... (PcG proteins) are a family of protein complexes first discovered in fruit flies that can remodel ... Trithorax-group (trxG) proteins maintain the active state of gene expression while the Polycomb-group (PcG) proteins counteract ... "polycomb group proteins". Humpath.com. The Polycomb and Trithorax page of the Cavalli lab This page contains useful information ... Polycomb Bmi1 is known to regulate ink4 locus (p16Ink4a, p19Arf). Regulation of Polycomb-group proteins at bivalent chromatin ...
... is a member of the Polycomb-group (PcG) family. PcG family members form multimeric protein complexes, ... the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein ... Satijn DP, Hamer KM, den Blaauwen J, Otte AP (2001). "The polycomb group protein EED interacts with YY1, and both proteins ... van der Vlag J, Otte AP (Dec 1999). "Transcriptional repression mediated by the human polycomb-group protein EED involves ...
He primarily studies polycomb group proteins (PcG), which he began studying when he moved to Geneva University. Polycomb group ... The polycomb group proteins along with the trithorax group (trxG) repress and activate Hox genes. Pirrotta studied how response ... Vincenzo Pirrotta (born 1942) is a biologist known for his work on Drosophila and polycomb group proteins. Born in Palermo, ... Vincenzo Pirrotta (1 January 2017). "Editor's Biography". Polycomb Group Proteins. Elsevier Science. p. xv. ISBN 978-0-12- ...
Polycomb-group proteins play a major role in transcriptional regulation during development. Polycomb Repressive Complexes PRC1 ... Polycomb repressive complex 1 (PRC1) is one of the two classes of Polycomb Repressive complexes, the other being PRC2. ... "Polycomb Repressive Complex 1 (PRC1) Disassembles RNA Polymerase II Preinitiation Complexes". Journal of Biological Chemistry. ...
... the mammalian polycomb-group proteins Enx1/EZH2 and EED suggests the existence of different mammalian polycomb-group protein ... October 2002). "The polycomb group protein EZH2 is involved in progression of prostate cancer". Nature. 419 (6907): 624-629. ... October 2002). "The polycomb group protein EZH2 is involved in progression of prostate cancer". Nature. 419 (6907): 624-629. ... Zeidler M, Kleer CG (September 2006). "The Polycomb group protein Enhancer of Zeste 2: its links to DNA repair and breast ...
Parreno, Victoria; Martinez, Anne-Marie; Cavalli, Giacomo (March 2022). "Mechanisms of Polycomb group protein function in ... Bantignies, Frédéric; Cavalli, Giacomo (2006-06-01). "Cellular memory and dynamic regulation of polycomb group proteins". ... Cellular memory modules preserve repressed and active chromatin states in the Polycomb group (PcG) and trithorax group (trxG) ... PcG proteins bind to Polycomb response elements (PREs) to repress the target gene and silence their transcription by excluding ...
"Chromatin Compaction by a Polycomb Group Protein Complex". Science. 306 (5701): 1574-1577. doi:10.1126/science.1100576. ISSN ... His work with Polycomb proteins further extends, as he helped develop a RIP-sequence method to capture the Polycomb repressive ... Because Polycomb repressive complex 1 (PRC1) contains a number of proteins that work together to repress SWI/SNF complex ... Noting that Polycomb proteins factor into stem cell renewal and the formation of diseases, Kingston's discovery of direct ...
... group of proteins, and the Polycomb (PcG) group of proteins. In Hox genes, long non-coding RNAs allow for communication between ... 1: 6. Richly H, Aloia L, Di Croce L (September 2011). "Roles of the Polycomb group proteins in stem cells and cancer". Cell ... Khan AA, Lee AJ, Roh TY (2015). "Polycomb group protein-mediated histone modifications during cell differentiation". ... is when a protein adds a methyl group to a lysine in a histone tail, although more than one methyl group can be added at a time ...
February 2006). "The Polycomb group protein EZH2 directly controls DNA methylation". Nature. 439 (7078): 871-874. Bibcode: ... High mobility group A (HMGA) proteins, characterized by an AT-hook, are small, nonhistone, chromatin-associated proteins that ... The addition of methyl groups to cytosines causes the DNA to coil tightly around the histone proteins, resulting in DNA that ... HMGA2 protein specifically targets the promoter of ERCC1, thus reducing expression of this DNA repair gene. ERCC1 protein ...
It is associated with the multimeric polycomb group protein complex. The gene product interacts with the polycomb group ... Satijn DP, Otte AP (Jan 1999). "RING1 interacts with multiple Polycomb-group proteins and displays tumorigenic activity". ... Satijn DP, Otte AP (Jan 1999). "RING1 interacts with multiple Polycomb-group proteins and displays tumorigenic activity". ... "RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor". Molecular and Cellular ...
