*GP1BA

Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain ... Platelet glycoprotein Ib alpha chain also known as glycoprotein Ib (platelet), alpha polypeptide or CD42b (Cluster of ... "Glycoprotein Ib and glycoprotein IX are fully complexed in the intact platelet membrane". Blood. 69 (5): 1524-7. PMID 2436691. ... Wenger RH, Kieffer N, Wicki AN, Clemetson KJ (1988). "Structure of the human blood platelet membrane glycoprotein Ib alpha gene ...

*Platelet membrane glycoprotein

Platelet membrane glycoproteins Platelet membrane glycoproteins at the US National Library of Medicine Medical Subject Headings ... Platelet membrane glycoproteins are surface glycoproteins found on platelets (thrombocytes) which play a key role in hemostasis ... platelet membrane glycoproteins interact with the extracellular matrix. Membrane glycoproteins GPIa/IIa, GPVI and probably GPIV ... Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation. The Journal of Biological Chemistry ...

*Crotalus

Chang, Mei-Chi (March 1998). "Antithormbotic Effect of Crotalin, a Platelet Membrane Glycoprotein Ib Antagonist From Venom of ... Second, the platelet antagonist crotalin creates a severe bleeding effect as it binds to the surface proteins, blocking ... First, zinc-containing metalloproteases act upon capillary endothelial cells to cause platelet aggregation and hemorrhage. ...

*Arginylglycylaspartic acid

"Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp--specific adhesion receptors". Science. 231 (4745): ... They block activation of the integrin responsible for aggregation of platelets (αIIbβ3, also known as glycoprotein IIb/IIIa) in ... "Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor". Cell. ... response to the blood glycoproteins fibrinogen and von Willebrand factor. Eptifibatide (marketed as Integrilin) is a cyclic ( ...

*CD36

"A platelet membrane glycoprotein (GP) deficiency in healthy blood donors: Naka- platelets lack detectable GPIV (CD36)". Blood. ... CD36 is also known as glycoprotein IV (gpIV) or glycoprotein IIIb (gpIIIb) in platelets and gives rise to the Naka antigen. The ... "Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets ... CD36 (cluster of differentiation 36), also known as platelet glycoprotein 4, fatty acid translocase (FAT), scavenger receptor ...

*Platelet adhesiveness

Platelet membrane glycoprotein Platelet adhesiveness at the US National Library of Medicine Medical Subject Headings (MeSH) ... Platelet adhesiveness is the adhesion of platelets to other structures. It can be contrasted with platelet aggregation, which ... May 2004). "Assessment of platelet adhesiveness and aggregation in mild acute pancreatitis using the PFA-100 system". JOP. 5 (3 ... refers to the processes or factors which lead to the adhesion of platelets to other platelets. ...

*GPVI

Glycoprotein VI (GP6) is a 58-kD platelet membrane glycoprotein that plays a crucial role in the collagen-induced activation ... Glycoprotein VI (platelet) also known as GPVI is a glycoprotein receptor for collagen which is expressed in platelets. In ... "Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets ... "Entrez Gene: GP6 glycoprotein VI (platelet)". Jandrot-Perrus M, Busfield S, Lagrue AH, Xiong X, Debili N, Chickering T, Le ...

*GP1BB

Analysis of the botrocetin-mediated interaction between von Willebrand factor and the human platelet membrane glycoprotein Ib- ... "Interaction of platelet glycoprotein V with glycoprotein Ib-IX regulates expression of the glycoproteins and binding of von ... 3-3 zeta signaling protein to discrete amino acid sequences within the cytoplasmic domain of the platelet membrane glycoprotein ... "Purification and preliminary characterization of the glycoprotein Ib complex in the human platelet membrane". Eur. J. Biochem. ...

*Glycoprotein IX

Platelet glycoprotein IX (GP9) is a small membrane glycoprotein found on the surface of human platelets. It forms a 1-to-1 ... 1987). "Glycoprotein Ib and glycoprotein IX are fully complexed in the intact platelet membrane". Blood. 69 (5): 1524-7. PMID ... "Alpha-granule membrane mirrors the platelet plasma membrane and contains the glycoproteins Ib, IX, and V". Blood. 87 (4): 1385- ... "Interaction of platelet glycoprotein V with glycoprotein Ib-IX regulates expression of the glycoproteins and binding of von ...

