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*  Chemokine
Platelet factor-4 superfamily or intercrines. Some chemokines are considered pro-inflammatory and can be induced during an ... Their name is derived from their ability to induce directed chemotaxis in nearby responsive cells; they are chemotactic ... the growth of new blood vessels), or guide cells to tissues that provide specific signals critical for cellular maturation. ... and MIP-1beta as the Major HIV-Suppressive Factors Produced by CD8+ T Cells". Science. 270 (5243): 1811-5. Bibcode:1995Sci... ...
*  Platelet factor 4
Platelet-activating factor Platelet-derived growth factor GRCh38: Ensembl release 89: ENSG00000163737 - Ensembl, May 2017 ... "The control of angiogenesis and tumor invasion by platelet factor-4 and platelet factor-4-derived molecules". Semin. Thromb. ... Maurer AM, Zhou B, Han ZC (2007). "Roles of platelet factor 4 in hematopoiesis and angiogenesis". Growth Factors. 24 (4): 242- ... 1987). "Cloning and characterization of platelet factor 4 cDNA derived from a human erythroleukemic cell line". Blood. 69 (1): ...
*  Vascular endothelial growth factor A
This gene is a member of the platelet-derived growth factor (PDGF)/vascular endothelial growth factor (VEGF) family and encodes ... "Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis". FASEB ... "Assignment of vascular endothelial growth factor (VEGF) and placenta growth factor (PLGF) genes to human chromosome 6p12-p21 ... "Neuropilin-1 binds vascular endothelial growth factor 165, placenta growth factor-2, and heparin via its b1b2 domain". J. Biol ...
*  Platelet-derived growth factor
... (PDGF) is one of numerous growth factors that regulate cell growth and division. In particular, ... Platelet-activating factor Platelet-derived growth factor receptor atheroma platelet involvement in smooth muscle proliferation ... Platelet-derived growth factor is a dimeric glycoprotein that can be composed of two A subunits (PDGF-AA), two B subunits (PDGF ... platelet-derived growth factor at the US National Library of Medicine Medical Subject Headings (MeSH). ...
*  Platelet-derived growth factor receptor
"Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex". ... Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet- ... Platelet-Derived Growth Factor Receptors at the US National Library of Medicine Medical Subject Headings (MeSH) Molecular and ... Heldin CH, Ostman A, Eriksson A, Siegbahn A, Claesson-Welsh L, Westermark B (March 1992). "Platelet-derived growth factor: ...
*  PDGFA
Platelet-derived growth factor subunit A is a protein that in humans is encoded by the PDGFA gene. The protein encoded by this ... 1991). "Expression of platelet-derived growth factor A-chain (PDGF-A) mRNA in lung tissue and cells. Complex regulation during ... "Entrez Gene: PDGFA platelet-derived growth factor alpha polypeptide". Nath K, Gogi R, Khan AA, Hameed S (1978). "Vascular ... 1992). "Platelet-derived growth factor A chain: confirmation of localization of PDGFA to chromosome 7p22 and description of an ...
*  TUSC2
"Characterization of a novel platelet-derived growth factor-associated protein". J Neurochem. 66 (5): 2213-6. doi:10.1046/j.1471 ... Lee DY, Deng Z, Wang CH, Yang BB (2008). "MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu ... of candidate tumor suppressor gene FUS1 isolated from the 3p21.3 homozygous deletion region leads to G1 arrest and growth ...
*  PDAP1
"Characterization of a novel platelet-derived growth factor-associated protein". J Neurochem. 66 (5): 2213-6. doi:10.1046/j.1471 ... 2001). "PDGF-D, a new protease-activated growth factor". Nat. Cell Biol. 3 (5): 517-21. doi:10.1038/35074593. PMID 11331882. ...
*  Becaplermin
It is also known as "platelet-derived growth factor BB". The drug is used for the treatment of diabetic foot ulcers. Studies of ... Regranex is a human platelet-derived growth factor indicated along with good wound care for the treatment of lower extremity ... recombinant platelet derived growth factor, a new treatment for healing diabetic foot ulcers". Expert Opin Biol Ther. 2 (2): ... Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev. 1999;79:1283-1316. FDA Professional Drug ...