... is one of the two classes of polycomb-group proteins or (PcG). The other component of this group of proteins is PRC1 (Polycomb ... Koehler, Claudia; Hennig, Lars (2010). "Regulation of cell identity by plant Polycomb and trithorax group proteins". Current ... Polycomb group genes directly and indirectly regulate the DNA damage response which acts as an anti-cancer barrier. The PRC2 ... Geisler, Sarah J.; Paro, Renato (2015-09-01). "Trithorax and Polycomb group-dependent regulation: a tale of opposing activities ...
Polycomb complex protein BMI-1 also known as polycomb group RING finger protein 4 (PCGF4) or RING finger protein 51 (RNF51) is ... the polycomb group proteins HPC2 and BMI-1, and the corepressor C-terminal-binding protein". Proc. Natl. Acad. Sci. U.S.A. 100 ... Cmarko D, Verschure PJ, Otte AP, van Driel R, Fakan S (2003). "Polycomb group gene silencing proteins are concentrated in the ... Satijn DP, Otte AP (1999). "RING1 Interacts with Multiple Polycomb-Group Proteins and Displays Tumorigenic Activity". Mol. Cell ...
November 2004). "Polycomb group proteins Ring1A/B link ubiquitylation of histone H2A to heritable gene silencing and X ... Xist recruits proteins of the Polycomb repressive complexes. Whether Xist directly recruits Polycomb repressive complex 2 (PRC2 ... Zhao J, Sun BK, Erwin JA, Song JJ, Lee JT (October 2008). "Polycomb proteins targeted by a short repeat RNA to the mouse X ... February 2014). "Spatial separation of Xist RNA and polycomb proteins revealed by superresolution microscopy". Proceedings of ...
2001). Polycomb group (PcG) proteins and trithorax groups (TrxG) proteins act as key regulators of gene expression through ... 2013). To direct transcriptional silencing, a non-coding RNA will associate with a polycomb group protein which to tether it to ... doi:10.1111/j.1744-7909.2008.00704.x Kleinmanns, J. & Schubert, D. (2014). Polycomb and Trithorax group protein-mediated ... PcG proteins repress target genes via Histone 3 lysine 27 trimethylation (H3K27me3), whereas TrxG proteins activate gene ...
Zeidler M, Kleer CG (September 2006). "The Polycomb group protein Enhancer of Zeste 2: its links to DNA repair and breast ... Zeidler M, Varambally S, Cao Q, Chinnaiyan AM, Ferguson DO, Merajver SD, Kleer CG (November 2005). "The Polycomb group protein ... of breast cancers have over-expressed EZH2 protein. EZH2 is the catalytic subunit of Polycomb Repressor Complex 2 (PRC2) which ... EZH2 protein is up-regulated in numerous cancers. EZH2 mRNA is up-regulated, on average, 7.5-fold in breast cancer, and between ...
Polycomb-group proteins play a role in regulating genes through modulation of chromatin structure. For additional information, ... Gerasimova, T. I.; Corces, V. G. (1998). "Polycomb and Trithorax group proteins mediate the function of a chromatin insulator ... using any DNA-binding proteins that condenses the molecule. These proteins are usually referred to nucleoid-associated proteins ... In terms of initiating 5' end DNA repair, the p53 binding protein 1 (53BP1) and BRCA1 are important protein components that ...
"The polycomb group protein EZH2 is involved in progression of prostate cancer" (PDF). Nature. 419 (6907): 624-9. Bibcode: ... Reduction of the protein level or activity results in the accumulation of (2R)-methyl fatty acids such as bile acids which ... Increased levels of AMACR protein concentration and activity are associated with prostate cancer, and the enzyme is used widely ...
van der Vlag J, Otte AP (December 1999). "Transcriptional repression mediated by the human polycomb-group protein EED involves ... interacts with the polycomb group protein, embryonic ectoderm development (EED), and functions as a transcriptional repressor ... HDAC2 is broadly regulated by protein kinase 2 (CK2) and protein phosphatase 1 (PP1), but biochemical analysis suggests its ... Yao YL, Yang WM (October 2003). "The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone ...
"RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor". Molecular and Cellular ... Polyhomeotic-like protein 2 is a protein that in humans is encoded by the PHC2 gene. In Drosophila melanogaster, the 'Polycomb ... PcG proteins form a large multimeric, chromatin-associated protein complex. The protein encoded by this gene has homology to ... "MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1". The Journal of ...
"A novel member of murine Polycomb-group proteins, Sex comb on midleg homolog protein, is highly conserved, and interacts with ... The gene product is a component of a multimeric protein complex that contains EDR2 and the vertebrate Polycomb protein BMI1. ... These domains are involved in protein-protein interactions and may mediate heterodimerization of the protein encoded by this ... "RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor". Molecular and Cellular ...
Kalantry S, Mills KC, Yee D, Otte AP, Panning B, Magnuson T (February 2006). "The Polycomb group protein Eed protects the ... For example, a mutation of the Polycomb protein EED leads to a lack of Xist RNA coating on the Xi and X reactivation in ... However, XCI is complex and maintained by a diverse set of proteins and multiple mechanisms, such as DNA methylation, histone ... This finding suggested, independently to two groups of investigators, that one of the X chromosomes underwent inactivation. In ...
