... (PDGF) is one among numerous growth factors that regulate cell growth and division. In ... VEGFD Platelet-activating factor Platelet-derived growth factor receptor atheroma platelet involvement in smooth muscle ... "Vascular endothelial growth factor: A new member of the platelet-derived growth factor gene family". Biochemical and ... Platelet-derived growth factor is a dimeric glycoprotein that can be composed of two A subunits (PDGF-AA), two B subunits (PDGF ...

"Structures of a platelet-derived growth factor/propeptide complex and a platelet-derived growth factor/receptor complex". ... Platelet-derived growth factor receptors (PDGF-R) are cell surface tyrosine kinase receptors for members of the platelet- ... Platelet-Derived+Growth+Factor+Receptors at the U.S. National Library of Medicine Medical Subject Headings (MeSH) Portal: ... Heldin CH, Ostman A, Eriksson A, Siegbahn A, Claesson-Welsh L, Westermark B (March 1992). "Platelet-derived growth factor: ...

... , also termed CD140a, is a receptor located on the surface of a wide range of cell ... This receptor binds to certain isoforms of platelet-derived growth factors (PDGFs) and thereby becomes active in stimulating ... cell surface tyrosine kinase receptor for members of the platelet-derived growth factor family. Activation of PDGFRA requires ... Finally, growth factors outside of the PDGFR family (non-PDGFs) activate PDGFRα indirectly. Non-PDGFs bind to their own ...

... receptor Platelet-derived growth factor Zimmerman GA, McIntyre TM, Prescott SM, Stafforini DM (May ... Platelet Activating Factor) Platelet+Activating+Factor at the U.S. National Library of Medicine Medical Subject Headings (MeSH ... cytoplasmic platelet-activating factor acetylhydrolase 2, and platelet-activating factor acetylhydrolase 1b. Cations are one ... an enzyme that catabolizes platelet-activating factor. It is an important mediator of bronchoconstriction. It causes platelets ...

... fibroblast growth factor, insulin-like growth factor 1, platelet-derived epidermal growth factor, and vascular endothelial ... platelet factor 4, transforming growth factor-β1, platelet-derived growth factor, fibronectin, B-thromboglobulin, vWF, ... Platelets also secrete platelet-derived growth factor (PDGF). Platelets modulate neutrophils by forming platelet-leukocyte ... Platelets release platelet-derived growth factor (PDGF), a potent chemotactic agent; and TGF beta, which stimulates the ...

Platelet-derived growth factor and prostacyclin inhibition. Levin who was Barratt's registrar at Great Ormond Street stated of ...

... platelet‑derived growth factor (PGDF), transforming growth factors‑β (TGF‑β), vascular endothelial growth factor (VEGF), and ... Platelet derived growth factor along with bone morphogenetic proteins are among the most researched growth factors in ... Platelet-rich fibrin (PRF) or leukocyte- and platelet-rich fibrin (L-PRF) is a derivative of PRP where autologous platelets and ... Dohan, DM; Choukroun, J (2006). "Platelet-rich fibrin (PRF): a second-generation platelet concentrate. Part II: platelet- ...

Platelet-derived growth factor subunit A is a protein that in humans is encoded by the PDGFA gene. The protein encoded by this ... 1991). "Expression of platelet-derived growth factor A-chain (PDGF-A) mRNA in lung tissue and cells. Complex regulation during ... "Entrez Gene: PDGFA platelet-derived growth factor alpha polypeptide". Nath K, Gogi R, Khan AA, Hameed S (1978). "Vascular ... 1992). "Platelet-derived growth factor A chain: confirmation of localization of PDGFA to chromosome 7p22 and description of an ...

... platelet derived growth factor receptor A or alpha-type-platelet derived growth factor receptor) gene with the FIP1L1 gene (see ... "Platelet-derived growth factor receptor association with Na(+)/H(+) exchanger regulatory factor potentiates receptor activity ... "Structural and functional properties of platelet-derived growth factor and stem cell factor receptors". Cold Spring Harbor ... Platelet-derived growth factor receptor beta is a protein that in humans is encoded by the PDGFRB gene. Mutations in PDGFRB are ...

Fischer WH, Schubert D (Jan 1997). "Characterization of a novel platelet-derived growth factor-associated protein". J Neurochem ... Lee DY, Deng Z, Wang CH, Yang BB (2008). "MicroRNA-378 promotes cell survival, tumor growth, and angiogenesis by targeting SuFu ... of candidate tumor suppressor gene FUS1 isolated from the 3p21.3 homozygous deletion region leads to G1 arrest and growth ...