*  PDGFRB
... platelet derived growth factor receptor A or alpha-type-platelet derived growth factor receptor) gene with the FIP1L1 gene (see ... "Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity ... Beta-type platelet-derived growth factor receptor is a protein that in humans is encoded by the PDGFRB gene. The PDGFRB gene is ... Yamamoto M, Toya Y, Jensen RA, Ishikawa Y (March 1999). "Caveolin is an inhibitor of platelet-derived growth factor receptor ...
*  Olaratumab
... inhibits growth of tumour cells by blocking subunit alpha of the platelet-derived growth factor receptor, a type of ... It is directed against the platelet-derived growth factor receptor alpha. Olaratumab is used in combination with doxorubicin ...
*  Proliferative vitreoretinopathy
... transforming growth factor beta 2 (TGFβ2), platelet derived growth factor (PDGF) and interleukins have been shown to play a ... Andrews A, Balciunaite E, Leong FL, Tallquist M, Soriano P, Refojo M, Kazlauskas A (1999). "Platelet-derived growth factor ... RPE cells express the receptor for hepatocyte growth factor (HGF). HGF stimulates RPE cell migration and its presence is also ... "Correlation of Fibrosis and Transforming Growth Factor-β Type 2 Levels in the Eye". The Journal of Clinical Investigation. 83 ( ...
*  Trapidil
It also acts as an antagonist of platelet-derived growth factor. Büyükafşar, K; Yazar, A; Düşmez, D; Oztürk, H; Polat, G; ... a Platelet-Derived Growth Factor Antagonist, Reduces Restenosis After Percutaneous Transluminal Coronary Angioplasty. Results ...
*  Caveolin 1
Yamamoto, M; Toya Y; Jensen R A; Ishikawa Y (March 1999). "Caveolin is an inhibitor of platelet-derived growth factor receptor ... Epidermal growth factor receptor, Endothelin receptor type B, PDGFRB, PDGFRA, PTGS2, TRAF2, Estrogen receptor alpha, Caveolin 2 ... "Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I ... "Caveolin-1 associates with TRAF2 to form a complex that is recruited to tumor necrosis factor receptors". J. Biol. Chem. United ...
*  CCL2
Platelet derived growth factor is a major inducer of CCL2 gene. To become activated CCL2 protein has to be cleaved by ... In the bone, CCL2 is expressed by mature osteoclasts and osteoblasts and it is under control of nuclear factor κB (NFκB). In ... Kim MS, Day CJ, Morrison NA (Apr 2005). "MCP-1 is induced by receptor activator of nuclear factor-{kappa}B ligand, promotes ... Wahl SM, Greenwell-Wild T, Hale-Donze H, Moutsopoulos N, Orenstein JM (Sep 2000). "Permissive factors for HIV-1 infection of ...
*  Warren Jackson Pledger
Platelet-derived growth factor modulates epidermal growth factor receptors by a mechanism distinct from that of phorbol esters ... Modulation of the epidermal growth factor receptor by platelet-derived growth factor and choleragen: effects on mitogenesis. ... Dual control of cell growth by somatomedins and platelet-derived growth factor. Proc Natl Acad Sci U S A. 1979 Mar;76(3):1279- ... including platelet derived growth factor (PDGF) and insulin-like growthfactor-1 (IGF-1) signal transduction. He investigated ...
*  PDGFB
Platelet-derived growth factor subunit B is a protein that in humans is encoded by the PDGFB gene. The protein encoded by this ... "Entrez Gene: PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)". Kurup S, ... This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha ( ... Platelet-derived growth factor GRCh38: Ensembl release 89: ENSG00000100311 - Ensembl, May 2017 GRCm38: Ensembl release 89: ...
