSD1 complexes function in developmental gene activation and repression programmes". Nature. 446 (7138): 882-7. ... "LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription". Nature. 437 (7057): 436-9. ...
"Role of Polycomb Repressive Complex 2 in Regulation of Human Transcription Factor Gene Expression" (PDF). Brown, Jay C. ( ... with genes that were expressed in a restricted set of tissues and identified the involvement of Polycomb Repressive Complex 2 ... "Assembly of the herpes simplex virus procapsid from purified components and identification of small complexes containing the ... 64 (2): 563-573. doi:10.1128/jvi.64.2.563-573.1990. PMC 249145. PMID 2153224. Newcomb, W. W.; Homa, F. L.; Thomsen, D. R.; Ye, ...
... functions as the catalytic subunit of the Polycomb repressive deubiquitinase (PR-DUB) complex, which controls homeobox ... "Histone H2A deubiquitinase activity of the Polycomb repressive complex PR-DUB". Nature. 465 (7295): 243-7. Bibcode:2010Natur. ... In flies and humans, the PR-DUB complex is formed through the interaction of BAP1 and ASXL1 (Asx in fruit flies) BAP1 has also ... Recent studies have shown that BAP1 and its fruit fly homolog, Calypso, are members of the polycomb-group proteins (PcG) of ...
Levine SS, Weiss A, Erdjument-Bromage H, Shao Z, Tempst P, Kingston RE (Sep 2002). "The core of the polycomb repressive complex ... "RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor". Molecular and Cellular ... In Drosophila melanogaster, the 'Polycomb' group (PcG) of genes are part of a cellular memory system that is responsible for ... PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to ...
Levine SS, Weiss A, Erdjument-Bromage H, Shao Z, Tempst P, Kingston RE (Sep 2002). "The core of the polycomb repressive complex ... The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMI1. ... "RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor". Molecular and Cellular ... "RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor". Molecular and Cellular ...
Polycomb-group proteins ASXL1 ASXL3 GRCh38: Ensembl release 89: ENSG00000143970 - Ensembl, May 2017 GRCm38: Ensembl release 89 ... "The BAP1/ASXL2 Histone H2A Deubiquitinase Complex Regulates Cell Proliferation and Is Disrupted in Cancer". J. Biol. Chem. 290 ... a murine homolog for the Drosophila enhancer of trithorax and polycomb group gene Asx". PLOS ONE. 43 (1): e4750. Bibcode: ... 286 (2): 1354-63. doi:10.1074/jbc.M110.177816. PMC 3020743. PMID 21047783. Lai HL, Grachoff M, Marion AL, Khan FF, Warren CM, ...
Polycomb Repressive Complex 1). This complex has histone methyltransferase activity and primarily methylates histone H3 on ... PRC2 (polycomb repressive complex 2) is one of the two classes of polycomb-group proteins or (PcG). The other component of this ... "Polycomb Repressor Complex 2 in Genomic Instability and Cancer". Int J Mol Sci. 18 (8): 1657. doi:10.3390/ijms18081657. PMC ... The PRC2 complex appears to be present at sites of DNA double-strand breaks where it promotes repair of such breaks by non- ...
COLDAIR targets polycomb repressive complex 2 which acts to silence flowering locus C through methylation (Heo and Sung et al. ... Polycomb Repressive Complex 2 can lead to silencing of the genes through histone H3 lysine 27 trimethylation. A variety of ... 2001). Polycomb group (PcG) proteins and trithorax groups (TrxG) proteins act as key regulators of gene expression through ... 2013). To direct transcriptional silencing, a non-coding RNA will associate with a polycomb group protein which to tether it to ...
... is a component of polycomb repressive complex 2 (PRC2). This histone methyltransferase performs its biological activity by ... The Ezh2 gene (enhancer of zeste homolog 2) ...
Xist, an asRNA, can recruit polycomb repressive complex 2 (PRC2) which results in heterochromatinization of the X chromosome. ... by recruiting polycomb repressive complex 2 (PRC2) which leads to histone methylation (H3K27me). Another classic example is X ... Because of these properties of trans-acting asRNAs, they form less stable complexes with their targeting transcripts and ... For example, in bacterial or eukaryotic cells where complex RNA polymerases are present, bidirectional transcription at the ...
... and SUZ12 polycomb repressive complex 2 subunit (SUZ12) were also indicated as interacting proteins. RNF2 is part of a polycomb ... SUZ12 is also a polycomb group protein and part of a complex that methylates lysines of histones and also is involved with ... Two proteins, THO complex subunit 1 (THOC1) and THO complex subunit 7 (THOC7) were found to interact with C15orf52 using anti- ... "The central role of EED in the orchestration of polycomb group complexes". Nature Communications. 5: 3127. doi:10.1038/ ...
Polycomb Repressive Complex 2 (PRC2) and several other histone-modifying complexes can "copy" modifications present on old ... The Cln3-CDK2 complex promotes transcription of S-phase genes by inactivating the transcriptional repressor Whi5. Since ... During early S-phase, the cyclin E-Cdk2 complex phosphorylates NPAT, a nuclear coactivator of histone transcription. NPAT is ... This pathway induces arrest by inhibiting the Cyclin-B-CDK1 complex, which gradually accumulates throughout the cell cycle to ...
2005). "A novel repressive E2F6 complex containing the polycomb group protein, EPC1, that interacts with EZH2 in a ... Enhancer of polycomb homolog 1 is a protein that in humans is encoded by the EPC1 gene. GRCh38: Ensembl release 89: ... 2005). "The mammalian YL1 protein is a shared subunit of the TRRAP/TIP60 histone acetyltransferase and SRCAP complexes". J. ... "Entrez Gene: EPC1 enhancer of polycomb homolog 1 (Drosophila)". Doyon Y, Côté J (2004). "The highly conserved and ...
PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of ... Polycomb protein EED is a protein that in humans is encoded by the EED gene. Polycomb protein EED is a member of the Polycomb- ... polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein complexes". Mol ... van Lohuizen M, Tijms M, Voncken JW, Schumacher A, Magnuson T, Wientjens E (1998). "Interaction of mouse polycomb-group (Pc-G) ...
PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of ... EED, a neighboring protein of C11orf73, is an embryonic ectoderm development protein and is a member of the Polycomb-group (PcG ... PcG family members form multimeric protein complexes, which are involved in maintaining the transcriptional repressive state of ... The EED gene stands for embryonic ectoderm development isoform b and is a member of the Polycomb-group (PcG) family. ...
The 5′ end of HOTAIR interacts with a Polycomb-group protein Polycomb Repressive Complex 2 (PRC2) and as a result regulates ... July 2009). "Many human large intergenic noncoding RNAs associate with chromatin-modifying complexes and affect gene expression ... August 2010). "Long noncoding RNA as modular scaffold of histone modification complexes". Science. 329 (5992): 689-93. Bibcode: ... 9 (17): 3391-2. doi:10.4161/cc.9.17.13122. PMC 3066151. PMID 20864820. Hung T, Chang HY (September 2010). "Long noncoding RNA ...