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*  GP1BA
... complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein ... Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain ... "Glycoprotein Ib and glycoprotein IX are fully complexed in the intact platelet membrane". Blood. 69 (5): 1524-7. PMID 2436691. ... Du X (2007). "Signaling and regulation of the platelet glycoprotein Ib-IX-V complex". Curr. Opin. Hematol. 14 (3): 262-9. doi: ...
*  Index of biochemistry articles
... platelet glycoprotein GPIb-IX complex - platelet membrane glycoprotein - platelet-derived growth factor - platelet-derived ... complement membrane attack complex - complement receptor - complex - computational biology - computational chemistry - ... membrane glycoprotein - Membrane protein - Membrane topology - Membrane transport - memory B cell - memory T cell - Mendelian ... major histocompatibility complex - Malpighi body - Malpighi layer - marine biology - Maslinic acid - Mass spectrometer - ...
*  List of MeSH codes (D12.776.395)
... platelet glycoprotein gpib-ix complex MeSH D12.776.395.550.625.785 -- platelet glycoprotein gpiib-iiia complex MeSH D12.776. ... platelet glycoprotein gpib-ix complex MeSH D12.776.395.550.625.800.790 -- receptor, par-1 MeSH D12.776.395.550.625.800.800 -- ... p-glycoproteins MeSH D12.776.395.550.020.610.610 -- p-glycoprotein MeSH D12.776.395.550.200.065 -- antigens, cd22 MeSH D12.776. ... This is a sub-part (glycoproteins only) of List of MeSH codes (D12.776), itself a part of the list of the "D" codes for MeSH. ...
*  List of MeSH codes (D12.776.543)
... platelet glycoprotein gpib-ix complex MeSH D12.776.543.550.625.785 -- platelet glycoprotein gpiib-iiia complex MeSH D12.776. ... platelet glycoprotein gpib-ix complex MeSH D12.776.543.750.705.675.784 -- platelet glycoprotein gpiib-iiia complex MeSH D12.776 ... platelet glycoprotein gpib-ix complex MeSH D12.776.543.550.625.800.790 -- receptor, par-1 MeSH D12.776.543.550.625.800.800 -- ... platelet glycoprotein gpiib-iiia complex MeSH D12.776.543.750.705.408.460.870 -- receptors, vitronectin MeSH D12.776.543.750. ...
*  Bernard-Soulier syndrome
... is associated with quantitative or qualitative defects of the platelet glycoprotein complex GPIb/V/IX ... BSS are seemingly due to the absence of GPIbα and the filamin A binding site that links the GPIb-IX-V complex to the platelet ... These mutations do not allow GPIb-IX-V complex to bind to the von Willebrand factor, which in turn is what would help platelets ... giant platelets may reach the size of red blood cells. The large platelets and low platelet count in ...
*  Cathepsin G
"Neutrophil cathepsin G modulates the platelet surface expression of the glycoprotein (GP) Ib-IX complex by proteolysis of the ... von Willebrand factor binding site on GPIb alpha and by a cytoskeletal-mediated redistribution of the remainder of the complex ... IX. Elastinolytic activity in granules of human polymorphonuclear leukocytes". The Journal of Experimental Medicine. 128 (5): ... platelet activation, and induction of airway submucosal gland secretion. Potential implications of the enzyme in blood-brain ...
*  Von Willebrand factor
... glycoprotein Ib/IX/V and the collagen fibrils vWF binds to platelet gpIb when it forms a complex with gpIX and gpV; this ... platelet GPIb-receptor heparin possibly collagen the A2 domain, which must partially unfold to expose the buried cleavage site ... In the 1950s, vWD was shown to be caused by a plasma factor deficiency (instead of being caused by platelet disorders), and, in ... Von Willebrand factor (vWF) (/ˌfʌnˈvɪlɪbrɑːnt/) is a blood glycoprotein involved in hemostasis. It is deficient or defective in ...
*  Platelet membrane glycoprotein
... results in conformational changes within the GPIb-V-IX complex. In consequence, this complex activates GPIIb / IIIa membrane ... IIIa complex. This transmembrane glycoprotein complex is composed of four subunits: GPIbα, GPIbβ, GPV and GPIX. Each of them ... The deficiency in glycoprotein Ib-IX-V complex synthesis leads to Bernard-Soulier syndrome. Glycoprotein VI is one of the ... Changes in the platelet membrane glycoprotein IIb.IIIa complex during platelet activation. The Journal of Biological Chemistry ...
*  Glycoprotein Ib
... (GPIb), also known as CD42, is a component of the GPIb-V-IX complex on platelets. The GPIb-V-IX complex binds ... It complexes with Glycoprotein IX. Bode AP, Read MS, Reddick RL (February 1999). "Activation and adherence of lyophilized human ... A gain-of-function mutation causes platelet-type von Willebrand's disease. Autoantibodies against Ib/IX can be produced in ... allowing platelet adhesion and platelet plug formation at sites of vascular injury. It is deficient in the Bernard-Soulier ...
