... begins the differentiation of pluripotent stem cells into cells with a neural fate by increasing their calcium ... It is located on Chromosome 20 in humans and is only expressed from the paternal allele in normal adults. It encodes the ... Neuronatin (Nnat) is a protein coding gene involved in mammalian brain development. ... This causes the cells to undergo apoptosis, thus leading to diabetes mellitus. Its effects on glycogen metabolism through the ...

Mobley AS (January 2019). "Chapter 4 - Induced Pluripotent Stem Cells". In Mobley AS (ed.). Neural Stem Cells and Adult ... Enukashvily NI (January 2013). "Chapter Two - Mammalian Satellite DNA: A Speaking Dumb". In Donev R, Ponomartsev NV (eds.). ... There is therefore a direct link to how actively productive a cell is and the amount of euchromatin that can be found in its ... It is thought that the cell uses transformation from euchromatin into heterochromatin as a method of controlling gene ...

... cell nuclei as well as the production of pluripotent stem cells from adult cells for therapeutic purposes. He retired in 2005, ... He made numerous key contributions to the study of mammalian fertilization, and he was also a pioneer in the cloning field. ... The first male animal cloned from adult cells was announced in 1999. In 2004 the laboratory participated in the cloning of an ... The so-called "testis" in an adult animal is a receptacle of cells from larval males. This discovery revolutionized biological ...

This molecule is one of the genes widely used now to reprogram adult non-stem cells into pluripotent stem cells. Since then, ... These types of modification are critical for cell fate determination in the developing and adult mammalian brain. DNA cytosine ... In symmetric cell division, both daughter cells are also stem cells. In asymmetric division, a stem cell produces one stem cell ... have been reported to contain neural stem cells. There are two basic types of stem cell: adult stem cells, which are limited in ...

Formation of pluripotent stem cells in the mammalian embryo depends on the POU transcription factor Oct4. Cell 95:379-391. ... of the adult body. For example, the transcription factor LIF4 is required for mouse ES cells to be maintained in vitro. ... Since segregation of pluripotent cells of the inner cell mass from the remainder of the blastocyst is integral to mammalian ... Blastomeres isolated from the ICM of mammalian embryos and grown in culture are known as embryonic stem (ES) cells. These ...

Muse cells (Multi-lineage differentiating stress enduring cell) are non-cancerous pluripotent stem cell found in adults. They ... Embryonic stem cells (ESCs), derived from the blastocyst stage of early mammalian embryos, are distinguished by their ability ... "Human Somatic Cell Nuclear Transfer Using Adult Cells". Cell Stem Cell. 14 (6): 777-780. doi:10.1016/j.stem.2014.03.015. ISSN ... are equivalent to embryonic stem cells, leading these cells to be known as induced pluripotent stem cells (iPS cells). This ...

"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors". Cell. 126 (4): 663- ... Three basic categories of cells make up the mammalian body: germ cells, somatic cells, and stem cells. Each of the ... Mesenchymal stem cells (adult stem cells) from the bone marrow that give rise to stromal cells, fat cells, and types of bone ... Hematopoietic stem cells (adult stem cells) from the bone marrow that give rise to red blood cells, white blood cells, and ...

... and the SSEA-3 molecule as a whole plays a key role in identifying many types of mammalian cells with pluripotent and stem cell ... "Unique multipotent cells in adult human mesenchymal cell populations". Proceedings of the National Academy of Sciences of the ... It is now known that sphingolipids function as key players in cell signaling ...

... are a type of pluripotent stem cell artificially derived from a non-pluripotent cell, typically an adult somatic cell, by ... July 2007). "Derivation of pluripotent epiblast stem cells from mammalian embryos". Nature. 448 (7150): 191-195. Bibcode: ... Liang G, Zhang Y (January 2013). "Embryonic stem cell and induced pluripotent stem cell: an epigenetic perspective". Cell ... Blog on treatment therapy using pluripotent stem cells and pluripotent stem cell derived exosomes (CS1 errors: periodical ...

For example, current research paves the way for use of pluripotent stem cells to derive urothelium, as they are highly and ... All cells touch the basement membrane.[citation needed] The urothelium is the most impermeable membrane in the mammalian body. ... List of distinct cell types in the adult human body Sapkota, Anupama (2020-09-28). "Transitional epithelium- definition, ... The cells of the superficial cell layer that lines the lumen are known as facet cells or umbrella cells. This layer is the only ...

A study conducted in 2020 explored whether the transplantation of functional tissue from induced-pluripotent stem cells could ... They showed that CK1ε interacts with the PERIOD gene, which has been established as a mammalian circadian gene, and this ... in adult hamsters. In fact, 11 of the hamsters that received SCN grafting outlived 50% of all controls, with grafting of other ... A recent meta-analysis (2022) of neural transplantation studies showed that replacing dopamine-producing cells with stem-cell ...

"Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors". Cell. 126 (4): 663- ... "Systematic analysis and nomenclature of mammalian F-box proteins". Genes & Development. 18 (21): 2573-80. doi:10.1101/gad. ... In fact, targeting of KBP is required to prevent an unscheduled mitochondrial biogenesis that, in naïve pluripotent stem cells ... "The TDH-GCN5L1-Fbxo15-KBP axis limits mitochondrial biogenesis in mouse embryonic stem cells". Nature Cell Biology. 19 (4): 341 ...

February 2006). "Evaluating human embryonic germ cells: concord and conflict as pluripotent stem cells". Stem Cells. 24 (2): ... a few cells of the early embryo are induced by signals of neighboring cells to become primordial germ cells. Mammalian eggs are ... Instead, germ cells can arise from somatic cells in the adult, such as the floral meristem of flowering plants. Multicellular ... These researchers produced primordial germ cell-like cells (PGLCs) from embryonic stem cells (ESCs) and skin cells in vitro. ...

In this context, it often refers to the creation of induced pluripotent stem cells from mature cells such as adult fibroblasts ... Induced stem cells Epigenome editing Reik W, Dean W, Walter J (August 2001). "Epigenetic reprogramming in mammalian development ... "Induction of pluripotent stem cells from adult human fibroblasts by defined factors". Cell. 131 (5): 861-872. doi:10.1016/j. ... "Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors" (PDF). Cell. 126 (4 ...

Hematopoietic stem cells, like all adult stem cells, mostly exist in a state of quiescence, or reversible growth arrest. The ... In mammalian embryology, the first definitive Hematopoietic stem cells are detected in the AGM (aorta-gonad-mesonephros), and ... Using a human induced pluripotent stem cell model of NHEJ1 deficiency, it was shown that NHEJ1 has an important role in ... Lymphoid cells include T cells, B cells, natural killer cells, and innate lymphoid cells. The definition of hematopoietic stem ...

"Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors". Cell. 131 (5): 861-872. doi:10.1016/j. ... "Viable offspring derived from fetal and adult mammalian cells". Nature. 385 (6619): 810-813. Bibcode:1997Natur.385..810W. doi: ... "Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors". Cell. 126 (4): 663- ... "Isolation of pluripotent embryonic stem cells from reprogrammed adult mouse somatic cell nuclei". Current Biology. 10 (16): 989 ...

from 1998), neuroecientist focusing on reprogrammed and induced pluripotent stem cells to study the epigenetic changes of the ... 2001), professor at the University of Maryland studying how the pasticity of juvenile and adult mammalian visual systems differ ... 2000s), neurosurgeon researching stem cell biology and strategies for cell-based therapies for the repair of radiation-induced ... 2000s), neuroscientist focusing on neural stem cells and therapies related to eye, brain, and spinal cord disorders Sujata ...

... when combined with normal mouse embryo cells through eight years of experiments using some of the first pluripotent stem cell ... He was interested in why only certain types of cancer occurred when he injected adult mice with viruses. Inspired by Mintz's ... In the mid 1950s, Mintz switched her research focus from amphibians to mammals and became a pioneer in mammalian transgenesis. ... traced the tissue contribution of each cell type made by studying the coat color. Her cell fusion technique was successful ...

"3D Chromosome Regulatory Landscape of Human Pluripotent Cells". Cell Stem Cell. 18 (2): 262-75. doi:10.1016/j.stem.2015.11.007 ... "Control of cell identity genes occurs in insulated neighborhoods in mammalian chromosomes". Cell. 159 (2): 374-87. doi:10.1016/ ... April 2014). "Prdm16 is required for the maintenance of brown adipocyte identity and function in adult mice". Cell Metabolism. ... "Super-enhancers in the control of cell identity and disease". Cell. 155 (4): 934-47. doi:10.1016/j.cell.2013.09.053. PMC ...

In mammalian germ cell development, sexually dimorphic gametes differentiates into primordial germ cells from pluripotent cells ... In vitro gametogenesis (IVG)-the generation of eggs and sperm from pluripotent stem cells in a culture dish. Currently feasible ... It allows scientists to create sperms and egg cells by reprograming adult cells. This way, they could grow embryos in a ... In plants, sister, non-gametic cells are connected to the female gametes (the egg cell and the central cell) (the synergids and ...

The CSC niche is very similar to normal stem cells niche (embryonic stem cell (ESC), Adult Stem Cell ASC) in function ( ... Defining characteristics of mammalian spermatogenic stem cells". Stem Cells. 31 (1): 8-11. doi:10.1002/stem.1253. PMC 5312674. ... which is believed to be supportive in maintaining the pluripotent characteristics of embryonic stem cells. However, even these ... cell-cell interactions between stem cells, as well as interactions between stem cells and neighbouring differentiated cells, ...