The TYMP gene is also known as ECGF1 (endothelial cell growth factor 1, platelet-derived) and MNGIE due to its role in MNGIE ... Identity of gliostatin and platelet-derived endothelial cell growth factor". J. Biol. Chem. 267 (28): 20311-6. doi:10.1016/ ... 1992). "Regional localization of the human platelet-derived endothelial cell growth factor (ECGF1) gene to chromosome 22q13". ... 1994). "Structural properties of 3.0 kb and 3.2 kb transcripts encoding platelet-derived endothelial cell growth factor/ ...

Fischer WH, Schubert D (Jan 1997). "Characterization of a novel platelet-derived growth factor-associated protein". J Neurochem ... 2001). "PDGF-D, a new protease-activated growth factor". Nat. Cell Biol. 3 (5): 517-21. doi:10.1038/35074593. PMID 11331882. ...

... including platelet-derived growth factor, fibroblast growth factor, and vascular endothelial growth factor). A randomized ... Epidermal Growth Factor Receptor (EGFR), Interleukin-13 (IL-13), Platelet-Derived Growth Factor (PDGF), Wnt/β-catenin signaling ... Andrae, Johanna; Gallini, Radiosa; Betsholtz, Christer (15 May 2008). "Role of platelet-derived growth factors in physiology ... Common genes implicated in fibrosis are Transforming Growth Factor-Beta (TGF-β), Connective Tissue Growth Factor (CTGF), ...

It is also known as "platelet-derived growth factor BB". The drug is used for the treatment of diabetic foot ulcers. Studies of ... Regranex is a human platelet-derived growth factor indicated along with good wound care for the treatment of lower extremity ... Heldin CH, Westermark B. Mechanism of action and in vivo role of platelet-derived growth factor. Physiol Rev. 1999;79:1283-1316 ... Nagai MK, Embil JM (February 2002). "Becaplermin: recombinant platelet derived growth factor, a new treatment for healing ...

FGF-2 is a more potent angiogenic factor than VEGF or PDGF (platelet-derived growth factor); however, it is less potent than ... by secreting various growth factors (e.g. VEGF) and proteins. Growth factors such as bFGF and VEGF can induce capillary growth ... "Platelet‐derived growth factor stabilises vascularisation in collagen‐glycosaminoglycan scaffolds". Journal of Tissue ... including several growth factors e.g. VEGF, FGF. The fibroblast growth factor (FGF) family with its prototype members FGF-1 ( ...

Cochran BH, Reffel AC, Stiles CD (July 1983). "Molecular cloning of gene sequences regulated by platelet-derived growth factor ... CXCL1 was first cloned from a cDNA library of genes induced by platelet-derived growth factor (PDGF) stimulation of BALB/c-3T3 ... July 1988). "Molecular characterization and chromosomal mapping of melanoma growth stimulatory activity, a growth factor ... "Enhanced tumor-forming capacity for immortalized melanocytes expressing melanoma growth stimulatory activity/growth-regulated ...

... transforming growth factor beta (TGF-β), fibroblast growth factors (FGFs), platelet-derived growth factor (PDGF), parathyroid ... A bone growth factor is a growth factor that stimulates the growth of bone tissue. Known bone growth factors include insulin- ... SMADS are transcription factors that will induce osteoblast growth. The majority of the substrates of platelet-derived growth ... There are 2 IGFs: Insulin-like growth factor 1 (IGF-1), and Insulin-like growth factor 2 (IGF-2). IGF-1 is induced by growth ...

... inhibits growth of tumour cells by blocking subunit alpha of the platelet-derived growth factor receptor, a type of ... It is directed against the platelet-derived growth factor receptor alpha. It was removed from the United States and European ...

... transforming growth factor beta 2 (TGFβ2), platelet derived growth factor (PDGF) and interleukins have been shown to play a ... Andrews A, Balciunaite E, Leong FL, Tallquist M, Soriano P, Refojo M, Kazlauskas A (1999). "Platelet-derived growth factor ... RPE cells express the receptor for hepatocyte growth factor (HGF). HGF stimulates RPE cell migration and its presence is also ... "Correlation of Fibrosis and Transforming Growth Factor-β Type 2 Levels in the Eye". The Journal of Clinical Investigation. 83 ( ...

It also acts as an antagonist of platelet-derived growth factor. An analog was assigned the codename AR 12-456. Büyükafşar K, ... December 1994). "Trapidil (triazolopyrimidine), a platelet-derived growth factor antagonist, reduces restenosis after ...

Yamamoto M, Toya Y, Jensen RA, Ishikawa Y (March 1999). "Caveolin is an inhibitor of platelet-derived growth factor receptor ... epidermal growth factor receptor, endothelin receptor type B, PDGFRB, PDGFRA, PTGS2, TRAF2, estrogen receptor alpha, caveolin 2 ... "Caveolin-1 regulates transforming growth factor (TGF)-beta/SMAD signaling through an interaction with the TGF-beta type I ... "Caveolin-1 associates with TRAF2 to form a complex that is recruited to tumor necrosis factor receptors". The Journal of ...