*Anogen

S20030093 Monoclonal antibodies recognizing human platelet membrane glycoproteins and use thereof in anti-thrombotic therapy [3 ... It has also developed a monoclonal antibody (R813) to human platelet surface glycoprotein IIIa. The Phase I clinical trial has ... been completed that this antibody effectively inhibits the aggregation of human platelet with less hemorrhagic risk. Both in ...

*Index of biochemistry articles

... platelet glycoprotein GPIb-IX complex - platelet membrane glycoprotein - platelet-derived growth factor - platelet-derived ... membrane glycoprotein - Membrane protein - Membrane topology - Membrane transport - memory B cell - memory T cell - Mendelian ... cell membrane - cell membrane transport - cell nucleus - cell surface receptor - cellular respiration - cellulose - centriole ... bacterial outer membrane protein - bacterial protein - bacteriorhodopsin - base (chemistry) - base pair - base sequence - basic ...

*List of MeSH codes (D23)

... platelet membrane glycoprotein iib MeSH D23.050.301.264.035.590 --- proto-oncogene proteins c-kit MeSH D23.050.301.264.035.595 ... platelet membrane glycoprotein iib MeSH D23.101.100.110.590 --- proto-oncogene proteins c-kit MeSH D23.101.100.110.595 --- ... lysosomal-associated membrane protein 1 MeSH D23.050.301.264.035.531 --- lysosomal-associated membrane protein 2 MeSH D23.050. ... lysosomal-associated membrane protein 1 MeSH D23.101.100.110.531 --- lysosomal-associated membrane protein 2 MeSH D23.101. ...

*GP5

"Alpha-granule membrane mirrors the platelet plasma membrane and contains the glycoproteins Ib, IX, and V". Blood. 87 (4): 1385- ... "Interaction of platelet glycoprotein V with glycoprotein Ib-IX regulates expression of the glycoproteins and binding of von ... 1995). "Expression of platelet membrane glycoprotein V in human megakaryocytes and megakaryocytic cell lines: a study using a ... Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for ...

*FYN

"Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets ... It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates ... Fyn is primarily localized to the cytoplasmic leaflet of the plasma membrane, where it phosphorylates tyrosine residues on key ... platelet activation, ion channel function, cell adhesion, axon guidance, fertilization, entry into mitosis, and differentiation ...

*YES1

"Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets ... Cichowski K, McCormick F, Brugge JS (1992). "p21rasGAP association with Fyn, Lyn, and Yes in thrombin-activated platelets". J. ...

*List of MeSH codes (D12.776.543)

... lysosomal-associated membrane protein 1 MeSH D12.776.543.750.705.675.568 -- platelet glycoprotein gpib-ix complex MeSH D12.776. ... platelet glycoprotein gpib-ix complex MeSH D12.776.543.550.625.785 -- platelet glycoprotein gpiib-iiia complex MeSH D12.776. ... platelet membrane glycoprotein iib MeSH D12.776.543.750.705.408.200 -- integrin beta chains MeSH D12.776.543.750.705.408. ... platelet glycoprotein gpib-ix complex MeSH D12.776.543.550.625.800.790 -- receptor, par-1 MeSH D12.776.543.550.625.800.800 -- ...

*CD49b

Charakida M, Tousoulis D, Stefanadis C, Toutouzas P (2003). "The impact of platelet glycoprotein IIIa and Ia polymorphisms in ... Integrins are heterodimeric integral membrane glycoproteins composed of a distinct alpha chain and a common beta chain. They ... Tsantes AE, Nikolopoulos GK, Bagos PG, Vaiopoulos G, Travlou A (2007). "Lack of association between the platelet glycoprotein ... CD49b antigen at the US National Library of Medicine Medical Subject Headings (MeSH) Moroi M, Jung SM (1997). "Platelet ...

*Borrelia burgdorferi

... will change its glycoproteins and proteases on its plasma membrane to facilitate its dissemination ... While infecting, B. burgdorferi will express proteins that will interact with endothelial cells, platelets, chondrocytes, and ... B. burgdorferi resembles other spirochetes in that it has an outer membrane and inner membrane with a thin layer of ... However, the outer membrane lacks lipopolysaccharide. Its shape is a flat wave. It is about 0.3 μm wide and 5 to 20 μm in ...

