Loading...
*  Platelet membrane glycoprotein
Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation. The Journal of Biological Chemistry ... Platelet membrane glycoproteins Platelet membrane glycoproteins at the US National Library of Medicine Medical Subject Headings ... Platelet membrane glycoproteins are surface glycoproteins found on platelets (thrombocytes) which play a key role in hemostasis ... platelet membrane glycoproteins interact with the extracellular matrix. Membrane glycoproteins GPIa/IIa, GPVI and probably GPIV ...
*  Arginylglycylaspartic acid
"Platelet membrane glycoprotein IIb/IIIa: member of a family of Arg-Gly-Asp--specific adhesion receptors". Science. 231 (4745): ... They block activation of the integrin responsible for aggregation of platelets (αIIbβ3, also known as glycoprotein IIb/IIIa) in ... "Identification and isolation of a 140 kd cell surface glycoprotein with properties expected of a fibronectin receptor". Cell. ... response to the blood glycoproteins fibrinogen and von Willebrand factor. Eptifibatide (marketed as Integrilin) is a cyclic ( ...
*  List of MeSH codes (D23)
... platelet membrane glycoprotein iib MeSH D23.050.301.264.035.590 --- proto-oncogene proteins c-kit MeSH D23.050.301.264.035.595 ... platelet membrane glycoprotein iib MeSH D23.101.100.110.590 --- proto-oncogene proteins c-kit MeSH D23.101.100.110.595 --- ... lysosomal-associated membrane protein 1 MeSH D23.050.301.264.035.531 --- lysosomal-associated membrane protein 2 MeSH D23.050. ... lysosomal-associated membrane protein 1 MeSH D23.101.100.110.531 --- lysosomal-associated membrane protein 2 MeSH D23.101. ...
*  List of MeSH codes (D12.776.543)
... platelet membrane glycoprotein iib MeSH D12.776.543.750.705.408.200 -- integrin beta chains MeSH D12.776.543.750.705.408. ... platelet glycoprotein gpib-ix complex MeSH D12.776.543.550.625.785 -- platelet glycoprotein gpiib-iiia complex MeSH D12.776. ... platelet glycoprotein gpib-ix complex MeSH D12.776.543.750.705.675.784 -- platelet glycoprotein gpiib-iiia complex MeSH D12.776 ... platelet glycoprotein gpib-ix complex MeSH D12.776.543.550.625.800.790 -- receptor, par-1 MeSH D12.776.543.550.625.800.800 -- ...
*  Abciximab
... is made from the Fab fragments of an immunoglobulin that targets the glycoprotein IIb/IIIa receptor on the platelet membrane. ... "Use of a monoclonal antibody directed against the platelet glycoprotein IIb/IIIa receptor in high-risk coronary angioplasty. ... It is a glycoprotein IIb/IIIa inhibitor. While abciximab has a short plasma half-life, due to its strong affinity for its ... Abciximab (previously known as c7E3 Fab), a glycoprotein IIb/IIIa receptor antagonist manufactured by Janssen Biologics BV and ...
*  Thromboxane
Platelet aggregation is achieved by mediating expression of the glycoprotein complex GP IIb/IIIa in the cell membrane of ... Thromboxane A2 (TXA2), produced by activated platelets, has prothrombotic properties, stimulating activation of new platelets ... If the cap of a vulnerable plaque erodes or ruptures, as in MI, platelets stick to the damaged lining of the vessel and to each ... The mechanism of secretion of thromboxanes from platelets is still unclear. They act in the formation of blood clots and reduce ...
*  Coagulation
The activated platelets change shape from spherical to stellate, and the fibrinogen cross-links with glycoprotein IIb/IIIa aid ... PLA2 then modifies the integrin membrane glycoprotein IIb/IIIa, increasing its affinity to bind fibrinogen. ... This localization of platelets to the extracellular matrix promotes collagen interaction with platelet glycoprotein VI. Binding ... which is released from the endothelium and from platelets; vWF forms additional links between the platelets' glycoprotein Ib/IX ...
*  ITGA2B
... platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)". Kato, Atsushi; Kawamata Norihiko; Tamayose Kenji; Egashira ... Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. Alpha chain 2b undergoes ... Fullard JF (2004). "The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis". Curr. Pharm. Des. 10 (14): ... Lincoff AM (1998). "Trials of platelet glycoprotein IIb/IIIa receptor antagonists during percutaneous coronary ...
*  Glycoprotein IIb/IIIa
In medicine, glycoprotein IIb/IIIa (GPIIb/IIIa, also known as integrin αIIbβ3) is an integrin complex found on platelets. It is ... this calcium increase triggers the calcium-dependent association of gpIIb and gpIIIa to form the activated membrane receptor ... Glycoprotein IIb/IIIa inhibitors Vickers JD (July 1999). "Binding of polymerizing fibrin to integrin alpha(IIb)beta(3) on ... Defects in glycoprotein IIb/IIIa cause Glanzmann's thrombasthenia. Autoantibodies against IIb/IIIa can be produced in immune ...