Platelet derived growth factor is a major inducer of CCL2 gene. CCR2 and CCR4 are two cell surface receptors that bind CCL2. ... In the bone, CCL2 is expressed by mature osteoclasts and osteoblasts and it is under control of nuclear factor κB (NFκB). In ... Kim MS, Day CJ, Morrison NA (April 2005). "MCP-1 is induced by receptor activator of nuclear factor-κB ligand, promotes human ... Wahl SM, Greenwell-Wild T, Hale-Donze H, Moutsopoulos N, Orenstein JM (September 2000). "Permissive factors for HIV-1 infection ...

Platelet-derived growth factor modulates epidermal growth factor receptors by a mechanism distinct from that of phorbol esters ... Modulation of the epidermal growth factor receptor by platelet-derived growth factor and choleragen: effects on mitogenesis. ... Dual control of cell growth by somatomedins and platelet-derived growth factor. Proc Natl Acad Sci U S A. 1979 Mar;76(3):1279- ... including platelet derived growth factor (PDGF) and insulin-like growthfactor-1 (IGF-1) signal transduction. He investigated ...

"Requirement for generation of H2O2 for platelet-derived growth factor signal transduction". Science. 270 (5234): 296-9. Bibcode ... including epidermal growth factor receptor, insulin-like growth factor 1 receptor, colony stimulating factor 1 receptor, c-Src ... epidermal growth factor receptor, Grb2 and IRS1. Vascular endothelial growth factor Receptor-2 and Vascular endothelial growth ... Buckley DA, Cheng A, Kiely PA, Tremblay ML, O'Connor R (April 2002). "Regulation of Insulin-Like Growth Factor Type I (IGF-I) ...

... and the related AKT2 are activated by platelet-derived growth factor. The activation is rapid and specific, and it is ... In the developing nervous system AKT is a critical mediator of growth factor-induced neuronal survival. Survival factors can ... Dickson LM, Rhodes CJ (2004). "Pancreatic beta-cell growth and survival in the onset of type 2 diabetes: a role for protein ... AKT8 was isolated from a spontaneous thymoma cell line derived from AKR mice by cocultivation with an indicator mink cell line ...

Cartel NJ, Wang J, Post M (2002). "Platelet-derived growth factor-BB-mediated glycosaminoglycan synthesis is transduced through ...

"Tyr-716 in the platelet-derived growth factor beta-receptor kinase insert is involved in GRB2 binding and Ras activation". ... "Protein-tyrosine-phosphatase SHPTP2 couples platelet-derived growth factor receptor beta to Ras". Proceedings of the National ... "Direct interaction between Shc and the platelet-derived growth factor beta-receptor". The Journal of Biological Chemistry. 269 ... Colony stimulating factor 1 receptor, DCTN1, DNM1, Dock180, Dystroglycan, EPH receptor A2, ETV6, Epidermal growth factor ...

... also regulates platelet-derived growth factor receptor-α (Pdgfrα) expression. This is responsible for lens fiber ... Foxe3, also known as Forkhead Box E3, is a transcription factor that is responsible for the formation of the lens placode, a ... Forkhead box protein E3 (FOXE3) also known as forkhead-related transcription factor 8 (FREAC-8) is a protein that in humans is ... 2010). "The immunodominant epitope of centromere-associated protein A displays homology with the transcription factor forkhead ...

Platelet-derived growth factor subunit B is a protein that in humans is encoded by the PDGFB gene. The protein encoded by this ... "Entrez Gene: PDGFB platelet-derived growth factor beta polypeptide (simian sarcoma viral (v-sis) oncogene homolog)". Kurup S, ... This gene product can exist either as a homodimer (PDGF-BB) or as a heterodimer with the platelet-derived growth factor alpha ( ... Platelet-derived growth factor GRCh38: Ensembl release 89: ENSG00000100311 - Ensembl, May 2017 GRCm38: Ensembl release 89: ...

Platelet-derived growth factor D is a protein that in humans is encoded by the PDGFD gene. The protein encoded by this gene is ... "Entrez Gene: PDGFD platelet derived growth factor D". Bergsten E, Uutela M, Li X, et al. (2001). "PDGF-D is a specific, ... 2005). "Platelet-derived growth factor D, tissue-specific expression in the eye, and a key role in control of lens epithelial ... 2003). "Platelet-derived growth factor-D expression in developing and mature human kidneys". Kidney Int. 62 (6): 2043-54. doi: ...