*  PTPN1
"Requirement for generation of H2O2 for platelet-derived growth factor signal transduction". Science. 270 (5234): 296-9. Bibcode ... including epidermal growth factor receptor, insulin-like growth factor 1 receptor, colony stimulating factor 1 receptor, c-Src ... Buckley DA, Cheng A, Kiely PA, Tremblay ML, O'Connor R (April 2002). "Regulation of Insulin-Like Growth Factor Type I (IGF-I) ... PTPN1 has been shown to interact with BCAR1, epidermal growth factor receptor, Grb2 and IRS1. PTP1B has clinical implications ...
*  AKT1
... and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is ... In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can ... Dickson LM, Rhodes CJ (2004). "Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein ... AKT8 was isolated from a spontaneous thymoma cell line derived from AKR mice by cocultivation with an indicator mink cell line ...
*  RAB3D
Cartel NJ, Wang J, Post M (2002). "Platelet-derived growth factor-BB-mediated glycosaminoglycan synthesis is transduced through ...
*  GRB2
"Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation". ... "Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras". Proceedings of the National ... "Direct interaction between Shc and the platelet-derived growth factor beta-receptor". The Journal of Biological Chemistry. 269 ... Riordan SM, Lidder S, Williams R, Skouteris GG (Sep 2000). "The beta-subunit of the hepatocyte growth factor/scatter factor ( ...
*  FOXE3
... also regulates platelet-derived growth factor receptor-α (Pdgfrα) expression. This is responsible for lens fiber ... Foxe3, also known as Forkhead Box E3, is a transcription factor that is responsible for the formation of the lens placode, a ... Forkhead box protein E3 (FOXE3) also known as forkhead-related transcription factor 8 (FREAC-8) is a protein that in humans is ... 2010). "The immunodominant epitope of centromere-associated protein A displays homology with the transcription factor forkhead ...
*  PDGFD
Platelet-derived growth factor D is a protein that in humans is encoded by the PDGFD gene. The protein encoded by this gene is ... "Entrez Gene: PDGFD platelet derived growth factor D". Bergsten E, Uutela M, Li X, et al. (2001). "PDGF-D is a specific, ... 2005). "Platelet-derived growth factor D, tissue-specific expression in the eye, and a key role in control of lens epithelial ... 2003). "Platelet-derived growth factor-D expression in developing and mature human kidneys". Kidney Int. 62 (6): 2043-54. doi: ...
*  Erdheim-Chester disease
"Imatinib mesylate for platelet-derived growth factor receptor-beta-positive Erdheim-Chester histiocytosis". Blood. 111 (11): ... 2011). "CNS involvement and treatment with interferon are independent prognostic factors in Erdheim-Chester Disease; a ...
*  PDGFC
2003). "Platelet-derived growth factor (PDGF)-C, a PDGF family member with a vascular endothelial growth factor-like structure ... 2005). "Regulation of fibrogenic/fibrolytic genes by platelet-derived growth factor C, a novel growth factor, in human dermal ... "Platelet-derived growth factor C (PDGF-C), a novel growth factor that binds to PDGF alpha and beta receptor". J. Biol. Chem. ... Platelet-derived growth factors are important in connective tissue growth, survival and function, and consist of disulphide- ...
*  Prostaglandin-endoperoxide synthase 2
Each subunit has three different structural domains: a short N-terminal epidermal growth factor (EGF) domain; an α-helical ... It sticks platelets together and promotes clotting; inhibiting this helps prevent heart disease. On the other hand, PTGS2 (COX- ... The absence of endoperoxide-containing products derived from 10,10-difluoroarachidonic acid has been thought to indicate the ... Callan OH, So OY, Swinney DC (February 1996). "The kinetic factors that determine the affinity and selectivity for slow binding ...
*  PTPN11
... on the human platelet-derived growth factor receptor". J. Biol. Chem. 268 (29): 21478-81. PMID 7691811. Chauhan D, Pandey P, ... "Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras". Proc. Natl. Acad. Sci. U.S.A ... C-epsilon are required for Grb2-associated binder-1 tyrosine phosphorylation in response to platelet-derived growth factor". J ... Growth hormone receptor, HoxA10, Insulin receptor, Insulin-like growth factor 1 receptor, IRS1, Janus kinase 1, Janus kinase 2 ...