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*  Glanzmann's thrombasthenia
... in which the platelets contain defective or low levels of glycoprotein IIb/IIIa (GpIIb/IIIa), which is a receptor for ... The role of GpIb is to enable platelet activation by contact with the von Willebrand factor-collagen complex that is exposed ... formerly known as glycoprotein IIb/IIIa (GpIIb/IIIa), which is an integrin aggregation receptor on platelets. This receptor is ... Understanding of the role of GpIIb/IIIa in Glanzmann's thrombasthenia led to the development of GpIIb/IIIa inhibitors, a class ...
*  List of MeSH codes (D12.776.395)
... platelet glycoprotein gpib-ix complex MeSH D12.776.395.550.625.785 -- platelet glycoprotein gpiib-iiia complex MeSH D12.776. ... platelet glycoprotein gpib-ix complex MeSH D12.776.395.550.625.800.790 -- receptor, par-1 MeSH D12.776.395.550.625.800.800 -- ... p-glycoproteins MeSH D12.776.395.550.020.610.610 -- p-glycoprotein MeSH D12.776.395.550.200.065 -- antigens, cd22 MeSH D12.776. ... This is a sub-part (glycoproteins only) of List of MeSH codes (D12.776), itself a part of the list of the "D" codes for MeSH. ...
*  List of MeSH codes (D12.776.543)
... platelet glycoprotein gpib-ix complex MeSH D12.776.543.550.625.785 -- platelet glycoprotein gpiib-iiia complex MeSH D12.776. ... platelet glycoprotein gpib-ix complex MeSH D12.776.543.750.705.675.784 -- platelet glycoprotein gpiib-iiia complex MeSH D12.776 ... platelet glycoprotein gpiib-iiia complex MeSH D12.776.543.750.705.408.460.870 -- receptors, vitronectin MeSH D12.776.543.750. ... platelet glycoprotein gpib-ix complex MeSH D12.776.543.550.625.800.790 -- receptor, par-1 MeSH D12.776.543.550.625.800.800 -- ...
*  Thromboxane A2
This is achieved by increasing expression of the glycoprotein complex GPIIb/IIIa on the cell membrane of platelets. The same ... it stimulates activation of new platelets as well as increases platelet aggregation. ... Lordkipanidzé M, Pharand C, Schampaert E, Turgeon J, Palisaitis DA, Diodati JG (2007). "A comparison of six major platelet ... Thromboxane A2 (TXA2) is a type of thromboxane that is produced by activated platelets and has prothrombotic properties: ...
*  Thromboxane
Platelet aggregation is achieved by mediating expression of the glycoprotein complex GP IIb/IIIa in the cell membrane of ... Thromboxane A2 (TXA2), produced by activated platelets, has prothrombotic properties, stimulating activation of new platelets ... If the cap of a vulnerable plaque erodes or ruptures, as in MI, platelets stick to the damaged lining of the vessel and to each ... The mechanism of secretion of thromboxanes from platelets is still unclear. They act in the formation of blood clots and reduce ...
*  Platelet membrane glycoprotein
... the platelets are joined by vWF due to its ability to bind the activated GPIIb / IIIa complex. This transmembrane glycoprotein ... Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation. The Journal of Biological Chemistry ... The IIb / IIIa complex is a major platelet membrane component. There are as many as 50 000 copies. The αIIb (GPIIb) is composed ... In consequence, this complex activates GPIIb / IIIa membrane glycoproteins allowing them to bind fibrinogen. Fibrinogen ...
*  Multiple electrode aggregometry
The GPIIb/IIIa antagonist blocks the binding of fibrinogen to the GPIIb/IIIa receptors, preventing the formation of platelet- ... Ristocetin forms complexes with von Willebrand Factor (vWF) that bind to the glycoprotein Ib (GP1b) receptors on platelets, ... Binding of fibrinogen to GPIIb/IIIa receptors leads to platelet-to-platelet bridges and results in platelet aggregation. ... Activation also induces a conformational change in the glycoprotein IIb/IIIa (GPIIb/IIIa) receptor, giving it high affinity for ...
*  Glycoprotein IIb/IIIa
In medicine, glycoprotein IIb/IIIa (GPIIb/IIIa, also known as integrin αIIbβ3) is an integrin complex found on platelets. It is ... Platelet activation by ADP (blocked by clopidogrel) leads to the aforementioned conformational change in platelet gpIIb/IIIa ... The complex is formed via calcium-dependent association of gpIIb and gpIIIa, a required step in normal platelet aggregation and ... The gpIIb/IIIa receptor is a target of several drugs including abciximab, eptifibatide, tirofiban. Once platelets are activated ...
*  Coagulation
It is characterized by a defect in GPIIb/IIIa fibrinogen receptor complex. When GPIIb/IIIa receptor is dysfunctional, ... The activated platelets change shape from spherical to stellate, and the fibrinogen cross-links with glycoprotein IIb/IIIa aid ... This localization of platelets to the extracellular matrix promotes collagen interaction with platelet glycoprotein VI. Binding ... abnormal glycoprotein Ib-IX-V complex), gray platelet syndrome (deficient alpha granules), and delta storage pool deficiency ( ...
*  GP5
The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX ( ... and GPIIb/IIIa are implicated in expression of thrombin-induced platelet procoagulant activity". Thromb. Haemost. 86 (4): 1065- ... "Interaction of platelet glycoprotein V with glycoprotein Ib-IX regulates expression of the glycoproteins and binding of von ... Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for ...
*  Platelet
... is rich in glycoproteins required for platelet adhesion, activation, and aggregation. For example, GPIb/IX/X; GPVI; GPIIb/IIIa ... An overview summarizing platelet dynamics, the complex process of converting inactive platelets into a platelet plug, is ... activated platelets with exposed GPIIb/IIIa can bind fibrinogen to aggregate. GPIIb/IIIa may also further anchor the platelets ... Platelets secrete thromboxane A2, which acts on the platelet's own thromboxane receptors on the platelet surface (hence the so- ...
*  Thromboelastometry
The use of cytochalasin is more favorable than using glycoprotein IIb/ IIIa inhibitors which block platelet incompletely, ... and only supratherapeutic doses of GPIIb/IIIa antagonists may influence results. The sensitivity for coagulation factor ... Moreover, it is successfully used in the complex situation of (poly)trauma, or in decision making for of alternative therapy ... FIBTEM eliminates the platelet contribution of clot formation by inhibiting the platelets irreversibly with cytochalasin D, a ...
*  Contrast-enhanced ultrasound
GPIIb/IIIa), which is the most abundant platelet surface receptor. Despite the high shear stress at the thrombus area, the ... Microbubbles can be conjugated to a recombinant single-chain variable fragment specific for activated glycoprotein IIb/IIIa ( ... This may be the surface of a small air bubble or a more complex structure. Commercially available contrast media are gas-filled ... GPIIb/IIIa-targeted microbubbles will specifically bind to activated platelets and allow real-time molecular imaging of ...