*  YWHAZ
... with the platelet glycoprotein Ib-IX complex". The Journal of Biological Chemistry. 269 (28): 18287-90. PMID 8034572. ... "Cytoplasmic domains of GpIbalpha and GpIbbeta regulate 14-3-3zeta binding to GpIb/IX/V". Blood. 95 (2): 551-7. PMID 10627461. ... Calverley DC, Kavanagh TJ, Roth GJ (Feb 1998). "Human signaling protein 14-3-3zeta interacts with platelet glycoprotein Ib ... platelet glycoprotein Ib alpha". The Journal of Biological Chemistry. 271 (13): 7362-7. doi:10.1074/jbc.271.13.7362. PMID ...
*  Glycoprotein IX
It forms a 1-to-1 noncovalent complex with glycoprotein Ib (GP Ib), a platelet surface membrane glycoprotein complex that ... 1987). "Glycoprotein Ib and glycoprotein IX are fully complexed in the intact platelet membrane". Blood. 69 (5): 1524-7. PMID ... Glycoprotein IX (platelet) (GP9) also known as CD42a (Cluster of Differentiation 42a), is a human gene. Platelet glycoprotein ... "Interaction of platelet glycoprotein V with glycoprotein Ib-IX regulates expression of the glycoproteins and binding of von ...
*  GP1BB
Kasirer-Friede A, Ware J, Leng L, Marchese P, Ruggeri ZM, Shattil SJ (2002). "Lateral clustering of platelet GP Ib-IX complexes ... "Interaction of platelet glycoprotein V with glycoprotein Ib-IX regulates expression of the glycoproteins and binding of von ... and GPIb/V/IX complex on the surface of human platelets is influenced by alphaIIbbeta3 conformational states". Eur. J. Biochem ... with the platelet glycoprotein Ib-IX complex". J. Biol. Chem. 269 (28): 18287-90. PMID 8034572. Kelly MD, Essex DW, Shapiro SS ...
*  Glycoprotein Ib-IX-V Receptor Complex
Abnormalities of the GPIb-V-IX complex result in abnormal appearance and functioning of platelets resulting in Bernard-Soulier ... "Glycoprotein Ib and glycoprotein IX are fully complexed in the intact platelet membrane". Blood. 69 (5): 1524-7. PMID 2436691. ... "Transmembrane domains are critical to the interaction between platelet glycoprotein V and glycoprotein Ib-IX complex". J. ... Li R, Emsley J (April 2013). "The organizing principle of the platelet glycoprotein Ib-IX-V complex". J. Thromb. Haemost. 11 (4 ...
*  Coagulation
... abnormal glycoprotein Ib-IX-V complex), gray platelet syndrome (deficient alpha granules), and delta storage pool deficiency ( ... In this disease, there is a defect in von Willebrand factor (vWF), which mediates the binding of glycoprotein Ib (GPIb) to ... which is released from the endothelium and from platelets; vWF forms additional links between the platelets' glycoprotein Ib/IX ... This localization of platelets to the extracellular matrix promotes collagen interaction with platelet glycoprotein VI. Binding ...
*  GP5
The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX ( ... and GPIb/V/IX complex on the surface of human platelets is influenced by alphaIIbbeta3 conformational states". Eur. J. Biochem ... "Interaction of platelet glycoprotein V with glycoprotein Ib-IX regulates expression of the glycoproteins and binding of von ... Human platelet glycoprotein V (GP5) is a part of the Ib-V-IX system of surface glycoproteins that constitute the receptor for ...
*  Von Willebrand disease
The ability of the qualitatively defective vWF to bind to glycoprotein Ib (GPIb) receptor on the platelet membrane is ... Testing for factor IX may also be performed if hemophilia B is suspected. Other coagulation factor assays may be performed ... In milder cases of type 1 vWD, a complex spectrum of molecular pathology may exist in addition to polymorphisms of the vWF gene ... normal donor platelets. However, when the assay is performed with the patient's own platelets (platelet-rich plasma), a lower- ...
*  Platelet
... is rich in glycoproteins required for platelet adhesion, activation, and aggregation. For example, GPIb/IX/X; GPVI; GPIIb/IIIa ... An overview summarizing platelet dynamics, the complex process of converting inactive platelets into a platelet plug, is ... There are around 60 000 of these receptors per platelet. When any one or more of at least nine different platelet surface ... When the endothelial layer is disrupted, collagen and VWF anchor platelets to the subendothelium. Platelet GP1b-IX-V receptor ...
*  CD47
... and GPIb/V/IX complex on the surface of human platelets is influenced by alphaIIbbeta3 conformational states". Eur. J. Biochem ... CD47 is a high affinity receptor for thrombospondin-1 (TSP-1), a secreted glycoprotein that plays a role in vascular ... These interactions result in CD47/integrin complexes that affect a range of cell functions including adhesion, spreading and ... Oldenborg, P. A. (2013). CD47: A Cell Surface Glycoprotein Which Regulates Multiple Functions of Hematopoietic Cells in Health ...