*  ITGA5
... localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and ... Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a beta chain. This gene encodes the ... Porter JC, Hogg N (1999). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends Cell ...
*  Onyalai
Both IgG and IgM autoantibodies to platelet and to glycoprotein IIb/IIIa is found in majority of patients. Treatment is ... and subconjunctival mucous membranes and skin, including on the soles of the feet. The patient initially is not in distress, ... High-dose methylprednisolone therapy in children with Onyalai has been shown to improve platelet count and reduce the ... High-dose intravenous gammaglobulin may help in increasing the platelet count and cessation of haemorrhage. Onyalai is limited ...
*  Glycoprotein
... glycoprotein IIb/IIIa, an integrin found on platelets that is required for normal platelet aggregation and adherence to the ... Glycoproteins are also often important integral membrane proteins, where they play a role in cell-cell interactions. It is ... Glycoprotein-41 (gp41) and glycoprotein-120 (gp120) are HIV viral coat proteins. Soluble glycoproteins often show a high ... Glycoproteins are important for white blood cell recognition, especially in mammals.[citation needed] Examples of glycoproteins ...
*  CD61
Fullard JF (2004). "The role of the platelet glycoprotein IIb/IIIa in thrombosis and haemostasis". Curr. Pharm. Des. 10 (14): ... The talin n-terminal head domain interacts with the membrane-proximal region of the beta(3) cytoplasmic tail". J. Biol. Chem. ... Integrin beta 3 is found along with the alpha IIb chain in platelets. Integrins are known to participate in cell adhesion as ... localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and ...
*  Antiphospholipid syndrome
A low platelet count and positivity for antibodies against β2-glycoprotein 1 or phosphatidylserine may also be observed in a ... lupus anticoagulant present alone IIb: anti-cardiolipin IgG and/or IgM present alone in medium or high titers IIc: anti-β2 ... react against proteins that bind to anionic phospholipids on plasma membranes. Like many autoimmune diseases, it is more common ... Anti-ApoH and a subset of anti-cardiolipin antibodies bind to ApoH, which in turn inhibits Protein C, a glycoprotein with ...
*  Vitamin B6
Also, PLP influences expression of glycoprotein IIb by interacting with various transcription factors. The result is inhibition ... The absorption of pyridoxal phosphate and pyridoxamine phosphate involves their dephosphorylation catalyzed by a membrane-bound ... of platelet aggregation. Vitamin B6 is widely distributed in foods in both its free and bound forms. Cooking, storage, and ...
*  Disintegrin
... sequence motif that binds specifically to integrin IIb-IIIa receptors on the platelet surface, thereby blocking the binding of ... Mammalian epididymial apical protein 1 (EAP I). EAP I is associated with the sperm membrane and may play a role in sperm ... fibrinogen to the receptor-glycoprotein complex of activated platelets. Disintegrins act as receptor antagonists, inhibiting ... serving as the final common pathway leading to aggregation via formation of platelet-platelet bridges, which are essential in ...
*  Outline of immunology
Dimers Cytoadhesin receptor Integrin alpha6beta4 Glycoprotein IIb/IIIa - Heterodimer: ITGA2B / ITGB3 Fibrinogen receptor ... Membrane-bound PRRs Toll-like receptors (TLRs) TLR1 TLR2 TLR3 TLR4 TLR5 TLR6 TLR7 TLR8 TLR9 TLR10 TLR11 TLR12 TLR13 C-type ... Platelets) Erythropoiesis Proerythroblast Normoblast Reticulocyte CFU-Mast Mast cell precursors B cells Antigen receptor - B ... C5a C3-convertase C5-convertase Late stage Membrane attack complex (MAC) C6 C7 C8 C9 Complement pathway inhibitors C1-inhibitor ...
*  Preclinical imaging
... microbubbles can be conjugated to markers such as activated glycoprotein IIb/IIIa (GPIIb/IIIa) receptors on platelets and clots ... Deng CX, Sieling F, Pan H, Cui J. Ultrasound-induced cell membrane porosity. Ultrasound Med Biol 2004 Apr;30(4):519-26. Li ML, ...
*  List of OMIM disorder codes
PAI1 Platelet disorder, familial, with associated myeloid malignancy; 601399; RUNX1 Platelet glycoprotein IV deficiency; 608404 ... type IIB; 608634; HSPB1 Neuropathy, distal hereditary motor, type V; 600794; BSCL2 Neuropathy, distal hereditary motor, type V ... epithelial basement membrane; 121820; TGFBI Corneal dystrophy, Fuchs endothelial, 1; 136800; COL8A2 Corneal dystrophy, Fuchs ... type IIb; 606056; GCS1 Congenital disorder of glycosylation type IIc; 266265; SLC35C1 Congenital disorder of glycosylation, ...
*  ITGAV
... localization of the genes for the vitronectin and fibronectin receptors alpha subunits and for platelet glycoproteins IIb and ... ITGAV encodes integrin alpha chain V. Integrins are heterodimeric integral membrane proteins composed of an alpha chain and a ... Porter JC, Hogg N (October 1998). "Integrins take partners: cross-talk between integrins and other membrane receptors". Trends ...