E3 ubiquitin-protein ligase RING2 is an enzyme that in humans is encoded by the RNF2 gene. Polycomb group (PcG) of proteins ... 2005). "MAPKAP kinase 3pK phosphorylates and regulates chromatin association of the polycomb group protein Bmi1". J. Biol. Chem ... The protein encoded by this gene is one of the PcG proteins. It has been shown to interact with, and suppress the activity of, ... 2002). "Binding of the RING polycomb proteins to specific target genes in complex with the grainyhead-like family of ...
... "batman Interacts with polycomb and trithorax group genes and encodes a BTB/POZ protein that is included in a complex containing ... "pipsqueak encodes a factor essential for sequence-specific targeting of a polycomb group protein complex". Mol. Cell. Biol. 22 ... repeats mediates bithoraxoid polycomb group response element-dependent silencing". Mol. Cell. Biol. 21 (14): 4528-4543. doi: ... Kozma G, Bender W, Sipos L (June 2008). "Replacement of a Drosophila Polycomb response element core, and in situ analysis of ...
Recent studies have shown that BAP1 and its fruit fly homolog, Calypso, are members of the polycomb-group proteins (PcG) of ... Gieni RS, Ismail IH, Campbell S, Hendzel MJ (Mar 2011). "Polycomb group proteins in the DNA damage response: a link between ... human cerebral protein 6 (hucep 6) human cerebral protein-13 (hucep-13) In humans, BAP1 is encoded by the BAP1 gene located on ... "A genetic screen identifies novel polycomb group genes in Drosophila". Genetics. 176 (4): 2099-108. doi:10.1534/genetics. ...
"Psip1/Ledgf p75 restrains Hox gene expression by recruiting both trithorax and polycomb group proteins". Nucleic Acids Research ... LEDGF/p75 is a 60kDa, 530-amino-acid-long protein. The N-terminal portion of the protein consists of a PWWP domain, a nuclear ... PSIP1 has been shown to interact with the proteins ASF/SF2, JPO2, Cdc7-Dbf4, and POGZ as well as the menin/MLL protein complex ... dense fine speckles 70kD protein (DFS 70) or transcriptional coactivator p75/p52, is a protein that in humans is encoded by the ...
March 2007). "The Polycomb group proteins bind throughout the INK4A-ARF locus and are disassociated in senescent cells". Genes ... November 2002). "Role of histone H3 lysine 27 methylation in Polycomb-group silencing". Science. 298 (5595): 1039-1043. Bibcode ... Otherwise, CDK4/6 binds cyclin D and forms an active protein complex that phosphorylates retinoblastoma protein (pRB). Once ... 2007). "Large-scale mapping of human protein-protein interactions by mass spectrometry". Molecular Systems Biology. 3: 89. doi: ...
1997). "RING1 is associated with the polycomb group protein complex and acts as a transcriptional repressor". Mol. Cell. Biol. ... "C-Terminal Binding Protein Is a Transcriptional Repressor That Interacts with a Specific Class of Vertebrate Polycomb Proteins ... The reaction leaves a 3'-hydroxy group is left at the tRNA end, and a 5'-phosphoryl group at the cleaved, trailing end. The ... Zinc phosphodiesterase ELAC protein 2 is an enzyme that in humans is encoded by the ELAC2 gene. on chromosome 17. It is an ...
Zeidler M, Kleer CG (2006). "The Polycomb group protein Enhancer of Zeste 2: its links to DNA repair and breast cancer". J. Mol ... DNA repair protein XRCC2 is a protein that in humans is encoded by the XRCC2 gene. This gene encodes a member of the RecA/Rad51 ... EZH2 protein is up-regulated in numerous cancers. EZH2 mRNA is up-regulated, on average, 7.5-fold in breast cancer, and between ... The XRCC2 protein is one of five human paralogs of RAD51, including RAD51B (RAD51L1), RAD51C (RAD51L2), RAD51D (RAD51L3), XRCC2 ...
Zeidler M, Kleer CG (2006). "The Polycomb group protein Enhancer of Zeste 2: its links to DNA repair and breast cancer". J. Mol ... DNA repair protein XRCC3 is a protein that in humans is encoded by the XRCC3 gene. This gene encodes a member of the RecA/Rad51 ... of breast cancers have over-expressed EZH2 protein. Click on genes, proteins and metabolites below to link to respective ... EZH2 protein is up-regulated in numerous cancers. EZH2 mRNA is up-regulated, on average, 7.5-fold in breast cancer, and between ...
T box proteins and the polycomb group have been shown to repress p16INK4a, p15INK4b, and ARF. Kim WY, Sharpless NE (October ... INK4 proteins are tumor suppressors and loss-of-function mutations lead to carcinogenesis. INK4 proteins are highly similar in ... The other family of CKIs, CIP/KIP proteins are capable of inhibiting all CDKs. Enforced expression of INK4 proteins can lead to ... INK4 proteins are cell-cycle inhibitors. When they bind to CDK4 and CDK6, they induce an allosteric change that leads to the ...