Endogenous cardiac stem cells (eCSCs) are tissue-specific stem progenitor cells harboured within the adult mammalian heart. It ... "Characterization and Therapeutic Potential of Induced Pluripotent Stem Cell-Derived Cardiovascular Progenitor Cells". PLOS ONE ... Indeed, recent evidence from a genetic fate-mapping study established that stem cells replenish adult mammalian cardiomyocytes ... 2003). "Adult cardiac stem cells are multipotent and support myocardial regeneration". Cell. 114 (6): 763-776. doi:10.1016/ ...

"CCND2 Overexpression Enhances the Regenerative Potency of Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes: ... "Functional interactions of the retinoblastoma protein with mammalian D-type cyclins". Cell. 73 (3): 487-97. doi:10.1016/0092- ... Bartkova J, Rajpert-de Meyts E, Skakkebaek NE, Bartek J (Apr 1999). "D-type cyclins in adult human testis and testicular cancer ... This cyclin forms a complex with and functions as a regulatory subunit of CDK4 or CDK6, whose activity is required for cell ...

The employment of adult somatic cells in lieu of embryonic stem cells for cloning emerged from the foundational work of John ... After Dolly, researchers realised that ordinary cells could be reprogrammed to induced pluripotent stem cells, which can be ... 1997). "Viable offspring derived from fetal and adult mammalian cells". Nature. 385 (6619): 810-3. Bibcode:1997Natur.385..810W ... She was created using the technique of somatic cell nuclear transfer, where the cell nucleus from an adult cell is transferred ...

October 2015). "Monitoring Human-Induced Pluripotent Stem Cell-Derived Cardiomyocytes with Genetically Encoded Calcium and ... Park JG, Palmer AE (2014). "Quantitative Measurement of Ca2+ and Zn2+ in Mammalian Cells Using Genetically Encoded Fluorescent ... February 2015). "In vivo odourant response properties of migrating adult-born neurons in the mouse olfactory bulb". Nature ... GECIs are used to study neurons, T-cells, cardiomyocytes, and other cell types. Some GECIs report calcium by direct emission of ...

... in differentiating neural stem cells and are critical for cell fate determination in the developing and adult mammalian brain. ... signaling can efficiently induce neural tissue from pluripotent stem cells. In a later stage of development the superior part ... where the principal neural stem cell is the radial glial cell. The first postmitotic cells must leave the stem cell niche and ... Neurogenesis is the process by which neurons are generated from neural stem cells and progenitor cells. Neurons are 'post- ...

They were first to manipulate endogenous neural progenitors/precursors/"stem cells" in situ (adult mouse) to undergo induced ... and core long-distance circuit formation via molecular manipulation of endogenous neural progenitors and pluripotent cells (ES/ ... and a number of other widely known controls over neuron subtype and area specification in mammalian cerebral cortex. Later ... "stem cell" biology; induction of adult neurogenesis (the birth of new neurons); and directed neuronal subtype differentiation ...

"Induction of Pluripotent Stem Cells from Adult Human Fibroblasts by Defined Factors". Cell. 131 (5): 861-72. doi:10.1016/j.cell ... "Viable offspring derived from fetal and adult mammalian cells". Nature. 385 (6619): 810-3. Bibcode:1997Natur.385..810W. doi: ... Human embryonic stem cells are pluripotent, that is, they can differentiate into any of the cell types present in the adult ... "Induction of Pluripotent Stem Cells from Mouse Embryonic and Adult Fibroblast Cultures by Defined Factors" (PDF). Cell. 126 (4 ...

Organoids are derived from three kinds of human or animal stem cells-embryonic pluripotent stem cells (ESCs), adult somatic ... Fungi like Cunninghamella elegans can be used as a microbial model of mammalian drug metabolism thereby reducing the need for ... stem cells (ASCs), and induced pluripotent stem cells (iPSCs). These organoids are grown in vitro and mimic the structure and ... Cell culture can be an alternative to animal use in some cases. For example, cultured cells have been developed to create ...

2007). "Induced pluripotent stem cell lines derived from human somatic cells". Science. 318 (5858): 1917-1920. Bibcode:2007Sci ... let-7 members as potential regulators of dedifferentiation in lens and inner ear hair cell regeneration of the adult newt". ... "Let-7 microRNA-mediated mRNA deadenylation and translational repression in a mammalian cell-free system". Genes Dev. 21 (15): ... Dröge P, Davey CA (2008). "Do cells let-7 determine stemness?". Cell Stem Cell. 2 (1): 8-9. doi:10.1016/j.stem.2007.12.003. ...

... or maintain the embryonic stem cell (ESC) phenotypic via epigenetic approach. Adult stem cells like bone marrow stem cells have ... totipotent stem cells become the various pluripotent cell lines of the embryo, which in turn become fully differentiated cells ... Badal S, Her YF, Maher LJ (September 2015). "Nonantibiotic Effects of Fluoroquinolones in Mammalian Cells". The Journal of ... In mammals, most cells terminally differentiate, with only stem cells retaining the ability to differentiate into several cell ...