*Coagulation

This localization of platelets to the extracellular matrix promotes collagen interaction with platelet glycoprotein VI. Binding ... a platelet membrane constituent) are required for the tenase and prothrombinase complexes to function. Calcium mediates the ... which is released from the endothelium and from platelets; vWF forms additional links between the platelets' glycoprotein Ib/IX ... The activated platelets change shape from spherical to stellate, and the fibrinogen cross-links with glycoprotein IIb/IIIa aid ...

*Thromboxane A2

This is achieved by increasing expression of the glycoprotein complex GPIIb/IIIa on the cell membrane of platelets. The same ... it stimulates activation of new platelets as well as increases platelet aggregation. ... Lordkipanidzé M, Pharand C, Schampaert E, Turgeon J, Palisaitis DA, Diodati JG (2007). "A comparison of six major platelet ... Thromboxane A2 (TXA2) is a type of thromboxane that is produced by activated platelets and has prothrombotic properties: ...

*Abciximab

... is made from the Fab fragments of an immunoglobulin that targets the glycoprotein IIb/IIIa receptor on the platelet membrane. ... "Use of a monoclonal antibody directed against the platelet glycoprotein IIb/IIIa receptor in high-risk coronary angioplasty. ... It is a glycoprotein IIb/IIIa inhibitor. While abciximab has a short plasma half-life, due to its strong affinity for its ... In practice, platelet aggregation gradually returns to normal about 96 to 120 hours after discontinuation of the drug. ...

*Thromboxane

Platelet aggregation is achieved by mediating expression of the glycoprotein complex GP IIb/IIIa in the cell membrane of ... Thromboxane A2 (TXA2), produced by activated platelets, has prothrombotic properties, stimulating activation of new platelets ... If the cap of a vulnerable plaque erodes or ruptures, as in MI, platelets stick to the damaged lining of the vessel and to each ... The mechanism of secretion of thromboxanes from platelets is still unclear. They act in the formation of blood clots and reduce ...

*Glycoprotein Ib-IX-V Receptor Complex

"Glycoprotein Ib and glycoprotein IX are fully complexed in the intact platelet membrane". Blood. 69 (5): 1524-7. PMID 2436691. ... "Transmembrane domains are critical to the interaction between platelet glycoprotein V and glycoprotein Ib-IX complex". J. ... "Glycoprotein Ibalpha forms disulfide bonds with 2 glycoprotein Ibbeta subunits in the resting platelet". Blood. 109 (2): 603-9 ... Li R, Emsley J (April 2013). "The organizing principle of the platelet glycoprotein Ib-IX-V complex". J. Thromb. Haemost. 11 (4 ...

*LAMP1

Lysosomal-associated membrane protein 1 is a glycoprotein from a family of Lysosome-associated membrane glycoproteins. The LAMP ... platelets and macrophages. Cell surface expression of LAMP1 and LAMP2 is also often seen in cancer cells, particularly cancers ... Lysosomal-associated membrane protein 1 (LAMP-1) also known as lysosome-associated membrane glycoprotein 1 and CD107a (Cluster ... and membrane insertion of the 120-kDa lysosomal membrane glycoprotein (lgp120): identification of a highly conserved family of ...

*Von Willebrand disease

The ability of the qualitatively defective vWF to bind to glycoprotein Ib (GPIb) receptor on the platelet membrane is ... normal donor platelets. However, when the assay is performed with the patient's own platelets (platelet-rich plasma), a lower- ... The defect lies in the qualitatively altered GPIb receptor on the platelet membrane which increases its affinity to bind to the ... Platelet-type vWD (also known as pseudo-vWD) is an autosomal dominant genetic defect of the platelets. The vWF is qualitatively ...

*Fibroblast-like synoviocyte

Synovial membrane is divided into two compartments - the outer layer (subintima) and the inner layer (intima). The inner layer ... These cells represent the main source of hyaluronic acid and also other glycoproteins, major components of the synovial fluid. ... 2010). "Platelets Amplify Inflammation in Arthritis via Collagen-Dependent Microparticle Production". Science. 327 (5965): 580- ... The inner lining of the joint consists of the synovium (also called the synovial membrane), a thin layer located between the ...